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Article ; Online: Negative radiation pressure in Bose-Einstein condensates.

Ciurla, Dominik / Forgács, Péter / Lukács, Árpád / Romańczukiewicz, Tomasz

2024 Volume 109, Issue 1-1, Page(s) 14228

Abstract: In two-component nonlinear Schrödinger equations, the force exerted by incident monochromatic plane waves on an embedded dark soliton and on dark-bright-type solitons is investigated, both perturbatively and by numerical simulations. When the incoming ... ...

Abstract	In two-component nonlinear Schrödinger equations, the force exerted by incident monochromatic plane waves on an embedded dark soliton and on dark-bright-type solitons is investigated, both perturbatively and by numerical simulations. When the incoming wave is nonvanishing only in the orthogonal component to that of the embedded dark soliton, its acceleration is in the opposite direction to that of the incoming wave. This somewhat surprising phenomenon can be attributed to the well-known negative effective mass of the dark soliton. When a dark-bright soliton, whose effective mass is also negative, is hit by an incoming wave nonvanishing in the component corresponding to the dark soliton, the direction of its acceleration coincides with that of the incoming wave. This implies that the net force acting on it is in the opposite direction to that of the incoming wave. This rather counterintuitive effect is a yet another manifestation of negative radiation pressure exerted by the incident wave, observed in other systems. When a dark-bright soliton interacts with an incoming wave in the component of the bright soliton, it accelerates in the opposite direction; hence the force is pushing it now. We expect that these remarkable effects, in particular the negative radiation pressure, can be experimentally verified in Bose-Einstein condensates.
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.109.014228
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Article: Lead acetate precursor based p-i-n perovskite solar cells with enhanced reproducibility and low hysteresis

Forgács, Dávid / Bolink, Henk J / Sessolo, Michele

Journal of materials chemistry A. 2015 June 30, v. 3, no. 27

2015

Abstract: A low temperature approach for the fabrication of p-i-n perovskite solar cells is presented. Using ...

Abstract	A low temperature approach for the fabrication of p-i-n perovskite solar cells is presented. Using lead acetate-based precursors, flat and homogeneous CH3NH3PbI3 films, compatible with the use of thin organic charge transport layers, can be obtained. The corresponding solar cells showed power conversion efficiency up to 12.5%, with remarkable reproducibility and very low hysteresis.
Keywords	chemistry ; hysteresis ; lead ; lead acetate ; solar cells ; solar energy ; temperature
Language	English
Dates of publication	2015-0630
Size	p. 14121-14125.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702232-8
ISSN	2050-7496 ; 2050-7488
ISSN (online)	2050-7496
ISSN	2050-7488
DOI	10.1039/c5ta03169a
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Article ; Online: Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Lo, Raymond / Celius, Trine / Forgacs, Agnes L / Dere, Edward / MacPherson, Laura / Harper, Patricia / Zacharewski, Timothy / Matthews, Jason

Toxicology and applied pharmacology

2011 Volume 257, Issue 1, Page(s) 38–47

Abstract: ... tetrachlorodibenzo-p-dioxin (TCDD) for 2 h and 24 h. These studies identified 1642 and 508 AHR-bound regions at 2h ...

Abstract	Genome-wide, promoter-focused ChIP-chip analysis of hepatic aryl hydrocarbon receptor (AHR) binding sites was conducted in 8-week old female C57BL/6 treated with 30 μg/kg/body weight 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for 2 h and 24 h. These studies identified 1642 and 508 AHR-bound regions at 2h and 24h, respectively. A total of 430 AHR-bound regions were common between the two time points, corresponding to 403 unique genes. Comparison with previous AHR ChIP-chip studies in mouse hepatoma cells revealed that only 62 of the putative target genes overlapped with the 2 h AHR-bound regions in vivo. Transcription factor binding site analysis revealed an over-representation of aryl hydrocarbon response elements (AHREs) in AHR-bound regions with 53% (2 h) and 68% (24 h) of them containing at least one AHRE. In addition to AHREs, E2f-Myc activator motifs previously implicated in AHR function, as well as a number of other motifs, including Sp1, nuclear receptor subfamily 2 factor, and early growth response factor motifs were also identified. Expression microarray studies identified 133 unique genes differentially regulated after 4 h treatment with TCDD. Of which, 39 were identified as AHR-bound genes at 2 h. Ingenuity Pathway Analysis on the 39 AHR-bound TCDD responsive genes identified potential perturbation in biological processes such as lipid metabolism, drug metabolism, and endocrine system development as a result of TCDD-mediated AHR activation. Our findings identify direct AHR target genes in vivo, highlight in vitro and in vivo differences in AHR signaling and show that AHR recruitment does not necessarily result in changes in target gene expression.
MeSH term(s)	Animals ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Dioxins/pharmacology ; Female ; Gene Expression Regulation/drug effects ; Liver/drug effects ; Liver/metabolism ; Liver Neoplasms/metabolism ; Mice ; Mice, Inbred C57BL ; Oligonucleotide Array Sequence Analysis ; Protein Interaction Domains and Motifs ; Receptors, Aryl Hydrocarbon/drug effects ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism ; Transcription Factors/metabolism
Chemical Substances	Dioxins ; Receptors, Aryl Hydrocarbon ; Transcription Factors ; 2,3,7,8-tetrabromodibenzo-4-dioxin (04PL7F455E)
Language	English
Publishing date	2011-11-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/j.taap.2011.08.016
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Article ; Online: o-p'-DDT-mediated uterotrophy and gene expression in immature C57BL/6 mice and Sprague-Dawley rats.

Kwekel, Joshua C / Forgacs, Agnes L / Williams, Kurt J / Zacharewski, Timothy R

Toxicology and applied pharmacology

2013 Volume 273, Issue 3, Page(s) 532–541

Abstract: 1,1,1-Trichloro-2,2-bis(2-chlorophenyl-4-chlorophenyl)ethane (o,p'-DDT) is an organochlorine ... morphological and gene expression responses elicited by o,p'-DDT and ethynyl estradiol (EE) in immature ... by both ligands in both species, 559 of which exhibited similar temporal expression profiles suggesting that o,p' ...

Abstract	1,1,1-Trichloro-2,2-bis(2-chlorophenyl-4-chlorophenyl)ethane (o,p'-DDT) is an organochlorine pesticide and endocrine disruptor known to activate the estrogen receptor. Comprehensive ligand- and species-comparative dose- and time-dependent studies were conducted to systematically assess the uterine physiological, morphological and gene expression responses elicited by o,p'-DDT and ethynyl estradiol (EE) in immature ovariectomized C57BL/6 mice and Sprague-Dawley rats. Custom cDNA microarrays were used to identify conserved and divergent differential gene expression responses. A total of 1256 genes were differentially expressed by both ligands in both species, 559 of which exhibited similar temporal expression profiles suggesting that o,p'-DDT elicits estrogenic effects at high doses when compared to EE. However, 51 genes exhibited species-specific uterine expression elicited by o,p'-DDT. For example, carbonic anhydrase 2 exhibited species- and ligand-divergent expression as confirmed by quantitative real-time PCR. The identification of comparable temporal phenotypic responses linked to gene expression demonstrates that systematic comparative gene expression assessments are valuable for elucidating conserved and divergent estrogen signaling mechanisms in rodent uterotrophy.
MeSH term(s)	Animals ; DDT/toxicity ; Endocrine Disruptors/toxicity ; Estrogens/toxicity ; Female ; Gene Expression ; Gene Expression Profiling ; Mice ; Mice, Inbred C57BL ; Oligonucleotide Array Sequence Analysis ; Pesticides/toxicity ; RNA/genetics ; RNA/isolation & purification ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism ; Species Specificity ; Uterus/drug effects ; Uterus/metabolism ; Uterus/pathology
Chemical Substances	Endocrine Disruptors ; Estrogens ; Pesticides ; Receptors, Estrogen ; RNA (63231-63-0) ; DDT (CIW5S16655) ; o,p'-DDT (D4K93Z1TBH)
Language	English
Publishing date	2013-12-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/j.taap.2013.09.024
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Article: o-p′-DDT-mediated uterotrophy and gene expression in immature C57BL/6 mice and Sprague–Dawley rats

Kwekel, Joshua C / Forgacs, Agnes L / Williams, Kurt J / Zacharewski, Timothy R

Toxicology and applied pharmacology. 2013 Dec. 15, v. 273, no. 3

2013

Abstract: 1,1,1-Trichloro-2,2-bis(2-chlorophenyl-4-chlorophenyl)ethane (o,p′-DDT) is an organochlorine ... morphological and gene expression responses elicited by o,p′-DDT and ethynyl estradiol (EE) in immature ... by both ligands in both species, 559 of which exhibited similar temporal expression profiles suggesting that o,p ...

Abstract	1,1,1-Trichloro-2,2-bis(2-chlorophenyl-4-chlorophenyl)ethane (o,p′-DDT) is an organochlorine pesticide and endocrine disruptor known to activate the estrogen receptor. Comprehensive ligand- and species-comparative dose- and time-dependent studies were conducted to systematically assess the uterine physiological, morphological and gene expression responses elicited by o,p′-DDT and ethynyl estradiol (EE) in immature ovariectomized C57BL/6 mice and Sprague–Dawley rats. Custom cDNA microarrays were used to identify conserved and divergent differential gene expression responses. A total of 1256 genes were differentially expressed by both ligands in both species, 559 of which exhibited similar temporal expression profiles suggesting that o,p′-DDT elicits estrogenic effects at high doses when compared to EE. However, 51 genes exhibited species-specific uterine expression elicited by o,p′-DDT. For example, carbonic anhydrase 2 exhibited species- and ligand-divergent expression as confirmed by quantitative real-time PCR. The identification of comparable temporal phenotypic responses linked to gene expression demonstrates that systematic comparative gene expression assessments are valuable for elucidating conserved and divergent estrogen signaling mechanisms in rodent uterotrophy.
Keywords	DDT (pesticide) ; carbonate dehydratase ; complementary DNA ; endocrine-disrupting chemicals ; estradiol ; estrogen receptors ; estrogenic properties ; ethane ; gene expression ; gene expression regulation ; genes ; mice ; microarray technology ; ovariectomy ; quantitative polymerase chain reaction ; rats
Language	English
Dates of publication	2013-1215
Size	p. 532-541.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/j.taap.2013.09.024
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Article ; Online: The Electrographic Effects of Ketamine on Patients With Refractory Status Epilepticus After Cardiac Arrest: A Single-Center Retrospective Cohort.

Qing, Kurt / Alkhachroum, Ayham / Claassen, Jan / Forgacs, Peter / Schiff, Nicholas

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

2024

Abstract: ... 95% confidence interval 1.16-44.65, P value of 0.0341) for ketamine versus no ketamine. Most ...

Abstract	Purpose: To investigate the effects of ketamine on patients with refractory status epilepticus after cardiac arrest. Methods: In this retrospective cohort, selected EEG segments from patients after cardiac arrest were classified into different EEG patterns (based on background continuity and burden of epileptiform discharges) and spectral profiles (based on the presence of frequency components). For patients who received ketamine, EEG data were compared before, during, and after ketamine infusion; for the no-ketamine group, EEG data were compared at three separated time points during recording. Ketamine usage was determined by clinical providers. Electrographic improvement in epileptiform activity was scored, and the odds ratio was calculated using the Fisher exact test. Functional outcome measures at time of discharge were also examined. Results: Of a total of 38 patients with postcardiac arrest refractory status epilepticus, 13 received ketamine and 25 did not. All patients were on ≥2 antiseizure medications including at least one sedative infusion (midazolam). For the ketamine group, eight patients had electrographic improvement, compared with only two patients in the no-ketamine group, with an odds ratio of 7.19 (95% confidence interval 1.16-44.65, P value of 0.0341) for ketamine versus no ketamine. Most of the patients who received ketamine had myoclonic status epilepticus, and overall neurologic outcomes were poor with no patients having a favorable outcome. Conclusions: For postarrest refractory status epilepticus, ketamine use was associated with electrographic improvement, but with the available data, it is unclear whether ketamine use or EEG improvement can be linked to better functional recovery.
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	605640-4
ISSN	1537-1603 ; 0736-0258
ISSN (online)	1537-1603
ISSN	0736-0258
DOI	10.1097/WNP.0000000000001065
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Article ; Online: Active matter shepherding and clustering in inhomogeneous environments.

Forgács, P / Libál, A / Reichhardt, C / Reichhardt, C J O

Physical review. E

2021 Volume 104, Issue 4-1, Page(s) 44613

Abstract: We consider a mixture of active and passive run-and-tumble disks in an inhomogeneous environment where only half of the sample contains quenched disorder or pinning. The disks are initialized in a fully mixed state of uniform density. We identify several ...

Abstract	We consider a mixture of active and passive run-and-tumble disks in an inhomogeneous environment where only half of the sample contains quenched disorder or pinning. The disks are initialized in a fully mixed state of uniform density. We identify several distinct dynamical phases as a function of motor force and pinning density. At high pinning densities and high motor forces, there is a two-step process initiated by a rapid accumulation of both active and passive disks in the pinned region, which produces a large density gradient in the system. This is followed by a slower species phase separation process where the inactive disks are shepherded by the active disks into the pin-free region, forming a nonclustered fluid and producing a more uniform density with species phase separation. For higher pinning densities and low motor forces, the dynamics becomes very slow and the system maintains a strong density gradient. For weaker pinning and large motor forces, a floating clustered state appears, and the time-averaged density of the system is uniform. We illustrate the appearance of these phases in a dynamic phase diagram.
Language	English
Publishing date	2021-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.104.044613
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Article ; Online: Transition from susceptible-infected to susceptible-infected-recovered dynamics in a susceptible-cleric-zombie-recovered active matter model.

Libál, A / Forgács, P / Néda, Á / Reichhardt, C / Hengartner, N / Reichhardt, C J O

Physical review. E

2022 Volume 107, Issue 2-1, Page(s) 24604

Abstract: The susceptible-infected (SI) and susceptible-infected-recovered (SIR) models provide two distinct representations of epidemic evolution, distinguished by whether or not the number of susceptibles always drops to zero at long times. Here we introduce a ... ...

Abstract	The susceptible-infected (SI) and susceptible-infected-recovered (SIR) models provide two distinct representations of epidemic evolution, distinguished by whether or not the number of susceptibles always drops to zero at long times. Here we introduce a new active matter epidemic model, the "susceptible-cleric-zombie-recovered" (SCZR) model, in which spontaneous recovery is absent but zombies can recover with probability γ via interaction with a cleric. Upon colliding with a zombie, both susceptibles and clerics enter the zombie state with probability β and α, respectively. By changing the initial fraction of clerics or their healing ability rate γ, we can tune the SCZR model between SI dynamics, in which no susceptibles or clerics remain at long times, and SIR dynamics, in which a finite number of clerics and susceptibles survive at long times. The model is relevant to certain real world diseases such as HIV where spontaneous recovery is impossible but where medical interventions by a limited number of caregivers can reduce or eliminate the spread of infection.
MeSH term(s)	Humans ; Clergy ; Epidemics ; Disease Susceptibility ; Probability
Language	English
Publishing date	2022-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.107.024604
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Article ; Online: Using active matter to introduce spatial heterogeneity to the susceptible infected recovered model of epidemic spreading.

Forgács, P / Libál, A / Reichhardt, C / Hengartner, N / Reichhardt, C J O

Scientific reports

2022 Volume 12, Issue 1, Page(s) 11229

Abstract: The widely used susceptible-infected-recovered (S-I-R) epidemic model assumes a uniform, well-mixed population, and incorporation of spatial heterogeneities remains a major challenge. Understanding failures of the mixing assumption is important for ... ...

Abstract	The widely used susceptible-infected-recovered (S-I-R) epidemic model assumes a uniform, well-mixed population, and incorporation of spatial heterogeneities remains a major challenge. Understanding failures of the mixing assumption is important for designing effective disease mitigation approaches. We combine a run-and-tumble self-propelled active matter system with an S-I-R model to capture the effects of spatial disorder. Working in the motility-induced phase separation regime both with and without quenched disorder, we find two epidemic regimes. For low transmissibility, quenched disorder lowers the frequency of epidemics and increases their average duration. For high transmissibility, the epidemic spreads as a front and the epidemic curves are less sensitive to quenched disorder; however, within this regime it is possible for quenched disorder to enhance the contagion by creating regions of higher particle densities. We discuss how this system could be realized using artificial swimmers with mobile optical traps operated on a feedback loop.
MeSH term(s)	Disease Susceptibility ; Epidemics ; Humans
Language	English
Publishing date	2022-07-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-15223-5
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Article ; Online: Interaction of Aqueous Bovine Serum Albumin with Silica Aerogel Microparticles

Attila Forgács / Madalina Ranga / István Fábián / József Kalmár

International Journal of Molecular Sciences, Vol 23, Iss 2816, p

Sorption Induced Aggregation

2022 Volume 2816

Abstract: Mesoporous silica aerogels have a wide range of potential applications in biotechnology, the food industry, pharmacy and medicine. Understanding the nature of the interactions of biomolecules with these porous nanostructured materials is essential for ... ...

Abstract	Mesoporous silica aerogels have a wide range of potential applications in biotechnology, the food industry, pharmacy and medicine. Understanding the nature of the interactions of biomolecules with these porous nanostructured materials is essential for achieving optimum performance in the targeted applications. In this study, the well-characterized bovine serum albumin (BSA) was chosen as a model protein to probe protein–aerogel interactions in the solution phase. Aqueous BSA was mixed with suspended silica aerogel microparticles, and the colloid system was monitored on-line by UV–vis spectrophotometry and turbidimetry. The global mathematical analysis of the time-resolved data reveals that the fast sorption of the protein on the aerogel microparticles follows a multistep binding mechanism. The extensive sorption of the protein eventually induces the aggregation of the covered aerogel due to the alteration of the electrical double layer of the particles. The interaction of BSA and silica aerogel is the strongest between pH = 4 and 5, because their native surface charges are the opposite in this pH range, as indicated by their respective zeta potentials.
Keywords	aerogel ; sorption ; serum albumin ; reaction kinetics ; mechanism ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	500
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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