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Article ; Online: Clinical Translation of Bio-Artificial Pancreas Therapies: Ethical, Legal and Psychosocial Interdisciplinary Considerations and Key Recommendations.

de Jongh, Dide / Thom, Rebecca L / Cronin, Antonia J / Bunnik, Eline M / Massey, Emma K

Transplant international : official journal of the European Society for Organ Transplantation

2023 Volume 36, Page(s) 11705

Abstract: The field of regenerative medicine offers potential therapies for Type 1 Diabetes, whereby metabolically active cellular components are combined with synthetic medical devices. These therapies are sometimes referred to as "bioartificial pancreases." For ... ...

Abstract	The field of regenerative medicine offers potential therapies for Type 1 Diabetes, whereby metabolically active cellular components are combined with synthetic medical devices. These therapies are sometimes referred to as "bioartificial pancreases." For these emerging and rapidly developing therapies to be clinically translated to patients, researchers must overcome not just scientific hurdles, but also navigate complex legal, ethical and psychosocial issues. In this article, we first provide an introductory overview of the key legal, ethical and psychosocial considerations identified in the existing literature and identify areas where research is currently lacking. We then highlight two principal areas of concern in which these discrete disciplines significantly overlap: 1) individual autonomy and 2) access and equality. Using the example of beta-cell provenance, we demonstrate how, by harnessing an interdisciplinary approach we can address these key areas of concern. Moreover, we provide practical recommendations to researchers, clinicians, and policymakers which will help to facilitate the clinical translation of this cutting-edge technology for Type 1 Diabetes patients. Finally, we emphasize the importance of exploring patient perspectives to ensure their responsible and acceptable translation from bench to body.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 1/surgery ; Pancreas, Artificial ; Regenerative Medicine
Language	English
Publishing date	2023-09-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2023.11705
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Article ; Online: The impact of COVID vaccination on incidence of long COVID and healthcare resource utilisation in a primary care cohort in England, 2021-2022

Yang, Jingyan / Rai, Kiran K. / Alfred, Tamuno / Massey, Lucy / Massey, Olivia / McGrath, Leah / Andersen, Kathleen M. / Tritton, Theo / Tsang, Carmen / Butfield, Rebecca / Reynard, Charlie / Mendes, Diana / Nguyen, Jennifer L

medRxiv

Abstract: Background Long COVID, a diverse set of symptoms that persist after a minimum of 4 weeks from the initial SARS-CoV-2 infection, has posed substantial burden to healthcare systems. There is some evidence that COVID-19 vaccination may be associated with ... ...

Abstract	Background Long COVID, a diverse set of symptoms that persist after a minimum of 4 weeks from the initial SARS-CoV-2 infection, has posed substantial burden to healthcare systems. There is some evidence that COVID-19 vaccination may be associated with lower risk of long COVID. However, little is known about the association between vaccination status and long COVID-associated healthcare resource utilisation (HCRU) and costs. Methods We conducted a cohort study using primary care electronic health record data in England from the Clinical Practice Research Datalink (CPRD) Aurum dataset linked to Hospital Episode Statistics where applicable. Adult (≥18 years) patients were indexed on a COVID-19 diagnosis between 1st March 2021 and 1st December 2021. Vaccination status was assessed at index: unvaccinated or completed primary series (two doses for immunocompetent and three doses for immunocompromised patients). Covariate balance was conducted using entropy balancing. Weighted multivariable Poisson regression was used to estimate the incidence rate ratio (IRR) for incident long COVID, and separately long COVID primary care resource use, by vaccination status. Patients were followed up to a maximum of 9-months post index. Results A total of 35,713 patients who had completed primary series vaccination, and 75,522 unvaccinated patients were included. The weighted and adjusted IRR for long COVID among patients vaccinated with the primary series compared to being unvaccinated was 0.81 (95% CI: 0.77-0.86) in the overall cohort, 0.83 (95% CI: 0.78-0.88) in the immunocompetent cohort and 0.28 (95% CI: 0.13-0.58) in the immunocompromised cohort. Among those with long COVID, there was no association between the rate of primary care consultations and vaccination status in the overall and immunocompetent cohorts. Cost of primary care consultations was greater in the unvaccinated group than for those who completed primary series. Conclusion Vaccination against COVID-19 may reduce the risk of long COVID in both immunocompetent and immunocompromised patients. However, no association was found between frequency of primary care visits and vaccination among patients diagnosed in 2021. Future studies with larger sample size, higher vaccine uptake, and longer study periods during the pandemic are needed to further quantify the impact of vaccination on long COVID.
Keywords	covid19
Language	English
Publishing date	2024-04-25
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2024.04.24.24306308
Database	COVID19

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Article ; Online: Physical therapy students' application of an imaging decision rule for acute knee pain.

Massey, B James / Grandeo, Jason / Favaro, Laura / Bliss, Rebecca / Gagnon, Kendra / Young, Jodi L

Physiotherapy theory and practice

2023 , Page(s) 1–11

Abstract: Background: Evidence supports direct referral for imaging by physical therapists. Accuracy and self-efficacy for imaging decisions have not been investigated in entry-level doctor of physical therapy (DPT) students.: Objective: The purpose of this ... ...

Abstract	Background: Evidence supports direct referral for imaging by physical therapists. Accuracy and self-efficacy for imaging decisions have not been investigated in entry-level doctor of physical therapy (DPT) students. Objective: The purpose of this study was to understand the relationship between entry-level DPT instruction and accuracy and self-efficacy for imaging referral due to acute knee trauma. A second purpose was to identify relationships between accuracy and self-efficacy. Methods: An online survey was sent via e-mail to program directors in accredited DPT programs in the United States with an invitation to forward the survey to DPT students. The survey captured demographic information and included five questions that assessed the respondent's ability to apply the Ottawa Knee Rules (OKR). Self-efficacy was assessed using the Physiotherapist Student Self-Efficacy (PSE) questionnaire, a self-rated 5-point Likert scaled tool. Results: Of 240 surveys, DPT students who completed imaging coursework had greater accuracy and higher self-efficacy (68.0% correct (95% CI, 63.6-72.5), PSE = 3.67,
Language	English
Publishing date	2023-05-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1045333-7
ISSN	1532-5040 ; 0959-3985
ISSN (online)	1532-5040
ISSN	0959-3985
DOI	10.1080/09593985.2023.2206482
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Zs.A 2190: Show issues

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Article ; Online: COVID-19-related work absenteeism and associated lost productivity cost in Germany: a population-based study.

Yang, Jingyan / Rai, Kiran K / Seif, Monica / Volkman, Hannah R / Ren, Jinma / Schmetz, Andrea / Gowman, Hannah / Massey, Lucy / Pather, Shanti / Nguyen, Jennifer L

Journal of occupational and environmental medicine

2024

Abstract: Objective: To estimate COVID-19 absenteeism and indirect costs, by care setting.: Methods: A population-based retrospective cohort study using data from the German Statutory Health Insurance (SHI) database to define outpatient (April 2020-December ... ...

Abstract	Objective: To estimate COVID-19 absenteeism and indirect costs, by care setting. Methods: A population-based retrospective cohort study using data from the German Statutory Health Insurance (SHI) database to define outpatient (April 2020-December 2021) and hospitalized (April 2020-October 2022) cohorts of employed working-aged individuals. Results: In the outpatient cohort (n = 369,220) median absenteeism duration and associated cost was 10.0 (IQR: 5.0, 15.0) days and €1,061 (530, 1,591), respectively. In the hospitalized cohort (n = 20,687), median absenteeism and associated cost was 15.0 (7.0, 32.0) days and €1,591 (743, 3,394), respectively. Stratified analyses showed greater absenteeism in older workers, those at risk and those with severe disease. Conclusions: The hospitalized cohort had longer absenteeism resulting in higher productivity loss. Being older, at risk of severe COVID-19 and higher disease severity during hospitalization were important drivers of higher absenteeism duration.
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1223932-x
ISSN	1536-5948 ; 1076-2752
ISSN (online)	1536-5948
ISSN	1076-2752
DOI	10.1097/JOM.0000000000003093
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Article ; Online: Relinquishing Anonymity in Living Donor Kidney Transplantation: Lessons Learned From the UK Policy for Anonymous Donors.

Pronk, Mathilde C / Burnapp, Lisa / Reinders, Marlies E J / Massey, Emma K

Transplant international : official journal of the European Society for Organ Transplantation

2022 Volume 35, Page(s) 10091

Abstract: Anonymous living donor kidney transplantation (LDKT) is performed in many countries and policies on anonymity differ. The UK is the only European country with a conditional policy, allowing pairs to break anonymity post-transplant. There is little ... ...

Abstract	Anonymous living donor kidney transplantation (LDKT) is performed in many countries and policies on anonymity differ. The UK is the only European country with a conditional policy, allowing pairs to break anonymity post-transplant. There is little evidence on how contact after anonymous LDKT is experienced. In this cross-sectional study participants who donated or received a kidney through non-directed altruistic kidney donation or within the UK living kidney sharing scheme completed a questionnaire on their experiences with and attitudes towards anonymity. Non-parametric statistics were used to analyse the data. 207 recipients and 354 donors participated. Anonymity was relinquished among 11% of recipients and 8% of donors. Non-anonymous participants were generally content with non-anonymity. They reported positive experiences with contact/meeting the other party. Participants who remained anonymous were content with anonymity, however, 38% would have liked to meet post-transplant. If the other party would like to meet, this number increased to 64%. Although participants agreed with anonymity before surgery, they believe that, if desired, a meeting should be allowed after surgery. UK donors and recipients were satisfied with conditional anonymity and experiences with breaking anonymity were positive. These results support the expansion of conditional anonymity to other countries that allow anonymous LDKT.
MeSH term(s)	Confidentiality ; Cross-Sectional Studies ; Humans ; Kidney ; Kidney Transplantation/methods ; Living Donors ; Policy ; United Kingdom
Language	English
Publishing date	2022-02-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2022.10091
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Article ; Online: Digital delivery of non-pharmacological intervention programmes for people living with dementia during the COVID-19 pandemic.

Quail, Zara / Bolton, Laura / Massey, Karina

BMJ case reports

2021 Volume 14, Issue 6

Abstract: The COVID-19 pandemic significantly impeded face-to-face health and social care delivery for people living with dementia and their carers. Interruption of meaningful activity engagement along with increased social isolation is known to be associated with ...

Abstract	The COVID-19 pandemic significantly impeded face-to-face health and social care delivery for people living with dementia and their carers. Interruption of meaningful activity engagement along with increased social isolation is known to be associated with loss of skills, increased loneliness, physical deterioration and decline in cognition and mood in people with dementia. To ensure continuity of care for people living with dementia, for whom multimodal, non-pharmacological intervention programmes were being provided, there was an urgent need to adopt a remote delivery model. Guidance on digitally delivered assessment and care specific to non-pharmacological interventions for dementia is lacking. Adoption of technology-enabled care for people with dementia requires overcoming barriers to technology use, adaptation of therapeutic guidelines, adaptation of communication methods and carer support. Despite these challenges, therapists successfully transitioned from in-person to digital delivery of therapeutic interventions with associated benefits of continued meaningful activity engagement discussed.
MeSH term(s)	COVID-19 ; Caregivers ; Dementia ; Humans ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2021-06-17
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2021-242550
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Robotic Optimization of Specimen Preparation Protocol for Astrocytes Seeded on Coverslips for Imaging by Transmission Electron Microscopy (TEM).

August, Benjamin K / Kong, Linghai / Massey, Randall J / Zhang, Su-Chun / Strader, Thomas E

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

2023 Volume 29, Issue Supplement_1, Page(s) 1106–1110

Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1385710-1
ISSN	1435-8115 ; 1431-9276
ISSN (online)	1435-8115
ISSN	1431-9276
DOI	10.1093/micmic/ozad067.569
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Article ; Online: Hormone Replacement Therapy Does Not Eliminate Risk Factors for Joint Complications following Total Joint Arthroplasty: A Matched Cohort Study.

Collins, Lacee K / Cole, Matthew W / Waters, Timothy L / Iloanya, Michael / Massey, Patrick A / Sherman, William F

Pathophysiology : the official journal of the International Society for Pathophysiology

2023 Volume 30, Issue 2, Page(s) 123–135

Abstract: Aging causes a reduction in testosterone and estrogen, which is linked to diminished bone mineral density. Hormone replacement therapy and its effect on the outcome of joint arthroplasties is unclear. The purpose of this study was to analyze the impact ... ...

Abstract	Aging causes a reduction in testosterone and estrogen, which is linked to diminished bone mineral density. Hormone replacement therapy and its effect on the outcome of joint arthroplasties is unclear. The purpose of this study was to analyze the impact of testosterone replacement therapy (TRT) and estrogen replacement therapy (ERT) on the medical and joint outcomes of total hip (THA) and total knee arthroplasties (TKA). A retrospective cohort study was conducted using the PearlDiver database. Patients who received TRT or ERT perioperatively were matched to controls. Rates of 90-day medical complications and 2-year joint complications were queried. Patients who received TRT had an increased risk of revision, periprosthetic joint infection, and pooled joint complications within 2 years following a THA and increased rates of septic and aseptic revisions, and aseptic loosening after TKA compared to the control cohort. Patients receiving ERT had increased rates of aseptic loosening and pooled joint complications within 2 years following THA and increased rates of all-cause revisions and pooled joint complications after TKA. Patients who received TRT demonstrated significantly higher rates of revision rates and PJI. Patients who received perioperative ERT were significantly more likely to have increased risks of revision rates and joint infections.
Language	English
Publishing date	2023-04-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1212740-1
ISSN	1873-149X ; 0928-4680
ISSN (online)	1873-149X
ISSN	0928-4680
DOI	10.3390/pathophysiology30020011
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Zs.A 4137: Show issues

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Article: Direct comparisons of four irrigation systems on a commercial rice farm: Irrigation water use efficiencies and water dynamics

Massey, J.H. / Reba, M.L. / Adviento-Borbe, M.A. / Chiu, Y.L. / Payne, G.K.

Agricultural water management. 2022 May 31, v. 266

2022

Abstract: This two-year field study compared the industry-standard rice (Oryza sativa L.) irrigation practice ...

Abstract	This two-year field study compared the industry-standard rice (Oryza sativa L.) irrigation practice, a continuous-flood delivered using cascade distribution (CASC), to two related levee-based systems (multiple-inlet rice flood distribution (MIRI) and MIRI plus alternate wetting-drying flood management (AWD)) and one furrow-irrigated with end-blocking (ROW) system. Seasonal applied irrigation, soil volumetric water holding content, water depth, grain yield and irrigation water use efficiency (IWUE) were determined for sixteen 16-ha commercial rice fields sown using the same hybrid each year. Also, runoff from one field for each system was measured each year. Average seasonal irrigation applications were 824 ± 197 mm for CASC, 641 ± 165 mm for MIRI, 696 ± 181 mm for AWD and 631 ± 125 mm for ROW. Although a minimum of two AWD dry-down cycles were performed each year and runoff was the least from MIRI (5% runoff) and AWD (3% runoff), ROW (13% runoff) was the only system to receive less irrigation (p = 0.0314) than CASC (14% runoff). In terms of grain yield, only the ROW fields, with an average yield of 8890 ± 417 kg ha⁻¹, differed (p = 0.0107) from CASC (9991 ± 751 kg ha⁻¹). This reduction in ROW yield was due primarily to herbicide injury in 2018 and resulted in average irrigation water use efficiency (IWUE) values that were not different between irrigation treatments (p > 0.05). Taken together, ROW with end-blocking (a) proved to be a more consistent method of water conservation than MIRI and AWD under field conditions complicated by variable soil textures, and (b) lends itself to automation as the ROW fields were irrigated regularly, on a three-to-four-day schedule, rather than depending on human judgement to decide when to irrigate as was required for CASC, MIRI and AWD.
Keywords	Oryza sativa ; automation ; farms ; flood control ; grain yield ; herbicides ; humans ; hybrids ; irrigation scheduling ; irrigation water ; rice ; runoff ; water conservation ; water use efficiency
Language	English
Dates of publication	2022-0531
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	751144-9
ISSN	1873-2283 ; 0378-3774
ISSN (online)	1873-2283
ISSN	0378-3774
DOI	10.1016/j.agwat.2022.107606
Database	NAL-Catalogue (AGRICOLA)

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Article: What can YOU do about health care costs?

Massey, K L

Canadian Medical Association journal

2010 Volume 117, Issue 6, Page(s) 578

Language	English
Publishing date	2010-03-22
Publishing country	Canada
Document type	Journal Article
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
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