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  1. Article ; Conference proceedings: Hepatozelluläres Karzinom (HCC) unter transarterieller Chemoembolisation (TACE) mit zwei verschiedenen Protokollen: c-TACE versus c-DSM-TACE

    Vogl, T / Langenbach, M / Gruber-Rouh, T / Hammerstingl, R / Yel, I / Scholz, J

    RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

    2018  Volume 190, Issue S 01

    Event/congress 99. Deutscher Röntgenkongress, Leipzig, 2018-05-09
    Language German
    Publishing date 2018-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    ISSN (online) 1438-9010
    ISSN 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    DOI 10.1055/s-0038-1641352
    Database Thieme publisher's database

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  2. Article: Revolutionäre Behandlungsmethode bei Lungenembolien

    Hammerstingl, Christoph

    Orthopress : Köln-Bonn-Aachen

    2022  Volume 28, Issue 4, Page(s) 60

    Language German
    Document type Article
    ZDB-ID 2213797-X
    Database Current Contents Medicine

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  3. Article ; Online: Feasibility of assessing pulmonary blood volume using C-arm CT during transpulmonary chemoperfusion and chemoembolization in primary and secondary lung tumours.

    Vogl, Thomas J / Nour-Eldin, Nour-Eldin A / Naguib, Nagy N N / Lehnert, Thomas / Ackermann, Hanns / Hammerstingl, Renate / Hezel, Marcus

    The British journal of radiology

    2016  Volume 89, Issue 1062, Page(s) 20150244

    Abstract: ... malignancies by using a C-arm CT, regarding its role in detecting early functional response to transpulmonary ... Imaging was performed on a flat detector, C-arm CT. Groups of response were classified according ... Assessment of PBV using C-arm CT during TPCE is a feasible technique. Assessment of PBV might be useful ...

    Abstract Objective: Assessment of parenchymal blood volume (PBV) of primary and secondary pulmonary malignancies by using a C-arm CT, regarding its role in detecting early functional response to transpulmonary chemoembolization (TPCE) and clinical practicability.
    Methods: 21 patients with a mean age of 56.77 years, who were assigned to TPCE during their palliative treatment, were included. PBV and the diameter of tumours were analyzed. PBV maps were calculated from three-dimensional CT-angiographic (3D-CTA) data sets. Imaging was performed on a flat detector, C-arm CT. Groups of response were classified according to the criteria of the response evaluation criteria in solid tumours. Statistically significant differences were determined and Pearson's regression analysis correlated PBV and diameter as parameters of response to treatment.
    Results: During 4.91 sessions, median diameter increased 18.18% (p > 0.05) and PBV reduced 39.62% (p > 0.05). Functional and imaging response per tumour was statistical significantly different (p ≤ 0.05). Correlation coefficient was r = 0.058. 2/41 tumours showed partial response; 31/41 tumours showed stable disease; and 8/41 tumours showed progressive disease. The highest pre-treatment PBV values were measured in decreasing tumours (206.93 ml l(-1)), and the lowest values were measured in increasing tumours (60.17 ml l(-1); p > 0.05). The lowest values were also measured in lung cancer (53.02 ml l(-1)) that was significantly different to uterine leiomyosarcoma (103.31 ml l(-1)) and renal cell cancer (113.14 ml l(-1); p ≤ 0.05).
    Conclusion: Assessment of PBV maps by using 3D-CTA image data is feasible in the clinical routine. PBV shows a stronger response to TPCE treatment than measurement in diameter and should be considered as a response parameter for early detection.
    Advances in knowledge: Assessment of PBV using C-arm CT during TPCE is a feasible technique. Assessment of PBV might be useful in assessing response to treatment.
    MeSH term(s) Adult ; Aged ; Blood Volume ; Chemoembolization, Therapeutic ; Computed Tomography Angiography/methods ; Drug Monitoring/methods ; Feasibility Studies ; Female ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/physiopathology ; Lung Neoplasms/therapy ; Male ; Middle Aged ; Neovascularization, Pathologic/diagnosis ; Neovascularization, Pathologic/pathology ; Neovascularization, Pathologic/physiopathology ; Radiography, Interventional/methods ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2016-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20150244
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  4. Article ; Online: Echokardiographische Bildgebung der Trikuspidalklappe.

    Hammerstingl, C

    Herz

    2017  Volume 42, Issue 7, Page(s) 629–633

    Abstract: Pathologies of the right heart and the tricuspid valve were not recognized to be of prognostic relevance for many years. Available evidence showing the progressive nature of right heart diseases with direct impact on patient survival have changed current ...

    Title translation Echocardiographic imaging of the tricuspid valve.
    Abstract Pathologies of the right heart and the tricuspid valve were not recognized to be of prognostic relevance for many years. Available evidence showing the progressive nature of right heart diseases with direct impact on patient survival have changed current understanding of its clinical importance. Visualization and a profound understanding of the right heart anatomy are prerequisites for the development of modern and still experimental treatment strategies. Transthoracic and transesophageal echocardiography enable a standardized and clear visualization and assessment of the right heart anatomy and its pathological changes.
    MeSH term(s) Echocardiography, Three-Dimensional ; Echocardiography, Transesophageal ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology ; Humans ; Papillary Muscles/diagnostic imaging ; Papillary Muscles/physiopathology ; Prognosis ; Reference Values ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/physiopathology ; Tricuspid Valve Insufficiency/classification ; Tricuspid Valve Insufficiency/diagnostic imaging ; Tricuspid Valve Insufficiency/physiopathology ; Tricuspid Valve Insufficiency/therapy
    Language German
    Publishing date 2017-08-23
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8262-4
    ISSN 1615-6692 ; 0340-9937 ; 0946-1299
    ISSN (online) 1615-6692
    ISSN 0340-9937 ; 0946-1299
    DOI 10.1007/s00059-017-4610-1
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  5. Book ; Thesis: Umstellung der Antikoagulation von dauerhaft oral antikoagulierten Patienten vor und nach einer Herzkatheteruntersuchung

    Hammerstingl, Christoph

    ein prospektiver randomisierter Vergleich zwischen einem niedermolekularen Heparin (Enoxaparin) und unfraktioniertem Heparin

    2002  

    Author's details vorgelegt von Christoph Hammerstingl
    Language German
    Size 45 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bonn, Univ., Diss., 2002
    HBZ-ID HT013333135
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 D 2418 order for loan Magazin

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  6. Article ; Online: 'Just the two of us': single-operator interventional left atrial appendage closure-a case report.

    Hammerstingl, Christoph / Yahya, Mohammed Ali / Völz, Alexander

    European heart journal. Case reports

    2023  Volume 7, Issue 3, Page(s) ytad078

    Abstract: Background: Different procedural strategies have been published targeting to facilitate transcatheter left atrial appendage closure (LAAc). We demonstrate feasibility of a procedural set-up allowing single-operator LAAc in a selected patient.: Case ... ...

    Abstract Background: Different procedural strategies have been published targeting to facilitate transcatheter left atrial appendage closure (LAAc). We demonstrate feasibility of a procedural set-up allowing single-operator LAAc in a selected patient.
    Case summary: A 87-year-old male with persistent Afib (CHA
    Discussion: To the best of our knowledge, this is the first report on successful single-operator LAAc in a selected patient. The intervention, pre-procedural screening, and intraprocedural 3D TEE were performed by one single experienced interventionalist. This simplified technique is based on a standardized pre-procedural imaging-protocol with 3D echocardiography. According to our experience, this streamlined approach is a valuable option in non-complex LAAc cases. In the growing field of structural cardiac interventions, this approach might be an interesting option for centres with limited personal and technical resources.
    Language English
    Publishing date 2023-02-13
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad078
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  7. Article ; Online: Intraprocedural blood volume measurement using C-arm CT as a predictor for treatment response of malignant liver tumours undergoing repetitive transarterial chemoembolization (TACE).

    Vogl, Thomas J / Schaefer, Patrik / Lehnert, Thomas / Nour-Eldin, Nour-Eldin A / Ackermann, Hanns / Mbalisike, Emmanuel / Hammerstingl, Renate / Eichler, Katrin / Zangos, Stephan / Naguib, Nagy N N

    European radiology

    2015  Volume 26, Issue 3, Page(s) 755–763

    Abstract: ... tumours using C-arm CT, test the changes in PBV following repeated transarterial chemoembolization (TACE ... intervention C-arm CT was performed. Images were post-processed to generate PBV maps. Blood volume data in C ... PBV measurement of malignant liver tumours using C-arm CT is feasible. Following TACE PBV decreased ...

    Abstract Purpose: To evaluate feasibility of measuring parenchymal blood volume (PBV) of malignant hepatic tumours using C-arm CT, test the changes in PBV following repeated transarterial chemoembolization (TACE) and correlate these changes with the change in tumour size in MRI.
    Methods: 111 patients with liver malignancy were included. Patients underwent MRI and TACE in a 4- to 6-week interval. During intervention C-arm CT was performed. Images were post-processed to generate PBV maps. Blood volume data in C-arm CT and change in size in MRI were evaluated. The correlation between PBV and size was tested using Spearman rank test.
    Results: Pre-interventional PBV maps showed a mean blood volume of 84.5 ml/1000 ml ± 62.0, follow-up PBV maps after multiple TACE demonstrated 61.1 ml/1000 ml ± 57.5. The change in PBV was statistically significant (p = 0.02). Patients with initial tumour blood volume >100 ml/1000 ml dropped 7.1% in size and 47.2% in blood volume; 50-100 ml/1000 ml dropped 4.6% in size and 25.7% in blood volume; and <50 ml/1000 ml decreased 2.8% in size and increased 82.2% in blood volume.
    Conclusion: PBV measurement of malignant liver tumours using C-arm CT is feasible. Following TACE PBV decreased significantly. Patients with low initial PBV show low local response rates and further increase in blood volume, whereas high initial tumour PBV showed better response to TACE.
    Key points: Parenchymal blood volume assessment of malignant hepatic lesions using C-arm CT is feasible. The parenchymal blood volume is reduced significantly following transarterial chemoembolization. Parenchymal blood volume can monitor the response of tumours after transarterial chemoembolization. Although not significant, high initial parenchymal blood volume yields better response to TACE.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Blood Volume ; Blood Volume Determination ; Chemoembolization, Therapeutic/methods ; Feasibility Studies ; Female ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Retreatment ; Tomography, X-Ray Computed/methods ; Treatment Outcome ; Tumor Burden ; Young Adult
    Language English
    Publishing date 2015-06-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-015-3869-y
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  8. Article ; Online: Gadoxetate acid-enhanced MRI of hepatocellular carcinoma in a c-myc/TGFα transgenic mouse model including signal intensity and fat content: initial experience.

    Korkusuz, Huedayi / Knau, Lea / Kromen, Wolfgang / Huebner, Frank / Hammerstingl, Renate / Lindemayr, Sebastian / Bihrer, Verena / Piiper, Albrecht / Vogl, Thomas J

    Cancer imaging : the official publication of the International Cancer Imaging Society

    2012  Volume 12, Page(s) 72–78

    Abstract: Genetically engineered mouse models, such as double transgenic c-myc/TGFα mice, with specific ... could be used to detect HCC in c-myc/TGFα transgenic mice by determining the relation between the signal ... In our study, 20 HCC in c-myc/TGFα transgenic male mice aged 20-34 weeks were analyzed. On gadoxetate acid ...

    Abstract Genetically engineered mouse models, such as double transgenic c-myc/TGFα mice, with specific pathway abnormalities might be more successful at predicting the clinical response of hepatocellular carcinoma (HCC) treatment. But a major drawback of the tumour models is the difficulty of visualizing endogenously formed tumours. The optimal imaging procedure should be brief and minimally invasive. Magnetic resonance imaging (MRI) satisfies these criteria and gadoxetate acid-enhanced MRI improves the detection of HCC. Fat content is stated to be an additional tool to help assess tumour responses, for example, in cases of radiofrequency ablation. Therefore the aim of this study was to investigate if gadoxetate acid-enhanced MRI could be used to detect HCC in c-myc/TGFα transgenic mice by determining the relation between the signal intensity of HCC and normal liver parenchyma and the corresponding fat content as a diagnostic marker of HCC. In our study, 20 HCC in c-myc/TGFα transgenic male mice aged 20-34 weeks were analyzed. On gadoxetate acid-enhanced MRI, the signal intensity was 752.4 for liver parenchyma and 924.5 for HCC. The contrast to noise ratio was 20.4, the percentage enhancement was 267.1% for normal liver parenchyma and 353.9% for HCC. The fat content was 11.2% for liver parenchyma and 16.2% for HCC. There was a correlation between fat content and signal intensity with r = 0.7791. All parameters were statistically significant with P < 0.05. Our data indicate that gadoxetate acid contrast enhancement allows sensitive detection of HCC in c-myc/TGFα transgenic mice and determination of the fat content seems to be an additional useful parameter for HCC.
    MeSH term(s) Animals ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/genetics ; Contrast Media ; Fats ; Gadolinium DTPA ; Image Enhancement/methods ; Liver/pathology ; Liver Neoplasms/diagnosis ; Magnetic Resonance Imaging/methods ; Male ; Mice ; Mice, Transgenic ; Proto-Oncogene Proteins c-myc/genetics ; Transforming Growth Factor alpha
    Chemical Substances Contrast Media ; Fats ; Myc protein, mouse ; Proto-Oncogene Proteins c-myc ; Transforming Growth Factor alpha ; gadolinium ethoxybenzyl DTPA ; Gadolinium DTPA (K2I13DR72L)
    Language English
    Publishing date 2012-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2104862-9
    ISSN 1470-7330 ; 1470-7330
    ISSN (online) 1470-7330
    ISSN 1470-7330
    DOI 10.1102/1470-7330.2012.0009
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  9. Article: Kathetergestütze Behandlung der Mitralinsuffizienz Therapeutische Alternative zur OP

    Hammerstingl, Christoph

    Cardiovasc

    2016  Volume 16, Issue 4, Page(s) 44

    Language German
    Document type Article
    ZDB-ID 2061994-7
    ISSN 1617-4933
    Database Current Contents Medicine

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  10. Article: Transarterielle Chemoperfusion mit Gemcitabine und Mitomycin C bei Pankreaskarzinom: Ergebnisse bei Rezidivtumoren und fortgeschrittenen Tumorstadien.

    Vogl, T J / Zangos, S / Heller, M / Hammerstingl, R M / Böcher, E / Jacob, U / Bauer, R W

    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

    2007  Volume 179, Issue 11, Page(s) 1181–1188

    Abstract: ... tumor stages, and 12 patients had locally recurrent tumors. Gemcitabine (1,000 mg/m(2)) and mitomycin C ...

    Title translation Transarterial chemoperfusion with gemcitabine and mitomycin C in pancreatic carcinoma: results in locally recurrent tumors and advanced tumor stages.
    Abstract Purpose: The purpose of this study was to evaluate local transarterial chemoperfusion (TACP) in locally recurrent pancreatic carcinoma and advanced tumor stages which did not respond to prior systemic chemotherapy. The tumor response, survival, and pain response were retrospectively analyzed.
    Materials and method: Forty outpatients (median age 62 years, range 36-79) were treated with a minimum of 3 (mean 6, range 3-12) applications per patient in four-week intervals. Twenty-eight patients were in advanced tumor stages, and 12 patients had locally recurrent tumors. Gemcitabine (1,000 mg/m(2)) and mitomycin C (8.5 mg/m(2)) were administered within 1 hour through a celiac trunk catheter. The tumor response (diameter, volume) was measured using MRI or CT and classified according to RECIST. The pain response was defined as a reduction of pain intensity of more than 50% on a visual analog scale, or a reduction of more than 50% in analgesics consumption, or a switch to a less potent analgesic agent.
    Results: The treatment was tolerated well by all patients. No clinically relevant problems or grade III or IV toxicity according to CTC (Common Toxicity Criteria) were observed. Tumor-related pain was relieved in 20/32 (62.5%) cases. Radiologically, "complete response" was found in 3/40 (7.5%), "partial response" in 9/40 (22.5%), "stable disease" in 16/40 (40%), and "progressive disease" in 12/40 (30%) of the patients. The median survival period since initial diagnosis and first TACP was 16.4 months and 8.1 months, respectively. Locally recurrent tumors showed better, but still not significant results regarding tumor response (41.7% vs. 25%) as well as survival (14.4 vs. 7 months) compared to advanced tumor stages. Responders (CR+PR) showed a significant survival advantage compared to patients with tumor progression (13.0 vs. 6.0 months; p=0.013).
    Conclusion: TACP is a minimally invasive outpatient treatment for therapy-resistant locally recurrent pancreatic carcinoma and advanced tumor stages. It may be considered as an important aspect in palliative symptomatic pain-relieving treatment, or may even result in improved survival by achieving tumor response.
    MeSH term(s) Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Deoxycytidine/administration & dosage ; Deoxycytidine/analogs & derivatives ; Drug Administration Schedule ; Humans ; Injections, Intra-Arterial/methods ; Middle Aged ; Mitomycin/administration & dosage ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Staging ; Outpatients ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Deoxycytidine (0W860991D6) ; Mitomycin (50SG953SK6) ; gemcitabine (B76N6SBZ8R)
    Language German
    Publishing date 2007-11
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    ISSN (online) 1438-9010
    ISSN 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    DOI 10.1055/s-2007-963568
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