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  1. Article ; Online: The Toxic Triad: Childhood Exposure to Parental Domestic Violence, Parental Addictions, and Parental Mental Illness as Factors Associated With Childhood Physical Abuse.

    Fuller-Thomson, Esme / Sawyer, Jami-Leigh / Agbeyaka, Senyo

    Journal of interpersonal violence

    2019  Volume 36, Issue 17-18, Page(s) NP9015–NP9034

    Abstract: Childhood physical abuse can result in serious behavioral, mental health, and physical health conditions. There is a need for improved strategies to identify households in which childhood physical abuse occurs. This article explores three potential ... ...

    Abstract Childhood physical abuse can result in serious behavioral, mental health, and physical health conditions. There is a need for improved strategies to identify households in which childhood physical abuse occurs. This article explores three potential correlates of childhood physical abuse: childhood exposure to parental domestic violence, parental addictions, and parental mental illness. Secondary analyses were conducted using the regionally representative 2010 Brief Risk Factor Surveillance Survey (BRFSS) of adults (
    MeSH term(s) Adult ; Child ; Child Abuse ; Domestic Violence ; Female ; Humans ; Male ; Mental Disorders/epidemiology ; Parents ; Physical Abuse ; Risk Factors
    Language English
    Publishing date 2019-06-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2028900-5
    ISSN 1552-6518 ; 0886-2605
    ISSN (online) 1552-6518
    ISSN 0886-2605
    DOI 10.1177/0886260519853407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Bridging the Gap: Exploring the Impact of Hospital Isolation on Peer Relationships Among Children and Adolescents with a Malignant Brain Tumor.

    Sawyer, Jami-Leigh / Mishna, Faye / Bouffet, Eric / Saini, Michael / Zlotnik-Shaul, Randi

    Child & adolescent social work journal : C & A

    2021  Volume 40, Issue 1, Page(s) 91–105

    Abstract: Children and adolescents with complex medical conditions are often uprooted from their environments and isolated in hospital while undergoing treatment. Little is known about how they perceive this isolation and its subsequent impact on their ... ...

    Abstract Children and adolescents with complex medical conditions are often uprooted from their environments and isolated in hospital while undergoing treatment. Little is known about how they perceive this isolation and its subsequent impact on their relationships with peers, both during and after isolation for treatment. This study describes the experience of hospital isolation from the perspectives of children and adolescents with a malignant brain tumor. The use and impact of information and communication technologies (ICT) as a possible bridge for contact is also explored. Following a qualitative approach utilizing interpretive phenomenological analysis, in-depth interviews were conducted with eight youth participants who had undergone treatment for medulloblastoma. Data analysis generated three main themes: (1) transforming children and relationships, (2) hospitalization in a digital world, and (3) ICTs as a promising bridge back to school. Study findings provide insight into the experience of hospital isolation for children and adolescents, while highlighting the positive social as well as academic outcomes of frequent, open ended ICT use throughout hospital isolation. This is timely, given the context of the COVID-19 pandemic and its resulting isolation. Considerations for hospital social workers to promote relationships and connection, while facilitating a smooth transition as these children return to school are included.
    Language English
    Publishing date 2021-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2015019-2
    ISSN 1573-2797 ; 0738-0151
    ISSN (online) 1573-2797
    ISSN 0738-0151
    DOI 10.1007/s10560-021-00764-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lifetime prevalence of suicidal ideation in a representative sample of Canadians with type 1 diabetes.

    Fuller-Thomson, Esme / Sawyer, Jami-Leigh

    Diabetes research and clinical practice

    2009  Volume 83, Issue 1, Page(s) e9–11

    Abstract: Data from a regionally representative sample were obtained from the Canadian Community Health Survey conducted by Statistics Canada. We compared the lifetime prevalence of suicidal ideation among those with and without Type 1 diabetes. ...

    Abstract Data from a regionally representative sample were obtained from the Canadian Community Health Survey conducted by Statistics Canada. We compared the lifetime prevalence of suicidal ideation among those with and without Type 1 diabetes.
    MeSH term(s) Canada ; Diabetes Mellitus, Type 1/psychology ; Female ; Humans ; Interview, Psychological ; Male ; Prevalence ; Suicide, Attempted/statistics & numerical data ; Surveys and Questionnaires
    Language English
    Publishing date 2009-01
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2008.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.

    Fachal, Laura / Aschard, Hugues / Beesley, Jonathan / Barnes, Daniel R / Allen, Jamie / Kar, Siddhartha / Pooley, Karen A / Dennis, Joe / Michailidou, Kyriaki / Turman, Constance / Soucy, Penny / Lemaçon, Audrey / Lush, Michael / Tyrer, Jonathan P / Ghoussaini, Maya / Moradi Marjaneh, Mahdi / Jiang, Xia / Agata, Simona / Aittomäki, Kristiina /
    Alonso, M Rosario / Andrulis, Irene L / Anton-Culver, Hoda / Antonenkova, Natalia N / Arason, Adalgeir / Arndt, Volker / Aronson, Kristan J / Arun, Banu K / Auber, Bernd / Auer, Paul L / Azzollini, Jacopo / Balmaña, Judith / Barkardottir, Rosa B / Barrowdale, Daniel / Beeghly-Fadiel, Alicia / Benitez, Javier / Bermisheva, Marina / Białkowska, Katarzyna / Blanco, Amie M / Blomqvist, Carl / Blot, William / Bogdanova, Natalia V / Bojesen, Stig E / Bolla, Manjeet K / Bonanni, Bernardo / Borg, Ake / Bosse, Kristin / Brauch, Hiltrud / Brenner, Hermann / Briceno, Ignacio / Brock, Ian W / Brooks-Wilson, Angela / Brüning, Thomas / Burwinkel, Barbara / Buys, Saundra S / Cai, Qiuyin / Caldés, Trinidad / Caligo, Maria A / Camp, Nicola J / Campbell, Ian / Canzian, Federico / Carroll, Jason S / Carter, Brian D / Castelao, Jose E / Chiquette, Jocelyne / Christiansen, Hans / Chung, Wendy K / Claes, Kathleen B M / Clarke, Christine L / Collée, J Margriet / Cornelissen, Sten / Couch, Fergus J / Cox, Angela / Cross, Simon S / Cybulski, Cezary / Czene, Kamila / Daly, Mary B / de la Hoya, Miguel / Devilee, Peter / Diez, Orland / Ding, Yuan Chun / Dite, Gillian S / Domchek, Susan M / Dörk, Thilo / Dos-Santos-Silva, Isabel / Droit, Arnaud / Dubois, Stéphane / Dumont, Martine / Duran, Mercedes / Durcan, Lorraine / Dwek, Miriam / Eccles, Diana M / Engel, Christoph / Eriksson, Mikael / Evans, D Gareth / Fasching, Peter A / Fletcher, Olivia / Floris, Giuseppe / Flyger, Henrik / Foretova, Lenka / Foulkes, William D / Friedman, Eitan / Fritschi, Lin / Frost, Debra / Gabrielson, Marike / Gago-Dominguez, Manuela / Gambino, Gaetana / Ganz, Patricia A / Gapstur, Susan M / Garber, Judy / García-Sáenz, José A / Gaudet, Mia M / Georgoulias, Vassilios / Giles, Graham G / Glendon, Gord / Godwin, Andrew K / Goldberg, Mark S / Goldgar, David E / González-Neira, Anna / Tibiletti, Maria Grazia / Greene, Mark H / Grip, Mervi / Gronwald, Jacek / Grundy, Anne / Guénel, Pascal / Hahnen, Eric / Haiman, Christopher A / Håkansson, Niclas / Hall, Per / Hamann, Ute / Harrington, Patricia A / Hartikainen, Jaana M / Hartman, Mikael / He, Wei / Healey, Catherine S / Heemskerk-Gerritsen, Bernadette A M / Heyworth, Jane / Hillemanns, Peter / Hogervorst, Frans B L / Hollestelle, Antoinette / Hooning, Maartje J / Hopper, John L / Howell, Anthony / Huang, Guanmengqian / Hulick, Peter J / Imyanitov, Evgeny N / Isaacs, Claudine / Iwasaki, Motoki / Jager, Agnes / Jakimovska, Milena / Jakubowska, Anna / James, Paul A / Janavicius, Ramunas / Jankowitz, Rachel C / John, Esther M / Johnson, Nichola / Jones, Michael E / Jukkola-Vuorinen, Arja / Jung, Audrey / Kaaks, Rudolf / Kang, Daehee / Kapoor, Pooja Middha / Karlan, Beth Y / Keeman, Renske / Kerin, Michael J / Khusnutdinova, Elza / Kiiski, Johanna I / Kirk, Judy / Kitahara, Cari M / Ko, Yon-Dschun / Konstantopoulou, Irene / Kosma, Veli-Matti / Koutros, Stella / Kubelka-Sabit, Katerina / Kwong, Ava / Kyriacou, Kyriacos / Laitman, Yael / Lambrechts, Diether / Lee, Eunjung / Leslie, Goska / Lester, Jenny / Lesueur, Fabienne / Lindblom, Annika / Lo, Wing-Yee / Long, Jirong / Lophatananon, Artitaya / Loud, Jennifer T / Lubiński, Jan / MacInnis, Robert J / Maishman, Tom / Makalic, Enes / Mannermaa, Arto / Manoochehri, Mehdi / Manoukian, Siranoush / Margolin, Sara / Martinez, Maria Elena / Matsuo, Keitaro / Maurer, Tabea / Mavroudis, Dimitrios / Mayes, Rebecca / McGuffog, Lesley / McLean, Catriona / Mebirouk, Noura / Meindl, Alfons / Miller, Austin / Miller, Nicola / Montagna, Marco / Moreno, Fernando / Muir, Kenneth / Mulligan, Anna Marie / Muñoz-Garzon, Victor M / Muranen, Taru A / Narod, Steven A / Nassir, Rami / Nathanson, Katherine L / Neuhausen, Susan L / Nevanlinna, Heli / Neven, Patrick / Nielsen, Finn C / Nikitina-Zake, Liene / Norman, Aaron / Offit, Kenneth / Olah, Edith / Olopade, Olufunmilayo I / Olsson, Håkan / Orr, Nick / Osorio, Ana / Pankratz, V Shane / Papp, Janos / Park, Sue K / Park-Simon, Tjoung-Won / Parsons, Michael T / Paul, James / Pedersen, Inge Sokilde / Peissel, Bernard / Peshkin, Beth / Peterlongo, Paolo / Peto, Julian / Plaseska-Karanfilska, Dijana / Prajzendanc, Karolina / Prentice, Ross / Presneau, Nadege / Prokofyeva, Darya / Pujana, Miquel Angel / Pylkäs, Katri / Radice, Paolo / Ramus, Susan J / Rantala, Johanna / Rau-Murthy, Rohini / Rennert, Gad / Risch, Harvey A / Robson, Mark / Romero, Atocha / Rossing, Maria / Saloustros, Emmanouil / Sánchez-Herrero, Estela / Sandler, Dale P / Santamariña, Marta / Saunders, Christobel / Sawyer, Elinor J / Scheuner, Maren T / Schmidt, Daniel F / Schmutzler, Rita K / Schneeweiss, Andreas / Schoemaker, Minouk J / Schöttker, Ben / Schürmann, Peter / Scott, Christopher / Scott, Rodney J / Senter, Leigha / Seynaeve, Caroline M / Shah, Mitul / Sharma, Priyanka / Shen, Chen-Yang / Shu, Xiao-Ou / Singer, Christian F / Slavin, Thomas P / Smichkoska, Snezhana / Southey, Melissa C / Spinelli, John J / Spurdle, Amanda B / Stone, Jennifer / Stoppa-Lyonnet, Dominique / Sutter, Christian / Swerdlow, Anthony J / Tamimi, Rulla M / Tan, Yen Yen / Tapper, William J / Taylor, Jack A / Teixeira, Manuel R / Tengström, Maria / Teo, Soo Hwang / Terry, Mary Beth / Teulé, Alex / Thomassen, Mads / Thull, Darcy L / Tischkowitz, Marc / Toland, Amanda E / Tollenaar, Rob A E M / Tomlinson, Ian / Torres, Diana / Torres-Mejía, Gabriela / Troester, Melissa A / Truong, Thérèse / Tung, Nadine / Tzardi, Maria / Ulmer, Hans-Ulrich / Vachon, Celine M / van Asperen, Christi J / van der Kolk, Lizet E / van Rensburg, Elizabeth J / Vega, Ana / Viel, Alessandra / Vijai, Joseph / Vogel, Maartje J / Wang, Qin / Wappenschmidt, Barbara / Weinberg, Clarice R / Weitzel, Jeffrey N / Wendt, Camilla / Wildiers, Hans / Winqvist, Robert / Wolk, Alicja / Wu, Anna H / Yannoukakos, Drakoulis / Zhang, Yan / Zheng, Wei / Hunter, David / Pharoah, Paul D P / Chang-Claude, Jenny / García-Closas, Montserrat / Schmidt, Marjanka K / Milne, Roger L / Kristensen, Vessela N / French, Juliet D / Edwards, Stacey L / Antoniou, Antonis C / Chenevix-Trench, Georgia / Simard, Jacques / Easton, Douglas F / Kraft, Peter / Dunning, Alison M

    Nature genetics

    2020  Volume 52, Issue 1, Page(s) 56–73

    Abstract: Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic ... ...

    Abstract Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants in each one. In parallel, we used a Bayesian approach (PAINTOR) that combines genetic association, linkage disequilibrium and enriched genomic features to determine variants with high posterior probabilities of being causal. Potentially causal variants were significantly over-represented in active gene regulatory regions and transcription factor binding sites. We applied our INQUSIT pipeline for prioritizing genes as targets of those potentially causal variants, using gene expression (expression quantitative trait loci), chromatin interaction and functional annotations. Known cancer drivers, transcription factors and genes in the developmental, apoptosis, immune system and DNA integrity checkpoint gene ontology pathways were over-represented among the highest-confidence target genes.
    MeSH term(s) Bayes Theorem ; Biomarkers, Tumor/genetics ; Breast Neoplasms/genetics ; Chromosome Mapping/methods ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Linkage Disequilibrium ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Regulatory Sequences, Nucleic Acid ; Risk Factors
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2020-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-019-0537-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

    Milne, Roger L / Kuchenbaecker, Karoline B / Michailidou, Kyriaki / Beesley, Jonathan / Kar, Siddhartha / Lindström, Sara / Hui, Shirley / Lemaçon, Audrey / Soucy, Penny / Dennis, Joe / Jiang, Xia / Rostamianfar, Asha / Finucane, Hilary / Bolla, Manjeet K / McGuffog, Lesley / Wang, Qin / Aalfs, Cora M / Adams, Marcia / Adlard, Julian /
    Agata, Simona / Ahmed, Shahana / Ahsan, Habibul / Aittomäki, Kristiina / Al-Ejeh, Fares / Allen, Jamie / Ambrosone, Christine B / Amos, Christopher I / Andrulis, Irene L / Anton-Culver, Hoda / Antonenkova, Natalia N / Arndt, Volker / Arnold, Norbert / Aronson, Kristan J / Auber, Bernd / Auer, Paul L / Ausems, Margreet G E M / Azzollini, Jacopo / Bacot, François / Balmaña, Judith / Barile, Monica / Barjhoux, Laure / Barkardottir, Rosa B / Barrdahl, Myrto / Barnes, Daniel / Barrowdale, Daniel / Baynes, Caroline / Beckmann, Matthias W / Benitez, Javier / Bermisheva, Marina / Bernstein, Leslie / Bignon, Yves-Jean / Blazer, Kathleen R / Blok, Marinus J / Blomqvist, Carl / Blot, William / Bobolis, Kristie / Boeckx, Bram / Bogdanova, Natalia V / Bojesen, Anders / Bojesen, Stig E / Bonanni, Bernardo / Børresen-Dale, Anne-Lise / Bozsik, Aniko / Bradbury, Angela R / Brand, Judith S / Brauch, Hiltrud / Brenner, Hermann / Bressac-de Paillerets, Brigitte / Brewer, Carole / Brinton, Louise / Broberg, Per / Brooks-Wilson, Angela / Brunet, Joan / Brüning, Thomas / Burwinkel, Barbara / Buys, Saundra S / Byun, Jinyoung / Cai, Qiuyin / Caldés, Trinidad / Caligo, Maria A / Campbell, Ian / Canzian, Federico / Caron, Olivier / Carracedo, Angel / Carter, Brian D / Castelao, J Esteban / Castera, Laurent / Caux-Moncoutier, Virginie / Chan, Salina B / Chang-Claude, Jenny / Chanock, Stephen J / Chen, Xiaoqing / Cheng, Ting-Yuan David / Chiquette, Jocelyne / Christiansen, Hans / Claes, Kathleen B M / Clarke, Christine L / Conner, Thomas / Conroy, Don M / Cook, Jackie / Cordina-Duverger, Emilie / Cornelissen, Sten / Coupier, Isabelle / Cox, Angela / Cox, David G / Cross, Simon S / Cuk, Katarina / Cunningham, Julie M / Czene, Kamila / Daly, Mary B / Damiola, Francesca / Darabi, Hatef / Davidson, Rosemarie / De Leeneer, Kim / Devilee, Peter / Dicks, Ed / Diez, Orland / Ding, Yuan Chun / Ditsch, Nina / Doheny, Kimberly F / Domchek, Susan M / Dorfling, Cecilia M / Dörk, Thilo / Dos-Santos-Silva, Isabel / Dubois, Stéphane / Dugué, Pierre-Antoine / Dumont, Martine / Dunning, Alison M / Durcan, Lorraine / Dwek, Miriam / Dworniczak, Bernd / Eccles, Diana / Eeles, Ros / Ehrencrona, Hans / Eilber, Ursula / Ejlertsen, Bent / Ekici, Arif B / Eliassen, A Heather / Engel, Christoph / Eriksson, Mikael / Fachal, Laura / Faivre, Laurence / Fasching, Peter A / Faust, Ulrike / Figueroa, Jonine / Flesch-Janys, Dieter / Fletcher, Olivia / Flyger, Henrik / Foulkes, William D / Friedman, Eitan / Fritschi, Lin / Frost, Debra / Gabrielson, Marike / Gaddam, Pragna / Gammon, Marilie D / Ganz, Patricia A / Gapstur, Susan M / Garber, Judy / Garcia-Barberan, Vanesa / García-Sáenz, José A / Gaudet, Mia M / Gauthier-Villars, Marion / Gehrig, Andrea / Georgoulias, Vassilios / Gerdes, Anne-Marie / Giles, Graham G / Glendon, Gord / Godwin, Andrew K / Goldberg, Mark S / Goldgar, David E / González-Neira, Anna / Goodfellow, Paul / Greene, Mark H / Alnæs, Grethe I Grenaker / Grip, Mervi / Gronwald, Jacek / Grundy, Anne / Gschwantler-Kaulich, Daphne / Guénel, Pascal / Guo, Qi / Haeberle, Lothar / Hahnen, Eric / Haiman, Christopher A / Håkansson, Niclas / Hallberg, Emily / Hamann, Ute / Hamel, Nathalie / Hankinson, Susan / Hansen, Thomas V O / Harrington, Patricia / Hart, Steven N / Hartikainen, Jaana M / Healey, Catherine S / Hein, Alexander / Helbig, Sonja / Henderson, Alex / Heyworth, Jane / Hicks, Belynda / Hillemanns, Peter / Hodgson, Shirley / Hogervorst, Frans B / Hollestelle, Antoinette / Hooning, Maartje J / Hoover, Bob / Hopper, John L / Hu, Chunling / Huang, Guanmengqian / Hulick, Peter J / Humphreys, Keith / Hunter, David J / Imyanitov, Evgeny N / Isaacs, Claudine / Iwasaki, Motoki / Izatt, Louise / Jakubowska, Anna / James, Paul / Janavicius, Ramunas / Janni, Wolfgang / Jensen, Uffe Birk / John, Esther M / Johnson, Nichola / Jones, Kristine / Jones, Michael / Jukkola-Vuorinen, Arja / Kaaks, Rudolf / Kabisch, Maria / Kaczmarek, Katarzyna / Kang, Daehee / Kast, Karin / Keeman, Renske / Kerin, Michael J / Kets, Carolien M / Keupers, Machteld / Khan, Sofia / Khusnutdinova, Elza / Kiiski, Johanna I / Kim, Sung-Won / Knight, Julia A / Konstantopoulou, Irene / Kosma, Veli-Matti / Kristensen, Vessela N / Kruse, Torben A / Kwong, Ava / Lænkholm, Anne-Vibeke / Laitman, Yael / Lalloo, Fiona / Lambrechts, Diether / Landsman, Keren / Lasset, Christine / Lazaro, Conxi / Le Marchand, Loic / Lecarpentier, Julie / Lee, Andrew / Lee, Eunjung / Lee, Jong Won / Lee, Min Hyuk / Lejbkowicz, Flavio / Lesueur, Fabienne / Li, Jingmei / Lilyquist, Jenna / Lincoln, Anne / Lindblom, Annika / Lissowska, Jolanta / Lo, Wing-Yee / Loibl, Sibylle / Long, Jirong / Loud, Jennifer T / Lubinski, Jan / Luccarini, Craig / Lush, Michael / MacInnis, Robert J / Maishman, Tom / Makalic, Enes / Kostovska, Ivana Maleva / Malone, Kathleen E / Manoukian, Siranoush / Manson, JoAnn E / Margolin, Sara / Martens, John W M / Martinez, Maria Elena / Matsuo, Keitaro / Mavroudis, Dimitrios / Mazoyer, Sylvie / McLean, Catriona / Meijers-Heijboer, Hanne / Menéndez, Primitiva / Meyer, Jeffery / Miao, Hui / Miller, Austin / Miller, Nicola / Mitchell, Gillian / Montagna, Marco / Muir, Kenneth / Mulligan, Anna Marie / Mulot, Claire / Nadesan, Sue / Nathanson, Katherine L / Neuhausen, Susan L / Nevanlinna, Heli / Nevelsteen, Ines / Niederacher, Dieter / Nielsen, Sune F / Nordestgaard, Børge G / Norman, Aaron / Nussbaum, Robert L / Olah, Edith / Olopade, Olufunmilayo I / Olson, Janet E / Olswold, Curtis / Ong, Kai-Ren / Oosterwijk, Jan C / Orr, Nick / Osorio, Ana / Pankratz, V Shane / Papi, Laura / Park-Simon, Tjoung-Won / Paulsson-Karlsson, Ylva / Lloyd, Rachel / Pedersen, Inge Søkilde / Peissel, Bernard / Peixoto, Ana / Perez, Jose I A / Peterlongo, Paolo / Peto, Julian / Pfeiler, Georg / Phelan, Catherine M / Pinchev, Mila / Plaseska-Karanfilska, Dijana / Poppe, Bruce / Porteous, Mary E / Prentice, Ross / Presneau, Nadege / Prokofieva, Darya / Pugh, Elizabeth / Pujana, Miquel Angel / Pylkäs, Katri / Rack, Brigitte / Radice, Paolo / Rahman, Nazneen / Rantala, Johanna / Rappaport-Fuerhauser, Christine / Rennert, Gad / Rennert, Hedy S / Rhenius, Valerie / Rhiem, Kerstin / Richardson, Andrea / Rodriguez, Gustavo C / Romero, Atocha / Romm, Jane / Rookus, Matti A / Rudolph, Anja / Ruediger, Thomas / Saloustros, Emmanouil / Sanders, Joyce / Sandler, Dale P / Sangrajrang, Suleeporn / Sawyer, Elinor J / Schmidt, Daniel F / Schoemaker, Minouk J / Schumacher, Fredrick / Schürmann, Peter / Schwentner, Lukas / Scott, Christopher / Scott, Rodney J / Seal, Sheila / Senter, Leigha / Seynaeve, Caroline / Shah, Mitul / Sharma, Priyanka / Shen, Chen-Yang / Sheng, Xin / Shimelis, Hermela / Shrubsole, Martha J / Shu, Xiao-Ou / Side, Lucy E / Singer, Christian F / Sohn, Christof / Southey, Melissa C / Spinelli, John J / Spurdle, Amanda B / Stegmaier, Christa / Stoppa-Lyonnet, Dominique / Sukiennicki, Grzegorz / Surowy, Harald / Sutter, Christian / Swerdlow, Anthony / Szabo, Csilla I / Tamimi, Rulla M / Tan, Yen Y / Taylor, Jack A / Tejada, Maria-Isabel / Tengström, Maria / Teo, Soo H / Terry, Mary B / Tessier, Daniel C / Teulé, Alex / Thöne, Kathrin / Thull, Darcy L / Tibiletti, Maria Grazia / Tihomirova, Laima / Tischkowitz, Marc / Toland, Amanda E / Tollenaar, Rob A E M / Tomlinson, Ian / Tong, Ling / Torres, Diana / Tranchant, Martine / Truong, Thérèse / Tucker, Kathy / Tung, Nadine / Tyrer, Jonathan / Ulmer, Hans-Ulrich / Vachon, Celine / van Asperen, Christi J / Van Den Berg, David / van den Ouweland, Ans M W / van Rensburg, Elizabeth J / Varesco, Liliana / Varon-Mateeva, Raymonda / Vega, Ana / Viel, Alessandra / Vijai, Joseph / Vincent, Daniel / Vollenweider, Jason / Walker, Lisa / Wang, Zhaoming / Wang-Gohrke, Shan / Wappenschmidt, Barbara / Weinberg, Clarice R / Weitzel, Jeffrey N / Wendt, Camilla / Wesseling, Jelle / Whittemore, Alice S / Wijnen, Juul T / Willett, Walter / Winqvist, Robert / Wolk, Alicja / Wu, Anna H / Xia, Lucy / Yang, Xiaohong R / Yannoukakos, Drakoulis / Zaffaroni, Daniela / Zheng, Wei / Zhu, Bin / Ziogas, Argyrios / Ziv, Elad / Zorn, Kristin K / Gago-Dominguez, Manuela / Mannermaa, Arto / Olsson, Håkan / Teixeira, Manuel R / Stone, Jennifer / Offit, Kenneth / Ottini, Laura / Park, Sue K / Thomassen, Mads / Hall, Per / Meindl, Alfons / Schmutzler, Rita K / Droit, Arnaud / Bader, Gary D / Pharoah, Paul D P / Couch, Fergus J / Easton, Douglas F / Kraft, Peter / Chenevix-Trench, Georgia / García-Closas, Montserrat / Schmidt, Marjanka K / Antoniou, Antonis C / Simard, Jacques

    Nature genetics

    2017  Volume 49, Issue 12, Page(s) 1767–1778

    Abstract: Most common breast cancer susceptibility variants have been identified through genome-wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease. We conducted a GWAS using 21,468 ER-negative cases and 100,594 controls ... ...

    Abstract Most common breast cancer susceptibility variants have been identified through genome-wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease. We conducted a GWAS using 21,468 ER-negative cases and 100,594 controls combined with 18,908 BRCA1 mutation carriers (9,414 with breast cancer), all of European origin. We identified independent associations at P < 5 × 10
    MeSH term(s) BRCA1 Protein/genetics ; Breast Neoplasms/ethnology ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Female ; Genetic Predisposition to Disease/ethnology ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study/methods ; Heterozygote ; Humans ; Mutation ; Polymorphism, Single Nucleotide ; Receptors, Estrogen/metabolism ; Risk Factors ; White People/genetics
    Chemical Substances BRCA1 Protein ; Receptors, Estrogen
    Language English
    Publishing date 2017-10-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/ng.3785
    Database MEDical Literature Analysis and Retrieval System OnLINE

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