LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 8 of total 8

Search options

  1. Article ; Online: Breastfeeding importance and its therapeutic potential against SARS-CoV-2.

    Vasques da Costa, Aline / Purcell Goes, Carolina / Gama, Patrícia

    Physiological reports

    2021  Volume 9, Issue 3, Page(s) e14744

    Abstract: During postnatal development, colostrum and breastmilk are sequentially the first sources of nutrition with protein components and bioactive molecules that confer protection and immunostimulatory function to the gut. Caseins, whey proteins, secretory ... ...

    Abstract During postnatal development, colostrum and breastmilk are sequentially the first sources of nutrition with protein components and bioactive molecules that confer protection and immunostimulatory function to the gut. Caseins, whey proteins, secretory immunoglobulin A (sIgA), mucins, tryptophan, and growth factors are among milk-borne elements that are directly important in the control of mucosa development and protection. Consequently, breastfeeding is associated with the low incidence of gastrointestinal inflammation and with the decrease in respiratory diseases during postnatal period. The novel coronavirus (SARS-CoV-2) binds to angiotensin II-converting enzyme (ACE2) on the cell membrane, allowing virus entrance, replication, and host commitment. ACE2 is expressed by different cell types, which include ciliated cells in the lungs and enterocytes in the intestine. Such cells are highly active in metabolism, as they internalize molecules to be processed and used by the organism. The disruption of ACE2 impairs leads to intestinal inflammation and decreased synthesis of serotonin, affecting motility. By reviewing the effects of SARS-CoV-2 in the gastrointestinal and respiratory tracts in infants, and gut responses to breastfeeding interruption, we suggest that it is important to maintain breastfeeding during SARS-CoV-2 infection, as it might be essential to protect newborns from gastrointestinal-associated disorders and relieve disease symptoms.
    MeSH term(s) Breast Feeding/trends ; COVID-19/metabolism ; COVID-19/prevention & control ; COVID-19/transmission ; Female ; Humans
    Language English
    Publishing date 2021-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.14744
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Breastfeeding lifespan control of growth, maintenance, and metabolism of small intestinal epithelium.

    Costa, Aline Vasques da / Rattes, Isadora Campos / Goes, Carolina Purcell / Lobo, Larissa Honda Greco / Barreto, Laylla Barreto E / Gama, Patricia

    Journal of cellular physiology

    2023  Volume 238, Issue 10, Page(s) 2304–2315

    Abstract: Gastrointestinal epithelial cells respond to milk-born molecules throughout breastfeeding, influencing growth, and development. The rapid renewal of the small intestine depends on the proliferation in the crypt that drives cell fates. We used early ... ...

    Abstract Gastrointestinal epithelial cells respond to milk-born molecules throughout breastfeeding, influencing growth, and development. The rapid renewal of the small intestine depends on the proliferation in the crypt that drives cell fates. We used early weaning model to investigate immediate and late effects of breastfeeding on proliferation, differentiation of jejunal epithelial cells. Wistar rats were either allowed to suckle (S) until 21 postnatal days or submitted to early weaning (EW) at 15 days. By comparing ages (18, 60, and 120 days), we found that EW decreased Ki67 indices and villi height at 18 and 60 days (p < 0.05), and at 120 days they were similar between diets. Proliferative reduction and augmented expression of Cdkn1b (p27 gene) were parallel. In the stem cell niche, EW increased the number and activity (Defa24) of Paneth cells at 18 and 60 days (p < 0.05), and Lgr5 and Ascl2 genes showed inverted responses between ages. Among target cells, EW decreased goblet cell number at 18 and 60 days (p < 0.05) and increased it at 120 days (p < 0.05), whereas enteroendocrine marker genes were differentially altered. EW reduced enterocytes density at 18 days (p < 0.05), and at 120 days this population was decreased (vs. 60 days). Among cell fate crypt-controlling genes, Notch and Atoh1 were the main targets of EW. Metabolically, intraperitoneal glucose tolerance was immediately reduced (18 days), being reverted until 120 days (p < 0.05). Currently, we showed that breastfeeding has a lifespan influence on intestinal mucosa and on its stem cell compartment. We suggest that, although jejunum absorptive function is granted after early weaning, the long lasting changes in gene expression might prime the mucosa with a different sensitivity to gut disorders that still have to be further explored.
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.31089
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Immediate and Late Effects of Early Weaning on Rat Gastric Cell Differentiation.

    Teles Silva, Melissa / Mesquita da Silva, Kethleen / Campos Rattes, Isadora / Maria Agostini Zonta, Gizela / Vasques da Costa, Aline / Galvão Figueredo Costa, Raquel / Karen Cordeiro Nogueira, Ludimila / Ogias, Daniela / Gama, Patricia

    International journal of molecular sciences

    2019  Volume 21, Issue 1

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Animals ; Cell Differentiation/physiology ; Epithelial Cells/physiology ; Female ; Gastric Mucosa/physiology ; Gene Expression/physiology ; Male ; Rats ; Rats, Wistar ; Stomach/physiology ; Weaning
    Language English
    Publishing date 2019-12-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21010196
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Immediate and Late Effects of Early Weaning on Rat Gastric Cell Differentiation

    Melissa Teles Silva / Kethleen Mesquita da Silva / Isadora Campos Rattes / Gizela Maria Agostini Zonta / Aline Vasques da Costa / Raquel Galvão Figueredo Costa / Ludimila Karen Cordeiro Nogueira / Daniela Ogias / Patricia Gama

    International Journal of Molecular Sciences, Vol 21, Iss 1, p

    2019  Volume 196

    Abstract: Background : Gastric glands grow and cells reach differentiation at weaning in rats. By considering that early weaning (EW) can affect the timing of development, we aimed to compare molecular and cellular markers of differentiation in pups and adults. ... ...

    Abstract Background : Gastric glands grow and cells reach differentiation at weaning in rats. By considering that early weaning (EW) can affect the timing of development, we aimed to compare molecular and cellular markers of differentiation in pups and adults. Methods : Wistar rats were separated into suckling-control (S) and EW groups at 15 days. Stomachs were collected at 15, 18, and 60 days for RNA and protein extraction, and morphology. Results : After EW, the expression of genes involved in differentiation ( Atp4b , Bhlha15 and Pgc ) augmented (18 days), and Atp4b and Gif were high at 60 days. EW increased the number of zymogenic cells (ZC) in pups and adults and augmented mucous neck cells only at 18 days, whereas parietal and transition cells (TC) were unchanged. Conclusions : EW affected the gastric mucosa mostly in a transient manner as the changes in gene expression and distribution of differentiated cells that were detected in pups were not fully maintained in adults, except for the size of ZC population. We concluded that though most of EW effects were immediate, such nutritional change in the infancy might affect part of gastric digestive functions in a permanent manner, as some markers were kept unbalanced in the adulthood.
    Keywords mucous neck cells ; zymogenic cells ; parietal cells ; breastfeeding ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  5. Article ; Online: Methylprednisolone as Adjunctive Therapy for Patients Hospitalized With Coronavirus Disease 2019 (COVID-19; Metcovid)

    Jeronimo, Christiane Maria Prado / Farias, Maria Eduarda Leão / Val, Fernando Fonseca Almeida / Sampaio, Vanderson Souza / Alexandre, Marcia Almeida Araújo / Melo, Gisely Cardoso / Safe, Izabella Picinin / Borba, Mayla Gabriela Silva / Netto, Rebeca Linhares Abreu / Maciel, Alex Bezerra Silva / Neto, João Ricardo Silva / Oliveira, Lucas Barbosa / Figueiredo, Erick Frota Gomes / Oliveira Dinelly, Kelry Mazurega / de Almeida Rodrigues, Maria Gabriela / Brito, Marcelo / Mourão, Maria Paula Gomes / Pivoto João, Guilherme Augusto / Hajjar, Ludhmila Abrahão /
    Bassat, Quique / Romero, Gustavo Adolfo Sierra / Naveca, Felipe Gomes / Vasconcelos, Heline Lira / de Araújo Tavares, Michel / Brito-Sousa, José Diego / Costa, Fabio Trindade Maranhão / Nogueira, Maurício Lacerda / Baía-da-Silva, Djane Clarys / Xavier, Mariana Simão / Monteiro, Wuelton Marcelo / Lacerda, Marcus Vinícius Guimarães / de Lemos Vasconcelos, Adria / Praia Marins, Adriana Ferreira / de Oliveira Trindade, Alexandre / Mendes Záu, Aline Sales / de Oliveira, Amanda Carvalho / Azevedo Furtado, Ana Carolina / Coelho Rocha, Ana Paula / da Silva Souza, Anderson / de Souza Dias, Andiana / Belém, Aníbal / dos Santos, Anna Gabriela Rezende / da Silva Sousa, Antonny Michael / da Silva, Beatriz França / Franco, Beatriz Leitão / da Silva, Bernardo Maia / da Costa, Bleno Leonam Gonçalves / Sato Barros do Amaral, Camila Miriam Suemi / Judice, Carla C / de Morais, Carlos Eduardo Padron / Camilo, Cecília Cunha / Sena da Silva, Danielle Severino / Gomes Duarte, Debora Camila / da Silva, Ejandre Garcia Negreiros / da Silva Lemos, Elias / de Fátima Ponte Frota, Elisângela / do Nascimento, Elizandra Freitas / de Almeida, Elson Silva / Marques, Elyana Almeida / de Almeida, Emanuel Medeiros Marinho / da Silva, Emanuelle Lira / dos Santos, Ester Galvão / da Silva Oliveira, Ezequiel / Martins Shimizu, Fábio Manabu / de Souza, Fabíola Ramalho Ferreira / da Silva do Vale, Felipe / dos Santos de Almeida Lima, Fernanda / da Fonseca, Fernando Hugo Jesus / Fontenelle, Flávia Alencar / de Azevedo Furtado, Francielen / Da Silva Pereira, Gabrielle / Bezerra, Geísa Aleixo / Maciel Salazar, Guilherme Kemeron / da Silva Pereira, Handerson / de Melo, Hilda Ferreira / Oliveira, Ingrid Nascimento / Pereira Filho, Ivanildo Vieira / Gomes, Jacimara Vasques / e Silva Rosa, Jaily / Lemos, Jonas Mota / Brutus, Josué Nélio / Pessoa, Karina Pinheiro / Costa Rodrigues, Laleyska Deucylane / Barros Cirino, Larissa Esthefani / Mourão Filho, Lauro Fragata / Moura, Leandro / Barbosa, Lisiane Rísia Pinto / de Souza, Lorenna Pereira / de Lima Ferreira, Luiz Carlos / dos Santos, Marcela Menezes / da Silva, Marcus Vinicius Ramos / Rodrigues, Mauro Pereira / de Menezes, Mayara Tavares / dos Santos Mota, Micaela Maciel / Freire, Monique / Corrêa, Nadya Fonseca / Rocha, Nagila Morais / Bittencourt, Najara / de Melo Silva, Natália Guedes / de Oliveira Saraiva, Priscilla / de Sousa Monteiro, Quézia / dos Santos, Rafael Theodoro / Freire, Raíssa Soares / de Araújo Pinto, Rebecca Augusta / Ferreira, Reinan Brotas / de Lima, Rodrigo Saboia / de Melo, Rosângela Francisca Tanantas / Saenz, Sabrina Teixeira / Alvarez Fernandes, Salete Sara / Vítor-Silva, Sheila / de Oliveira, Tânia Maria Rodrigues / Tavella, Tatyana A / Câmara, Thais Tavares / Santos, Thalie Cavalcante / Pinto, Thiago Serrão / dos Santos, Tilza Waleska Rocha / do Nascimento, Valdinete Alves / Sousa Barbosa, Wanessa Pessoa / de Melo, Wellinthon Ferreira / Salgado Sobrinho, Wlademir Braga

    Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

    A Randomized, Double-blind, Phase IIb, Placebo-controlled Trial

    2020  

    Abstract: Abstract Background Steroid use for coronavirus disease 2019 (COVID-19) is based on the possible role of these drugs in mitigating the inflammatory response, mainly in the lungs, triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ... ...

    Abstract Abstract Background Steroid use for coronavirus disease 2019 (COVID-19) is based on the possible role of these drugs in mitigating the inflammatory response, mainly in the lungs, triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to evaluate the efficacy of methylprednisolone (MP) among hospitalized patients with suspected COVID-19. Methods A parallel, double-blind, placebo-controlled, randomized, Phase IIb clinical trial was performed with hospitalized patients aged ≥18 years with clinical, epidemiological, and/or radiological suspected COVID-19 at a tertiary care facility in Manaus, Brazil. Patients were randomly allocated (1:1 ratio) to receive either intravenous MP (0.5 mg/kg) or placebo (saline solution) twice daily for 5 days. A modified intention-to-treat (mITT) analysis was conducted. The primary outcome was 28-day mortality. Results From 18 April to 16 June 2020, 647 patients were screened, 416 were randomized, and 393 were analyzed as mITT, with 194 individuals assigned to MP and 199 to placebo. SARS-CoV-2 infection was confirmed by reverse transcriptase polymerase chain reaction in 81.3%. The mortality rates at Day 28 were not different between groups. A subgroup analysis showed that patients over 60 years old in the MP group had a lower mortality rate at Day 28. Patients in the MP arm tended to need more insulin therapy, and no difference was seen in virus clearance in respiratory secretion until Day 7. Conclusions The findings of this study suggest that a short course of MP in hospitalized patients with COVID-19 did not reduce mortality in the overall population. Clinical Trials Registration NCT04343729.
    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    DOI 10.1093/cid/ciaa1177
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  6. Article: Brazilian Flora 2020: Leveraging the power of a collaborative scientific network

    Gomes‐da‐Silva, Janaína / Filardi, Fabiana L.R. / Barbosa, Maria Regina V. / Baumgratz, José Fernando A. / Bicudo, Carlos E.M. / Cavalcanti, Taciana B. / Coelho, Marcus A.N. / Costa, Andrea F. / Costa, Denise P. / Dalcin, Eduardo Couto / Labiak, Paulo / Lima, Haroldo C. / Lohmann, Lúcia G. / Maia, Leonor C. / Mansano, Vidal F. / Menezes, Mariângela / Morim, Marli P. / Moura, Carlos Wallace N. / Lughadha, Eimear Nic /
    Peralta, Denilson F. / Prado, Jefferson / Roque, Nádia / Stehmann, João Renato / Sylvestre, Lana S. / Trierveiler‐Pereira, Larissa / Walter, Bruno M.T. / Zimbrão, Geraldo / Forzza, Rafaela C. / Abreu, Fernanda P. / Abreu, Maria C. / Abreu, Vanessa H.R. / Acuña‐Castillo, Rafael / Afonso, Edgar A.L. / Agra, Leandro A.N.N. / Agra, Maria F. / Aguiar, Daniel P.P. / Aires, Elisa T. / Almeda, Frank / Almeida, Gracineide S.S. / Almeida, Mariana M. / Almeida, Nicolli B.C. / Almeida, Rafael F. / Almeida, Roberto B.P. / Almeida, Thaís E. / Almeida, Eduardo B., Júnior / Alves, Daniela M. / Alves, Flávio M. / Alves, Karina N.L. / Alves, Maria B.B. / Alves, Rodolfo F. / Amaral, Maria C.E. / Amaral, André L.S., Junior / Amélio, Leandro A. / Amorim, André M.A. / Amorim, Bruno S. / Amorim, Eduardo T. / Amorim, Vivian O. / Andrade, Ivanilza M. / Andrade, Ray S. / André, Thiago / Andreata, Regina H.P. / Andrino, Caroline O. / Ângulo, María B. / Anjos, Cassiane B. / Antar, Guilherme M. / Antonicelli, Mirian C.A. / Antunes, Lorena L.C. / Aona, Lidyanne Y.S. / Arana, Marcelo D. / Aranha, João L.M., Filho / Araújo, Anderson G.A. / Araujo, Andréa O. / Araújo, Camila C. / Araujo, Cintia A.T. / Araujo, Flávia M. / Araújo, Mário H.T. / Arbo, Maria M. / Arnou, Emily S. / Asprino, Renata C. / Assis, Francine C. / Assis, Leandro C.S. / Assis, Marta C. / Athayde Filho, Francisco / Athiê‐Souza, Sarah M. / Azevedo, Igor H.F. / Bacci, Lucas F. / Barbosa, Camilo V.O. / Barbosa, Juliana F. / Barbosa‐Silva, Rafael G. / Barcellos, Ian C. / Barboza, Gloria E. / Barcelos, Flávia R.B. / Barcelos, Laísa B. / Barreto, Kamilla L. / Barros, Fábio / Barros, Thamires L.A. / Barros‐Barreto, Maria B.B. / Bastos, Cid J.P. / Bastos, Cláudia A. / Batista, João A.N. / Batista, Marcella M.I. / Bautista, Hortencia P. / Benelli, Adarilda P. / Berguecio, Nicolás G. / Bernacci, Luís C. / Beyer, Maila / Bezerra, Andrea C.C. / Bezerra, Luísa M.P.A. / Bezerra, Yuri R.L. / Bianchetti, Luciano B. / Bigio, Narcísio C. / Biral, Leonardo / Bissoli, Vinícius F. / Bittencourt, Felipe / Bochorny, Thuane / Bohn, Amabily / Bohs, Lynn / Bojacá, Gabriel F.P. / Boldorini, Abril / Boldrini, Ilsi I. / Bolson, Mônica / Bordin, Juçara / Bordon, Natali G. / Borges, Rafael A.X. / Borges, Rodrigo L. / Bortoluzzi, Roseli L.C. / Bove, Claudia P. / Bovini, Massimo G. / Braga, João M.A. / Braga, Nayara S.S. / Branco, Suema / Brauner, Laiana M. / Braz, Denise M. / Bringel, João B.A., Júnior / Brito, Antonio L.V.T. / Brito, Eliete S. / Bruniera, Carla P. / Buchoski, Monica G. / Buck, William R. / Bueno, Norma C. / Bueno, Vinicius R. / Büneker, Henrique M. / Bünger, Mariana / Buril‐Vital, Maria T.A. / Burton, George P. / Cabral, Andressa / Cabral, Elsa L. / Cabral, Fernanda N. / Cabral, Tiara S. / Caddah, Mayara K. / Caires, Claudenir S. / Caires, Taiara A. / Calazans, Luana S.B. / Caldas, Diana K.D. / Calió, Maria F. / Calvo, Joel / Câmara, Paulo E.A.S. / Camargo, Rodrigo A. / Camelo, Mel C. / Campos‐Rocha, Antonio / Cândido, Elisa S. / Canestraro, Bianca K. / Canto‐Dorow, Thais S. / Cantuária, Patrick C. / Cara, Álison L. / Cárdenas, Gabriela G. / Cardoso, Andréia G. / Cardoso, Domingos B.O.S. / Cardoso, Jesiane M. / Cardoso, Leandro J.T. / Cardoso, Pedro H. / Cardozo, Andrey L. / M.D. Cardozo, Nállarett / Carmo, Dimas M. / Carmo, João A.M. / Carneiro, Camila R. / Carneiro, Cláudia E. / Carrijo, Tatiana T. / Caruzo, Maria B.R. / Carvalho, Catarina S. / Carvalho, Dariane A.S. / Carvalho, Fernanda A. / Carvalho, Maria L.S. / Carvalho, Jefferson G., Sobrinho / Carvalho‐Silva, Micheline / Castello, Ana C.D. / Castro, Márcia S. / Castro e Silva, Isabella C. / Catenacci, Fernanda S. / Cavalcanti, Laise H. / Cavalheiro, Larissa / Cervi, Armando C. / Chacon, Roberta G. / Chagas, Aline P. / Chagas, Earl C.O. / Chautems, Alain / Chauveau, Olivier / Chequín, Renata N. / Christ, Anderson L. / Christ, Jheniffer A. / Cidrão, Bruno B. / Clark, Lynn G. / Coelho, Alexa A.O.P. / Coelho, Guilherme P. / Coelho, Rubens L.G. / Colletta, Gabriel D. / Colli‐Silva, Matheus / Conceição, Adilva S. / Conceição, Tulio C. / Condack, João P.S. / Contro, Fernanda L. / Cordeiro, Inês / Cordeiro, Luciana S. / Cordeiro, Wesley P.F.S. / Côrtes, Ana L.A. / Costa, Daniel S. / Costa, Fabiane N. / Costa, Fernanda S.N. / Costa, Francisco C.P. / Costa, Géssica A.G. / Costa, Isabelle G.C.M. / Costa, Itayguara R. / Costa, Jeferson M. / Costa, Jorge A.S. / Costa, José G.S. / Costa, Maria T.R. / Costa, Mitchel I.A. / Costa, Suzana M. / Costa, Thiago V. / Costa, Tiago S. / Costa e Silva, Maria B. / Costa‐Lima, James L. / Cota, Matheus M.T. / Couceiro, Yuri S.V. / Coutinho, Thales S. / Couto, Dayvid R. / Couto, Ricardo S. / Couvo, Anielly F. / Cyrillo, Stephany B. / Dal Molin, Luis H. / Dalastra, Claudenice H. / Damasceno, Rafaella G.L. / De Lazzari, Lara R.P. / Deble, Leonardo P. / Delfini, Carolina / Delgado Junior, Geadelande C. / Delgado‐Salinas, Alfonso / Della, Aline P. / Delprete, Piero G. / Dematteis, Massimiliano / Dettke, Greta A. / Devecchi, Marcelo F. / Dewes, Talita S. / Di Maio, Fernando R. / Dias, Kauê N.L. / Dias, Micheli C. / Dias, Pedro / Díaz, Yani C.A. / Dittrich, Vinícius A.O. / Domínguez, Yoannis / Dórea, Marcos C. / Dorneles, Mariane P. / Dressler, Stefan / Duarte, Marilia C. / Duran, Juan D.T. / Dutilh, Julie H.A. / Dutra, Letícia L. / Dutra, Valquíria F. / Echternacht, Livia / Eggers, Lilian / Erkens, Roy H.J. / Eslabão, Marcelo P. / Espírito Santo, Fábio S. / Esser, Hans‐Joachim / Essi, Liliana / Esteves, Gerleni L. / Esteves, Roberto L. / Everling, Joel F. / Ezcurra, Cecilia / Facco, Marlon G. / Fader, Andrea A.C. / Falcão, Marcus J.A., Junior / Fantecelle, Laura B. / Farco, Gabriela E. / Faria, Allan L.A. / Faria, Ana P.G. / Faria, Aparecida D. / Faria, Maria T. / E.Q. Faria, Jair, Júnior / Farias, Sabrina Q. / Farias‐Singer, Rosana / Farinaccio, Maria A. / Fernandes, Ana C. / Fernandes, Fernando / Fernandes, José M. / Fernandes, Rozijane S. / Fernandes, Thiago / Fernandes, Ulisses G. / Fernandes, Aluisio J., Júnior / Fernando, Emanoel M.P. / Ferreira, Carlos D.M. / Ferreira, Fabrício M. / Ferreira, Gabriel E. / Ferreira, João P.R. / Ferreira, Priscila P.A. / Ferreira, Silvana C. / Ferrucci, María S. / Fiaschi, Pedro / Fidanza, Karina / Filgueiras, Tarciso S. / Firetti, Fabiana / Fleischmann, Andreas / Florentín, Javier E. / Florentín, Mariela N. / Flores, Andréia S. / Flores, Jerônimo M.M. / Flores, Thiago B. / Fonseca, Luiz H.M. / Fontelas, Jean C. / Fontella‐Pereira, Jorge / Forster, Wellington / Fraga, Claudio N. / Fraga, Fernanda R.M. / Fraga, Santiago / França, Flávio / França, Juliana R.K.G. / Francisco, Jéssica N.C. / Freire‐Fierro, Alina / Freitas, Fernanda S. / Freitas, Joelcio / Freitas, Maria F. / Fritsch, Peter / Funez, Luís A. / Furtado, Samyra G. / Gaem, Paulo H. / Gaglioti, André L. / Gagnon, Edeline / Gama, Beatriz R.A. / Garcia, Flávia C.P. / Gasper, André L. / Gerace, Samuele / Giacomin, Leandro L. / Giaretta, Augusto / Gil, André S.B. / Gissi, Danilo S. / Giuffre, Pamela M.W. / Giulietti, Ana M. / Giussani, Liliana M. / Goebel, Gabriela / Goes, Monique B. / Góes, Luiz A.A., Neto / Goldenberg, Renato / Gomes, Beatriz M. / Gomes, Fernanda P. / Gomes, Mario / Gomes‐Klein, Vera L. / Gonçalez, Victor M. / Gonçalves, Ana P.S. / Gonçalves, Deise J.P. / Gonella, Paulo M. / Gonzaga, Augusto F.N. / Gonzaga, Diego R. / González, Favio / Gonzatti, Felipe / Gouvêa, Yuri F. / Graham, Shirley A.T. / Gregório, Bernarda S. / Grings, Martin / Groppo, Milton / Grossi, Mariana A. / Guarçoni, Elidio A.E. / Guedes, Felipe M. / Guedes, Juliana S. / Guerra, Ethiéne / Guimarães, Elsie F. / Guimarães, Leonardo R.S. / Guimarães, Paulo J.F. / Gurgel, Ely S.C. / Gutiérrez, Diego G. / Hall, Climbiê F. / Harley, Raymond M. / Hassemer, Gustavo / Hattori, Eric K.O. / Hechenleitner, Paulina / Hefler, Sonia M. / Heiden, Gustavo / Henning, Tilo / Henriques, Diego K. / Hensold, Nancy / Hinoshita, Lucas K.R. / Hirai, Regina Y. / Hirao, Yasmin V. / Hiriart, Florencia D. / Hopkins, Michael J.G. / Hoyos‐Gómez, Saúl E. / Huamantupa, Isau / Hurbath, Fernanda / Iganci, João R.V. / Ilkiu‐Borges, Anna L. / Imig, Daniela C. / Inácio, Camila D. / Indriunas, Alexandre / Jacques, Eliane L. / Jacques, Suara S.A. / Jaimes, Juliana N. / Jardim, Jomar G. / Jesus, Jôane C. / Jesus, Priscila B. / Jiménez‐Mejías, Pedro / Johnson, David / Jordão, Lucas S.B. / Jordão, Valner M.M. / Jorge, Taciane S. / Kaehler, Miriam / Kameyama, Cíntia / Kataoka, Eric Y. / Kessous, Igor M. / Kilipper, Julia T. / Kinoshita, Luiza S. / Klein, Viviane P. / Klitgaard, Bente B. / Knapp, Sandra / Koch, Ana K. / Koch, Ingrid / Kochanovski, Fábio J. / Kominami, Gabriel F.G. / Konno, Tatiana U.P. / Koschnitzke, Cristiana / Kotovski, Emília R. / Kriebel, Ricardo / Külkamp, Josimar / Leal, Brígida A. / Leal, Eduardo S. / Leite, Áurea C.F. / Leite, Wellerson P. / Leitman, Paula M. / Lewis, Gwilym P. / Lima, Adriana Q. / Lima, Alexandre G. / Lima, Duane F.S. / Lima, Eliene / Lima, Jessica S. / Lima, Laíce F.G. / Lima, Laura C.P. / Lima, Letícia R. / Lima, Lucas V. / Lima, Luis F.P. / Lima, Rita B. / Lima, Vanessa L. / Link‐Perez, Melanie / Lirio, Elton J. / Lobão, Adriana Q. / Loeuille, Benoit F.P. / Loiola, Maria I.B. / Lombardi, Julio A. / Longhi‐Wagner, Hilda M. / Lopes, Gabriel S.R. / Lopes, Jenifer C. / Lopes, Letícia O. / Lopes, Raimundo / Lopes, Rosana C. / López, Maria G. / Lorencini, Tiago S. / Lorenzi, Harri / Lourenço, Ana R.L. / Lourenço, Arthur R. / Louzada, Rafael B. / Lovo, Juliana / Lozano, Eduardo D. / Luber, Jaquelini / Lucas, Dióber B. / Lucas, Eve J. / Lüdtke, Raquel / Luebert, Federico / Luizi‐Ponzo, Andrea P. / Luna, Bruna N. / Luna, Naédja K.M. / Luz, Cíntia L.S. / Machado, Anderson F.P. / Machado, Evandro P. / Machado, Talita M. / Maciel, Jefferson R. / Maciel, Sebastião / Magalhães, Rodrigo A. / Magenta, Mara A.G. / Maia, Talita A. / Mamede, Maria C.H. / Marchioretto, Maria S. / Margalho, Luciano F. / Marinho, Lucas C. / Marques, Danilo / Marquete, Ronaldo / Marra, Raquel C. / Martins, Angela B. / Martins, Márcio L.L. / Martins, Marcos B.S. / Martins, Milena V. / Martins, Renata C. / Martins, Suzana E. / Masson, Victória / Matias, Ligia Q. / Matos, Agnes M.M.V. / Matos, Andreza O. / Matos, Fernando B. / Matozinhos, Carolina N. / Mattos, Cilene M.J. / Mattos, Leticia / Matzenauer, William / Mauad, Anna V.S.R. / Maya‐Lastra, Carlos A. / Mayo, Simon J. / Mazine, Fiorella F. / Medeiros, Débora / Medeiros, Erika V.S.S. / Medeiros, Herison / Medeiros, Maria C.M.P. / Meerow, Alan W. / Meireles, Jose E. / Meireles, Leonardo D. / Meirelles, Julia / Melchor‐Castro, Briggitthe / Mello, Zelia R. / Mello‐Silva, Renato / Melo, André L. / Melo, Caio V.V.D. / Melo, Efigenia / Melo, José I.M. / Mendes, Jone C.R. / Mendes, Maria C.Q. / Mendes‐Silva, Ingrid / Meneguzzo, Thiago E.C. / Menezes, Cristine G. / Menezes, Felipe G.P. / Menini Neto, Luiz / Mentz, Lilian A. / Mesquita, Antônio L. / Messias, Patrícia A. / Mezzonato‐Pires, Ana C. / Michelangeli, Fabián A. / Miguel, João R. / Miguel, Laila M. / Milward‐de‐Azevedo, Michaele A. / Miotto, Silvia T.S. / Miranda, Cecília V. / Miranda, Vitor F.O. / Mitchell, John D. / Molina, José M.P. / Mondin, Cláudio A. / Monge, Marcelo / Monteiro, Daniele / Monteiro, Fernanda K.S. / Monteiro, Raquel F. / Monteiro, Silvana H.N. / Monteiro, Thiago C. / Monzoli, João V.L. / Moore, Paloma G.P. / Mora, Martha M. / Moraes, Marta D. / Moraes, Mónica R. / Morales, Juan F. / Morales, Matías / Moran, Robbin C. / Moreira, André L.C. / Moreira, Andréia D.R. / Moreira, Ariane S. / Moreira, Bianca A. / Moreira, Giselle L. / Moreira, Kassio V.C. / Moreira, Pablo F.F. / Morokawa, Rosemeri / Moroni, Pablo / Mota, Aline C. / Mota, Michelle C.A. / Mota, Nara F.O. / Moura, Beryl E.L. / Moura, Ingridy O. / Moura, Luíza C. / Moura, Ricardo L. / Moura, Tania M. / Mundim, Júlia V. / Muniz, Francisca H. / Muniz, Leticia N. / Muniz Filho, Eduardo / Mynssen, Claudine M. / Nakajima, Jimi N. / Nascimento, Janaina G.A. / Nascimento, José E., Júnior / Nascimento, Silvia M. / Nepomuceno, Francisco A.A. / Nervo, Michelle H. / Nery, Eduardo K. / Neves, Beatriz / Nóbrega, Giseli A. / Nogueira, Matheus G.C. / Nunes, Annelise F. / Nunes, Clebiana S. / Nunes, Teonildes S. / Oellgaard, Benjamin / O'Leary, Nataly / Oliveira, Adriana L.R. / Oliveira, Ana C.S. / Oliveira, Andreza G.S. / Oliveira, Aron B. / Oliveira, Bárbara A. / Oliveira, Caetano T. / Oliveira, Fernanda M.C. / Oliveira, Filipe G.A. / Oliveira, Gleison S. / Oliveira, Gustavo R. / Oliveira, Hermeson C. / Oliveira, Iasmin L.C. / Oliveira, Joésili C.P. / Oliveira, José F.C. / Oliveira, Juliana A. / Oliveira, Juliana R.P.M. / Oliveira, Leticia G.R. / Oliveira, Lilian F.A. / Oliveira, Lorena C. / Oliveira, Luciana S.D. / Oliveira, Marcia C.R. / Oliveira, Márcio L.B. / Oliveira, Marcos G.M. / Oliveira, Marise H.V. / Oliveira, Marla I.U. / Oliveira, Regina C. / Oliveira, Renata S. / Oliveira, Reyjane P. / Oliveira, Rodrigo C.G. / Oliveira, Sylvia M. / Oliveira, Ykaro R. / Orlandini, Priscila / Orsolano, Guilherme N. / Pacífico, Ricardo / Paglia, Isis / Paiva, Gabrielle C.P. / Paixão, Liliane C. / Pastore, José F.B. / Pastore, Mayara / Pastori, Tamara / Paucar, Jenny O.A. / Paula‐Souza, Juliana / Pederneiras, Leandro C. / Peichoto, Myriam C. / Peixoto, Ariane L. / Pell, Susan K. / Pellegrini, Marco O.O. / Pena, Nelson T.L. / Pennington, Richard T. / Pereira, Amanda P.N. / Pereira, Andreza S.S. / Pereira, Jovani B.S. / Pereira, Maria S. / Pereira, Paulo E.E. / Pereira, Sidney S. / Pereira‐Silva, Rafaela A. / Perez, Ana P.F. / Pessoa, Cleiton S. / Pessoa, Clenia S. / Pessoa, Edlley M. / Pessoa, Maria C.R. / Petrongari, Fernanda S. / Philbrick, Thomas C. / Pignal, Marc / Pimenta, Karena M. / Pinto, Rafael B. / Pioner, Natália C. / Pirani, José R. / Pizzardo, Raquel C. / Plos, Anabela / Ponce, Marta M. / Pontes, Juliana S. / Pontes, Ricardo A.S. / Pontes, Tiago A. / Pontes‐Pires, Aline F. / Pott, Vali J. / Prado, Thainá C. / Praia, Talita S. / Prance, Ghillean T. / Prange, Carolina K. / Prata, Ana P.N. / Prochazka, Luana S. / Proença, Carolyn E.B. / Prudêncio, Renato X.A. / Pscheidt, Allan C. / Quaresma, Aclebia A. / Quaresma, Aline S. / Queiroz, George A. / Queiroz, Luciano P. / Queiroz, Rubens T. / Quinet, Alexandre / Ramos, Eliana / Ramos, Geraldo J.P. / Rando, Juliana G. / Rebouças, Natanael C. / Reginato, Marcelo / Reis, Miguel M.R. / Reis, Priscila A. / Reis‐Silva, Genilson A. / Ribas, Osmar S. / Ribeiro, André R.O. / Ribeiro, Carolina L. / Ribeiro, José E.L.S. / Ribeiro, Michel / Ribeiro, Pétala G. / Ribeiro, Rayane T.M. / Ribeiro, Ricardo S. / Ribeiro, Rogério N. / Riina, Ricarda / Ritter, Mara R. / Rivadavia, Fernando / Rivera, Vanessa L. / Rizzo, Beatriz D. / Rocha, Antônio E.S. / Rocha, Lamarck / Rocha, Maria J.R. / Rodrigues, Carine M. / Rodrigues, Christchellyn K. / Rodrigues, Izabella M.C. / Rodrigues, Marianna C. / Rodrigues, Rodrigo Sampaio / Rodrigues, Rodrigo Schütz / Rodríguez, Juan F.C. / Rodríguez, Pedro A. / Rollim, Isis M. / Romanini, Rebeca P. / Romão, Gerson O. / Romão, Marcos V.V. / Romero, María F. / Romero, Rosana / Rosa, Bárbara R. / Rosa, Patrícia / Rosa, Priscila O. / Rosário, Alessandro S. / Rossa, Iago M. / Rossetto, Elson F.S. / Rossi, Lucia / Rossini, Josiene / Royer, Carla A. / Rua, Gabriel H. / Sá, Cyl F.C. / Saavedra, Mariana M. / Saka, Mariana N. / Sakuragui, Cassia M. / Salas, Roberto M. / Sales, Margareth F. / Salgado, Vanina G. / Salimena, Fátima R.G. / Salino, Alexandre / Salvador, Rafael B. / Sampaio, Daniela / Sancho, Gisela / Sano, Paulo T. / Santana, Jéssica C.O. / Santana, Karoline C. / Santana, Mariana H. / Santiago, Augusto C.P. / Santos, Alessandra / Santos, Amanda P.B. / Santos, Ana C.A.S. / Santos, Andrea K.A. / Santos, Carlos A.G. / Santos, Emanuelle L. / Santos, Felipe S. / Santos, Fernanda B. / Santos, João U.M. / Santos, Karin / Santos, Leidiana L. / Santos, Matheus F. / Santos, Otilene A. / Santos, Rafaela F. / Santos, Renata G.P. / Santos, Thaíla V.A. / Santos, Thiago F. / Santos, Vanessa T. / Santos‐Silva, Fernanda / Santos‐Silva, Juliana / São‐Mateus, Wallace M.B. / Saraiva, Deisy P. / Sarkinen, Tiina / Sartori, Ângela L.B. / Sassone, Agostina B. / Sauthier, Luana J. / Scalon, Viviane R. / Scatigna, André V. / Schaefer, Juliana / Scheidegger, Najla M.B. / Schliewe, Marcos A. / Schmidt, Eduard D.L. / Schneider, Angelo A. / Schneider, Layla J.C. / Schuettpelz, Eric / Schwartsburd, Pedro B. / Schwarz, Elizabeth A. / Scudeler, Ana L. / Sebastiani, Renata / Secco, Ricardo S. / Secretti, Elisangela / Segalla, Rosane / Seleme, Elidiene P. / Semir, João / Senna, Luisa R. / Setubal, Robberson B. / Shimizu, Gustavo H. / Shirasuna, Regina T. / Silva, Adaíses S.M. / Silva, Aline V.M. / Silva, Amanda L. / Silva, Anádria S. / Silva, Caroline C.A. / Silva, Cassio R. / Silva, Christian / Silva, Cintia V. / Silva, Diego N. / Silva, Dilana F. / Silva, Fabio A. / Silva, Fernanda O. / Silva, Francismeire B. / Silva, Gabriel B. / Silva, Gledson J. / Silva, Guilherme S. / Silva, Gustavo H.L. / Silva, João P.S. / Silva, Juliana L. / Silva, Juliene F.M. / Silva, Leonardo N. / Silva, Lucas V. / Silva, Luciana P. / Silva, Luiza N. / Silva, Márcio A. / Silva, Marcio R.P. / Silva, Marcos J. / Silva, Marcus F.O. / Silva, Maria L.B. / Silva, Maria S.D. / Silva, Nilda M.F. / Silva, Otávio L.M. / Silva, Rafael C. / Silva, Raphael / Silva, Renata S.A. / Silva, Renato R. / Silva, Ronaldo V. / Silva, Saura R. / Silva, Suelma R. / Silva, Tânia R.S. / Silva, Tatiane S. / Silva, Thaynara S. / Silva, Wanderson L.S. / Silva Filho, Pedro J.S. / Silva‐Castro, Milene M. / Silva‐Cobra, Gisele O. / Silva‐Gonçalves, Kelly C. / Silveira, Fernanda S. / Silveira, João B. / Silveira, Thamyres C. / Simão‐Bianchini, Rosangela / Simões, Ana R. / Simões, André O. / Simon, Marcelo F. / Siniscalchi, Carolina M. / Siqueira, Carlos E. / Smidt, Eric C. / Smith, Alan R. / Smith, Nathan P. / Snak, Cristiane / Soares, Abel E.R. / Soares, Arthur S. / Soares, Edson L.C. / Soares, Kelen P. / Soares, Luanda P. / Soares, Marcos V.B. / Soares, Maria L.C. / Soares, Polyana N. / L. Soares, Raimundo, Neto / Sobrado, Sandra V. / Sobral, Marcos / Somner, Genise V. / Sothers, Cynthia / Sousa, Ana A.C. / Sousa, Danilo J.L. / Sousa, Francisco S. / Sousa, Gardene M. / Sousa, Hian C.F. / Sousa, Leandro O.F. / Sousa, Mayco W.S. / Sousa, Valdeci F. / Souza, Aline M. / Souza, Bruno P. / Souza, Elnatan B. / Souza, Élvia R. / Souza, Filipe S. / Souza, Luzia F. / Souza, Marcelo C. / Souza, Maria A.D. / Souza, Raquel M.B.S. / Souza, Vinicius C. / Souza‐Buturi, Fátima O. / Spina, Andréa P. / Stadnik, Aline M.S. / Staggemeier, Vanessa G. / Stapf, María N.S. / Stefano, Rodrigo D. / Stern, Stephen / Streher, Nathália S. / Suchoronczek, Andréia / Sundue, Michael / Takeuchi, Cátia / Tardivo, Rosângela C. / Taylor, Nigel P. / Teixeira, Michella D.R. / Teles, Aristônio M. / Temponi, Livia G. / Thode, Verônica A. / Thomas, William W. / Tierno, Lorena R. / Tissot‐Squalli, Mara / Toledo, Cássio A.P. / Torke, Benjamin M. / Torres, Alicia M. / Torres, Daniela S.C. / Torres‐Leite, Filipe / Tozzi, Ana M.G.A. / Trad, Rafaela J. / Trevisan, Rafael / Trovó, Marcelo / Tuler, Amélia C. / Tyrrell, Christopher / Udulutsch, Renata G. / Uribbe, Fernando P. / Vahl, Daiane R. / Valadares, Rodrigo T. / Valdemarin, Karinne S. / Valduga, Eduardo / Valente, Emilia B. / Valls, Jose F.M. / van den Berg, Cássio / Vasconcelos, Liziane V. / Vasconcelos, Thaís N.C. / Vasques, Diego T. / Vaz, Angela M.S.F. / Versiane, Ana F.A. / Versieux, Leonardo M. / Via do Pico, Gisela M. / Viana, Pedro L. / Vianna, Suelen A. / Vianna Filho, Marcelo D.M. / Vidal, Kaio V.A. / Vidal, João D., Júnior / Vieira, Fábio C.S. / Vieira, Jaqueline A. / Vieira, João P.S. / Vieira, Lucas L.A. / Vieira, Tamara A.F. / Vieira, Tiago L. / Viera‐Barreto, Jéssica N. / Vignoli‐Silva, Márcia / Vilas Bôas‐Bastos, Silvana B. / Villarreal, Juan C. / Vincent, Michael A. / Vita, Marcela D. / Vitta, Fabio A. / Viveros, Raquel S. / Viviurka, Fernanda / Vogel Ely, Cleusa / Volet, Danilo P. / Völtz, Rafael R. / Wallnöfer, Bruno / Wanderley, Maria G.L. / Watanabe, Mauricio T.C. / Weber, Philipy A.P. / Weigend, Maximilian / Welker, Cassiano A.D. / Windisch, Paulo G. / Yoshikawa, Vania N. / Zamengo, Henrique B. / Zanatta, Maria R.V. / Zannin, Ana / Zappi, Daniela C. / Zeferino, Laís C. / Zelenski, Andréia / Zuloaga, Fernando O. / Zuntini, Alexandre R.

    Taxon. 2022 Feb., v. 71, no. 1

    2022  

    Abstract: The shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant ...

    Institution The Brazil Flora Group
    Abstract The shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora.
    Keywords algae ; biodiversity ; cerrado ; flora ; fungi ; geographical distribution ; indigenous species ; rain forests ; Brazil
    Language English
    Dates of publication 2022-02
    Size p. 178-198.
    Publishing place John Wiley & Sons, Inc.
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 204216-2
    ISSN 0040-0262
    ISSN 0040-0262
    DOI 10.1002/tax.12640
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  7. Article ; Online: Impact of an inpatient multidisciplinary glucose control management program.

    Momesso, Denise P / Costa Filho, Rubens Carmo / Costa, João Luiz Ferreira / Saddy, Felipe / Mesquita, Ayla / Calomeni, Marcela / Silva, Claudia Dos Santos / Farret, Jacqueline / Vasques, Mariana Leon / Santos, Aline G / Cabral, Ana Paula Vieira / Ribeiro, Dayane / Reis, Luciana / Muino, Maria de Fátima M / Vitorino, Roberta Santiago / Monteiro, Claudio Amorim / Tinoco, Evandro / Volschan, Andre

    Archives of endocrinology and metabolism

    2018  Volume 62, Issue 5, Page(s) 514–522

    Abstract: Objective: Glycemic control has been increasingly recognized as a critical element in inpatient care, but optimal management of blood glucose in the hospital setting remains challenging. The aims of this study were to describe and evaluate the impact of ...

    Abstract Objective: Glycemic control has been increasingly recognized as a critical element in inpatient care, but optimal management of blood glucose in the hospital setting remains challenging. The aims of this study were to describe and evaluate the impact of the implementation of an inpatient multidisciplinary glucose control management program on glucose control in hospitalized patients.
    Materials and methods: Retrospective analysis of medical records and glucose monitoring data obtained by point- of-care testing (POCT) in hospitalized patients before (May 2014) and after (June 2015 and May 2017) the implementation of the program.
    Results: We analyzed 6888, 7290, and 7669 POCTs from 389, 545, and 475 patients in May 2014, June 2015, and May 2017, respectively. Hyperglycemia (≥ 180 mg/ dL) occurred in 23.5%, 19.6%, and 19.3% POCTs in May 2014, June 2015, and May/2017, respectively (p < 0.001), while severe hyperglycemia (≥ 300 mg/dL) was observed in 2.5%, 2.2%, and 1.8% of them, respectively (p = 0.003). Hyperglycemia (≥ 180 mg/dL) reduced significantly from May 2014 to June 2015 (16.3%, p < 0.001) and from May 2014 to May 2017 (178%, p < 0.001). No significant changes occurred in hypoglycemic parameters.
    Conclusions: The implementation of an inpatient multidisciplinary glucose control management program led to significant reductions in hyperglycemic events. The key elements for this achievement were the development of institutional inpatient glycemic control protocols, establishment of a multidisciplinary team, and continuing educational programs for hospital personnel. Altogether, these actions resulted in improvements in care processes, patient safety, and clinical outcomes of hospitalized patients.
    MeSH term(s) Aged ; Aged, 80 and over ; Blood Glucose/analysis ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/prevention & control ; Female ; Humans ; Hyperglycemia/drug therapy ; Hyperglycemia/prevention & control ; Hypoglycemia/etiology ; Hypoglycemic Agents/therapeutic use ; Inpatients/statistics & numerical data ; Insulin/therapeutic use ; Male ; Middle Aged ; Point-of-Care Testing/statistics & numerical data ; Program Evaluation ; Reference Standards ; Reproducibility of Results ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Adherence and Compliance
    Chemical Substances Blood Glucose ; Hypoglycemic Agents ; Insulin
    Language English
    Publishing date 2018-11-15
    Publishing country Brazil
    Document type Evaluation Study ; Journal Article
    ISSN 2359-4292
    ISSN (online) 2359-4292
    DOI 10.20945/2359-3997000000071
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Impact of an inpatient multidisciplinary glucose control management program

    Denise P Momesso / Rubens Carmo Costa Filho / João Luiz Ferreira Costa / Felipe Saddy / Ayla Mesquita / Marcela Calomeni / Claudia dos Santos Silva / Jacqueline Farret / Mariana Leon Vasques / Aline G. Santos / Ana Paula Vieira Cabral / Dayane Ribeiro / Luciana Reis / Maria de Fátima M. Muino / Roberta Santiago Vitorino / Claudio Amorim Monteiro / Evandro Tinoco / Andre Volschan

    Archives of Endocrinology and Metabolism, Vol 62, Iss 5, Pp 514-522

    Abstract: ABSTRACT Objective: Glycemic control has been increasingly recognized as a critical element in inpatient care, but optimal management of blood glucose in the hospital setting remains challenging. The aims of this study were to describe and evaluate the ... ...

    Abstract ABSTRACT Objective: Glycemic control has been increasingly recognized as a critical element in inpatient care, but optimal management of blood glucose in the hospital setting remains challenging. The aims of this study were to describe and evaluate the impact of the implementation of an inpatient multidisciplinary glucose control management program on glucose control in hospitalized patients. Materials and methods: Retrospective analysis of medical records and glucose monitoring data obtained by point- of-care testing (POCT) in hospitalized patients before (May 2014) and after (June 2015 and May 2017) the implementation of the program. Results: We analyzed 6888, 7290, and 7669 POCTs from 389, 545, and 475 patients in May 2014, June 2015, and May 2017, respectively. Hyperglycemia (≥ 180 mg/ dL) occurred in 23.5%, 19.6%, and 19.3% POCTs in May 2014, June 2015, and May/2017, respectively (p < 0.001), while severe hyperglycemia (≥ 300 mg/dL) was observed in 2.5%, 2.2%, and 1.8% of them, respectively (p = 0.003). Hyperglycemia (≥ 180 mg/dL) reduced significantly from May 2014 to June 2015 (16.3%, p < 0.001) and from May 2014 to May 2017 (178%, p < 0.001). No significant changes occurred in hypoglycemic parameters. Conclusions: The implementation of an inpatient multidisciplinary glucose control management program led to significant reductions in hyperglycemic events. The key elements for this achievement were the development of institutional inpatient glycemic control protocols, establishment of a multidisciplinary team, and continuing educational programs for hospital personnel. Altogether, these actions resulted in improvements in care processes, patient safety, and clinical outcomes of hospitalized patients.
    Keywords Hyperglycemia ; hypoglycemia ; inpatient glucose control ; diabetes mellitus ; systems ; point-of-care ; Medicine ; R ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665
    Subject code 005
    Language English
    Publisher Brazilian Society of Endocrinology and Metabolism
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

To top