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  1. Article: Buchbesprechungen. Frank Matakas: Psychodynamik der Schizophrenie. Symptomatik, Entwicklung, Therapie, Bedeutung (Harm Stehr)

    Stehr, Harm

    Psyche

    2021  Volume 75, Issue 4, Page(s) 358

    Language German
    Document type Article
    ZDB-ID 123814-0
    ISSN 0033-2623
    Database Current Contents Medicine

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  2. Book ; Online ; Thesis: Sekretierte Lipasen des humanpathogenen Pilzes Candida albicans und ihre Bedeutung als Virulenzfaktoren

    Stehr, Frank

    2003  

    Author's details vorgelegt von Frank Stehr
    Language German
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Hamburg, Univ., Diss., 2003
    Note Open Access
    HBZ-ID HT013953349
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Evidenzbasierte | evidenzinformierte Gesundheitskommunikation

    Stehr, Paula / Heinemeier, Dorothee / Rossmann, Constanze

    2018  

    Abstract: ... Wiebke Möhring, Ingrid Mühlhauser, Doreen Reifegerste, Frank Renkewitz, Constanze Rossmann, Sebastian ... Scherr, Paula Stehr, Lisa Steinmeyer, Freya Sukalla, Anna Wagner, Winja Weber ...

    Abstract This volume discusses the relevance of evidence-based practice in health communication. Evidence-based medicine has largely established itself as a criterion of good practice, which means the conscientious, explicit and judicious use of the current best evidence in making decisions about healthcare. Similar attempts can be observed in health communication. However, health communication not only examines what kind of information is spread, but also how information has to be displayed in order for it to be perceived and processed adequately. The 19 chapters in this volume are partly theoretical and partly empirical illustrations of how evidence is reflected on in medicine, psychology and communication science. They deal, for example, with the criteria of evidence-based health communication, medical evidence in journalism and evidence-based campaigns.With contributions byMartina Albrecht, Violetta Aust, Eva Baumann, Cornelia Betsch, Viorela Dan, Sarah Eitze, Florian Fischer, Benjamin Fretwurst, Tobias Frey, Thomas N. Friemel, Michael Grimm, Lars Guenther, Regina Hanke, Dorothee Heinemeier, Jakob Henke, Eckart von Hirschhausen, Veronika Karnowski, Laura Leißner, Elena Link, Antonia Markiewitz, Hanna Marzinkowski, Cynthia Meißner, Wiebke Möhring, Ingrid Mühlhauser, Doreen Reifegerste, Frank Renkewitz, Constanze Rossmann, Sebastian Scherr, Paula Stehr, Lisa Steinmeyer, Freya Sukalla, Anna Wagner, Winja Weber
    Keywords Communication. Mass media ; Evidenz-basierte Medizin ; Präventivmedizin ; Gesundheitsindikator
    Subject Prophylaktische Medizin ; Vorsorgemedizin ; Prävention ; Präventive Medizin ; Evidence-based medicine ; Gutachtenbasierte Medizin ; Evidenzbasierte Medizin
    Size 1 electronic resource ( p.)
    Publisher Nomos Verlagsgesellschaft mbH & Co. KG
    Document type Book ; Online
    Note de ; Open Access
    HBZ-ID HT020099777
    ISBN 9783845291963 ; 3845291966
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: The parent and family impact of CLN3 disease: an observational survey-based study.

    Schulz, Angela / Patel, Nita / Brudvig, Jon J / Stehr, Frank / Weimer, Jill M / Augustine, Erika F

    Orphanet journal of rare diseases

    2024  Volume 19, Issue 1, Page(s) 125

    Abstract: Background: CLN3 disease (also known as CLN3 Batten disease or Juvenile Neuronal Ceroid Lipofuscinosis) is a rare pediatric neurodegenerative disorder caused by biallelic mutations in CLN3. While extensive efforts have been undertaken to understand CLN3 ...

    Abstract Background: CLN3 disease (also known as CLN3 Batten disease or Juvenile Neuronal Ceroid Lipofuscinosis) is a rare pediatric neurodegenerative disorder caused by biallelic mutations in CLN3. While extensive efforts have been undertaken to understand CLN3 disease etiology, pathology, and clinical progression, little is known about the impact of CLN3 disease on parents and caregivers. Here, we investigated CLN3 disease progression, clinical care, and family experiences using semi-structured interviews with 39 parents of individuals with CLN3 disease. Analysis included response categorization by independent observers and quantitative methods.
    Results: Parents reported patterns of disease progression that aligned with previous reports. Insomnia and thought- and mood-related concerns were reported frequently. "Decline in visual acuity" was the first sign/symptom noticed by n = 28 parents (70%). A minority of parents reported "behavioral issues" (n = 5, 12.5%), "communication issues" (n = 3, 7.5%), "cognitive decline" (n = 1, 2.5%), or "seizures" (n = 1, 2.5%) as the first sign/symptom. The mean time from the first signs or symptoms to a diagnosis of CLN3 disease was 2.8 years (SD = 4.1). Misdiagnosis was common, being reported by n = 24 participants (55.8%). Diagnostic tests and treatments were closely aligned with observed symptoms. Desires for improved or stabilized vision (top therapeutic treatment concern for n = 14, 32.6%), cognition (n = 8, 18.6%), and mobility (n = 3, 7%) dominated parental concerns and wishes for therapeutic correction. Family impacts were common, with n = 34 (81%) of respondents reporting a financial impact on the family and n = 20 (46.5%) reporting marital strain related to the disease.
    Conclusions: Collectively, responses demonstrated clear patterns of disease progression, a strong desire for therapies to treat symptoms related to vision and cognition, and a powerful family impact driven by the unrelenting nature of disease progression.
    MeSH term(s) Humans ; Child ; Neuronal Ceroid-Lipofuscinoses/genetics ; Molecular Chaperones/genetics ; Molecular Chaperones/therapeutic use ; Membrane Glycoproteins/genetics ; Parents ; Disease Progression ; Surveys and Questionnaires
    Chemical Substances Molecular Chaperones ; Membrane Glycoproteins ; CLN3 protein, human
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2225857-7
    ISSN 1750-1172 ; 1750-1172
    ISSN (online) 1750-1172
    ISSN 1750-1172
    DOI 10.1186/s13023-024-03119-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Demenzerkrankung im Kindesalter - Allein unter Millionen

    Stehr, Frank

    Hospiz-Dialog Nordrhein-Westfalen

    2016  Volume 66, Issue -, Page(s) 17

    Language German
    Document type Article
    ZDB-ID 2257959-X
    Database Current Contents Medicine

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  6. Article ; Online: Der Primär Obstruktive Megaureter (POM) – Eine Domäne konservativer Therapie.

    Stehr, Maximilian / Schäfer, Frank-Mattias

    Aktuelle Urologie

    2019  Volume 51, Issue 2, Page(s) 127–131

    Abstract: The term "megaureter" is an entirely descriptive designation for a number of different entities. It is crucial to distinguish between primary and secondary forms of megaureter and between obstructive and/or refluxive forms. In the majority of cases, ... ...

    Title translation Primary obstructive megaureter: a domain of conservative treatment.
    Abstract The term "megaureter" is an entirely descriptive designation for a number of different entities. It is crucial to distinguish between primary and secondary forms of megaureter and between obstructive and/or refluxive forms. In the majority of cases, there is a primary obstruction in the terminal ureterovesical segment. The treatment of primary obstructive megaureter has changed fundamentally over the last 3 decades. Whereas ureteral reimplantation was the treatment of choice in the past, conservative treatment is now preferred in 85 to 90 % of patients. With the advent of endoscopic balloon dilatation, a modern, minimally-invasive treatment option has become an alternative to ureteral reimplantation in selected patients. However, due to the possibility of postoperative VUR (vesicoureteral reflux), it is necessary to emphasize that this option should not weaken the generally strict indication for surgical treatment of primary obstructive megaureter.
    MeSH term(s) Conservative Treatment ; Endoscopy ; Humans ; Postoperative Complications ; Ureter/physiopathology ; Ureter/surgery ; Ureteral Obstruction/physiopathology ; Ureteral Obstruction/therapy ; Vesico-Ureteral Reflux
    Language German
    Publishing date 2019-12-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124847-9
    ISSN 1438-8820 ; 0001-7868
    ISSN (online) 1438-8820
    ISSN 0001-7868
    DOI 10.1055/a-1010-3697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Embolization of Type 2 Endoleaks in the Abdominal Aorta Using Ethylene Vinyl Alcohol Copolymer.

    Nolte-Ernsting, Claus / Mecklenbeck, Frank-Peter / Stehr, Alexander

    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

    2021  Volume 193, Issue 12, Page(s) 1426–1435

    Abstract: ... format: · Nolte-Ernsting C, Mecklenbeck F, Stehr A. Embolization of Type 2 Endoleaks ...

    Title translation Embolisation von Typ-2-Endoleaks der Bauchaorta mit Ethylen-Vinylalkohol-Copolymer.
    Abstract Background:  Type 2 endoleaks (T2EL) are the most frequent complication following endovascular aortic repair. Multiple studies primarily deal with the technical and clinical success of the embolization of persisting T2EL, thereby revealing controversial outcomes. Current reports rarely focus on the detailed execution of such a complex interventional procedure with respect to the difficult anatomic setting.
    Methods:  The present review provides an in-depth depiction and evaluation of the interventional methodology of the embolization of T2EL in the abdominal aorta with use of ethylene vinyl alcohol copolymer (EVOH). Complicating anatomic conditions are taken into account as well as technical and clinical success rates.
    Results:  Using the transarterial approach, there are at least 4 different pathways to access the nidus of a T2EL. CT-guided direct puncture of the aneurysm sac provides an alternative method of high technical success. EVOH with its slow solidification characteristics enables good control to achieve complete filling of the T2EL. During the intervention, however, it remains difficult to meet exactly the embolization endpoint, especially in large T2ELs.
    Conclusion:  T2EL embolization using EVOH is an effective treatment with low major complication rates when conducted by skilled interventionists with detailed knowledge of diverse complex access routes.
    Key points:   · Many roads lead to Rome to access the nidus of a T2EL including diverse complex transarterial pathways and direct aneurysm sac puncture.. · Ethylene vinyl alcohol co-polymer enables good control for slow filling of the nidus with low risk of major complications.. · Identification of the embolization endpoint remains difficult during the procedure and may result in secondary interventions.. · Successful T2EL embolization requires detailed knowledge of all access routes to the nidus and skilled handling of liquid embolics..
    Citation format: · Nolte-Ernsting C, Mecklenbeck F, Stehr A. Embolization of Type 2 Endoleaks in the Abdominal Aorta Using Ethylene Vinyl Alcohol Copolymer. Fortschr Röntgenstr 2021; 193: 1426 - 1435.
    MeSH term(s) Aorta, Abdominal ; Aortic Aneurysm, Abdominal/diagnostic imaging ; Aortic Aneurysm, Abdominal/surgery ; Blood Vessel Prosthesis Implantation ; Endoleak/surgery ; Endoleak/therapy ; Endovascular Procedures ; Humans ; Polyvinyls ; Retrospective Studies ; Time Factors
    Chemical Substances Polyvinyls ; ethylene-vinyl alcohol copolymer (25067-34-9)
    Language German
    Publishing date 2021-06-17
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    ISSN (online) 1438-9010
    ISSN 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    DOI 10.1055/a-1502-7883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Contribution of patient organisations to the NCLs.

    Band, Heather / Stehr, Frank / Murphy, Noreen

    Biochimica et biophysica acta. Molecular basis of disease

    2020  Volume 1866, Issue 9, Page(s) 165773

    Abstract: This review will summarise the achievements of Patient Organisations and Foundations started by affected Batten disease families, with an emphasis on their recent contribution to Batten disease, examine the benefits and pitfalls of their interactions ... ...

    Abstract This review will summarise the achievements of Patient Organisations and Foundations started by affected Batten disease families, with an emphasis on their recent contribution to Batten disease, examine the benefits and pitfalls of their interactions with scientists and propose a way forward.
    MeSH term(s) Biomedical Research ; Humans ; Neuronal Ceroid-Lipofuscinoses/diagnosis ; Organizations ; Patient Advocacy
    Language English
    Publishing date 2020-03-26
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2020.165773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Tissue engineering in pediatric urology - a critical appraisal.

    Schäfer, Frank-Mattias / Stehr, Maximilian

    Innovative surgical sciences

    2018  Volume 3, Issue 2, Page(s) 107–118

    Abstract: Tissue engineering is defined as the combination of biomaterials and bioengineering principles together with cell transplantation or directed growth of host cells to develop a biological replacement tissue or organ that can be a substitute for normal ... ...

    Abstract Tissue engineering is defined as the combination of biomaterials and bioengineering principles together with cell transplantation or directed growth of host cells to develop a biological replacement tissue or organ that can be a substitute for normal tissue both in structure and function. Despite early promising preclinical studies, clinical translation of tissue engineering in pediatric urology into humans has been unsuccessful both for cell-seeded and acellular scaffolds. This can be ascribed to various factors, including the use of only non-diseased models that inaccurately describe the structural and functional modifications of diseased tissue. The paper addresses potential future strategies to overcome the limitations experienced in clinical applications so far. This includes the use of stem cells of various origins (mesenchymal stem cells, hematopoietic stem/progenitor cells, urine-derived stem cells, and progenitor cells of the urothelium) as well as the need for a deeper understanding of signaling pathways and directing tissue ingrowth and differentiation through the concept of dynamic reciprocity. The development of smart scaffolds that release trophic factors in a set and timely manner will probably improve regeneration. Modulation of innate immune response as a major contributor to tissue regeneration outcome is also addressed. It is unlikely that only one of these strategies alone will lead to clinically applicable tissue engineering strategies in pediatric urology. In the meanwhile, the fundamental new insights into regenerative processes already obtained in the attempts of tissue engineering of the lower urogenital tract remain our greatest gain.
    Language English
    Publishing date 2018-05-25
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2364-7485
    ISSN (online) 2364-7485
    DOI 10.1515/iss-2018-0011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Plötzliche Sehstörung nach Blasenaugmentation – Ein Fallbericht.

    Michel-Einsiedler, Nadja / Rompel, Oliver / Neustädter, Irena / Galler, Axel / Stehr, Maximilian / Schäfer, Frank-Mattias

    Klinische Padiatrie

    2021  Volume 233, Issue 2, Page(s) 88–90

    Title translation Sudden Blindness after Enterocystoplasty – A Case Report.
    MeSH term(s) Blindness/etiology ; Humans ; Intestines/transplantation ; Postoperative Complications/etiology
    Language German
    Publishing date 2021-01-04
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 120650-3
    ISSN 1439-3824 ; 0300-8630
    ISSN (online) 1439-3824
    ISSN 0300-8630
    DOI 10.1055/a-1301-1906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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