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Article: Feasibility of Mobile Health App-Based Home Aerobic Exercise for Physical Performance in Healthy Young Adults.

Nam, Je Shik / Kim, Hyun-Ah / Kwak, Tae-Jin / Cho, Kang Hee / Jung, Il-Young / Moon, Chang-Won

2024 Volume 48, Issue 1, Page(s) 75–85

Abstract: Objective: To investigate the feasibility and effects of a mobile app-based home cycling exercise program compared to home cycling exercise without additional monitoring system. Compared with fitness facilities or outdoor exercise, home-based exercise ... ...

Abstract	Objective: To investigate the feasibility and effects of a mobile app-based home cycling exercise program compared to home cycling exercise without additional monitoring system. Compared with fitness facilities or outdoor exercise, home-based exercise programs effectively improve physical performance in an indwelling community. However, a flexible, informal environment may decrease motivation and impair adherence to physical exercise. Mobile devices for aerobic exercise and mobile applications provide real-time monitoring, immediate feedback, and encouragement to increase motivation and promote physical performance. We investigated the feasibility and effects of a mobile app-based home exercise program on body composition, muscular strength, and cardiopulmonary function. Methods: Between February and May 2023, 20 participants were randomly allocated to the intervention (mobile application with a tablet) and control groups, and they performed aerobic exercise using a stationary bicycle for ≥150 minutes per week for 6 weeks (≤30-minute exercise session, with 3-minute warm-up and 3-minute cool-down). Karvonen formula-based heartrate defined the weekly increase in exercise intensity. Outcome measures included body-composition parameters, isokinetic knee flexor and extensor strength tests, cardiopulmonary exercise test results, and rate of target heart rate (HR) achievement. Participants were assessed at baseline and after the intervention. Results: Unrelated personal events led two participants to drop out. The intervention and control groups had similar baseline characteristics. Compared with the control group, in the post-intervention isokinetic strength test, bilateral knee flexor and extensor power, and time to target HR achievement significantly increased each week in the intervention group. Conclusion: Home-based exercise to achieve long-term cardiovascular fitness with portable electronic/mobile devices facilitates individualized exercise using real-time feedback to improve motivation and adherence.
Language	English
Publishing date	2024-02-28
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2659431-6
ISSN	2234-0653 ; 2234-0645
ISSN (online)	2234-0653
ISSN	2234-0645
DOI	10.5535/arm.230023
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Article ; Online: Colorectal cancer in young adults.

Kim, Bradford J / Hanna, Mark H

Journal of surgical oncology

2023 Volume 127, Issue 8, Page(s) 1247–1251

Abstract: The incidence of colorectal cancer in young adults (CRCYAs) is increasing globally, and it is now ... the third leading cause of cancer death among young adults under 50 years old. The rising incidence is ...

Abstract	The incidence of colorectal cancer in young adults (CRCYAs) is increasing globally, and it is now the third leading cause of cancer death among young adults under 50 years old. The rising incidence is attributed to various emerging risk factors such as genetics, lifestyle factors, and microbiome profiles. Delayed diagnosis and more advanced disease presentation contribute to worse outcomes. A multidisciplinary approach to care is crucial to ensure comprehensive and personalized treatment plans for CRCYA.
MeSH term(s)	Humans ; Young Adult ; Middle Aged ; Risk Factors ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/therapy
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	82063-5
ISSN	1096-9098 ; 0022-4790
ISSN (online)	1096-9098
ISSN	0022-4790
DOI	10.1002/jso.27320
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Article ; Online: Factors associated with the risk of colorectal neoplasia in young adults under age 40.

Kim, Ilsoo / Lee, Han Hee / Ko, Young Jae / Chang, Ho Eun / Cheung, Dae Young / Lee, Bo-In / Cho, Young-Seok / Kim, Jin Il / Choi, Myung-Gyu

The Korean journal of internal medicine

2022 Volume 37, Issue 5, Page(s) 969–978

Abstract: ... of young-onset colorectal neoplasia (CRN).: Methods: A cross-sectional analysis was performed ... 621 included participants, 2,023 (14.9%) had one and more CRN. Young patients with CRN tended to be ... Conclusion: Obesity and smoking were modifiable risk factors for CRN in young adults. They increased ...

Abstract	Background/aims: Recent epidemiologic studies have shown a continued increase in colorectal cancer incidence among younger adults. Little is known about the factors that contribute to the development of young-onset colorectal neoplasia (CRN). Methods: A cross-sectional analysis was performed for individuals younger than 40 years who underwent colonoscopy in Seoul St. Mary's Hospital and its affiliated health screening center. High-risk CRN was defined as adenoma or sessile serrated lesion ≥ 10 mm, with three or more adenomas, villous histology, high grade dysplasia, or carcinoma. Results: Of these 13,621 included participants, 2,023 (14.9%) had one and more CRN. Young patients with CRN tended to be elderly, male, obese, smoker, having a habit of drinking, and having comorbidities such as hypertension, dyslipidemia, diabetes, and chronic kidney disease. In a multivariate analysis adjusted for age, sex, obesity, smoking status, and alcohol intake, old age (odds ratio [OR], 1.086; 95% confidence interval [CI], 1.054 to 1.119), male sex (OR, 1.748; 95% CI, 1.247 to 2.451), obesity (OR, 1.439; 95% CI, 1.133 to 1.828), and smoking (OR, 1.654; 95% CI, 1.287 to 2.127) were independent risk factors for overall CRN. Obesity and smoking as two modifiable factors increased the risk for high-risk CRN even more than for overall CRN (OR, 1.734; 95% CI, 1.168 to 2.575 and OR, 1.797; 95% CI, 1.172 to 2.753, respectively). Conclusion: Obesity and smoking were modifiable risk factors for CRN in young adults. They increased the risk for highrisk CRN even more than for overall CRN. A colonoscopy might be beneficial for young individuals with these factors.
MeSH term(s)	Adenoma/diagnosis ; Adult ; Age Factors ; Aged ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Cross-Sectional Studies ; Humans ; Male ; Obesity/complications ; Obesity/epidemiology ; Retrospective Studies ; Risk Factors ; Young Adult
Language	English
Publishing date	2022-07-25
Publishing country	Korea (South)
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639023-7
ISSN	2005-6648 ; 1226-3303
ISSN (online)	2005-6648
ISSN	1226-3303
DOI	10.3904/kjim.2021.506
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Article: Characteristics of Hirayama Disease in Young South Korean Soldiers.

Yun, Jae-Hyun / Jung, Chul / Kim, Eun Jin / Park, Jaechan / Yeom, Jiwoon / Jung, Ji Su / Kim, Kyoung-Eun

Journal of clinical neurology (Seoul, Korea)

2024 Volume 20, Issue 3, Page(s) 293–299

Abstract: ... features in electrodiagnostic and imaging investigations of young South Korean males diagnosed ... of HD in the young South Korean male population. ...

Abstract	Background and purpose: The purpose of this study was to describe the clinical presentation and features in electrodiagnostic and imaging investigations of young South Korean males diagnosed with Hirayama disease (HD). Methods: We reviewed the electronic medical records of South Korean enlisted soldiers who were diagnosed with HD and discharged from military service during 2011-2021. We investigated the clinical characteristics and results of electrodiagnostic and magnetic resonance imaging (MRI) investigations. We analyzed laterality and identified the involved muscles using needle electromyography (EMG). Loss of lordosis, localized cervical cord atrophy, loss of attachment between the posterior dura and subjacent lamina, asymmetric flattening of the cord, crescent-shaped mass in the posterior epidural space, and noncompressive intramedullary T2-weighted high signal intensity were investigated using neutral- or flexion-position MRI. Results: Forty-two male patients aged 20.2±0.8 years (mean±standard deviation) were identified. All patients complained of hand weakness, and 10 complained of hand tremor (23.8%). Four patients (9.5%) had symptoms in both upper limbs, and five (11.9%) had sensory disturbances. Needle EMG revealed that muscles in the C7-T1 myotome were commonly involved, and C5-C6 involvement of the deltoid (10.5%) and biceps brachii (12.5%) was also observed. In cervical MRI, localized cord atrophy (90.0%) was the most characteristic finding, and cord atrophy was most severe at the C5-C6 level (58.3%). Conclusions: This is the first description of a large number of patients with HD in South Korea. The clinical presentation and features found in electrodiagnostic and imaging investigations will improve the understanding of HD in the young South Korean male population.
Language	English
Publishing date	2024-02-05
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2500489-X
ISSN	2005-5013 ; 1738-6586
ISSN (online)	2005-5013
ISSN	1738-6586
DOI	10.3988/jcn.2023.0244
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Article ; Online: Long Sleep Duration and Dissatisfaction with Sleep Quality Are Associated with Ischemic Stroke in Young Patients.

Kwon, Hyuk Sung / Kim, Chulho / Kim, Young Seo / Koh, Seong-Ho / Kim, Hyun Young / Lee, Seung-Hoon / Jung, Keun-Hwa / Kim, Jeong-Min / Kim, Young Dae / Kwon, Hyung-Min / Koo, Dae Lim / Kim, Beom Joon / Kim, Bum Joon / Heo, Sung Hyuk / Chang, Dae-Il / Bushnell, Cheryl D

Cerebrovascular diseases (Basel, Switzerland)

2023 Volume 52, Issue 6, Page(s) 671–678

Abstract: ... stroke risk. However, their significance in young ischemic stroke is unclear. We aimed to investigate ... the importance of sleep duration and quality on young ischemic stroke patients.: Methods: A multicenter ... matched case-control study was performed to evaluate under-recognized risk factors in young (<45 years) ischemic stroke ...

Abstract	Introduction: Suboptimal sleep duration and poor sleep quality have been proposed to increase stroke risk. However, their significance in young ischemic stroke is unclear. We aimed to investigate the importance of sleep duration and quality on young ischemic stroke patients. Methods: A multicenter matched case-control study was performed to evaluate under-recognized risk factors in young (<45 years) ischemic stroke patients in 8 tertiary hospitals in Korea. A total of 225 patients and 225 age- and sex-matched controls were enrolled in the same period. Detailed information about patients' demographics, socioeconomic state, and traditional and nontraditional risk factors including sleep-related factors were obtained using structured questionnaires. Risk of ischemic stroke was estimated using conditional logistic regression analysis. Results: Although average sleep duration was similar in patients and controls, patients were more likely to have long (≥9 h) or extremely short (<5 h) sleep durations. In addition, the proportion of subjects with dissatisfaction with sleep quality was higher in patients than controls (66.2 vs. 49.3%, p < 0.001). In multivariable conditional logistic regression analysis, long sleep duration (OR: 11.076, 95% CI: 1.819-67.446, p = 0.009) and dissatisfaction with sleep quality (OR: 2.116, 95% CI: 1.168-3.833, p = 0.013) were independently associated with risk of ischemic stroke. Conclusions: Long sleep duration and dissatisfaction with sleep quality may be associated with increased risk of ischemic stroke in young adults. Improving sleep habit or quality could be important for reducing the risk of ischemic stroke.
MeSH term(s)	Young Adult ; Humans ; Ischemic Stroke/complications ; Sleep Quality ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/etiology ; Sleep Duration ; Case-Control Studies ; Patient Satisfaction ; Sleep ; Risk Factors
Language	English
Publishing date	2023-03-21
Publishing country	Switzerland
Document type	Multicenter Study ; Journal Article
ZDB-ID	1069462-6
ISSN	1421-9786 ; 1015-9770
ISSN (online)	1421-9786
ISSN	1015-9770
DOI	10.1159/000530003
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Article ; Online: Factors associated with the risk of colorectal neoplasia in young adults under age 40

Ilsoo Kim / Han Hee Lee / Young Jae Ko / Ho Eun Chang / Dae Young Cheung / Bo-In Lee / Young-Seok Cho / Jin Il Kim / Myung-Gyu Choi

The Korean Journal of Internal Medicine, Vol 37, Iss 5, Pp 969-

2022 Volume 978

Abstract: ... of young-onset colorectal neoplasia (CRN). Methods A cross-sectional analysis was performed for individuals ... participants, 2,023 (14.9%) had one and more CRN. Young patients with CRN tended to be elderly, male, obese ... smoking were modifiable risk factors for CRN in young adults. They increased the risk for high-risk CRN ...

Abstract	Background/Aims Recent epidemiologic studies have shown a continued increase in colorectal cancer incidence among younger adults. Little is known about the factors that contribute to the development of young-onset colorectal neoplasia (CRN). Methods A cross-sectional analysis was performed for individuals younger than 40 years who underwent colonoscopy in Seoul St. Mary’s Hospital and its affiliated health screening center. High-risk CRN was defined as adenoma or sessile serrated lesion ≥ 10 mm, with three or more adenomas, villous histology, high grade dysplasia, or carcinoma. Results Of these 13,621 included participants, 2,023 (14.9%) had one and more CRN. Young patients with CRN tended to be elderly, male, obese, smoker, having a habit of drinking, and having comorbidities such as hypertension, dyslipidemia, diabetes, and chronic kidney disease. In a multivariate analysis adjusted for age, sex, obesity, smoking status, and alcohol intake, old age (odds ratio [OR], 1.086; 95% confidence interval [CI], 1.054 to 1.119), male sex (OR, 1.748; 95% CI, 1.247 to 2.451), obesity (OR, 1.439; 95% CI, 1.133 to 1.828), and smoking (OR, 1.654; 95% CI, 1.287 to 2.127) were independent risk factors for overall CRN. Obesity and smoking as two modifiable factors increased the risk for high-risk CRN even more than for overall CRN (OR, 1.734; 95% CI, 1.168 to 2.575 and OR, 1.797; 95% CI, 1.172 to 2.753, respectively). Conclusions Obesity and smoking were modifiable risk factors for CRN in young adults. They increased the risk for high-risk CRN even more than for overall CRN. A colonoscopy might be beneficial for young individuals with these factors.
Keywords	colonoscopy ; colorectal neoplasms ; early detection of cancer ; risk factors ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	The Korean Association of Internal Medicine
Document type	Article ; Online
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Article: Genetic Characteristics of Patients with Young-Onset Myelodysplastic Neoplasms.

Kim, Hyun-Young / Yoo, Keon Hee / Jung, Chul Won / Kim, Hee-Jin / Kim, Sun-Hee

Journal of clinical medicine

2023 Volume 12, Issue 24

Abstract: ... and somatic genetic alterations. The incidence of MDS increases with age but rarely occurs at a young ... age. We investigated the germline and somatic genetic alterations of Korean patients with young-onset ...

Abstract	Myelodysplastic neoplasm (MDS) is a heterogeneous group of myeloid neoplasms affected by germline and somatic genetic alterations. The incidence of MDS increases with age but rarely occurs at a young age. We investigated the germline and somatic genetic alterations of Korean patients with young-onset MDS (<40 years). Among the thirty-one patients, five (16.1%) had causative germline variants predisposing them to myeloid neoplasms (three with
Language	English
Publishing date	2023-12-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12247651
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Article ; Online: Development of innate and adaptive immunity to RSV in young children.

Parsons, Emily L / Kim, Jisung S / Malloy, Allison M W

Cellular immunology

2024 Volume 399-400, Page(s) 104824

Abstract: ... repeatedly throughout life with most severe disease occurring at the extremes of age: in young infants and ... in the design of therapeutics and vaccines for young infants. However, advancements in structural biology have ... in infants and young children as well as highlight areas where more research is needed. ...

Abstract	Infection of the respiratory tract with respiratory syncytial virus (RSV) is common and occurs repeatedly throughout life with most severe disease occurring at the extremes of age: in young infants and the elderly. Effective anti-viral therapeutics are not available and therefore prevention has been the primary strategy for reducing the disease burden. Our current understanding of respiratory mucosal cell biology and the immune response within the respiratory tract is inadequate to prevent infection caused by a pathogen like RSV that does not disseminate outside of this environment. Gaps in our understanding of the activation of innate and adaptive immunity in response to RSV and the role of age upon infection also limit improvements in the design of therapeutics and vaccines for young infants. However, advancements in structural biology have improved our ability to characterize antibodies against viral proteins and in 2023 the first vaccines for those over 60 years and pregnant women became available, potentially reducing the burden of disease. This review will examine our current understanding of the critical facets of anti-RSV immune responses in infants and young children as well as highlight areas where more research is needed.
Language	English
Publishing date	2024-03-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2024.104824
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Article ; Online: Cumulative exposure to hypertriglyceridemia and risk of type 2 diabetes in young adults.

Lee, Min-Kyung / Han, Kyungdo / Kim, Bongsung / Kim, Jong-Dai / Jung Kim, Moon / Kim, Byungpyo / Heo, Jung / Ahn, Jiyeon / Sohn, Seo-Young / Lee, Jae-Hyuk

Diabetes research and clinical practice

2024 Volume 208, Page(s) 111109

Abstract: ... with an increased risk of developing type 2 diabetes in young adults.: Methods: The study included 1,840,251 ... of 0.: Conclusions: In this large-scale prospective cohort study of young adults, cumulative ...

Abstract	Aim: This study aimed to examine whether cumulative exposure to hypertriglyceridemia is associated with an increased risk of developing type 2 diabetes in young adults. Methods: The study included 1,840,251 participants aged 20-39 years who had undergonefourconsecutiveannualhealth checkups and had no history of type 2 diabetes. Participants werecategorized into five groups (exposure score 0-4) based on the frequencies of hypertriglyceridemia diagnosis over a four-year period. The primary outcome was newly diagnosed type 2 diabetes. Exploratory analyses were performed for the different subgroups. Results: During a follow-up period of 6.53 years, 40,286 participants developed type 2 diabetes. The cumulative incidence of type 2 diabetes significantly increased with higher exposure scores for hypertriglyceridemia (log-rank test, P < 0.001). The multivariable-adjusted hazard ratios for incident diabetes were 1.674 (95 % CI, 1.619, 1.732), 2.192 (95 % CI, 2.117, 2.269), 2.637 (95 % CI, 2.548, 2.73), and 3.715 (95 % CI, 3.6, 3.834) for participants with scores of 1-4, respectively, compared with those with an exposure score of 0. Conclusions: In this large-scale prospective cohort study of young adults, cumulative exposure to hypertriglyceridemia was significantly associated with an increased risk of type 2 diabetes, independent of lifestyle-related factors.
MeSH term(s)	Humans ; Young Adult ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/etiology ; Prospective Studies ; Hypertriglyceridemia/complications ; Hypertriglyceridemia/epidemiology ; Incidence ; Life Style ; Risk Factors
Language	English
Publishing date	2024-01-21
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2024.111109
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Article ; Online: Different glaucoma progression rates by age groups in young myopic glaucoma patients.

Lee, Eun Jung / Lee, Dongyoung / Kim, Min-Ji / Kim, Kyunga / Han, Jong Chul / Kee, Changwon

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2589

Abstract: ... evidence of rapid glaucoma progression in the young adulthood and stabilization in older age in myopic NTG ...

Abstract	We aimed to investigate the age-related glaucoma progression rates in myopic normal tension glaucoma (NTG). In this long-term retrospective cohort (7.2 ± 3.5 years), we grouped patients based on their age at initial presentation: group A (age < 30 years, 60 eyes), group B (30 ≤ age < 40, 66 eyes), and group C (40 ≤ age < 50 years, 63 eyes). We used a linear mixed-effects model to estimate retinal nerve fiber layer (RNFL) defect width enlargement rates. Group A showed a significantly faster rate of RNFL defect progression (3.01 ± 1.74°/year) than those of groups B and C (2.05 ± 1.55°/year and 2.06 ± 1.29°/year, P = 0.004 and 0.002). The difference was more marked when calculated for the first 10 years of follow-up in group A, B, and C (3.95 ± 2.70°/year, 2.39 ± 1.64°/year, and 1.98 ± 1.31°/year), and between the periods of age < 30 years, 30 ≤ age < 40 years, and 40 ≤ age < 50 years within group A. This is the first evidence of rapid glaucoma progression in the young adulthood and stabilization in older age in myopic NTG. Clinicians should consider the potentially aggressive course of glaucoma, especially in younger patients with myopic NTG, in contrast to the general slow progression in adulthood.
MeSH term(s)	Humans ; Young Adult ; Adult ; Middle Aged ; Optic Disk ; Retrospective Studies ; Visual Fields ; Intraocular Pressure ; Nerve Fibers ; Disease Progression ; Glaucoma ; Low Tension Glaucoma ; Myopia ; Tomography, Optical Coherence
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53133-w
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