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Article ; Online: Regulation of negative emotional behavior.

Ikemoto, Satoshi

2019 Volume 366, Issue 6469, Page(s) 1071–1072

MeSH term(s)	Animals ; Emotions ; Mice ; Social Control, Formal
Language	English
Publishing date	2019-11-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Comment
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.aaz8638
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Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

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Article ; Online: Prediction of endogenous mineralocorticoid receptor activity by depressor effects of mineralocorticoid receptor antagonists in patients with primary aldosteronism.

Ikemoto, Makiko / Morimoto, Satoshi / Ichihara, Atsuhiro

Hypertension research : official journal of the Japanese Society of Hypertension

2024

Abstract: Patients with primary aldosteronism have an increased risk of developing cardiovascular disease. The response to mineralocorticoid receptor antagonists varies among individuals, indicating diverse mineralocorticoid receptor activities in these patients. ... ...

Abstract	Patients with primary aldosteronism have an increased risk of developing cardiovascular disease. The response to mineralocorticoid receptor antagonists varies among individuals, indicating diverse mineralocorticoid receptor activities in these patients. This study explored the factors linked to the efficacy of blood pressure reduction through mineralocorticoid receptor antagonists in patients with primary aldosteronism. We examined the relationship between the reduction in blood pressure and patient characteristics in a group of 41 patients with primary aldosteronism (24 males, mean age 55 ± 13 years, including 34 patients diagnosed with bilateral primary aldosteronism) before and after undergoing treatment with mineralocorticoid receptor antagonists. Significant reductions in office blood pressure were observed 3 and 6 months after treatment initiation. Single correlation analyses showed that the urinary chloride-to-potassium ratio displayed the strongest positive association with blood pressure reduction, surpassing plasma aldosterone concentration, plasma renin activity, and urinary sodium-to-potassium ratio, at 3 and 6 months. Multiple correlation analyses revealed a consistent and independent positive correlation between the urinary chloride-to-potassium ratio and blood pressure reduction at 3 and 6 months. The optimal threshold for the urinary chloride-to-potassium ratio with respect to its ability to lower blood pressure, was determined as 3.18. These results imply that the urinary chloride-to-potassium ratio may be independently associated with the effectiveness of blood pressure reduction facilitated by mineralocorticoid receptor antagonists. Moreover, it could potentially serve as a valuable predictor of the effectiveness of these agents and function as an indicator of endogenous mineralocorticoid receptor activity in patients with primary aldosteronism.
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1175297-x
ISSN	1348-4214 ; 0916-9636
ISSN (online)	1348-4214
ISSN	0916-9636
DOI	10.1038/s41440-024-01651-5
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Zs.A 3898: Show issues

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Article ; Online: Seeking motivation and reward: Roles of dopamine, hippocampus, and supramammillo-septal pathway.

Kesner, Andrew J / Calva, Coleman B / Ikemoto, Satoshi

Progress in neurobiology

2022 Volume 212, Page(s) 102252

Abstract: Reinforcement learning and goal-seeking behavior are thought to be mediated by midbrain dopamine neurons. However, little is known about neural substrates of curiosity and exploratory behavior, which occur in the absence of clear goal or reward. This is ... ...

Abstract	Reinforcement learning and goal-seeking behavior are thought to be mediated by midbrain dopamine neurons. However, little is known about neural substrates of curiosity and exploratory behavior, which occur in the absence of clear goal or reward. This is despite behavioral scientists having long suggested that curiosity and exploratory behaviors are regulated by an innate drive. We refer to such behavior as information-seeking behavior and propose 1) key neural substrates and 2) the concept of environment prediction error as a framework to understand information-seeking processes. The cognitive aspect of information-seeking behavior, including the perception of salience and uncertainty, involves, in part, the pathways from the posterior hypothalamic supramammillary region to the hippocampal formation. The vigor of such behavior is modulated by the following: supramammillary glutamatergic neurons; their projections to medial septal glutamatergic neurons; and the projections of medial septal glutamatergic neurons to ventral tegmental dopaminergic neurons. Phasic responses of dopaminergic neurons are characterized as signaling potentially important stimuli rather than rewards. This paper describes how novel stimuli and uncertainty trigger seeking motivation and how these neural substrates modulate information-seeking behavior.
MeSH term(s)	Dopamine ; Dopaminergic Neurons ; Hippocampus ; Humans ; Motivation ; Reward
Chemical Substances	Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2022-02-25
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
ZDB-ID	185535-9
ISSN	1873-5118 ; 0301-0082
ISSN (online)	1873-5118
ISSN	0301-0082
DOI	10.1016/j.pneurobio.2022.102252
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Article ; Online: Median Raphe Nonserotonergic Neurons Modulate Hippocampal Theta Oscillations.

Huang, Wenqiang / Ikemoto, Satoshi / Wang, Dong V

The Journal of neuroscience : the official journal of the Society for Neuroscience

2022 Volume 42, Issue 10, Page(s) 1987–1998

Abstract: Hippocampal theta oscillations (HTOs) during rapid eye movement (REM) sleep play an important role in mnemonic processes by coordinating hippocampal and cortical activities. However, it is not fully understood how HTOs are modulated by subcortical ... ...

Abstract	Hippocampal theta oscillations (HTOs) during rapid eye movement (REM) sleep play an important role in mnemonic processes by coordinating hippocampal and cortical activities. However, it is not fully understood how HTOs are modulated by subcortical regions, including the median raphe nucleus (MnR). The MnR is thought to suppress HTO through its serotonergic outputs. Here, our study on male mice revealed a more complex framework indicating roles of nonserotonergic MnR outputs in regulating HTO. We found that nonselective optogenetic activation of MnR neurons at theta frequency increased HTO amplitude. Granger causality analysis indicated that MnR theta oscillations during REM sleep influence HTO. By using three transgenic mouse lines, we found that MnR serotonergic neurons exhibited little or no theta-correlated activity during HTO. Instead, most MnR GABAergic neurons and Vglut3 neurons respectively increased and decreased activities during HTO and exhibited hippocampal theta phase-locked activities. Although MnR GABAergic neurons do not directly project to the hippocampus, they could modulate HTO through local Vglut3 and serotonergic neurons as we found that MnR GABAergic neurons monosynaptically targeted Vglut3 and serotonergic neurons. Additionally, pontine wave recorded from the MnR during REM sleep accompanied nonserotonergic activity increase and HTO acceleration. These results suggest that MnR nonserotonergic neurons modulate hippocampal theta activity during REM sleep, which regulates memory processes.
MeSH term(s)	Animals ; GABAergic Neurons/physiology ; Hippocampus/physiology ; Male ; Mice ; Raphe Nuclei ; Septum of Brain ; Serotonergic Neurons ; Theta Rhythm/physiology
Language	English
Publishing date	2022-01-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.1536-21.2022
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Zs.A 1668: Show issues

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Article ; Online: Effect of Left Ventricular Hyperenhancement in Magnetic Resonance Imaging on Reverse Remodeling After Mitral Valve Repair for Moderate Ischemic Mitral Regurgitation.

Yamazaki, Sachiko / Numata, Satoshi / Kawajiri, Hidetake / Manabe, Kaichiro / Ikemoto, Koki / Teramukai, Satoshi / Yaku, Hitoshi

Seminars in thoracic and cardiovascular surgery

2022 Volume 35, Issue 2, Page(s) 239–248

Abstract: We aimed to investigate cardiac magnetic resonance imaging (MRI)-derived predictors of a lack of left ventricular (LV) reverse remodeling after undersized mitral annuloplasty (uMAP) for moderate ischemic mitral regurgitation (IMR). We retrospectively ... ...

Abstract	We aimed to investigate cardiac magnetic resonance imaging (MRI)-derived predictors of a lack of left ventricular (LV) reverse remodeling after undersized mitral annuloplasty (uMAP) for moderate ischemic mitral regurgitation (IMR). We retrospectively reviewed 31 patients who underwent uMAP for moderate IMR and cardiac MRI evaluation between 2004 and 2017. Cardiac MRI evaluation included cine MRI LV and right ventricular volumetric measurements and gadolinium-enhanced MRI assessment of myocardial scarring. LV dimensions were assessed preoperatively, postoperatively, and at follow-up using serial transthoracic echocardiography, and the mid-term (median, 49 months) predictors of a lack of LV reverse remodeling were analyzed. At the mid-term follow-up (mean follow-up period: 85 ± 40 months), 15 patients exhibited reverse LV remodeling. The relative reduction in LV dimension at follow-up was negatively correlated with the preoperative number of LV segments with myocardial infarction (MI) (defined as an LV segment with >25% enhancement). The optimal cut-off for predicting a lack of reverse LV remodeling at follow-up was >5 LV segments with MI, with a sensitivity and specificity of 92% and 92%, respectively. This cut-off value also predicted all-cause mortality at follow-up, with a sensitivity and specificity of 88% and 67%, respectively. The presence of >5 LV segments with MI on gadolinium-enhanced MRI might be a useful predictor of lack of reverse LV remodeling and all-cause mortality outcomes after undersized mitral annuloplasty for moderate IMR.
MeSH term(s)	Humans ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery ; Mitral Valve Insufficiency/etiology ; Myocardial Ischemia/complications ; Myocardial Ischemia/diagnostic imaging ; Myocardial Ischemia/surgery ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Coronary Artery Bypass/adverse effects ; Retrospective Studies ; Gadolinium ; Treatment Outcome ; Ischemia ; Magnetic Resonance Imaging/adverse effects ; Ventricular Remodeling ; Mitral Valve Annuloplasty/adverse effects
Chemical Substances	Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2022-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1038278-1
ISSN	1532-9488 ; 1043-0679
ISSN (online)	1532-9488
ISSN	1043-0679
DOI	10.1053/j.semtcvs.2022.02.007
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Zs.A 2747: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Dissociation Between Incubation of Cocaine Craving and Anxiety-Related Behaviors After Continuous and Intermittent Access Self-Administration.

Nicolas, Celine / Russell, Trinity I / Shaham, Yavin / Ikemoto, Satoshi

Frontiers in neuroscience

2022 Volume 15, Page(s) 824741

Abstract: Studies using either continuous or intermittent access cocaine self-administration procedures showed that cocaine seeking increases during abstinence (incubation of cocaine craving), and that this effect is higher after intermittent cocaine access. Other ...

Abstract	Studies using either continuous or intermittent access cocaine self-administration procedures showed that cocaine seeking increases during abstinence (incubation of cocaine craving), and that this effect is higher after intermittent cocaine access. Other studies showed that cocaine abstinence is characterized by the emergence of stress- and anxiety-related states which were hypothesized to increase relapse vulnerability. We examined whether incubation of cocaine craving and anxiety-related behaviors are correlated and whether intermittent cocaine self-administration would potentiate these behaviors during abstinence. Male rats self-administered cocaine either continuously (6 h/day) or intermittently (5 min ON, 25 min OFF × 12) for 14 days, followed by relapse tests after 1 or 21 abstinence days. A group of rats that self-administered saline served as a control. Anxiety-related behaviors were measured on the same abstinence days, using the novelty induced-hypophagia test. Finally, motivation for cocaine was measured using a progressive ratio reinforcement schedule. Lever-presses after 21 abstinence days were higher than after 1 day and this incubation effect was higher in the intermittent access group. Progressive ratio responding was also higher after intermittent cocaine access. Intermittent and continuous cocaine access did not induce anxiety-like responses in the novelty-induced hypophagia test after 1 or 21 abstinence days. Independent of the access condition, incubation of cocaine seeking was not correlated with the novelty-induced hypophagia measures. Results suggest that cocaine-induced anxiety-related states during protracted abstinence do not contribute to incubation of cocaine craving. However, this conclusion is tentative because we used a single anxiety-related measure and did not test female rats.
Language	English
Publishing date	2022-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2021.824741
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Article ; Online: Water-dispersible donor-acceptor-donor π-conjugated bolaamphiphiles enabling a humidity-responsive luminescence color change.

Enjou, Tomoya / Goto, Shimpei / Liu, Qiming / Ishiwari, Fumitaka / Saeki, Akinori / Uemtasu, Taro / Ikemoto, Yuka / Watanabe, Sora / Matsuba, Go / Ishibashi, Kouichiro / Watanabe, Go / Minakata, Satoshi / Sagara, Yoshimitsu / Takeda, Youhei

Chemical communications (Cambridge, England)

2024 Volume 60, Issue 27, Page(s) 3653–3656

Abstract: Novel water-dispersible donor-acceptor-donor π-conjugated bolaamphiphiles, having dibenzophenazine as the acceptor and heteroatom-bridged amphiphilic diarylamines as the donors, have been developed. The materials displayed a distinct photoluminescence ... ...

Abstract	Novel water-dispersible donor-acceptor-donor π-conjugated bolaamphiphiles, having dibenzophenazine as the acceptor and heteroatom-bridged amphiphilic diarylamines as the donors, have been developed. The materials displayed a distinct photoluminescence color change in response to humidity in a poly(vinylalcohol) matrix.
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc05749f
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Article ; Online: Correction: Water-dispersible donor-acceptor-donor π-conjugated bolaamphiphiles enabling a humidity-responsive luminescence color change.

Enjou, Tomoya / Goto, Shimpei / Liu, Qiming / Ishiwari, Fumitaka / Saeki, Akinori / Uematsu, Taro / Ikemoto, Yuka / Watanabe, Sora / Matsuba, Go / Ishibashi, Kouichiro / Watanabe, Go / Minakata, Satoshi / Sagara, Yoshimitsu / Takeda, Youhei

Chemical communications (Cambridge, England)

2024 Volume 60, Issue 28, Page(s) 3862

Abstract: Correction for 'Water-dispersible donor-acceptor-donor π-conjugated bolaamphiphiles enabling a humidity-responsive luminescence color change' by Tomoya ... ...

Abstract	Correction for 'Water-dispersible donor-acceptor-donor π-conjugated bolaamphiphiles enabling a humidity-responsive luminescence color change' by Tomoya Enjou
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Published Erratum
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d4cc90105c
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Article ; Online: Mechanochemical Synthesis of Non-Solvated Dialkylalumanyl Anion and XPS Characterization of Al(I) and Al(II) Species.

Kurumada, Satoshi / Yamanashi, Ryotaro / Sugita, Kengo / Kubota, Koji / Ito, Hajime / Ikemoto, Satoru / Chen, Chaoqi / Moriyama, Takumi / Muratsugu, Satoshi / Tada, Mizuki / Koitaya, Takanori / Ozaki, Taisuke / Yamashita, Makoto

Chemistry (Weinheim an der Bergstrasse, Germany)

2023 Volume 30, Issue 7, Page(s) e202303073

Abstract: A non-solvated alkyl-substituted Al(I) anion dimer was synthesized by a reduction of haloalumane precursor using a mechanochemical method. The crystallographic and theoretical analysis revealed its structure and electronic properties. Experimental XPS ... ...

Abstract	A non-solvated alkyl-substituted Al(I) anion dimer was synthesized by a reduction of haloalumane precursor using a mechanochemical method. The crystallographic and theoretical analysis revealed its structure and electronic properties. Experimental XPS analysis of the Al(I) anions with reference compounds revealed the lower Al 2p binding energy corresponds to the lower oxidation state of Al species. It should be emphasized that the experimentally obtained XPS binding energies were reproduced by delta SCF calculations and were linearly correlated with NPA charges and 2p orbital energies.
Language	English
Publishing date	2023-12-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202303073
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Article ; Online: Effect of ginger extract ingestion on skeletal muscle glycogen contents and endurance exercise in male rats.

Hattori, Satoshi / Omi, Naomi / Yang, Zhou / Nakamura, Moeka / Ikemoto, Masahiro

Physical activity and nutrition

2021 Volume 25, Issue 2, Page(s) 15–19

Abstract: Purpose: Skeletal muscle glycogen is a determinant of endurance capacity for some athletes. Ginger is well known to possess nutritional effects, such as anti-diabetic effects. We hypothesized that ginger extract (GE) ingestion increases skeletal muscle ... ...

Abstract	Purpose: Skeletal muscle glycogen is a determinant of endurance capacity for some athletes. Ginger is well known to possess nutritional effects, such as anti-diabetic effects. We hypothesized that ginger extract (GE) ingestion increases skeletal muscle glycogen by enhancing fat oxidation. Thus, we investigated the effect of GE ingestion on exercise capacity, skeletal muscle glycogen, and certain blood metabolites in exercised rats. Methods: First, we evaluated the influence of GE ingestion on body weight and elevation of exercise performance in rats fed with different volumes of GE. Next, we measured the skeletal muscle glycogen content and free fatty acid (FFA) levels in GE-fed rats. Finally, we demonstrated that GE ingestion contributes to endurance capacity during intermittent exercise to exhaustion. Results: We confirmed that GE ingestion increased exercise performance (p<0.05) and elevated the skeletal muscle glycogen content compared to the non- GE-fed (CE, control exercise) group before exercise (Soleus: p<0.01, Plantaris: p<0.01, Gastrocnemius: p<0.05). Blood FFA levels in the GE group were significantly higher than those in the CE group after exercise (p<0.05). Moreover, we demonstrated that exercise capacity was maintained in the CE group during intermittent exercise (p<0.05). Conclusion: These findings indicate that GE ingestion increases skeletal muscle glycogen content and exercise performance through the upregulation of fat oxidation.
Language	English
Publishing date	2021-06-30
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2733-7545
ISSN (online)	2733-7545
DOI	10.20463/pan.2021.0010
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