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  1. Book ; Online ; E-Book: Neuroanatomy of neuroendocrine systems

    Grinevich, Valery / Dobolyi, Árpád

    (Masterclass in Neuroendocrinology ; v.12)

    2022  

    Author's details edited by Valery Grinevich and Árpád Dobolyi
    Series title Masterclass in Neuroendocrinology ; v.12
    Keywords Neuroanatomy ; Endocrine glands ; Neuroanatomia ; Glàndules endocrines
    Subject code 611.81
    Language English
    Size 1 online resource (521 pages)
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-86630-0 ; 9783030866297 ; 978-3-030-86630-3 ; 3030866297
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Neuroanatomy of Neuroendocrine Systems

    Dobolyi, Árpád / Grinevich, Valery

    (Masterclass in Neuroendocrinology)

    2022  

    Author's details Valery Grinevich received his MD in 1992 (Kursk State Medical University, Russia) and PhD in 1996 (Russian Academy of Sciences, Saint-Petersburg). As a postdoctoral fellow, he worked with leading experts in neuroendocrinology, Georges Pelletier and Ferdinand Labrie (Quebec), and Greti Aguilera (NIH) focusing on neuroendocrine mechanisms of the stress response. In 2003, he joined the team of Peter H. Seeburg at the Max Planck Institute for Medical Research (MPIMF) Heidelberg. In 2008, he established his own group at the MPIMF and in 2012 - the Independent Schaller Group on Neuropeptides in Heidelberg. During the last decade, Grinevich's team deciphered a novel mechanism of neuropeptide signalling in the brain: axonal oxytocin release modulating brain region specific behaviors. His work was supported by the Chica and Heinz Schaller Foundation, a number of German and European Agencies, and by the Human Frontier Science Program. In 2019 he has been promoted as Full University Professor
    Series title Masterclass in Neuroendocrinology
    Keywords Hypothalamic Circuits ; Metabolism and Behavior ; neuropeptides ; Neuroendocrine Neurons ; Hypothalamus ; Pituitary ; Releasing hormones ; oxytocin ; Circadian clock ; pituitary hormones ; Neuropeptides ; Releasing Hormones ; neuroanatomy ; circadian clock
    Language English
    Size 532 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_13
    Format 160 x 241 x 34
    ISBN 9783030866297 ; 3030866297
    Database PDA

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  3. Book ; Online ; E-Book: Behavioral pharmacology of neuropeptides: Oxytocin

    Hurlemann, René / Grinevich, Valéry

    (Current topics of behavioral neurosciences ; volume 35)

    2018  

    Author's details Editors René Hurlemann, Valery Grinevich
    Series title Current topics of behavioral neurosciences ; volume 35
    Current topics in behavioral neurosciences
    Collection Current topics in behavioral neurosciences
    Language English
    Size 1 Online-Ressource (viii, 592 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019826495
    ISBN 978-3-319-63739-6 ; 9783319637389 ; 3-319-63739-8 ; 331963738X
    DOI 10.1007/978-3-319-63739-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Social neuroscience: How we learn to avoid the bully.

    Maier, Eduard / Grinevich, Valery

    Current biology : CB

    2024  Volume 34, Issue 8, Page(s) R320–R322

    Abstract: During social interactions, individuals evaluate relationships with their peers and switch from approach to avoidance, particularly in response to aggressive encounters. A new study in mice investigated the underlying brain mechanisms and identified ... ...

    Abstract During social interactions, individuals evaluate relationships with their peers and switch from approach to avoidance, particularly in response to aggressive encounters. A new study in mice investigated the underlying brain mechanisms and identified oxytocin as a key regulator of social avoidance learning.
    MeSH term(s) Animals ; Oxytocin/metabolism ; Oxytocin/physiology ; Mice ; Aggression ; Avoidance Learning/physiology ; Social Behavior ; Brain/physiology ; Neurosciences ; Social Interaction ; Humans
    Chemical Substances Oxytocin (50-56-6)
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2024.03.012
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Book ; Online: Development of the Hypothalamus

    Puelles, Luis / Grinevich, Valery / Alvarez-Bolado, Gonzalo

    2015  

    Abstract: The hypothalamus is the region of the brain in charge of the maintenance of the internal milieu of the organism. It is also essential to orchestrate reproductive, parental, aggressive-defensive, and other social behaviors, and for the expression of ... ...

    Abstract The hypothalamus is the region of the brain in charge of the maintenance of the internal milieu of the organism. It is also essential to orchestrate reproductive, parental, aggressive-defensive, and other social behaviors, and for the expression of emotions. Due to the structural complexity of the hypothalamus, however, many basic aspects of its ontogenesis are still mysterious. Nowadays we assist to a renewal of interest spurred in part by the growing realization that prenatal and early postnatal influences on the hypothalamus could entail pathological conditions later in life. Intriguing questions for the future include: do early specification phenomena reflect on adult hypothalamic function and possibly on some kinds of behavior? Can early events like specification, migration or formation of nuclei influence adult hypothalamic function? A change in morphological paradigm, from earlier columnar interpretations to neuromeric ones, is taking place. Concepts long taken for granted start to be challenged in view of advances in developmental and comparative neurobiology, and notably also in the molecular characterization of hypothalamic structures. How should we understand the position of the hypothalamus in relation to other brain regions? Should we bundle it together with the thalamus, a functionally, genetically and developmentally very different structure? Does the classic concept of "diencephalon" make sense, or should the hypothalamus be separated? Does the preoptic area belong to the hypothalamus or the telencephalon? The answer to these questions in the context of recent causal molecular analysis will help to understand hypothalamic evolution and morphogenesis as well as its adult function and connectivity. In this Research Topic we have reviewed the fundamentals of hypothalamic ontogenesis and evolution, summarizing present-day knowledge, taking stock of the latest advances, and anticipating future challenges
    Keywords Science (General) ; Neurosciences. Biological psychiatry. Neuropsychiatry
    Size 1 electronic resource (264 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020091827
    ISBN 9782889196340 ; 2889196348
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article: The Relationship Between Oxytocin and Alcohol Dependence.

    Schimmer, Jonas / Patwell, Ryan / Küppers, Stephanie / Grinevich, Valery

    Current topics in behavioral neurosciences

    2023  

    Abstract: The hypothalamic neuropeptide oxytocin (OT) is well known for its prosocial, anxiolytic, and ameliorating effects on various psychiatric conditions, including alcohol use disorder (AUD). In this chapter, we will first introduce the basic neurophysiology ... ...

    Abstract The hypothalamic neuropeptide oxytocin (OT) is well known for its prosocial, anxiolytic, and ameliorating effects on various psychiatric conditions, including alcohol use disorder (AUD). In this chapter, we will first introduce the basic neurophysiology of the OT system and its interaction with other neuromodulatory and neurotransmitter systems in the brain. Next, we provide an overview over the current state of research examining the effects of acute and chronic alcohol exposure on the OT system as well as the effects of OT system manipulation on alcohol-related behaviors in rodents and humans. In rodent models of AUD, OT has been repeatedly shown to reduce ethanol consumption, particularly in models of acute alcohol exposure. In humans however, the results of OT administration on alcohol-related behaviors are promising but not yet conclusive. Therefore, we further discuss several physiological and methodological limitations to the effective application of OT in the clinic and how they may be mitigated by the application of synthetic OT receptor (OTR) agonists. Finally, we discuss the potential efficacy of cutting-edge pharmacology and gene therapies designed to specifically enhance endogenous OT release and thereby rescue deficient expression of OT in the brains of patients with severe forms of AUD and other incurable mental disorders.
    Language English
    Publishing date 2023-09-12
    Publishing country Germany
    Document type Journal Article
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2023_444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The multiple faces of the oxytocin and vasopressin systems in the brain.

    Grinevich, Valery / Ludwig, Mike

    Journal of neuroendocrinology

    2021  Volume 33, Issue 11, Page(s) e13004

    Abstract: Classically, hypothalamic neuroendocrine cells that synthesise oxytocin and vasopressin were categorised in two major cell types: the magnocellular and parvocellular neurones. It was assumed that magnocellular neurones project exclusively to the ... ...

    Abstract Classically, hypothalamic neuroendocrine cells that synthesise oxytocin and vasopressin were categorised in two major cell types: the magnocellular and parvocellular neurones. It was assumed that magnocellular neurones project exclusively to the pituitary gland where they release oxytocin and vasopressin into the systemic circulation. The parvocellular neurones, on the other hand, project within the brain to regulate discrete brain circuitries and behaviours. Within the last few years, it has become evident that the classical view of these projections is outdated. It is now clear that oxytocin and vasopressin in the brain are released extrasynaptically from dendrites and from varicosities in distant axons. The peptides act principally to modulate information transfer through conventional synapses (such as glutamate synapses) by actions at respective receptors that may be preferentially localised to synaptic regions (on either side of the synapse) to alter the 'gain' of conventional synapses.
    MeSH term(s) Brain/metabolism ; Hypothalamus/metabolism ; Neurons/metabolism ; Oxytocin/physiology ; Vasopressins/metabolism
    Chemical Substances Vasopressins (11000-17-2) ; Oxytocin (50-56-6)
    Language English
    Publishing date 2021-07-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1007517-3
    ISSN 1365-2826 ; 0953-8194
    ISSN (online) 1365-2826
    ISSN 0953-8194
    DOI 10.1111/jne.13004
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    Zs.A 2634: Show issues Location:
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  8. Book ; Online ; Thesis: Organoid assembloids modelling the role of serotonin during human cortical development

    Siekmann, Marco Torben [Verfasser] / Grinevich, Valéry [Akademischer Betreuer]

    2023  

    Author's details Marco Torben Siekmann ; Betreuer: Valery Grinevich
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek Heidelberg
    Publishing place Heidelberg
    Document type Book ; Online ; Thesis
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  9. Article ; Online: Brain oxytocin: how puzzle stones from animal studies translate into psychiatry.

    Grinevich, Valery / Neumann, Inga D

    Molecular psychiatry

    2020  Volume 26, Issue 1, Page(s) 265–279

    Abstract: The neuropeptide oxytocin has attracted great attention of the general public, basic neuroscience researchers, psychologists, and psychiatrists due to its profound pro-social, anxiolytic, and "anti-stress" behavioral and physiological effects, and its ... ...

    Abstract The neuropeptide oxytocin has attracted great attention of the general public, basic neuroscience researchers, psychologists, and psychiatrists due to its profound pro-social, anxiolytic, and "anti-stress" behavioral and physiological effects, and its potential application for treatment of mental diseases associated with altered socio-emotional competence. During the last decade, substantial progress has been achieved in understanding the complex neurobiology of the oxytocin system, including oxytocinergic pathways, local release patterns, and oxytocin receptor distribution in the brain, as well as intraneuronal oxytocin receptor signaling. However, the picture of oxytocin actions remains far from being complete, and the central question remains: "How does a single neuropeptide exert such pleotropic actions?" Although this phenomenon, typical for many of about 100 identified neuropeptides, may emerge from the anatomical divergence of oxytocin neurons, their multiple central projections, distinct oxytocin-sensitive cell types in different brain regions, and multiple intraneuronal signaling pathways determining the specific cellular response, further basic studies are required. In conjunction, numerous reports on positive effects of intranasal application of oxytocin on human brain networks controlling socio-emotional behavior in health and disease require harmonic tandems of basic researchers and clinicians. During the COVID-19 crisis in 2020, oxytocin research seems central as question of social isolation-induced inactivation of the oxytocin system, and buffering effects of either activation of the endogenous system or intranasal application of synthetic oxytocin need to be thoroughly investigated.
    MeSH term(s) Animals ; Brain/physiology ; COVID-19/psychology ; Humans ; Models, Neurological ; Neural Pathways/physiology ; Oxytocin/physiology ; Social Isolation/psychology
    Chemical Substances Oxytocin (50-56-6)
    Keywords covid19
    Language English
    Publishing date 2020-06-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-020-0802-9
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  10. Book ; Online ; Thesis: Characterization of mouse preoptic area cellular populations involved in thermoregulation

    Žuža, Kristina [Verfasser] / Grinevich, Valéry [Akademischer Betreuer]

    2022  

    Author's details Kristina Zuza ; Betreuer: Valery Grinevich
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language English
    Publisher Universitätsbibliothek Heidelberg
    Publishing place Heidelberg
    Document type Book ; Online ; Thesis
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