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  1. Article: De Novo Postinfectious Glomerulonephritis Secondary to Nephritogenic Streptococci as the Cause of Transplant Acute Kidney Injury: A Case Report and Review of the Literature.

    Bullen, Alexander / Shah, Mita M

    Case reports in transplantation

    2018  Volume 2018, Page(s) 2695178

    Abstract: Acute kidney injury is common among kidney transplant recipients. Postinfectious glomerulonephritis secondary to nephritogenic streptococci is one of the oldest known etiologies of acute kidney injury in native kidneys but rarely reported among kidney ... ...

    Abstract Acute kidney injury is common among kidney transplant recipients. Postinfectious glomerulonephritis secondary to nephritogenic streptococci is one of the oldest known etiologies of acute kidney injury in native kidneys but rarely reported among kidney transplant recipients. This report is of a biopsy-proven case of acute kidney injury in a renal allograft recipient caused by de novo poststreptococcal glomerulonephritis.
    Language English
    Publishing date 2018-05-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627657-4
    ISSN 2090-6951 ; 2090-6943
    ISSN (online) 2090-6951
    ISSN 2090-6943
    DOI 10.1155/2018/2695178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An Adapted Process and Organ Procurement Perspective on Heart Retransplantation for a Healthy Heart's Third Life.

    Nethercot, Darryl C / Shah, Mita / Stocks, Lisa M / Trageser, Jeffrey M / Pretorius, Victor / Morris, Gerald P

    Progress in transplantation (Aliso Viejo, Calif.)

    2021  Volume 31, Issue 3, Page(s) 267–270

    Abstract: As organ procurement organizations nationwide see an increased opportunity to retransplant already transplanted hearts, we would like to share the overview and process of our 2 successful cases. Heart retransplantation increased our cardiac placement ... ...

    Abstract As organ procurement organizations nationwide see an increased opportunity to retransplant already transplanted hearts, we would like to share the overview and process of our 2 successful cases. Heart retransplantation increased our cardiac placement rates by 2.64% and 2% in 2015 and 2019, respectively. Spread across a nation that sees over 3500 heart placements annually, a 2% increase would be substantial. Since 2009, our cases stand as the only documented heart retransplantations in the United States. However, United Network for Organ Sharing data shows that potential exists. From a facilitation perspective, we have developed a protocol to ease the matching process. From a surgical perspective, these cases had no complications and saved 2 lives, with each heart now beating in a third person. We hope that by sharing our process and success, we can familiarize fellow organ procurement organizations and transplant communities with this viable opportunity.
    MeSH term(s) Heart Transplantation ; Humans ; Reoperation ; Tissue and Organ Procurement ; United States
    Language English
    Publishing date 2021-06-11
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2864264-8
    ISSN 2164-6708 ; 1526-9248
    ISSN (online) 2164-6708
    ISSN 1526-9248
    DOI 10.1177/15269248211024616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A Pilot Trial for Prevention of Hepatitis C Virus Transmission From Donor to Organ Transplant Recipient With Short-Course Glecaprevir/Pibrentasvir.

    Ramirez-Sanchez, Claudia / Kozuch, Jade / Shah, Mita M / Berumen, Jennifer / Mekeel, Kristin / Schnickel, Gabriel / Taremi, Mahnaz / Golts, Eugene / Afshar, Kamyar / Adler, Eric / Pretorius, Victor / Aslam, Saima

    Open forum infectious diseases

    2022  Volume 9, Issue 11, Page(s) ofac550

    Abstract: A 7-day course of glecaprevir/pibrentasvir started in the preoperative period prevented transmission of hepatitis C virus (HCV) from viremic donors to 10 HCV-negative recipients (2 heart, 1 lung, 6 kidney, 1 heart/kidney) with 100% sustained virological ... ...

    Abstract A 7-day course of glecaprevir/pibrentasvir started in the preoperative period prevented transmission of hepatitis C virus (HCV) from viremic donors to 10 HCV-negative recipients (2 heart, 1 lung, 6 kidney, 1 heart/kidney) with 100% sustained virological response at 12 weeks.
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofac550
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  4. Article ; Online: Interaction Between Cyclosporine and Palbociclib in a Renal Transplant Patient: Case Report and Pharmacokinetic Perspective.

    Momper, Jeremiah D / Yang, Jin / Kerr, Janice / Saunders, Ila / Smith, Jennifer / Shah, Mita M

    Journal of pharmacy practice

    2019  Volume 33, Issue 6, Page(s) 912–914

    Abstract: Solid organ transplant recipients have increased cancer risk due in part to chronic immunosuppression and opportunistic oncogenic viral infections. The management of drug interactions in transplant recipients being treated for cancer is important both to ...

    Abstract Solid organ transplant recipients have increased cancer risk due in part to chronic immunosuppression and opportunistic oncogenic viral infections. The management of drug interactions in transplant recipients being treated for cancer is important both to minimize the likelihood of drug-related toxicities and to optimize therapeutic outcomes. We present a case of a 41-year-old woman with a stable living-related kidney transplant maintained on an immunosuppressive regimen of cyclosporine, mycophenolate mofetil, and prednisone, who was subsequently diagnosed with a metastatic lobular breast carcinoma and papillary thyroid cancer and started palbociclib, a time-dependent CYP3A inhibitor. After initiation of palbociclib, cyclosporine trough and peak concentrations were increased by 159% and 81%, respectively, relative to the average cyclosporine concentrations pre-palbociclib. Using the Drug Interaction Probability Scale (DIPS), the interaction between palbociclib and cyclosporine was rated as "probable." Dose reductions of immunosuppressive agents that are CYP3A substrates are warranted if palbociclib is initiated, followed by close monitoring of blood concentrations. This report also highlights the challenges of coadministering a time-dependent inhibitor with a narrow therapeutic index drug that is metabolized by the same enzyme, particularly when the inhibitor is given in cycles with off-treatment periods.
    MeSH term(s) Adult ; Cyclosporine/adverse effects ; Female ; Humans ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation ; Mycophenolic Acid ; Piperazines/adverse effects ; Pyridines/adverse effects
    Chemical Substances Immunosuppressive Agents ; Piperazines ; Pyridines ; Cyclosporine (83HN0GTJ6D) ; palbociclib (G9ZF61LE7G) ; Mycophenolic Acid (HU9DX48N0T)
    Language English
    Publishing date 2019-06-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1027474-1
    ISSN 1531-1937 ; 0897-1900
    ISSN (online) 1531-1937
    ISSN 0897-1900
    DOI 10.1177/0897190019851887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2893: Show issues Location:
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  5. Article: Drug Interaction between Sirolimus and Ranolazine in a Kidney Transplant Patient.

    Masters, Joanna C / Shah, Mita M / Feist, Ashley A

    Case reports in transplantation

    2014  Volume 2014, Page(s) 548243

    Abstract: Purpose. The case of a kidney transplant recipient who experienced a probable drug interaction between sirolimus and ranolazine is reported. Summary. The narrow therapeutic window of immunosuppressive therapy in transplant recipients requires close ... ...

    Abstract Purpose. The case of a kidney transplant recipient who experienced a probable drug interaction between sirolimus and ranolazine is reported. Summary. The narrow therapeutic window of immunosuppressive therapy in transplant recipients requires close monitoring for potential drug-drug interactions. The patient, a 57-year-old Caucasian male kidney transplant recipient, was stable for years on sirolimus as his primary immunosuppressive agent and had a history of chronic angina, for which he was prescribed ranolazine. Upon addition and dose escalation of ranolazine, whole blood sirolimus levels more than tripled, rising to immeasurably high concentrations. After holding sirolimus on multiple occasions and reducing dosage more than 50%, blood levels returned to therapeutic range, while continuing ranolazine. Conclusion. Since ranolazine is a documented P-GP and CYP3A inhibitor, and sirolimus a known substrate for both pathways, it is proposed that ranolazine inhibition of P-GP and CYP3A4 contributed to the significant elevation in sirolimus exposure. No alternative causes for the rise in sirolimus exposure were found, and assessment with the Drug Interaction Probability Scale finds this interaction to be probable. Clinicians should be aware of the potential for this interaction to cause elevated sirolimus exposure and subsequent increase in clinical effect or toxicity, in this case overimmunosuppression.
    Language English
    Publishing date 2014-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2627657-4
    ISSN 2090-6951 ; 2090-6943
    ISSN (online) 2090-6951
    ISSN 2090-6943
    DOI 10.1155/2014/548243
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  6. Article: Efficacy and Safety of Canagliflozin in Kidney Transplant Patients.

    Shah, Mita / Virani, Zaheer / Rajput, Prashant / Shah, Bharat

    Indian journal of nephrology

    2019  Volume 29, Issue 4, Page(s) 278–281

    Abstract: Introduction: There is no report of efficacy and safety of canagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor in post kidney transplant patients with diabetes.: Materials and methods: A pilot study was undertaken in stable renal ... ...

    Abstract Introduction: There is no report of efficacy and safety of canagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor in post kidney transplant patients with diabetes.
    Materials and methods: A pilot study was undertaken in stable renal transplant recipients with preexisting diabetes or new onset diabetes after transplantation (NODAT) to look at the efficacy of SGLT2 inhibitor, cangliflozin. With the introduction of canagliflozin (100 mg), the dose of insulin and/or other oral hypoglycemic agents was reduced if the blood sugar control improved. The parameters monitored were body weight, blood pressure (BP), serum creatinine, HbA1c, and tacrolimus trough level. Safety was assessed by adverse event (AE) reports. Each patient was followed for a minimum period of 6 months.
    Results: The study included 24 (23 males and 1 females) stable kidney transplant patients with diabetes. The mean age of the patients was 53.8 ± 7.12 years. The mean body weight of study subjects was 78.6 ± 12.1 kg before and 76.1 ± 11.2 kg 6 months after starting canagliflozin (
    Conclusion: Canagliflozin provided reductions in body weight, BP, HbA1c, and the requirement of other hypoglycemic agents without any hypoglycemic episodes and without significant AEs.
    Language English
    Publishing date 2019-08-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 2134388-3
    ISSN 1998-3662 ; 0971-4065
    ISSN (online) 1998-3662
    ISSN 0971-4065
    DOI 10.4103/ijn.IJN_2_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: How does the ureteric bud branch?

    Nigam, Sanjay K / Shah, Mita M

    Journal of the American Society of Nephrology : JASN

    2008  Volume 20, Issue 7, Page(s) 1465–1469

    Abstract: Many genes that modulate kidney development have been identified; however, the molecular interactions that direct arborization of the ureteric bud (UB) remain incompletely understood. This article discusses how "systems" approaches may shed light on the ... ...

    Abstract Many genes that modulate kidney development have been identified; however, the molecular interactions that direct arborization of the ureteric bud (UB) remain incompletely understood. This article discusses how "systems" approaches may shed light on the structure of the gene network during UB branching morphogenesis and the mechanisms involved in the formation of a branched collecting system from a straight epithelial tube in the context of a stage model. In vitro and genetic studies suggest that the stages seem to be governed by a conserved network of genes that establish a "tip-stalk generator"; these genes sustain iterative UB branching tubulogenesis through minimal alterations in the network architecture as a budding system shifts to one that autocatalytically branches through budding. The differential expression of stage-specific positive and inhibitory factors in the mesenchyme, likely presented in the context of heparan sulfate proteoglycans, and effector molecules in the epithelium seems to regulate advancement between stages; similar principles may apply to other branching epithelia such as the lung, salivary gland, pancreas, mammary gland, and prostate. Active mesenchymal interactions with the UB seem to govern vectorial arborization and tapering of the collecting system and its terminal differentiation. Cessation of branching correlates with induction of mesenchyme as well as local extracellular matrix changes. Perturbations of these mechanisms and/or single-nucleotide polymorphisms in genes regulating UB branching may predispose to a variety of renal diseases (e.g., hypertension and chronic kidney disease) by altering nephron number. Decentralization of the gene-protein interaction network may explain the relative paucity of branching phenotypes in mutant mice and in human disease.
    MeSH term(s) Animals ; Cell Communication/physiology ; Cell Differentiation/physiology ; Epithelial Cells/cytology ; Epithelial Cells/physiology ; Humans ; Kidney/cytology ; Kidney/embryology ; Kidney/physiology ; Mesoderm/cytology ; Mesoderm/physiology ; Models, Animal ; Morphogenesis/genetics ; Morphogenesis/physiology
    Language English
    Publishing date 2008-12-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2008020132
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
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  8. Article ; Online: Subtle Changes in Tacrolimus Levels Have an Impact on Early Donor-Specific Antibodies in Kidney Transplantation.

    Henderson, Megan / Awdishu, Linda / Morris, Gerald P / Fabbri, Kassandra / Shah, Mita / Khan, Adnan / Kerr, Janice

    Progress in transplantation (Aliso Viejo, Calif.)

    2023  Volume 33, Issue 4, Page(s) 335–340

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Adult ; Humans ; Kidney Transplantation/adverse effects ; Tacrolimus/therapeutic use ; Isoantibodies ; Graft Rejection/epidemiology ; Immunosuppressive Agents/therapeutic use ; Steroids ; Graft Survival ; Retrospective Studies ; HLA Antigens
    Chemical Substances Tacrolimus (WM0HAQ4WNM) ; Isoantibodies ; Immunosuppressive Agents ; Steroids ; HLA Antigens
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2864264-8
    ISSN 2164-6708 ; 1526-9248
    ISSN (online) 2164-6708
    ISSN 1526-9248
    DOI 10.1177/15269248231212923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Successful heart and kidney transplantation from a deceased donor with PCR positive COVID-19.

    Sigler, Rachel / Shah, Mita / Schnickel, Gabriel / Pretorius, Victor / Dan, Jennifer / Taremi, Mahnaz / Aslam, Saima

    Transplant infectious disease : an official journal of the Transplantation Society

    2021  Volume 23, Issue 5, Page(s) e13707

    MeSH term(s) COVID-19 ; Humans ; Kidney Transplantation/adverse effects ; Polymerase Chain Reaction ; SARS-CoV-2 ; Tissue Donors
    Language English
    Publishing date 2021-08-05
    Publishing country Denmark
    Document type Letter ; Comment
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13707
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  10. Article ; Online: Single-center Experience on Nonlung Solid Organ Transplantation From SARS-CoV-2-positive Donors.

    Covarrubias, Karina / Brubaker, Aleah L / Mekeel, Kristin / Pretorius, Victor / Shah, Mita / Adler, Eric / Ajmera, Veeral / Schnickel, Gabriel T / Aslam, Saima

    Transplantation

    2022  Volume 107, Issue 1, Page(s) e41–e42

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Organ Transplantation/adverse effects ; Tissue Donors
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004400
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