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Article ; Online: Quantitative evaluation of OCT angiography images in healthy and glaucomatous subjects through a novel approach: exploring inter-image variability.

Cassottana, Paola / Iester, Costanza / Bonzano, Laura / Traverso, Carlo E / Iester, Michele

2024

Abstract: Purpose: This study aims to investigate inter-image intra-observer variability of macular, and optic disc (ONH) microvasculature measurements of glaucomatous and normal subjects using Swept-Source Optical Coherence Tomography Angiography (OCT-A) (OCT ... ...

Abstract	Purpose: This study aims to investigate inter-image intra-observer variability of macular, and optic disc (ONH) microvasculature measurements of glaucomatous and normal subjects using Swept-Source Optical Coherence Tomography Angiography (OCT-A) (OCT Topcon ImageNet 6; DRI OCT Triton, Topcon Corporation, JAPAN) - based imaging data analysis and processing with a newly made quantitative approach. Methods: A total of 20 glaucomatous and 20 healthy eyes underwent three OCT-A scanning of the ONH and macula. Macular and papillary and peripapillary vascular networks were calculated. For each eye, eighteen scans were analyzed using a novel approach: custom MATLAB 2021b scripts were employed for imaging analyses. Grayscale distribution was performed using the histcounts MATLAB function with 51 bins. For all layers, the vascular layer coefficient of variation (vl CoV) of the three measures were performed. The vl CoV difference between the two groups was analyzed by Student t-test. Results: In glaucomatous eyes, the vl CoV ranged from 4.49% to 8.54%, while in the control group from 3.58% to 8.32%. Both groups exhibited higher CoVs when assessing the optic disc. The papillary and macular microvasculature reproducibility was comparable between groups. Conclusions: Utilizing Swept-Source OCT-A images our study has identified an easy and reproducible method that appears to be fast and can assist physicians in assessing macular and ONH perfusion with less inter-image variability, particularly in the 70 μm superficial area of the optic disc. The high reliability obtained suggested that this method could be useful as early clinical biomarker.
Language	English
Publishing date	2024-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-024-03038-9
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Article: Current treatment options for treating

Ferro Desideri, Lorenzo / Traverso, Carlo Enrico / Iester, Michele

Drugs of today (Barcelona, Spain : 1998)

2022 Volume 58, Issue 11, Page(s) 547–552

Abstract: Dominant optic atrophy (DOA) is caused by OPA1 gene mutation, and it represents one of the most frequently diagnosed forms of hereditary optic neuropathies. This neurodegenerative disorder typically occurs in the first decades of life, and it is often ... ...

Abstract	Dominant optic atrophy (DOA) is caused by OPA1 gene mutation, and it represents one of the most frequently diagnosed forms of hereditary optic neuropathies. This neurodegenerative disorder typically occurs in the first decades of life, and it is often associated with severe visual impairment. For this reason, several treatment options have been examined for the management of DOA, including vitamin supplements, ubiquinone analogues (in particular idebenone) and, more recently, gene therapy. Among them, idebenone has shown the most promising clinical outcomes in recent real-life studies. Furthermore, gene therapy represents also a promising therapeutic approach; however, more evidence in clinical trials is needed. In this review, we will summarize and discuss all the possible treatment options for DOA, in order to identify the current optimal management in these patients, whose visual prognosis remains unfortunately poor and unsatisfactory in the everyday clinical practice.
MeSH term(s)	Humans ; Optic Atrophy, Autosomal Dominant/genetics ; Optic Atrophy, Autosomal Dominant/therapy ; GTP Phosphohydrolases/genetics ; Mutation ; Genetic Therapy
Chemical Substances	GTP Phosphohydrolases (EC 3.6.1.-) ; OPA1 protein, human (EC 3.6.1.-)
Language	English
Publishing date	2022-10-19
Publishing country	Spain
Document type	Review ; Journal Article
ISSN	1699-3993
ISSN	1699-3993
DOI	10.1358/dot.2022.58.11.3448291
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Article ; Online: A Scoping Review of Quality of Life Questionnaires in Glaucoma Patients.

Gazzard, Gus / Kolko, Miriam / Iester, Michele / Crabb, David P

Journal of glaucoma

2021 Volume 30, Issue 8, Page(s) 732–743

Abstract: Precis: Multiple questionnaires exist to measure glaucoma's impact on quality of life (QoL). Selecting the right questionnaire for the research question is essential, as is patients' acceptability of the questionnaire to enable collection of relevant ... ...

Abstract	Precis: Multiple questionnaires exist to measure glaucoma's impact on quality of life (QoL). Selecting the right questionnaire for the research question is essential, as is patients' acceptability of the questionnaire to enable collection of relevant patient-reported outcomes. Purpose: QoL relating to a disease and its treatment is an important dimension to capture. This scoping review sought to identify the questionnaires most appropriate for capturing the impact of glaucoma on QoL. Methods: A literature search of QoL questionnaires used in glaucoma, including patient-reported outcomes measures, was conducted and the identified questionnaires were analyzed using a developed quality criteria assessment. Results: Forty-one QoL questionnaires were found which were analyzed with the detailed quality criteria assessment leading to a summary score. This identified the top 10 scoring QoL questionnaires rated by a synthesis of the quality criteria grid, considering aspects such as reliability and reproducibility, and the authors' expert clinical opinion. The results were ratified in consultation with an international panel of ophthalmologists (N=49) from the Educational Club of Ocular Surface and Glaucoma representing 23 countries. Conclusions: Wide variability among questionnaires used to determine vision related QoL in glaucoma and in the responses elicited was identified. In conclusion, no single existing QoL questionnaire design is suitable for all purposes in glaucoma research, rather we have identified the top 10 from which the questionnaire most appropriate to the study objective may be selected. Development of a new questionnaire that could better distinguish between treatments in terms of vision and treatment-related QoL would be useful that includes the patient perspective of treatment effects as well as meeting requirements of regulatory and health authorities. Future work could involve development of a formal weighting system with which to comprehensively assess the quality of QoL questionnaires used in glaucoma.
MeSH term(s)	Glaucoma ; Humans ; Intraocular Pressure ; Quality of Life ; Reproducibility of Results ; Surveys and Questionnaires
Language	English
Publishing date	2021-05-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	913494-3
ISSN	1536-481X ; 1057-0829
ISSN (online)	1536-481X
ISSN	1057-0829
DOI	10.1097/IJG.0000000000001889
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Article ; Online: Eosinophilic granulomatosis with polyangiitis associated with abducens nerve palsy.

Toma, Chiara / Sindaco, Daniele / Musolino, Maria / Traverso, Carlo Enrico / Iester, Michele / Vagge, Aldo

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

2022

Abstract: We present the case of a 61-year-old man who reported diplopia due to a right abducens nerve palsy. The patient complained of fever every night (37.5° C), paresthesia of the second and third hand fingers, and he showed an increased C-reactive protein, ... ...

Abstract	We present the case of a 61-year-old man who reported diplopia due to a right abducens nerve palsy. The patient complained of fever every night (37.5° C), paresthesia of the second and third hand fingers, and he showed an increased C-reactive protein, high erythrocyte sedimentation rate, and high eosinophilia. He had a history of allergic asthma, chronic rhinosinusitis, and surgically treated nasal polyps. His past medical history and labs led us to identify the eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg-Strauss syndrome. EGPA is a potentially life-threatening condition, and a proper diagnosis was critical to managing this patient's abducens nerve palsy.
Language	English
Publishing date	2022-09-28
Publishing country	United States
Document type	Case Reports
ZDB-ID	1412476-2
ISSN	1528-3933 ; 1091-8531
ISSN (online)	1528-3933
ISSN	1091-8531
DOI	10.1016/j.jaapos.2022.08.266
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Zs.A 5188: Show issues

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Article: Bilateral Choroidal Osteomas in an Elderly Woman: A Case Report.

Maltese, Cristina / Cassottana, Paola / Vagge, Aldo / Traverso, Carlo Enrico / Iester, Michele

Case reports in ophthalmology

2022 Volume 13, Issue 2, Page(s) 643–648

Abstract: Choroidal osteoma is a rare clinical entity of unknown etiology. It is a benign ossifying tumor characterized by mature bone replacing choroid. It typically affects young females, unilaterally. Vision loss occurs mainly due to photoreceptor degeneration ... ...

Abstract	Choroidal osteoma is a rare clinical entity of unknown etiology. It is a benign ossifying tumor characterized by mature bone replacing choroid. It typically affects young females, unilaterally. Vision loss occurs mainly due to photoreceptor degeneration secondary to decalcification and/or development of choroidal neovascularization, especially if located near the macular area. We present a case of an old woman with bilateral choroidal osteomas identified incidentally. An 84-year-old Caucasian woman who was asymptomatic, without clinical features suggestive of choroidal osteoma, was referred to our hospital for a follow-up visit. On the fundus examination, both eyes showed a suspected lesion. B-scan ultrasound demonstrated bilateral highly reflective calcified lesions within the choroid, with an evident cone of shadow, suggestive of choroidal osteoma. Further investigations have performed to confirm the diagnosis. Although the literature reports a more common one-sidedness and typical manifestation of choroidal osteoma in the teenage years, our case report refers to bilateral choroidal osteomas in an elderly woman.
Language	English
Publishing date	2022-08-19
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2577666-6
ISSN	1663-2699
ISSN	1663-2699
DOI	10.1159/000525739
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Article ; Online: A Case of Bilateral Choroidal Effusion after XEN Gel Stent Implantation.

Cassottana, Paola / Toma, Chiara / Maltese, Cristina / Villa, Viviana / Ricciarelli, Roberta / Traverso, Carlo Enrico / Iester, Michele

Gels (Basel, Switzerland)

2023 Volume 9, Issue 4

Abstract: Purpose: This study aimed to describe a rare case of bilateral choroidal effusion following a XEN45 implantation.: Case report: An 84-year-old man with primary open-angle glaucoma underwent uneventful ab interno XEN45 device implantation in the right ...

Abstract	Purpose: This study aimed to describe a rare case of bilateral choroidal effusion following a XEN45 implantation. Case report: An 84-year-old man with primary open-angle glaucoma underwent uneventful ab interno XEN45 device implantation in the right eye. The immediate postoperative period was complicated by hypotony and serous choroidal detachment, which were treated and resolved using steroids and cycloplegic drops. Eight months later, the fellow eye underwent the same surgery, which was followed by choroidal detachment that required transscleral surgical drainage. Conclusions: This case highlights the importance of a careful postoperative follow-up and a timely intervention in the context of XEN45 implantation, and suggests that choroidal effusion in one eye may be a risk factor for choroidal effusion in the other eye when undergoing the same type of surgery.
Language	English
Publishing date	2023-03-27
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2813982-3
ISSN	2310-2861 ; 2310-2861
ISSN (online)	2310-2861
ISSN	2310-2861
DOI	10.3390/gels9040276
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Article ; Online: Managing Side Effects on Ocular Surface Caused by Glaucoma Eye Drops.

Ferreras, Antonio / Figus, Michele / Fogagnolo, Paolo / Iester, Michele / Frezzotti, Paolo

Current medicinal chemistry

2019 Volume 26, Issue 22, Page(s) 4223–4224

MeSH term(s)	Antihypertensive Agents/therapeutic use ; Benzalkonium Compounds/therapeutic use ; Corneal Diseases/drug therapy ; Glaucoma/drug therapy ; Humans ; Ophthalmic Solutions/therapeutic use ; Preservatives, Pharmaceutical/chemistry ; Preservatives, Pharmaceutical/therapeutic use ; Surface Properties
Chemical Substances	Antihypertensive Agents ; Benzalkonium Compounds ; Ophthalmic Solutions ; Preservatives, Pharmaceutical
Language	English
Publishing date	2019-10-29
Publishing country	United Arab Emirates
Document type	Editorial ; Introductory Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/092986732622190920092210
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Zs.A 4432: Show issues

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Article: Choroidal Congestion after Trabeculectomy.

Marenco, Maria / Borgia, Luigi / Vagge, Aldo / Iester, Michele

Case reports in ophthalmology

2019 Volume 10, Issue 3, Page(s) 384–390

Abstract: The aim of this study is to report a case of choroidal congestion after trabeculectomy. This is a retrospective case report. An 85-year-old male with advanced open-angle glaucoma underwent trabeculectomy in both eyes and during follow-up he complained of ...

Abstract	The aim of this study is to report a case of choroidal congestion after trabeculectomy. This is a retrospective case report. An 85-year-old male with advanced open-angle glaucoma underwent trabeculectomy in both eyes and during follow-up he complained of visual impairment in the right eye. Thus, spectral domain optical coherence tomography (OCT) was performed and showed choroidal congestion in one eye 1 month after surgery together with a decrease of visual acuity. Symptoms and exam findings resolved with systemic steroids after a 6-month follow-up. OCT is essential for detecting choroidal congestion. This finding can be a possible complication after trabeculectomy and can benefit from steroid treatment.
Language	English
Publishing date	2019-11-21
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2577666-6
ISSN	1663-2699
ISSN	1663-2699
DOI	10.1159/000504318
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Article: Classification and Statistical Trend Analysis in Detecting Glaucomatous Visual Field Progression.

Valente, Cristiana / D'Alessandro, Elisa / Iester, Michele

Journal of ophthalmology

2019 Volume 2019, Page(s) 1583260

Abstract: Aim: To evaluate the agreement between different methods in detection of glaucomatous visual field progression using two classification-based methods and four statistical approaches based on trend analysis.: Methods: This is a retrospective and ... ...

Abstract	Aim: To evaluate the agreement between different methods in detection of glaucomatous visual field progression using two classification-based methods and four statistical approaches based on trend analysis. Methods: This is a retrospective and longitudinal study. Twenty Caucasian patients (mean age 73.8 ± 13.43 years) with open-angle glaucoma were recruited in the study. Each visual field was assessed by Humphrey Field Analyzer, program SITA standard 30-2 or 24-2 (Carl Zeiss Meditec, Inc., Dublin, CA). Full threshold strategy was also accepted for baseline tests. Progression was analyzed by using Hodapp-Parrish-Anderson classification and the Advanced Glaucoma Intervention Study visual field defect score. For the statistical analysis, linear regression ( Results: Thirty-eight visual field series were analyzed. The mean follow-up time was 6.2 ± 1.53 years (mean ± standard deviation). At baseline, the mean MD was -7.34 ± 7.18 dB; at the end of the follow-up, the mean MD was -9.25 ± 8.65 dB; this difference was statistically significant ( Conclusions: The best agreement to detect progression was found between MD
Language	English
Publishing date	2019-05-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2546525-9
ISSN	2090-0058 ; 2090-004X
ISSN (online)	2090-0058
ISSN	2090-004X
DOI	10.1155/2019/1583260
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Article: Timolol 0.1% in Glaucomatous Patients: Efficacy, Tolerance, and Quality of Life.

Negri, Letizia / Ferreras, Antonio / Iester, Michele

Journal of ophthalmology

2019 Volume 2019, Page(s) 4146124

Abstract: Glaucoma is a progressive, chronic optic neuropathy characterized by a typical visual field defects. Four main classes of topical medication are actually available on the market: beta-blockers, prostaglandins, alpha2-agonists, and topical carbonic ... ...

Abstract	Glaucoma is a progressive, chronic optic neuropathy characterized by a typical visual field defects. Four main classes of topical medication are actually available on the market: beta-blockers, prostaglandins, alpha2-agonists, and topical carbonic anhydrase inhibitor to treat intraocular pressure (IOP). The aim of this review is to outline the efficacy of timolol and to evaluate the impact of this treatment on patients' quality of life. Among beta-blockers, timolol is most used at three different concentrations: 0.1%, 0.25%, and 0.5%. While the first one is a gel, the other two products are solution. Timolol has few topical side effects, while it has some important systemic side effects on the cardiac and respiratory systems. The balance between efficacy and safety is always the main aspect to care patients. Because of the less efficacy of timolol 0.1% solution, the possibility to use carbomers as vehicle in the gel drops helped timolol 0.1 to be used in clinics, extending the time contact between the active ingredient and the surface of the cornea. Using preservative-free timolol 0.1 for treatment, IOP was at the same level of the other beta-blockers at higher concentration, but it was better tolerated. Preservative-free treatment improved the quality of life reducing dry-eye like symptoms; furthermore, the presence of an artificial tear in the medication bottle could help adherence. The once daily dosing improves compliance.
Language	English
Publishing date	2019-05-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2546525-9
ISSN	2090-0058 ; 2090-004X
ISSN (online)	2090-0058
ISSN	2090-004X
DOI	10.1155/2019/4146124
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