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Article ; Online: Pharmacokinetics Study of Jin-Gu-Lian Prescription and Its Core Drug Pair (

Zheng, Lin / Zhou, Ting / Liu, Hui / Zhou, Zuying / Chi, Mingyan / Li, Yueting / Gong, Zipeng / Huang, Yong

2022 Volume 27, Issue 13

Abstract: Jin-Gu-Lian (JGL) is traditionally used by Miao for the treatment of rheumatism arthralgia ...

Abstract	Jin-Gu-Lian (JGL) is traditionally used by Miao for the treatment of rheumatism arthralgia. At the same time, the combination of
MeSH term(s)	Administration, Oral ; Alangiaceae ; Animals ; Chlorogenic Acid ; Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid/methods ; Cytidine Diphosphate ; Drugs, Chinese Herbal/analysis ; Melia azedarach ; Plants, Medicinal ; Prescriptions ; Ranunculales ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry/methods
Chemical Substances	Drugs, Chinese Herbal ; Chlorogenic Acid (318ADP12RI) ; Cytidine Diphosphate (63-38-7)
Language	English
Publishing date	2022-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27134025
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Article ; Online: Quercetin serves as the major component of Xiang-lian Pill to ameliorate ulcerative colitis via tipping the balance of STAT1/PPARγ and dictating the alternative activation of macrophage.

Zhou, Hai-Feng / Yang, Chao / Li, Jun-Yi / He, Yu-Yao / Huang, Yun / Qin, Ren-Jie / Zhou, Qiao-Li / Sun, Fei / Hu, De-Sheng / Yang, Jia

Journal of ethnopharmacology

2023 Volume 313, Page(s) 116557

Abstract: Ethnopharmacological relevance: The traditional Chinese herbal formula, Xiang-lian Pill (XLP), is ...

Abstract	Ethnopharmacological relevance: The traditional Chinese herbal formula, Xiang-lian Pill (XLP), is commonly prescribed for ulcerative colitis (UC) patients to relieve their clinical symptom. Nonetheless, the underlying cellular and molecular mechanisms of XLP's anti-UC effect remain incompletely understood. Aim of the study: To evaluate the therapeutic effect and elucidate the possible working mechanisms of XLP in UC treatment. The major active component of XLP was also characterized. Materials and methods: Colitis was induced in C57BL/6 mice with 3% dextran sulfate sodium (DSS) dissolved in drinking water for 7 consecutive days. The UC mice were grouped and treated with XLP (3640 mg/kg) or vehicle orally during the procedure of DSS induction. Mouse body weight, disease activity index (DAI) score and colon length were recorded. Histopathological changes and inflammatory cell infiltration were evaluated by pathological staining and flow cytometric analysis (FACS). Network pharmacology, bioinformatic analysis, widely targeted and targeted metabolomics analysis were performed to screen the potential effective ingredients and key targets. Bone marrow derived macrophages (BMDMs), peripheral blood mononuclear cells (PBMCs), RAW264.7 and THP-1 cells were used to dissect the anti-inflammatory effect of XLP. Results: Oral administration of XLP ameliorated DSS induced mouse colitis, as evidenced by reduced DAI and colonic inflammatory destruction. FACS results demonstrated that XLP treatment effectively restored immune tolerance in colon, inhibited the generation of monocyte derived macrophages and skewed macrophage polarization into M2 phenotype. Network pharmacology analysis suggested that innate effector modules related to macrophage activation comprise the major targets of XLP, and the counter-regulatory STAT1/PPARγ signaling possibly serves as the critical downstream pathway. Subsequent experiments unveiled an imbalance of STAT1/PPARγ signaling in monocytes derived from UC patients, and validated that XLP suppressed LPS/IFN-γ induced macrophage activation (STAT1 mediated) but facilitated IL-4 induced macrophage M2 polarization (PPARγ dependent). Meanwhile, our data showed that quercetin served as the major component of XLP to recapitulate the regulatory effect on macrophages. Conclusion: Our findings revealed that quercetin serves as the major component of XLP that regulates macrophage alternative activation via tipping the balance of STAT1/PPARγ, which provides a mechanistic explanation for the therapeutic effect of XLP in UC treatment.
MeSH term(s)	Animals ; Mice ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/metabolism ; PPAR gamma/metabolism ; Quercetin/pharmacology ; Quercetin/therapeutic use ; Quercetin/metabolism ; Leukocytes, Mononuclear/metabolism ; Mice, Inbred C57BL ; Colon ; Colitis/drug therapy ; Macrophages ; Dextran Sulfate/toxicity ; Disease Models, Animal ; STAT1 Transcription Factor/metabolism
Chemical Substances	PPAR gamma ; Quercetin (9IKM0I5T1E) ; Dextran Sulfate (9042-14-2) ; Stat1 protein, mouse ; STAT1 Transcription Factor
Language	English
Publishing date	2023-05-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116557
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Article: Intermodule Coupling Analysis of Huang-Lian-Jie-Du Decoction on Stroke.

Wang, Pengqian / Dai, Li / Zhou, Weiwei / Meng, Jing / Zhang, Miao / Wu, Yin / Huo, Hairu / Xiong, Xingjiang / Sui, Feng

Frontiers in pharmacology

2019 Volume 10, Page(s) 1288

Abstract: Huang-Lian-Jie-Du Decoction (HLJDD) is a "Fangji" made up of well-designed Chinese herb array and ...

Abstract	Huang-Lian-Jie-Du Decoction (HLJDD) is a "Fangji" made up of well-designed Chinese herb array and widely used to treat ischemic stroke. Here we aimed to investigate pharmacological mechanism by introducing an inter-module analysis to identify an overarching view of target profile and action mode of HLJDD. Stroke-related genes were obtained from OMIM (Online Mendelian Inheritance in Man). And the potential target proteins of HLJDD were identified according to TCMsp (Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform). The two sets of molecules related to stroke and HLJDD were respectively imported into STRING database to construct the stroke network and HLJDD network, which were dissected into modules through MCODE, respectively. We analyzed the inter-module connectivity by quantify "coupling score" (CS) between HLJDD-modules (H-modules) and stroke-modules (S-module) to explore the pharmacological acting pattern of HLJDD on stroke. A total of 267 stroke-related proteins and 15 S-modules, 335 HLJDD putative targeting proteins, and 13 H-modules were identified, respectively. HLJDD directly targeted 28 proteins in stroke network, majority (16, 57.14%) of which were in S-modules 1 and 4. According to the modular map based on inter-module CS analysis, H-modules 1, 2, and 8 densely connected with S-modules 1, 3, and 4 to constitute a module-to-module bridgeness, and the enriched pathways of this bridgeness with top significance were TNF signaling pathway, HIF signaling pathway, and PI3K-Akt signaling pathway. Furthermore, through this bridgeness, H-modules 2 and 4 cooperatively work together to regulate mitochondrial apoptosis against the ischemia injury. Finally, the core protein in H-module 4 account for mitochondrial apoptosis was validated by an
Language	English
Publishing date	2019-11-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2019.01288
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Article: Effects of Huang-Lian-Jie-Du Decoction on Oxidative Stress and AMPK-SIRT1 Pathway in Alzheimer's Disease Rat.

Gu, Xinru / Zhao, Haiyu / Zhou, Junyi / Zhou, Yanyan / Wei, Xiaolu / Wang, Hongjie / Bian, Baolin / Yang, Jian / Ren, Wei / Si, Nan

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 6212907

Abstract: Huang-Lian-Jie-Du Decoction (HLJDD), traditional Chinese medicine (TCM), is proven to have ...

Abstract	Huang-Lian-Jie-Du Decoction (HLJDD), traditional Chinese medicine (TCM), is proven to have ameliorative effects on learning and memory deficits of Alzheimer's disease (AD). The current study aims to reveal the underlying mechanism of HLJDD in the treatment of AD by simultaneous determination on the regulation of HLJDD on oxidative stress, neurotransmitters, and AMPK-SIRT1 pathway in AD. AD model rat was successfully established by injection of D-galactose and A
Language	English
Publishing date	2020-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/6212907
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Article ; Online: Combination of multi-model statistical analysis and quantitative fingerprinting in quality evaluation of Shuang-huang-lian oral liquid.

Si, Wei / Qiao, Yali / Liu, Zhe / Jin, Gaowa / Liu, Yanfang / Xue, Xingya / Zhou, Han / Liu, Yanming / Shen, Aijin / Liang, Xinmiao

Analytical and bioanalytical chemistry

2020 Volume 412, Issue 26, Page(s) 7073–7083

Abstract: ... was established to carry out quality control analysis of Shuang-huang-lian (SHL) oral liquid ...

Abstract	A model consisting of quantitative fingerprinting integrated with fundamental statistical analysis was established to carry out quality control analysis of Shuang-huang-lian (SHL) oral liquid. The quantitative fingerprinting approach was developed by systematic investigation of the chromatographic condition and optimization of a gradient using a complex sample analysis software system (CSASS). Five pivotal components from three traditional Chinese medicines of SHL oral liquid were determined at dual wavelengths, including phillyrin, baicalin, chlorogenic acid, neochlorogenic acid and cryptochlorogenic acid. Among them, neochlorogenic acid and cryptochlorogenic acid were quantified by quantitative analysis of multi-components with a single marker (QAMS) method. Further, the developed quantitative fingerprinting approach was validated. Good linearity with correlation coefficients (R
MeSH term(s)	Administration, Oral ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/standards ; Models, Statistical ; Principal Component Analysis ; Quality Control
Chemical Substances	Drugs, Chinese Herbal ; shuang-huang-lian
Language	English
Publishing date	2020-08-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-020-02841-z
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Article ; Online: Correction to: Combination of multi-model statistical analysis and quantitative fingerprinting in quality evaluation of Shuang-huang-lian oral liquid.

Si, Wei / Qiao, Yali / Liu, Zhe / Jin, Gaowa / Liu, Yanfang / Xue, Xingya / Zhou, Han / Liu, Yanming / Shen, Aijin / Liang, Xinmiao

Analytical and bioanalytical chemistry

2020 Volume 412, Issue 29, Page(s) 8223

Abstract: The authors would like to call the reader's attention to the fact that unfortunately there was a mistake in Table 1 of this contribution. ...

Abstract	The authors would like to call the reader's attention to the fact that unfortunately there was a mistake in Table 1 of this contribution.
Language	English
Publishing date	2020-10-01
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-020-02937-6
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Article ; Online: Chemical profiling and quantification of multiple components in Jin-Gu-Lian capsule using a multivariate data processing approach based on UHPLC-Orbitrap Exploris 240 MS and UHPLC-MS/MS.

Zhou, Zu-Ying / Huang, Yong / Xiao, Jin-Chao / Liu, Hui / Wang, Yong-Lin / Gong, Zi-Peng / Li, Yue-Ting / Wang, Ai-Min / Li, Yong-Jun / Zheng, Lin

Journal of separation science

2022 Volume 45, Issue 6, Page(s) 1282–1291

Abstract: The Jin-Gu-Lian capsule, a Chinese Miao herbal compound, is widely used to treat rheumatoid ... developed to analyze the chemical composition of Jin-Gu-Lian capsules. A total of 88 compounds were ... simultaneously determined in the Jin-Gu-Lian capsules. The established method was successfully validated and ...

Abstract	The Jin-Gu-Lian capsule, a Chinese Miao herbal compound, is widely used to treat rheumatoid arthritis. In this study, a rapid, selective, and sensitive UHPLC-Orbitrap Exploris 240 MS method was developed to analyze the chemical composition of Jin-Gu-Lian capsules. A total of 88 compounds were identified, including 23 flavonoids, 23 organic acids, 14 phenylpropanoids, 12 phenols, eight alkaloids, four terpenes, three quinones, and one ketone. Among these, 21 compounds were clearly detected based on a comparison with reference standards and selected as quality control markers. Thereafter, these compounds were simultaneously determined in the Jin-Gu-Lian capsules. The established method was successfully validated and applied for the simultaneous determination of 21 biologically active compounds in Jin-Gu-Lian capsules of 27 sample batches. Quantitative data of the analytes were analyzed using multivariate statistical analysis to determine the quality of the Jin-Gu-Lian capsules. Four compounds (JGLC6 [salidroside], JGLC8 [chlorogenic acid], JGLC12 [liriodendrin], JGLC19 [quercetin]) were identified as chemical markers for quality control of Jin-Gu-Lian capsules. Altogether, the established method was validated as a novel and efficient tool, that can be used for rapid analysis of Jin-Gu-Lian capsules. Accordingly, this study serves as a reference for scientific research on traditional Chinese and ethnic medicine.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/analysis ; Flavonoids/analysis ; Quality Control ; Tandem Mass Spectrometry/methods
Chemical Substances	Drugs, Chinese Herbal ; Flavonoids
Language	English
Publishing date	2022-02-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202100762
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Article: Active Ingredients and Potential Mechanisms of the Gan Jiang-Huang Qin-Huang Lian-Ren Shen Decoction against Ulcerative Colitis: A Network Pharmacology and Molecular Docking-Based Study.

Zhou, Ce / Zhou, Hang / Zhang, Furong / Hao, Liangliang / Guo, Jing

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 1925718

Abstract: ... which is often used to treat chronic diseases, including UC. The Gan Jiang-Huang Qin-Huang Lian-Ren Shen ...

Abstract	Background: Ulcerative colitis (UC), a chronic and nonspecific inflammatory bowel disease, seriously affects the quality of patients' life. Han Re Bing Yong Fa (treating diseases with both cool- and warm-natured herbs) is a classical therapeutic principle of traditional Chinese medicine (TCM), which is often used to treat chronic diseases, including UC. The Gan Jiang-Huang Qin-Huang Lian-Ren Shen decoction (GJHQHLRSD), a representative of Han Re Bing Yong Fa, is effective in alleviating inflammatory symptoms in UC. However, the pharmacological mechanism underlying its anti-inflammatory effect remains unclear. Methods: A network pharmacology strategy, including the construction and analysis of the drug-disease network, was used to explore the complex mechanism of GJHQHLRSD treatment of UC. In addition, molecular docking technology was used to preliminarily examine the binding ability of the potential active components and core therapeutic targets of GJHQHLRSD. Results: The network pharmacology results revealed 140 targets of GJHQHLRSD which are involved in UC. The PPI network analysis identified seven target genes: Conclusions: This study reflects the multicomponent, multitarget, and multipathway characteristics of the action mechanism of GJHQHLRSD in treating UC. Furthermore, it helps better understand the TCM therapeutic principle of Han Re Bing Yong Fa and explore novel candidate drug targets for UC treatment.
Language	English
Publishing date	2021-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/1925718
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Article: Effect of Rhizoma coptidis (Huang Lian) on Treating Diabetes Mellitus.

Pang, Bing / Yu, Xiao-Tong / Zhou, Qiang / Zhao, Tian-Yu / Wang, Han / Gu, Cheng-Juan / Tong, Xiao-Lin

Evidence-based complementary and alternative medicine : eCAM

2015 Volume 2015, Page(s) 921416

Abstract: ... which usually contains various active ingredients could provide multiple therapeutic effects. Huang Lian ...

Abstract	The rapidly increasing diabetes mellitus (DM) is becoming a major public health issue globally; considerable progress has been made in the field of western hypoglycemic drug and insulin, but some shortages still exist. As one of the most important parts in complementary and alternative therapies, traditional Chinese medicine (TCM) performs a good clinical practice and is showing a bright future in the treatment of DM. TCM therapy has certain advantages of less toxicity and/or side effects, and Chinese herbal medicine which usually contains various active ingredients could provide multiple therapeutic effects. Huang Lian (Rhizoma coptidis, RC) is a herb frequently used in many traditional formulas for properties of "clearing damp-heat, quenching fire, and counteracting poison" in Asia for centuries. In this review, we summarize the application of RC in the treatment of DM from two aspects of contents. Firstly, theoretical principles are explained, including the properties and related records about RC in ancient references and modern pharmacological researches and pharmacokinetics on RC and its active components. Secondly, the clinical application of RC is mainly reviewed, such as applicable stage and syndrome, the reasonable dose range, the preparation formulations, and the toxicity and/or side effects and solutions to its adverse actions. This review provides scientific evidence about the effective components, pharmacological researches, and toxicity of RC, as well as introducing traditional Chinese medical theory and clinical experience, in order to guide clinician to use RC more suitably and reasonably in the clinical practice.
Language	English
Publishing date	2015-10-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2015/921416
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Article ; Online: Effects of Huang-Lian-Jie-Du Decoction on Oxidative Stress and AMPK-SIRT1 Pathway in Alzheimer’s Disease Rat

Xinru Gu / Haiyu Zhao / Junyi Zhou / Yanyan Zhou / Xiaolu Wei / Hongjie Wang / Baolin Bian / Jian Yang / Wei Ren / Nan Si

Evidence-Based Complementary and Alternative Medicine, Vol

2020 Volume 2020

Abstract: Huang-Lian-Jie-Du Decoction (HLJDD), traditional Chinese medicine (TCM), is proven to have ...

Abstract	Huang-Lian-Jie-Du Decoction (HLJDD), traditional Chinese medicine (TCM), is proven to have ameliorative effects on learning and memory deficits of Alzheimer’s disease (AD). The current study aims to reveal the underlying mechanism of HLJDD in the treatment of AD by simultaneous determination on the regulation of HLJDD on oxidative stress, neurotransmitters, and AMPK-SIRT1 pathway in AD. AD model rat was successfully established by injection of D-galactose and Aβ25-35-ibotenic acid. Morris Water Maze (MWM) test was used to evaluate the success of AD modelling. On this basis, an advanced technique with UPLC-QqQ MS/MS was built up and applied to determine the levels of 8 neurotransmitters in rat plasma. Significant alternation in methionine, glutamine, and tryptophan was observed in AD rats’ plasma after the administration of HLJDD, relative to the model group. Meanwhile, HLJDD could upregulate the levels of SOD, GSH-Px, AMPK, and SIRT1 and downregulate the content of MDA in the peripheral system of the AD rats. The underlying therapeutic mechanism of HLJDD for the treatment of AD was associated with alleviating oxidation stress, inflammation, neurotransmitters, and energy metabolism. These data provide solid foundation for the potential use of HLJDD to treat AD.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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