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Article ; Online: Development of amyloid beta-directed antibodies against Alzheimer's disease: Twists and turns.

Lu, Daoran / Dou, Fangzhou / Gao, Jianjun

2024 Volume 17, Issue 6, Page(s) 440–444

Abstract: Alzheimer's disease (AD) is a severe and progressive neurodegenerative disease, and the treatment options that are currently available are limited. The amyloid cascade hypothesis has had a significant influence in explaining the pathology underlying AD. ... ...

Abstract	Alzheimer's disease (AD) is a severe and progressive neurodegenerative disease, and the treatment options that are currently available are limited. The amyloid cascade hypothesis has had a significant influence in explaining the pathology underlying AD. Inhibiting the production and aggregation of amyloid-beta (Aβ) and promoting its clearance have been important strategies in the development of anti-AD drugs over the past two decades. Specifically, Aβ directed antibodies have been highly anticipated, but drug development has been fraught with obstacles and challenges. Antibodies targeting the C-terminal or central region of Aβ, such as ponezumab, solanezumab, and crenezumab, primarily bind to Aβ monomers, yet no significant clearance of brain plaques or slowing of disease progression has been observed in clinical trials. Antibodies targeting the N-terminal region of Aβ, including aducanumab, lecanemab, and donanemab, primarily bind to aggregated forms of Aβ, and have shown efficacy in clearing brain plaques and slowing early-stage AD progression in clinical trials. However, clinical trials of gantenerumab, which targets conformational epitopes in the N-terminal and central sequences of Aβ and which selectively binds to aggregated forms, have failed, raising some new questions about the Aβ hypothesis. Advances in research on the pathological mechanisms of AD and advances in early diagnostic techniques may shift the time window for drug intervention and offer a potential pathway for developing effective drugs to delay the onset and progression of AD in the future.
MeSH term(s)	Humans ; Amyloid beta-Peptides/metabolism ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal/pharmacology ; Neurodegenerative Diseases ; Antibodies, Monoclonal, Humanized
Chemical Substances	donanemab ; Amyloid beta-Peptides ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2024-01-14
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2568828-5
ISSN	1881-784X ; 1881-784X
ISSN (online)	1881-784X
ISSN	1881-784X
DOI	10.5582/ddt.2023.01215
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Article ; Online: Network Complexity and Stability of Microbes Enhanced by Microplastic Diversity.

Wu, Hao / Gao, Tianheng / Hu, Ang / Wang, Jianjun

Environmental science & technology

2024 Volume 58, Issue 9, Page(s) 4334–4345

Abstract: Microplastic mixtures are ubiquitously distributed in global ecosystems and include varying types. However, it remains unknown how microplastic diversity affects the biotic interactions of microbes. Here, we developed novel experiments of 600 microcosms ... ...

Abstract	Microplastic mixtures are ubiquitously distributed in global ecosystems and include varying types. However, it remains unknown how microplastic diversity affects the biotic interactions of microbes. Here, we developed novel experiments of 600 microcosms with microplastic diversity ranging from 1 to 6 types and examined ecological networks for microbial communities in lake sediments after 2 months of incubation at 15 and 20 °C. We found that microplastic diversity generally enhanced the complexity of microbial networks at both temperatures, such as increasing network connectance and reducing average path length. This phenomenon was further confirmed by strengthened species interactions toward high microplastic diversity except for the negative interactions at 15 °C. Interestingly, increasing temperatures further exaggerated the effects of microplastic diversity on network structures, resulting in higher network connectivity and species interactions. Consistently, using species extinction simulations, we found that higher microplastic diversity and temperature led to more robust networks, and their effects were additionally and positively mediated by the presence of biodegradable microplastics. Our findings provide the first evidence that increasing microplastic diversity could unexpectedly promote the complexity and stability of microbial networks and that future warming could amplify this effect.
MeSH term(s)	Microplastics ; Plastics ; Ecosystem ; Environmental Monitoring/methods ; Water Pollutants, Chemical/analysis ; Microbiota
Chemical Substances	Microplastics ; Plastics ; Water Pollutants, Chemical
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c08704
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Article: The Role of Peroxisome Proliferator-Activated Receptors in Kidney Diseases.

Gao, Jianjun / Gu, Zhaoyan

Frontiers in pharmacology

2022 Volume 13, Page(s) 832732

Abstract: Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors. Accumulating evidence suggests that PPARs may play an important role in the pathogenesis of kidney ... ...

Abstract	Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors. Accumulating evidence suggests that PPARs may play an important role in the pathogenesis of kidney disease. All three members of the PPAR subfamily, PPARα, PPARβ/δ, and PPARγ, have been implicated in many renal pathophysiological conditions, including acute kidney injury, diabetic nephropathy, and chronic kidney disease, among others. Emerging data suggest that PPARs may be potential therapeutic targets for renal disease. This article reviews the physiological roles of PPARs in the kidney and discusses the therapeutic utility of PPAR agonists in the treatment of kidney disease.
Language	English
Publishing date	2022-03-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.832732
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Article ; Online: Oral Regurgitation of a Large Esophageal Mass.

Wei, Penghui / Gao, Xiang / Li, Jianjun

Gastroenterology

2022 Volume 163, Issue 4, Page(s) e5–e7

MeSH term(s)	Esophageal Diseases ; Esophageal Neoplasms/diagnostic imaging ; Esophageal Neoplasms/surgery ; Esophagoscopy ; Humans ; Polyps ; Vomiting
Language	English
Publishing date	2022-03-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2022.03.042
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Article ; Online: Incidence of hyperkalemia in anuric hemodialysis patients treated with sacubitril/valsartan.

Li, Xiaofan / Ma, Fei / Wang, Yan / Zhao, Haidan / Gao, Jianjun

Hemodialysis international. International Symposium on Home Hemodialysis

2024

Abstract: Introduction: Sacubitril/valsartan is increasingly used in hemodialysis patients due to its cardioprotective benefits. However, its impact on serum potassium levels in anuric patients undergoing hemodialysis remains controversial.: Methods: We ... ...

Abstract	Introduction: Sacubitril/valsartan is increasingly used in hemodialysis patients due to its cardioprotective benefits. However, its impact on serum potassium levels in anuric patients undergoing hemodialysis remains controversial. Methods: We conducted a retrospective data from patients undergoing hemodialysis at two dialysis centers. A total of 71 out of 332 patients receiving hemodialysis treatment were enrolled. Mean serum potassium (mean value of 6-8 determinations), peak serum potassium (maximum K value observed during follow-up observations), and other biochemical parameters were recorded at baseline and during the follow-up period. Findings: After 6 months of follow-up, mean serum potassium increased from 4.84 ± 0.45 mmol/L at baseline to 5.07 ± 0.46 mmol/L at 3 months and 5.04 ± 0.46 mmol/L at 6 months (p < 0.001). Notably, no significant group differences were found in peak serum potassium concentrations between baseline and 6 months after sacubitril/valsartan therapy (5.69 ± 0.56 vs. 5.75 ± 0.41, p = 0.419). Prior to starting sacubitril/valsartan treatment, none of the patients had severe hyperkalemia; however, after 3 and 6 months of sacubitril/valsartan therapy, two (2.80%) and three (4.20%) patients experienced severe hyperkalemia, respectively; however, this difference was not statistically significant. Additionally, there was a significant reduction in blood pressure; however, serum sodium, bicarbonate, and Kt/V values did not change significantly during either period. Discussion: Sacubitril/valsartan therapy is associated with an increase in serum potassium levels in anuric hemodialysis patients. Nevertheless, the proportion of patients with severe hyperkalemia did not increase significantly. This suggests that the use of sacubitril/valsartan in anuric patients on hemodialysis is relatively safe.
Language	English
Publishing date	2024-04-01
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2192458-2
ISSN	1542-4758 ; 1492-7535
ISSN (online)	1542-4758
ISSN	1492-7535
DOI	10.1111/hdi.13150
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Article ; Online: Multi-omics pan-cancer analyses identify MCM4 as a promising prognostic and diagnostic biomarker.

Li, Yanxing / Gao, Wentao / Yang, Zhen / Hu, Zhenwei / Li, Jianjun

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6517

Abstract: Minichromosome Maintenance Complex Component 4 (MCM4) is a vital component of the mini-chromosome maintenance complex family, crucial for initiating the replication of eukaryotic genomes. Recently, there has been a growing interest in investigating the ... ...

Abstract	Minichromosome Maintenance Complex Component 4 (MCM4) is a vital component of the mini-chromosome maintenance complex family, crucial for initiating the replication of eukaryotic genomes. Recently, there has been a growing interest in investigating the significance of MCM4 in different types of cancer. Despite the existing research on this topic, a comprehensive analysis of MCM4 across various cancer types has been lacking. This study aims to bridge this knowledge gap by presenting a thorough pan-cancer analysis of MCM4, shedding light on its functional implications and potential clinical applications. The study utilized multi-omics samples from various databases. Bioinformatic tools were employed to explore the expression profiles, genetic alterations, phosphorylation states, immune cell infiltration patterns, immune subtypes, functional enrichment, disease prognosis, as well as the diagnostic potential of MCM4 and its responsiveness to drugs in a range of cancers. Our research demonstrates that MCM4 is closely associated with the oncogenesis, prognosis and diagnosis of various tumors and proposes that MCM4 may function as a potential biomarker in pan-cancer, providing a deeper understanding of its potential role in cancer development and treatment.
MeSH term(s)	Humans ; Minichromosome Maintenance Complex Component 4/genetics ; Minichromosome Maintenance Complex Component 4/metabolism ; Prognosis ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Multiomics ; Minichromosome Maintenance Complex Component 6/metabolism ; Neoplasms/diagnosis ; Neoplasms/genetics
Chemical Substances	Minichromosome Maintenance Complex Component 4 (EC 3.6.4.12) ; Cell Cycle Proteins ; Minichromosome Maintenance Complex Component 6 (EC 3.6.4.12) ; MCM4 protein, human (EC 3.6.4.12)
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57299-1
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Article ; Online: Effect of

Gao, Fang / Zhang, Kaiping / Wang, Daixun / Xia, Lingyan / Gu, Yue / Tian, Jianjun / Jin, Ye

Food chemistry: X

2024 Volume 21, Page(s) 101205

Abstract: The decomposition and oxidation of fat is essential for the formation and quality of the unique flavor of sausage. To explore the effect of lactic acid bacteria on fat decomposition and oxidation in fermented sausage, free fatty acids and volatile flavor ...

Abstract	The decomposition and oxidation of fat is essential for the formation and quality of the unique flavor of sausage. To explore the effect of lactic acid bacteria on fat decomposition and oxidation in fermented sausage, free fatty acids and volatile flavor compounds were determined by gas chromatography (GC) and headspace solid-phase microextraction (HS-SPME)-GC-MS, respectively. The results showed that the addition of
Language	English
Publishing date	2024-02-08
Publishing country	Netherlands
Document type	Journal Article
ISSN	2590-1575
ISSN (online)	2590-1575
DOI	10.1016/j.fochx.2024.101205
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Article ; Online: Effects of denosumab on bone mineral density and bone metabolism in patients with end-stage renal disease: A systematic review and meta-analysis.

Gu, Zhaoyan / Yang, Xuhui / Wang, Yan / Gao, Jianjun

Hemodialysis international. International Symposium on Home Hemodialysis

2023 Volume 27, Issue 4, Page(s) 352–363

Abstract: Introduction: The effects of denosumab on bone mineral density (BMD) and metabolism in patients with end-stage renal disease (ESRD) remain controversial. Hence, we performed a systematic review and meta-analysis of observational studies.: Methods: ... ...

Abstract	Introduction: The effects of denosumab on bone mineral density (BMD) and metabolism in patients with end-stage renal disease (ESRD) remain controversial. Hence, we performed a systematic review and meta-analysis of observational studies. Methods: The MEDLINE, EMBASE, and Cochrane Library databases were searched in June 2022 to identify studies that evaluated the risk of denosumab-associated hypocalcemia and changes in bone metabolism, changes in BMD from baseline to post-treatment in patients with ESRD. Findings: Twelve studies with 348 participants were included. The pooled incidence of hypocalcemia during denosumab treatment was 35.0% (95% confidence interval [CI], 25%-46%; I Discussion: Denosumab increased the BMDs of the lumbar spine and femoral neck in patients with ESRD. The onset of hypocalcemia must be carefully monitored during denosumab administration.
MeSH term(s)	Humans ; Bone Density ; Denosumab/adverse effects ; Hypocalcemia/chemically induced ; Bone Density Conservation Agents/pharmacology ; Renal Dialysis ; Kidney Failure, Chronic
Chemical Substances	Denosumab (4EQZ6YO2HI) ; Bone Density Conservation Agents
Language	English
Publishing date	2023-06-01
Publishing country	Canada
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2192458-2
ISSN	1542-4758 ; 1492-7535
ISSN (online)	1542-4758
ISSN	1492-7535
DOI	10.1111/hdi.13098
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Article ; Online: Safety assessment of slope on in-service dump under severe dry-wet cycles at high-altitude.

Dong, Jianjun / Jiang, Hao / Yang, Di / Gao, Ke

Scientific reports

2023 Volume 13, Issue 1, Page(s) 16992

Abstract: This study aimed to evaluate the safety of dump slopes in high-altitude areas subjected to severe dry-wet cycles. The slope of No. 1 and No. 2 in-service dumps in limestone mining areas for cement in high-altitude mining areas is taken as the research ... ...

Abstract	This study aimed to evaluate the safety of dump slopes in high-altitude areas subjected to severe dry-wet cycles. The slope of No. 1 and No. 2 in-service dumps in limestone mining areas for cement in high-altitude mining areas is taken as the research object. The unsaturated soil shear strength and matrix suction distribution equations were imported based on the unsaturated-saturated seepage theory. Therefore, the evolution characteristics of the unsaturated-saturated seepage field in the dump are analyzed by numerical calculation, and the safety state of the dump slope is evaluated. The results indicated the following rules: under the action of four dry-wet cycles, the surface soil of the dump slope changes from an unsaturated state to a saturated state. Furthermore, with the increase in the times of the dry-wet cycle, the maximum vertical displacement of the No. 1 and No. 2 dump slopes increased. The numerical calculations of the maximum cumulative vertical displacement of the slope were consistent with the actual monitoring data. The factor of safety of the dump slope decreased continuously with the increase in the times of dry-wet cycles. Nevertheless, it still met the safety and stability standards. It was concluded that the slope of the in-service dump remains stable after enduring four severe cycles of dry-wet.
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-44002-z
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Article ; Online: Involvement of adaptive immune responses in a model of subacute colitis induced with dextran sulfate sodium in C57BL/6 mice.

Li, Jing / Dou, Fangzhou / Hu, Shasha / Gao, Jianjun

Drug discoveries & therapeutics

2023 Volume 17, Issue 4, Page(s) 294–298

Abstract: Inflammatory bowel disease (IBD) is a non-specific chronic intestinal inflammatory disorder. Pharmacotherapy serves as the main treatment strategy for IBD; however, the current medications have certain limitations, such as inefficacy and a tendency to ... ...

Abstract	Inflammatory bowel disease (IBD) is a non-specific chronic intestinal inflammatory disorder. Pharmacotherapy serves as the main treatment strategy for IBD; however, the current medications have certain limitations, such as inefficacy and a tendency to induce tolerance, thereby requiring the development of innovative drugs to fulfill therapeutic requirements. A model of acute colitis induced with a solution of approx. 3% dextran sulfate sodium (DSS) has been widely used in preclinical drug development. Nevertheless, this model has some drawbacks, including rapid disease progression leading to mortality in some mice and disparities between the inflammatory characteristics of mice and the pathological features of human IBD. The current study found that mice freely consuming a lower concentration of a DSS solution (1-1.5%) for 10-15 days exhibited milder colitis symptoms. Continued consumption of the DSS solution for 15-20 days resulted in chronic inflammation in colon tissue, accompanied by a significant increase in the proportion of Th1 cells, indicating the involvement of adaptive immune responses. Subsequently, mice were treated with mesalazine or Centella triterpenes while concurrently consuming the DSS solution for 10 days. The treated mice had significant improvements in body weight and colon length compared to the control group. The advantages of this subacute model include minimal mortality among experimental mice and the fact that intestinal mucosal inflammation in mice resembles the pathological features of human IBD, enabling the assessment of drug efficacy against IBD.
MeSH term(s)	Animals ; Mice ; Humans ; Dextran Sulfate/adverse effects ; Cytokines/adverse effects ; Mice, Inbred C57BL ; Colitis/chemically induced ; Colitis/drug therapy ; Inflammation ; Inflammatory Bowel Diseases/chemically induced ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/pathology ; Colon ; Immunity ; Disease Models, Animal
Chemical Substances	Dextran Sulfate (9042-14-2) ; Cytokines
Language	English
Publishing date	2023-07-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2568828-5
ISSN	1881-784X ; 1881-784X
ISSN (online)	1881-784X
ISSN	1881-784X
DOI	10.5582/ddt.2023.01015
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