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Article ; Online: Wild brains: The value of neuroethological approaches in preclinical behavioral neuroscience animal models.

Lambert, Kelly

2023 Volume 146, Page(s) 105044

Abstract: ... slowly navigated toward the inclusion of more diverse species (e.g., nonhuman primate models, wild rats ...

Abstract	For three decades, IBNS has provided a forum for the dissemination of behavioral neuroscience research, broadly defined. Throughout this time, research presented at the annual meetings has reflected representative trends in the field with an emphasis on relevant preclinical animal models. From its inception, IBNS has contributed to my professional development and evolving research interests. Unsurprisingly, throughout the three decades of its existence, IBNS annual programs have reflected research trends that have been thoughtfully evaluated, challenged, and, in some cases, recalibrated. An emphasis in my lab, for example, has slowly navigated toward the inclusion of more diverse species (e.g., nonhuman primate models, wild rats, wild and captive raccoons) assessed in settings that reflect more ethological relevance than typically observed in traditional laboratory settings. Consequently, my research interests are pivoting from laboratory animal model exclusive (L.A.M.E.) endeavors to more natural, diverse, ethoexperimental approaches. As progress toward translational findings for psychiatric and neurological conditions is considered, it is recommended that researchers remain open to nontraditional methodological approaches that incorporate diverse animal models and assessments to inform laboratory-generated findings.
MeSH term(s)	Animals ; Rats ; Models, Animal ; Behavior, Animal ; Neurosciences ; Behavioral Research ; Brain
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	282464-4
ISSN	1873-7528 ; 0149-7634
ISSN (online)	1873-7528
ISSN	0149-7634
DOI	10.1016/j.neubiorev.2023.105044
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Zs.A 1371: Show issues

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Article ; Online: The potential effects of climate change on the prevalence of gestational diabetes are less apparent with different diagnostic criteria.

Van Gemert, Tegan E / Moses, Robert G / Lambert, Kelly

The Australian & New Zealand journal of obstetrics & gynaecology

2021 Volume 61, Issue 1, Page(s) E3–E4

MeSH term(s)	Climate Change ; Diabetes, Gestational/diagnosis ; Diabetes, Gestational/epidemiology ; Female ; Glucose Tolerance Test ; Humans ; Pregnancy ; Pregnancy Outcome ; Prevalence
Language	English
Publishing date	2021-02-01
Publishing country	Australia
Document type	Letter ; Comment
ZDB-ID	390815-x
ISSN	1479-828X ; 0004-8666
ISSN (online)	1479-828X
ISSN	0004-8666
DOI	10.1111/ajo.13239
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Zs.A 424: Show issues

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Article ; Online: Challenges to the parental brain: Neuroethological and translational considerations.

Lambert, Kelly G / Byrnes, Elizabeth M

Frontiers in neuroendocrinology

2019 Volume 53, Page(s) 100747

Abstract: Extending from research documenting adaptive parental responses in nonthreatening contexts, the influences of various neuroethological and physiological challenges on effective parenting responses are considered in the current review. In natural habitats, ...

Abstract	Extending from research documenting adaptive parental responses in nonthreatening contexts, the influences of various neuroethological and physiological challenges on effective parenting responses are considered in the current review. In natural habitats, rodent family units are exposed to predators, compromised resources, and other environmental stressors that disrupt HPA axis functions. With the additional physiological demands associated with caring for offspring, alterations in stress-related neuroendocrine responsiveness contribute to adaptive responses in many challenging contexts. Some environmental contexts, however, such as restricted nesting resources, result in disrupted maternal responses that have a negative impact on offspring wellbeing. Additionally, parental dysregulation associated with exposure to environmental chemicals or pharmacological substances, also compromise maternal responses with effects that often extend to future generations. Continued preclinical and clinical research elucidating parental responses to various stressors and physiological disruptors is necessary to provide valuable translational information identifying threats to effective parenting outcomes.
MeSH term(s)	Animals ; Brain/physiology ; Humans ; Hypothalamo-Hypophyseal System/physiology ; Parenting/psychology ; Parents/psychology ; Pituitary-Adrenal System/physiology ; Stress, Psychological/physiopathology
Language	English
Publishing date	2019-04-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	390985-2
ISSN	1095-6808 ; 0532-7466 ; 0091-3022
ISSN (online)	1095-6808
ISSN	0532-7466 ; 0091-3022
DOI	10.1016/j.yfrne.2019.04.004
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Article ; Online: mRNA vaccines expressing malaria transmission-blocking antigens Pfs25 and Pfs230D1 induce a functional immune response.

Scaria, Puthupparampil V / Roth, Nicole / Schwendt, Kim / Muratova, Olga V / Alani, Nada / Lambert, Lynn E / Barnafo, Emma K / Rowe, Christopher G / Zaidi, Irfan U / Rausch, Kelly M / Narum, David L / Petsch, Benjamin / Duffy, Patrick E

NPJ vaccines

2024 Volume 9, Issue 1, Page(s) 9

Abstract: Malaria transmission-blocking vaccines (TBV) are designed to inhibit the sexual stage development of the parasite in the mosquito host and can play a significant role in achieving the goal of malaria elimination. Preclinical and clinical studies using ... ...

Abstract	Malaria transmission-blocking vaccines (TBV) are designed to inhibit the sexual stage development of the parasite in the mosquito host and can play a significant role in achieving the goal of malaria elimination. Preclinical and clinical studies using protein-protein conjugates of leading TBV antigens Pfs25 and Pfs230 domain 1 (Pfs230D1) have demonstrated the feasibility of TBV. Nevertheless, other promising vaccine platforms for TBV remain underexplored. The recent success of mRNA vaccines revealed the potential of this technology for infectious diseases. We explored the mRNA platform for TBV development. mRNA constructs of Pfs25 and Pfs230D1 variously incorporating signal peptides (SP), GPI anchor, and Trans Membrane (TM) domain were assessed in vitro for antigen expression, and selected constructs were evaluated in mice. Only mRNA constructs with GPI anchor or TM domain that resulted in high cell surface expression of the antigens yielded strong immune responses in mice. These mRNA constructs generated higher transmission-reducing functional activity versus the corresponding alum-adjuvanted protein-protein conjugates used as comparators. Pfs25 mRNA with GPI anchor or TM maintained >99% transmission reducing activity through 126 days, the duration of the study, demonstrating the potential of mRNA platform for TBV.
Language	English
Publishing date	2024-01-06
Publishing country	England
Document type	Journal Article
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-023-00783-y
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Article: Editorial: Environmental Enrichment: Enhancing Neural Plasticity, Resilience, and Repair.

Kentner, Amanda C / Lambert, Kelly G / Hannan, Anthony J / Donaldson, S Tifffany

Frontiers in behavioral neuroscience

2019 Volume 13, Page(s) 75

Language	English
Publishing date	2019-04-16
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2452960-6
ISSN	1662-5153
ISSN	1662-5153
DOI	10.3389/fnbeh.2019.00075
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Article ; Online: Post-COVID care delivery: The experience from an Irish tertiary centre's post-COVID clinic.

Heeney, Aoife / Connolly, Stephen P / Dillon, Rachel / O'Donnell, Aisling / McSweeney, Tara / O'Kelly, Brendan / Cotter, Aoife G / Sheehan, Gerard / Lambert, John S / Muldoon, Eavan G / McGinty, Tara

PloS one

2023 Volume 18, Issue 8, Page(s) e0289245

Abstract: Background: The long-term effects of SARS-CoV-2 infection and optimal follow-up approach are not well-recognised. Here we describe the implementation of a post-COVID clinic in an Irish tertiary centre after the first wave of the pandemic. This study ... ...

Abstract	Background: The long-term effects of SARS-CoV-2 infection and optimal follow-up approach are not well-recognised. Here we describe the implementation of a post-COVID clinic in an Irish tertiary centre after the first wave of the pandemic. This study describes the characteristics of our patient cohort and the operations and outcomes of the clinic, exploring some of the risk factors for developing post-COVID syndrome and the appropriateness of the triage system employed. Methods: All SARS-CoV-2 positive patients from March 10th to June 14th 2020 were telephone-triaged as red, amber or green based on ongoing symptoms with clinic appointments scheduled accordingly. All clinic visits were face-to-face with the infectious diseases medical team and a proforma for each patient was completed. Data were collected retrospectively by reviewing the proformas and the electronic medical record (EMR). Results: 311 patients attended the clinic. Median time from illness to clinic appointment was 95 days (IQR 77-105.5). 204 patients (66%) were female, 192 (62%) were hospital staff, and the median age was 43 years (IQR 31-53). 138 patients (44%) had required hospital admission. At their first clinic visit 219 patients (70%) had ongoing symptoms. A further appointment was made for 62 patients (20%). 34 patients (11%) were discussed at an MDT meeting, and 55 (18%) were referred onward to a specialist service. 85% of those triaged green, 73% of those triaged amber, and 39% of those triaged red did not receive further follow up after one clinic visit. Patients were more likely to require follow up with reported dyspnoea (OR 5.6; 95% CI 2.8-11.3; p <0.001), cough (OR 3.0; 95% CI 1.1-8.4, p = 0.04), and palpitations (OR 3.6; 95% CI 1.0-12.3; p = 0.04). Female sex was associated with increased odds of a higher triage category (OR 1.8; 95% CI 1.08 to 3.20; p = 0.02), as was requiring admission to hospital (OR 4.0; 95% CI 2.34 to 6.90; p < 0.001). Conclusion: The long-term effects of COVID-19 are significant with 70% of our cohort experiencing persistent symptoms. Persistent dyspnoea, cough and palpitations were associated with increased need for follow up. This study also suggests that a traffic light telephone-triage service followed by a face-to-face medical-led clinic could be an effective way of identifying patients who require further management.
MeSH term(s)	Humans ; Female ; Adult ; Male ; COVID-19/epidemiology ; SARS-CoV-2 ; Retrospective Studies ; Amber ; Cough
Chemical Substances	Amber
Language	English
Publishing date	2023-08-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0289245
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Article ; Online: Dietary Patterns, Dietary Adequacy and Nutrient Intake in Adults Commencing Peritoneal Dialysis: Outcomes from a Longitudinal Cohort Study.

Lambert, Kelly / Ryan, Michele / Flanagan, Jade / Broinowski, Georgie / Nicdao, Maryann / Stanford, Jordan / Chau, Katrina

Nutrients

2024 Volume 16, Issue 5

Abstract: 1) Background: Optimal dietary intake is integral to good health in people receiving peritoneal dialysis (PD). We investigated how dietary patterns, dietary adequacy and nutrient intake may change over time in people commencing PD. (2) Methods: ... ...

Abstract	(1) Background: Optimal dietary intake is integral to good health in people receiving peritoneal dialysis (PD). We investigated how dietary patterns, dietary adequacy and nutrient intake may change over time in people commencing PD. (2) Methods: Participants were attending the PD training unit for the commencement of peritoneal dialysis, aged ≥18 years and willing to complete food records. Misreporters were excluded from the analysis. Dietary intake was compared at PD commencement and at 12 months. Intake was also compared to reference standards. Dietary patterns were derived using principal component analysis. (3) Results: There were no significant changes between baseline and 12 months for grains, fruit, vegetables and meat. Dairy and added sugar intake was significantly lower (
MeSH term(s)	Adult ; Humans ; Adolescent ; Longitudinal Studies ; Dietary Patterns ; Quality of Life ; Diet ; Energy Intake ; Eating ; Cohort Studies ; Peritoneal Dialysis ; Feeding Behavior
Language	English
Publishing date	2024-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16050663
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Article ; Online: The parental brain: transformations and adaptations.

Lambert, Kelly G

Physiology & behavior

2012 Volume 107, Issue 5, Page(s) 792–800

Abstract: Few evolutionary transformations rival the complex neurobiological modifications accompanying the mammalian transition to parenthood. Research conducted primarily in maternal rodents highlights the engagement of multiple areas of the brain to initiate ... ...

Abstract	Few evolutionary transformations rival the complex neurobiological modifications accompanying the mammalian transition to parenthood. Research conducted primarily in maternal rodents highlights the engagement of multiple areas of the brain to initiate and maintain interest in resource-depleting vulnerable pups throughout lactation. Interestingly, many modifications marking the transition to motherhood result in adaptive response options that persist well beyond the weaning of pups; specifically, adaptations such as cognitive flexibility, emotional regulation and enhanced social attentiveness coincide with the parenthood transition and have emerged as defining characteristics of the most adaptive mammalian species. The paternal brain also results in interesting modifications that, in some biparental species, mimic the effects observed in females. Taken together, research suggests that the designation of "parent" is less of a categorical variable and more of a continuous variable, with the quality of nurturing responses directed toward offspring influenced by many factors such as predisposed sensitivity to reproductive hormones, nature and duration of exposure to offspring, number of reproductive experiences, adequate resources, and composition of the social environment. Indeed, the transition from an animal focused on self-preservation to one that is responsive to the needs of other animals, and the accompanying increases in reproductive fitness, represent a significant evolutionary transition, or upgrade of sorts, leading to a more diverse array of response options to meet the challenging demands of changing environmental and social terrains.
MeSH term(s)	Adaptation, Physiological/physiology ; Animals ; Behavior, Animal/physiology ; Brain/physiology ; Female ; Male ; Mammals/physiology ; Sex Factors ; Sexual Behavior, Animal/physiology
Language	English
Publishing date	2012-12-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2012.03.018
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Article ; Online: The reactivation of herpesviruses in severe COVID-19; a retrospective analysis of a critical care cohort.

Moynan, David / Barkat, Rizwan / Avramovic, Gordana / Morley, Deirdre / O'Kelly, Brendan / Lambert, John S

Clinical infection in practice

2023 Volume 19, Page(s) 100232

Language	English
Publishing date	2023-05-23
Publishing country	England
Document type	Journal Article
ISSN	2590-1702
ISSN (online)	2590-1702
DOI	10.1016/j.clinpr.2023.100232
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Article: Predictors and Outcomes for COVID-19 Re-Admissions in the Anticipate Cohort.

O'Kelly, B / Vidal, L / Avramovic, G / Broughan, J / Cotter, A G / Cullen, W / McHugh, T / O'Gorman, T / Woo, J / Lambert, J S

Irish medical journal

2022 Volume 115, Issue 5, Page(s) 599

Abstract: Aims To describe readmissions of hospitalised patients with COVID-19, define predictors of readmission and explore the long term outcomes using the SF-12 score compared to patients who were not readmitted and those not hospitalised. Methods A single ... ...

Abstract	Aims To describe readmissions of hospitalised patients with COVID-19, define predictors of readmission and explore the long term outcomes using the SF-12 score compared to patients who were not readmitted and those not hospitalised. Methods A single centre retrospective in North Inner-City Dublin. Recruitment was done through a COVID follow up clinic. Predictors of readmission and SF-12 scores at two timepoints post follow up at median 3 months and 12 months. Results Seventy (45%) participants were admitted, with a median age of 49.5 years (IQR 41.3-56.9), 36(51%) of whom were female. Unscheduled readmissions at ≤30 days in COVID-19 patients were 9(12.9%) and length of stay was four days (IQR 2-5). Readmissions were due to ongoing symptoms(n=9(64.3%)) or new complications(n=5(35.7%)). Mechanical ventilation and having symptoms of nausea and vomiting on index admission were predictive of readmission. (p=0.002). SF-12 scores at one year of readmitted patients were not different to patients who were never admitted at median one year follow up, p=.089. Conclusions Most readmissions were of short duration. Early follow up of patients post MV or who had nausea and vomiting on index admission should be prioritised. Wellbeing of readmitted patients was not different to those never hospitalised, at one year.
MeSH term(s)	Adult ; COVID-19 ; Female ; Humans ; Male ; Middle Aged ; Nausea ; Patient Readmission ; Retrospective Studies ; Risk Factors ; Vomiting
Language	English
Publishing date	2022-05-25
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	193134-9
ISSN	0332-3102 ; 0021-129X
ISSN	0332-3102 ; 0021-129X
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