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Book ; Online ; E-Book: Zika virus and diseases

da Silva, Suzane Ramos / Cheng, Fan / Gao, Shou-Jiang

from molecular biology to epidemiology

2018

Author's details	Suzane Ramos da Silva, Fan Cheng, Shou-Jiang Gao
Keywords	Zika Virus Infection / epidemiology ; Zika Virus / physiology
Language	English
Size	1 Online-Ressource (xvi, 248 Seiten, [10 Blätter]), Illustrationen, Diagramme, Blätter
Publisher	Wiley Blackwell
Publishing place	Hoboken, NJ
Publishing country	United States
Document type	Book ; Online ; E-Book
Note	Includes bibliographical references and index
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019635734
ISBN	9781119408659 ; 9781119408642 ; 1119408652 ; 1119408644
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: First Published Study with Embryonated Hen Egg Infected with Zika Virus Is Dated from 1952.

Ramos da Silva, Suzane

Stem cells and development

2017 Volume 26, Issue 12, Page(s) 875

MeSH term(s)	Animals ; Chickens/virology ; Female ; History, 20th Century ; Ovum/virology ; Peer Review, Research ; Zika Virus/pathogenicity ; Zika Virus Infection/history ; Zika Virus Infection/virology
Language	English
Publishing date	2017-04-24
Publishing country	United States
Document type	Historical Article ; Journal Article
ZDB-ID	2142214-X
ISSN	1557-8534 ; 1547-3287
ISSN (online)	1557-8534
ISSN	1547-3287
DOI	10.1089/scd.2017.0056
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reversible switching of primary cells between normal and malignant state by oncogenic virus KSHV and CRISPR/Cas9-mediated targeting of a major viral latent protein.

Ju, Enguo / Li, Tingting / Ramos da Silva, Suzane / Markazi, Ashley / Gao, Shou-Jiang

Journal of medical virology

2021 Volume 93, Issue 8, Page(s) 5065–5075

Abstract: Viral infection has been implicated in the pathogenesis of a plethora of human diseases. Although antiviral therapies effectively confront the viral spread and infection, how to completely eradicate the viral genome from infected cells remains a ... ...

Abstract	Viral infection has been implicated in the pathogenesis of a plethora of human diseases. Although antiviral therapies effectively confront the viral spread and infection, how to completely eradicate the viral genome from infected cells remains a challenge. In this study, we demonstrated the reversible switching of primary cells between normal and malignant states by an oncogenic virus Kaposi's sarcoma-associated herpesvirus (KSHV) and CRISPR/Cas9-mediated targeting of a major viral latent protein. Primary cells can be transformed into malignant status by infection of KSHV, while elimination of the KSHV genome from latent KSHV-infected cells reverses KSHV-transformed primary cells back to a "normal state" by CRISPR/Cas-mediated knockout of viral major latent gene LANA. As a proof of concept, we demonstrated efficient elimination of KSHV episome in KSHV-associated primary effusion lymphoma cells resulting in the induction of apoptosis by liposome-encapsulated CRISPR/Cas9 ribonucleoprotein complexes (Lipo/Cas9-LANAsgRNA). Our work illustrates CRISPR/Cas as a promising technology for eliminating oncogenic viruses from persistently infected cells by taking advantage of the genetic differences between viral and cellular genomes. Compared to traditional antiviral therapy, our study offer an approach for antagonizing human oncogenic virus-related cancers by directly targeting as well as clearing viral genomes.
MeSH term(s)	Animals ; Antigens, Viral/genetics ; Antigens, Viral/metabolism ; Apoptosis ; CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/metabolism ; CRISPR-Cas Systems ; Cell Cycle ; Cell Proliferation ; Cell Transformation, Neoplastic/genetics ; Gene Knockout Techniques ; Genome, Viral/genetics ; Herpesvirus 8, Human/genetics ; Herpesvirus 8, Human/pathogenicity ; Humans ; Lymphoma, Primary Effusion/pathology ; Mesenchymal Stem Cells ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Oncogenic Viruses/genetics ; Oncogenic Viruses/pathogenicity ; RNA, Guide, CRISPR-Cas Systems/genetics ; Rats ; Virus Latency/genetics
Chemical Substances	Antigens, Viral ; Nuclear Proteins ; RNA, Guide, CRISPR-Cas Systems ; latency-associated nuclear antigen ; CRISPR-Associated Protein 9 (EC 3.1.-) ; Cas9 endonuclease Streptococcus pyogenes (EC 3.1.-)
Language	English
Publishing date	2021-05-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.27046
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Article ; Online: RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation

Tingting Li / Xian Wang / Enguo Ju / Suzane Ramos da Silva / Luping Chen / Xinquan Zhang / Shan Wei / Shou-Jiang Gao

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 13

Abstract: CASTOR1 is an arginine sensor that inhibits mTORC1 activation, for which this pathway is frequently dysregulated in cancers. Here the authors show that AKT and E3 ubiquitin ligase RNF167 mediate CASTOR1 phosphorylation and degradation to activate mTORC1 ... ...

Abstract	CASTOR1 is an arginine sensor that inhibits mTORC1 activation, for which this pathway is frequently dysregulated in cancers. Here the authors show that AKT and E3 ubiquitin ligase RNF167 mediate CASTOR1 phosphorylation and degradation to activate mTORC1 and promote tumorigenesis.
Keywords	Science ; Q
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Zika virus update II: Recent development of animal models-Proofs of association with human pathogenesis.

Ramos da Silva, Suzane / Gao, Shou-Jiang

Journal of medical virology

2016 Volume 88, Issue 10, Page(s) 1657–1658

Abstract: Three recent studies in pregnant mice and one ongoing study in rhesus macaques evaluating the effect of ZIKV infection have provided important information about maternal-fetus transmission and ZIKV-related pathogenesis, confirming a causal role of ZIKV ... ...

Abstract	Three recent studies in pregnant mice and one ongoing study in rhesus macaques evaluating the effect of ZIKV infection have provided important information about maternal-fetus transmission and ZIKV-related pathogenesis, confirming a causal role of ZIKV in neurological problems observed in humans. Here, we present an update of these works published in the past few weeks. J. Med. Virol. 88:1657-1658, 2016. © 2016 Wiley Periodicals, Inc.
MeSH term(s)	Animals ; Disease Models, Animal ; Female ; Humans ; Infectious Disease Transmission, Vertical ; Macaca mulatta ; Mice ; Pregnancy ; Pregnancy Complications, Infectious/virology ; Zika Virus/pathogenicity ; Zika Virus Infection/complications ; Zika Virus Infection/transmission ; Zika Virus Infection/virology
Language	English
Publishing date	2016-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.24582
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Zika virus: An update on epidemiology, pathology, molecular biology, and animal model.

Ramos da Silva, Suzane / Gao, Shou-Jiang

Journal of medical virology

2016 Volume 88, Issue 8, Page(s) 1291–1296

Abstract: Zika virus (ZIKV) was first described in 1947, and became a health emergency problem in 2016 when its association with fetal microcephaly cases was confirmed by Centers for Disease Control and Prevention (CDC) in the United States. To date, ZIKV ... ...

Abstract	Zika virus (ZIKV) was first described in 1947, and became a health emergency problem in 2016 when its association with fetal microcephaly cases was confirmed by Centers for Disease Control and Prevention (CDC) in the United States. To date, ZIKV infection has been documented in 66 countries. ZIKV is recognized as a neurotropic virus and numerous diseases manifested in multiple neurological disorders have been described, mainly in countries that have been exposed to ZIKV after the 2007 outbreak in the Federated States of Micronesia. The most dramatic consequence of ZIKV infection documented is the abrupt increase in fetal microcephaly cases in Brazil. Here, we present an update of the published research progress in the past few months. J. Med. Virol. 88:1291-1296, 2016. © 2016 Wiley Periodicals, Inc.
MeSH term(s)	Aedes/virology ; Animals ; Brazil/epidemiology ; Disease Models, Animal ; Disease Outbreaks ; Humans ; Insect Vectors/virology ; Mice ; Microcephaly/virology ; Micronesia/epidemiology ; Nervous System Diseases/virology ; Primates ; Zika Virus/genetics ; Zika Virus Infection/epidemiology ; Zika Virus Infection/physiopathology ; Zika Virus Infection/virology
Language	English
Publishing date	2016-05-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.24563
Database	MEDical Literature Analysis and Retrieval System OnLINE

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation.

Li, Tingting / Wang, Xian / Ju, Enguo / da Silva, Suzane Ramos / Chen, Luping / Zhang, Xinquan / Wei, Shan / Gao, Shou-Jiang

Nature communications

2021 Volume 12, Issue 1, Page(s) 1055

Abstract: mTORC1, a central controller of cell proliferation in response to growth factors and nutrients, is dysregulated in cancer. Whereas arginine activates mTORC1, it is overridden by high expression of cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1). ...

Abstract	mTORC1, a central controller of cell proliferation in response to growth factors and nutrients, is dysregulated in cancer. Whereas arginine activates mTORC1, it is overridden by high expression of cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1). Because cancer cells often encounter low levels of nutrients, an alternative mechanism might exist to regulate CASTOR1 expression. Here we show K29-linked polyubiquitination and degradation of CASTOR1 by E3 ubiquitin ligase RNF167. Furthermore, AKT phosphorylates CASTOR1 at S14, significantly increasing its binding to RNF167, and hence its ubiquitination and degradation, while simultaneously decreasing its affinity to MIOS, leading to mTORC1 activation. Therefore, AKT activates mTORC1 through both TSC2- and CASTOR1-dependent pathways. Several cell types with high CASTOR1 expression are insensitive to arginine regulation. Significantly, AKT and RNF167-mediated CASTOR1 degradation activates mTORC1 independent of arginine and promotes breast cancer progression. These results illustrate a mTORC1 regulating mechanism and identify RNF167 as a therapeutic target for mTORC1-dysregulated diseases.
MeSH term(s)	Animals ; Arginine/metabolism ; Breast Neoplasms/pathology ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Line, Tumor ; Disease Progression ; Female ; Intercellular Signaling Peptides and Proteins/pharmacology ; Intracellular Signaling Peptides and Proteins/metabolism ; Kinetics ; Lysine/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mice, Nude ; Phosphorylation/drug effects ; Proteolysis/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination/drug effects ; Mice
Chemical Substances	CASTOR1 protein, human ; Intercellular Signaling Peptides and Proteins ; Intracellular Signaling Peptides and Proteins ; Arginine (94ZLA3W45F) ; TTC3 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2021-02-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-21206-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Gold Nanocluster-Mediated Efficient Delivery of Cas9 Protein through pH-Induced Assembly-Disassembly for Inactivation of Virus Oncogenes.

Ju, Enguo / Li, Tingting / Ramos da Silva, Suzane / Gao, Shou-Jiang

ACS applied materials & interfaces

2019 Volume 11, Issue 38, Page(s) 34717–34724

Abstract: The CRISPR/Cas gene editing system has been successfully applied to combating bacteria, cancer, virus, and genetic disorders. While viral vectors have been used for the delivery of the CRISPR/Cas9 system, the time required for insert cloning, and virus ... ...

Abstract	The CRISPR/Cas gene editing system has been successfully applied to combating bacteria, cancer, virus, and genetic disorders. While viral vectors have been used for the delivery of the CRISPR/Cas9 system, the time required for insert cloning, and virus packaging and standardization, hinders its efficient use. Additionally, the high molecular weight of the Cas9 endonuclease makes it not easy for packing into the vehicles. Herein we report the self-assembly of gold nanoclusters (AuNCs) with SpCas9 protein (SpCas9-AuNCs) under physiological conditions and the efficient delivery of SpCas9 into the cell nucleus. This assembly process is highly dependent on pH. SpCas9-AuNCs are stable at a higher pH but are disassembled at a lower pH. Significantly, this assembly-disassembly process facilitates the delivery of SpCas9 into cells and the cell nucleus, where the SpCas9 exerts its cleavage function. As a proof-of-concept, the assembled SpCas9-AuNCs nanoparticles are successfully used for efficient knockout of the E6 oncogene, restoring the function of tumor-suppressive protein p53 and inducing apoptosis in cervical cancer cells with little effect on normal human cells. The SpCas9-AuNCs are useful for sgRNA functional validation, sgRNA library screening, and genomic manipulation.
MeSH term(s)	CRISPR-Associated Protein 9/chemistry ; CRISPR-Associated Protein 9/pharmacology ; Female ; Genes, Viral ; Gold/chemistry ; Gold/pharmacology ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/therapeutic use ; Oncogenes ; Tumor Suppressor Protein p53/metabolism ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/virology
Chemical Substances	Tumor Suppressor Protein p53 ; Gold (7440-57-5) ; CRISPR-Associated Protein 9 (EC 3.1.-) ; Cas9 endonuclease Streptococcus pyogenes (EC 3.1.-)
Language	English
Publishing date	2019-09-10
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.9b12335
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Green propolis as an adjuvant against nontuberculous mycobacteria

Suzane Olachea Allend / Lisiane Volcão / Carolina da Silva Canielles / Israel Barbosa / Dara Biatobock / Pedro Eduardo Almeida da Silva / Daniela Fernandes Ramos

Rodriguésia, Vol

2021 Volume 72

Abstract: Abstract Natural products have been touted as important tools because of their vast potential for the development of compounds with antimicrobial activity and the possible inhibitory activity and/or adjuvant resistance mechanisms. Propolis has been ... ...

Abstract	Abstract Natural products have been touted as important tools because of their vast potential for the development of compounds with antimicrobial activity and the possible inhibitory activity and/or adjuvant resistance mechanisms. Propolis has been empirically used for many years for the treatment of diseases, mainly due to its antioxidant, anti inflammatory and antimicrobial activities. This study aimed to evaluate the in vitro antimycobacterial activity of the ethanol extract of propolis alone and in combination with rifampicin (RIF), amikacin (AMI) and ciprofloxacin (CIP). The ethanol extract of propolis showed antibacterial activity against Mycobacterium chelonae and M. kansasii and was capable of increasing AMI, RIF and CIP activity in combination. On the other hand, compared to M. absecessus, M. fortuitum and M. avium, the extract was not active at 200 µg/mL and did not show pronounced adjuvant capacity when evaluated in association with the drugs. Based on these results, it can be concluded that the ethanol extract of propolis could be an alternative in the development of new drugs and can be used complementary with the current mycobacteriosis treatment.
Keywords	additivity ; antimicrobial ; Mycobacterium sp ; propolis ; Biology (General) ; QH301-705.5 ; Botany ; QK1-989
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Instituto de Pesquisas Jardim Botânico do Rio de Janeiro
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Specific Inhibition of Viral MicroRNAs by Carbon Dots-Mediated Delivery of Locked Nucleic Acids for Therapy of Virus-Induced Cancer.

Ju, Enguo / Li, Tingting / Liu, Zhen / da Silva, Suzane Ramos / Wei, Shan / Zhang, Xinquan / Wang, Xian / Gao, Shou-Jiang

ACS nano

2020 Volume 14, Issue 1, Page(s) 476–487

Abstract: Viruses are associated with up to 15% of human cancer. MicroRNAs (miRNAs) encoded by numerous oncogenic viruses including Kaposi's sarcoma-associated herpesvirus (KSHV) play significant roles in regulating the proliferation and survival of virus-induced ... ...

Abstract	Viruses are associated with up to 15% of human cancer. MicroRNAs (miRNAs) encoded by numerous oncogenic viruses including Kaposi's sarcoma-associated herpesvirus (KSHV) play significant roles in regulating the proliferation and survival of virus-induced cancer cells, hence representing attractive therapeutic targets. Here, we report that specific inhibition of viral miRNAs by carbon dots (Cdots)-mediated delivery of locked nucleic acid (LNA)-based suppressors inhibit the proliferation of KSHV-associated primary effusion lymphoma (PEL) cells. Specifically, a combination of Cdots-LNAs to knock down the levels of KSHV miR-K12-1, miR-K12-4, and miR-K12-11 induces apoptosis and inhibits proliferation of PEL cells. Significantly, these Cdots-LNAs effectively inhibit the initiation of PEL and regress established PEL in a xenograft mouse model. These results demonstrate the feasibility of using Cdots to deliver miRNA suppressors for targeting viral cancers. Our study with viral miRNAs as targets may provide the scientific basis for using antisense drugs for human cancers associated with oncogenic viruses.
MeSH term(s)	Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Carbon/chemistry ; Cell Proliferation/drug effects ; Cells, Cultured ; Drug Screening Assays, Antitumor ; Female ; Herpesvirus 8, Human/chemistry ; Lymphoma/drug therapy ; Lymphoma/pathology ; Lymphoma/virology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred NOD ; Mice, SCID ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology ; Neoplasms, Experimental/virology ; Oligonucleotides/chemistry ; Oligonucleotides/pharmacology ; Particle Size ; Quantum Dots/chemistry ; RNA, Viral/antagonists & inhibitors ; Rats ; Surface Properties
Chemical Substances	Antineoplastic Agents ; Oligonucleotides ; RNA, Viral ; locked nucleic acid ; Carbon (7440-44-0)
Language	English
Publishing date	2020-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.9b06333
Database	MEDical Literature Analysis and Retrieval System OnLINE

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