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  1. AU=Sorbo Grazia
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  3. AU="Deng, Qiyuan"
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  1. Artikel: Fungal metabolite 6-pentyl-α-pyrone reduces canine coronavirus infection.

    Cerracchio, Claudia / Del Sorbo, Luca / Serra, Francesco / Staropoli, Alessia / Amoroso, Maria Grazia / Vinale, Francesco / Fiorito, Filomena

    Heliyon

    2024  Band 10, Heft 6, Seite(n) e28351

    Abstract: Canine coronavirus (CCoV) can produce a self-limited enteric disease in dogs but, because of notable biological plasticity of coronaviruses (CoVs), numerous mutations as well as recombination events happen leading to the emergence of variants often more ... ...

    Abstract Canine coronavirus (CCoV) can produce a self-limited enteric disease in dogs but, because of notable biological plasticity of coronaviruses (CoVs), numerous mutations as well as recombination events happen leading to the emergence of variants often more dangerous for both animals and humans. Indeed, the emergence of new canine-feline recombinant alphacoronaviruses, recently isolated from humans, highlight the cross-species transmission potential of CoVs. Consequently, new effective antiviral agents are required to treat CoV infections. Among the candidates for the development of drugs against CoVs infection, fungal secondary metabolites (SMs) represent an important source to investigate. Herein, antiviral ability of 6-pentyl-α-pyrone (6 PP), a SM obtained by
    Sprache Englisch
    Erscheinungsdatum 2024-03-20
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28351
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: In Vitro Evaluation of Antiviral Activities of Funicone-like Compounds Vermistatin and Penisimplicissin against Canine Coronavirus Infection.

    Cerracchio, Claudia / Salvatore, Maria Michela / Del Sorbo, Luca / Serra, Francesco / Amoroso, Maria Grazia / DellaGreca, Marina / Nicoletti, Rosario / Andolfi, Anna / Fiorito, Filomena

    Antibiotics (Basel, Switzerland)

    2023  Band 12, Heft 8

    Abstract: Recent studies have demonstrated that 3- ...

    Abstract Recent studies have demonstrated that 3-
    Sprache Englisch
    Erscheinungsdatum 2023-08-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12081319
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Breast unit Efficacy with the relocation of the surgical breast team during the COVID-19 pandemic.

    Sorbo, Grazia / Gagliano, Stefania / La Tessa, Cristina / Ferrarini, Riccardo / Galluzzo, Valentina / Cucchi, Maria Cristina

    The breast journal

    2020  Band 26, Heft 8, Seite(n) 1613–1614

    Mesh-Begriff(e) Betacoronavirus ; Breast Neoplasms/surgery ; COVID-19 ; Coronavirus Infections/epidemiology ; Female ; Humans ; Pandemics ; Patient Care Team ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-06-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1289960-4
    ISSN 1524-4741 ; 1075-122X
    ISSN (online) 1524-4741
    ISSN 1075-122X
    DOI 10.1111/tbj.13934
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Breast unit Efficacy with the relocation of the surgical breast team during the COVID-19 pandemic

    Sorbo, Grazia / Gagliano, Stefania / La Tessa, Cristina / Ferrarini, Riccardo / Galluzzo, Valentina / Cucchi, Maria Cristina

    Breast J

    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #602033
    Datenquelle COVID19

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  5. Artikel ; Online: Breast unit Efficacy with the relocation of the surgical breast team during the COVID‐19 pandemic

    Sorbo, Grazia / Gagliano, Stefania / La Tessa, Cristina / Ferrarini, Riccardo / Galluzzo, Valentina / Cucchi, Maria Cristina

    The Breast Journal

    2020  Band 26, Heft 8, Seite(n) 1613–1614

    Schlagwörter Internal Medicine ; Surgery ; Oncology ; covid19
    Sprache Englisch
    Verlag Wiley
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 1289960-4
    ISSN 1075-122X
    ISSN 1075-122X
    DOI 10.1111/tbj.13934
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Onset and mortality of Parkinson's disease in relation to type II diabetes.

    Pezzoli, Gianni / Cereda, Emanuele / Amami, Paolo / Colosimo, Santo / Barichella, Michela / Sacilotto, Giorgio / Zecchinelli, Anna / Zini, Michela / Ferri, Valentina / Bolliri, Carlotta / Calandrella, Daniela / Bonelli, Maria Grazia / Cereda, Viviana / Reali, Elisa / Caronni, Serena / Cassani, Erica / Canesi, Margherita / Del Sorbo, Francesca / Soliveri, Paola /
    Zecca, Luigi / Klersy, Catherine / Cilia, Roberto / Isaias, Ioannis U

    Journal of neurology

    2022  Band 270, Heft 3, Seite(n) 1564–1572

    Abstract: Objectives: There is growing evidence that Parkinson's disease and diabetes are partially related diseases; however, the association between the two, and the impact of specific treatments, are still unclear. We evaluated the effect of T2D and ... ...

    Abstract Objectives: There is growing evidence that Parkinson's disease and diabetes are partially related diseases; however, the association between the two, and the impact of specific treatments, are still unclear. We evaluated the effect of T2D and antidiabetic treatment on age at PD onset and on all-cause mortality.
    Research design and methods: The standardized rate of T2D was calculated for PD patients using the direct method and compared with subjects with essential tremor (ET) and the general Italian population. Age at onset and survival were also compared between patients without T2D (PD-noT2D), patients who developed T2D before PD onset (PD-preT2D) and patients who developed T2D after PD onset (PD-postT2D).
    Results: We designed a retrospective and prospective study. The T2D standardized ratio of PD (N = 8380) and ET (N = 1032) patients was 3.8% and 6.1%, respectively, while in the Italian general population, the overall prevalence was 5.3%. In PD-preT2D patients, on antidiabetic treatment, the onset of PD was associated with a + 6.2 year delay (p < 0.001) while no difference was observed in PD-postT2D. Occurrence of T2D before PD onset negatively affected prognosis (adjusted hazard ratio = 1.64 [95% CI 1.33-2.02]; p < 0.001), while no effect on survival was found in PD-postT2D subjects (hazard ratio = 0.86, [95% CI 0.53-1.39]; p = 0.54).
    Conclusions: T2D, treated with any antidiabetic therapy before PD, is associated with a delay in its onset. Duration of diabetes increases mortality in PD-preT2D, but not in PD-postT2D. These findings prompt further studies on antidiabetic drugs as a potential disease-modifying therapy for PD.
    Mesh-Begriff(e) Humans ; Parkinson Disease/drug therapy ; Parkinson Disease/epidemiology ; Parkinson Disease/complications ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Retrospective Studies ; Prospective Studies ; Essential Tremor/complications ; Hypoglycemic Agents/therapeutic use
    Chemische Substanzen Hypoglycemic Agents
    Sprache Englisch
    Erscheinungsdatum 2022-11-27
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-022-11496-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Skin Biopsy May Help to Distinguish Multiple System Atrophy-Parkinsonism from Parkinson's Disease With Orthostatic Hypotension.

    Donadio, Vincenzo / Incensi, Alex / Rizzo, Giovanni / De Micco, Rosa / Tessitore, Alessandro / Devigili, Grazia / Del Sorbo, Francesca / Bonvegna, Salvatore / Infante, Rossella / Magnani, Martina / Zenesini, Corrado / Vignatelli, Luca / Cilia, Roberto / Eleopra, Roberto / Tedeschi, Gioacchino / Liguori, Rocco

    Movement disorders : official journal of the Movement Disorder Society

    2020  Band 35, Heft 9, Seite(n) 1649–1657

    Abstract: Background: The differential diagnosis between multiple system atrophy parkinsonism type (MSA-P) and Parkinson's disease with orthostatic hypotension (PD+OH) is difficult because the 2 diseases have a similar clinical picture. The aim of this study is ... ...

    Abstract Background: The differential diagnosis between multiple system atrophy parkinsonism type (MSA-P) and Parkinson's disease with orthostatic hypotension (PD+OH) is difficult because the 2 diseases have a similar clinical picture. The aim of this study is to distinguish MSA-P from PD+OH by immunostaining for abnormal phosphorylated α-synuclein at serine 129 (p-syn) in cutaneous nerves.
    Method: We recruited 50 patients with parkinsonism and chronic orthostatic hypotension: 25 patients fulfilled the diagnostic criteria for MSA-P and 25 patients for PD+OH. The patients underwent a skin biopsy from the cervical area, thigh, and leg to analyze somatic and autonomic skin innervation and p-syn in skin nerves.
    Results: Intraneural p-syn positivity was found in 72% of patients with MSA-P, mainly in distal skin sites. More important, p-syn deposits in MSA-P differed from PD+OH because they were mainly found in somatic fibers of subepidermal plexi, whereas scant autonomic fiber involvement was found in only 3 patients. All patients with PD+OH displayed widely distributed p-syn deposits in the autonomic skin fibers of proximal and distal skin sites, whereas somatic fibers were affected only slightly in 4 patients with PD+OH. Skin innervation mirrored p-syn deposits because somatic innervation was mainly reduced in MSA-P. Sympathetic innervation was damaged in PD+OH but fairly preserved in MSA-P.
    Conclusions: The p-syn in cutaneous nerves allows the differentiation of MSA-P from PD+OH; MSA-P mainly shows somatic fiber involvement with relatively preserved autonomic innervation; and by contrast, PD+OH displays prevalent abnormal p-syn deposits and denervation in autonomic postganglionic nerves. © 2020 International Parkinson and Movement Disorder Society.
    Mesh-Begriff(e) Biopsy ; Humans ; Hypotension, Orthostatic/diagnosis ; Hypotension, Orthostatic/etiology ; Multiple System Atrophy/complications ; Multiple System Atrophy/diagnosis ; Parkinson Disease/complications ; Parkinson Disease/diagnosis ; alpha-Synuclein
    Chemische Substanzen alpha-Synuclein
    Sprache Englisch
    Erscheinungsdatum 2020-06-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.28126
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  8. Artikel ; Online: Protamine-like proteins have bactericidal activity. The first evidence in Mytilus galloprovincialis.

    Notariale, Rosaria / Basile, Adriana / Montana, Elena / Romano, Nunzia Colonna / Cacciapuoti, Maria Grazia / Aliberti, Francesco / Gesuele, Renato / De Ruberto, Francesca / Sorbo, Sergio / Tenore, Gian Carlo / Guida, Marco / Good, Katrina V / Ausió, Juan / Piscopo, Marina

    Acta biochimica Polonica

    2018  Band 65, Heft 4, Seite(n) 585–594

    Abstract: The major acid-soluble protein components of the mussel Mytilus galloprovincialis sperm chromatin consist of the protamine-like proteins PL-II, PL-III and PL-IV, an intermediate group of sperm nuclear basic proteins between histones and protamines. The ... ...

    Abstract The major acid-soluble protein components of the mussel Mytilus galloprovincialis sperm chromatin consist of the protamine-like proteins PL-II, PL-III and PL-IV, an intermediate group of sperm nuclear basic proteins between histones and protamines. The aim of this study was to investigate the bactericidal activity of these proteins since, to date, there are reports on bactericidal activity of protamines and histones, but not on protamine-like proteins. We tested the bactericidal activity of these proteins against Gram-positive bacteria: Enterococcus faecalis and two different strains of Staphylococcus aureus, as well as Gram-negative bacteria: Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella typhmurium, Enterobacter aerogenes, Enterobacter cloacae, and Escherichia coli. Clinical isolates of the same bacterial species were also used to compare their sensitivity to these proteins. The results show that Mytilus galloprovincialis protamine-like proteins exhibited bactericidal activity against all bacterial strains tested with different minimum bactericidal concentration values, ranging from 15.7 to 250 µg/mL. Furthermore, these proteins were active against some bacterial strains tested that are resistant to conventional antibiotics. These proteins showed very low toxicity as judged by red blood cell lysis and viability MTT assays and seem to act both at the membrane level and within the bacterial cell. We also tested the bactericidal activity of the product obtained from an in vitro model of gastrointestinal digestion of protamine-like proteins on a Gram-positive and a Gram-negative strain, and obtained the same results with respect to undigested protamine-like proteins on the Gram-positive bacterium. These results provide the first evidence of bactericidal activity of protamine-like-proteins.
    Mesh-Begriff(e) Animals ; Anti-Bacterial Agents/pharmacology ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Microbial Sensitivity Tests ; Mytilus ; Nuclear Proteins/pharmacology ; Protamines/pharmacology
    Chemische Substanzen Anti-Bacterial Agents ; Nuclear Proteins ; Protamines ; protamine-like protein III ; sperm basic nuclear proteins
    Sprache Englisch
    Erscheinungsdatum 2018-11-15
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ZDB-ID 595762-x
    ISSN 1734-154X ; 0001-527X
    ISSN (online) 1734-154X
    ISSN 0001-527X
    DOI 10.18388/abp.2018_2638
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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