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Article ; Online: The Anti-Inflammatory and Uric Acid Lowering Effects of Si-Miao-San on Gout.

Cao, Ling / Zhao, Tianyi / Xue, Yu / Xue, Luan / Chen, Yueying / Quan, Feng / Xiao, Yu / Wan, Weiguo / Han, Man / Jiang, Quan / Lu, Liwei / Zou, Hejian / Zhu, Xiaoxia

Frontiers in immunology

2022 Volume 12, Page(s) 777522

Abstract: Background: Si-Miao-San (SMS) is a well-known traditional Chinese medicine. This study aims ...

Abstract	Background: Si-Miao-San (SMS) is a well-known traditional Chinese medicine. This study aims to evaluate the anti-inflammatory effects of SMS on gouty arthritis and its potential mechanism of action. Methods: The effects and mechanism of SMS were evaluated in monosodium urate (MSU)-treated mice or macrophages. The expression of cytokines and PI3K/Akt was analyzed using real-time PCR and Western blotting analyses. Macrophage polarization was assessed with immunofluorescence assays, real-time PCR, and Western blotting. Mass spectrometry was used to screen the active ingredients of SMS. Results: Pretreatment with SMS ameliorated MSU-induced acute gouty arthritis in mice with increased PI3K/Akt activation and M2 macrophage polarization in the joint tissues. Conclusion: SMS ameliorated MSU-induced gouty arthritis and inhibited hyperuricemia. The anti-inflammatory mechanism of SMS may exert anti-inflammatory effects by promoting M2 polarization
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Chromones/pharmacology ; Drugs, Chinese Herbal/pharmacology ; Gout/drug therapy ; Gout/immunology ; Gout/metabolism ; Humans ; Macrophages/immunology ; Macrophages/metabolism ; Male ; Mice ; Morpholines/pharmacology ; Phosphatidylinositol 3-Kinases/immunology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/immunology ; Proto-Oncogene Proteins c-akt/metabolism ; THP-1 Cells ; Uric Acid/immunology ; Uric Acid/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Chromones ; Drugs, Chinese Herbal ; Morpholines ; Uric Acid (268B43MJ25) ; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (31M2U1DVID) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2022-01-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.777522
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Article ; Online: Classic Kaposi sarcoma in a patient of Miao ethnicity followed up for 7 years: a case report.

Zhou, Jing / Shen, Xiaoping / Wang, Xiaodong / Xiao, Kun / Cao, Yu / Jiang, Yanping

Journal of medical case reports

2021 Volume 15, Issue 1, Page(s) 179

Abstract: ... rarely reported in inland China. Here, we followed a case of CKS for 7 years in a patient of Miao ethnic ... background in southwestern China.: Case presentation: A 63-year-old Miao (southwestern China) man was ... Conclusions: We describe spontaneous partial regression of CKS in a patient of Miao ethnicity in inland China ...

Abstract	Background: Classic Kaposi sarcoma (CKS) is a vascular sarcoma associated with human herpesvirus 8 (HHV-8), which is known to be more common in Mediterranean elderly men and is characterized by indolent clinical behavior. Xinjiang province in China is considered an endemic region for Kaposi's sarcoma-associated herpesvirus (KSHV), with higher incidence among adults of Kazak and Uyghur ethnicities. Cases of CKS are rarely reported in inland China. Here, we followed a case of CKS for 7 years in a patient of Miao ethnic background in southwestern China. Case presentation: A 63-year-old Miao (southwestern China) man was initially diagnosed with CKS in 2010, having a history of limb lesions for 37 years, with left eyelid and binaural lesions for 9 years. He did not have sexual contact with men and was human immunodeficiency virus (HIV)-negative. Due to his lumbago and fever, spinal tuberculosis in the lumbar vertebra was highly suspected after computed tomography (CT) scan. However, diagnostic antituberculosis treatment for 4 weeks failed. The patient was followed up in 2016, when the rash was recovering as the systemic symptoms improved. A new CT was performed, which showed a partial response despite the absence of any medical treatment. The open reading frame (ORF)-K1 of KSHV from skin tissue of the foot was amplified and sequenced, and K1 belonged to subtype A. This genotype is consistent with the typical subtype present in Xinjiang. Conclusions: We describe spontaneous partial regression of CKS in a patient of Miao ethnicity in inland China. Our sample may represent an unknown, novel genotype. Surveillance and regulating the immune state may represent a valuable approach for this rare disease.
MeSH term(s)	Adult ; Aged ; China ; Ethnic Groups ; Genome, Viral ; Genotype ; Herpesvirus 8, Human/classification ; Herpesvirus 8, Human/genetics ; Herpesvirus 8, Human/isolation & purification ; Humans ; Male ; Membrane Proteins ; Middle Aged ; Sarcoma, Kaposi/pathology ; Sarcoma, Kaposi/virology ; Skin Neoplasms/pathology ; Skin Neoplasms/virology ; Viral Envelope Proteins/classification ; Viral Envelope Proteins/genetics
Chemical Substances	Membrane Proteins ; ORF-K1 protein, Human herpesvirus 8 ; Viral Envelope Proteins
Language	English
Publishing date	2021-04-19
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-021-02777-7
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Article ; Online: Classic Kaposi sarcoma in a patient of Miao ethnicity followed up for 7 years

Jing Zhou / Xiaoping Shen / Xiaodong Wang / Kun Xiao / Yu Cao / Yanping Jiang

Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-

a case report

2021 Volume 7

Abstract: ... rarely reported in inland China. Here, we followed a case of CKS for 7 years in a patient of Miao ethnic ... background in southwestern China. Case presentation A 63-year-old Miao (southwestern China) man was initially ... We describe spontaneous partial regression of CKS in a patient of Miao ethnicity in inland China. Our sample ...

Abstract	Abstract Background Classic Kaposi sarcoma (CKS) is a vascular sarcoma associated with human herpesvirus 8 (HHV-8), which is known to be more common in Mediterranean elderly men and is characterized by indolent clinical behavior. Xinjiang province in China is considered an endemic region for Kaposi’s sarcoma-associated herpesvirus (KSHV), with higher incidence among adults of Kazak and Uyghur ethnicities. Cases of CKS are rarely reported in inland China. Here, we followed a case of CKS for 7 years in a patient of Miao ethnic background in southwestern China. Case presentation A 63-year-old Miao (southwestern China) man was initially diagnosed with CKS in 2010, having a history of limb lesions for 37 years, with left eyelid and binaural lesions for 9 years. He did not have sexual contact with men and was human immunodeficiency virus (HIV)-negative. Due to his lumbago and fever, spinal tuberculosis in the lumbar vertebra was highly suspected after computed tomography (CT) scan. However, diagnostic antituberculosis treatment for 4 weeks failed. The patient was followed up in 2016, when the rash was recovering as the systemic symptoms improved. A new CT was performed, which showed a partial response despite the absence of any medical treatment. The open reading frame (ORF)-K1 of KSHV from skin tissue of the foot was amplified and sequenced, and K1 belonged to subtype A. This genotype is consistent with the typical subtype present in Xinjiang. Conclusions We describe spontaneous partial regression of CKS in a patient of Miao ethnicity in inland China. Our sample may represent an unknown, novel genotype. Surveillance and regulating the immune state may represent a valuable approach for this rare disease.
Keywords	Human herpesvirus 8 ; Kaposi sarcoma ; Tomography ; Ethnic groups ; Genotype ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Role of Selenoprotein W in participating in the progression of non-alcoholic fatty liver disease.

Miao, Zhiruo / Wang, Wei / Miao, Zhiying / Cao, Qiyuan / Xu, Shiwen

Redox biology

2024 Volume 71, Page(s) 103114

Abstract: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease worldwide. Numerous evidence has demonstrated that metabolic reprogramming serves as a hallmark associated with an elevated risk of NAFLD progression. Selenoprotein W (SelW) is an ... ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease worldwide. Numerous evidence has demonstrated that metabolic reprogramming serves as a hallmark associated with an elevated risk of NAFLD progression. Selenoprotein W (SelW) is an extensively expressed hepatic selenoprotein that plays a crucial role in antioxidant function. Here, we first demonstrated that SelW is a significantly distinct factor in the liver tissue of NAFLD patients through the Gene Expression Omnibus (GEO) database. Additionally, loss of SelW alleviated hepatic steatosis induced by a high-fat diet (HFD), and was accompanied by the regulation of metabolic and inflammatory pathways as verified by transcriptomic analysis. Moreover, co-immunoprecipitation (CO-IP), liquid chromatography-tandem mass spectrometry (LC-MS), laser scanning confocal microscopy (LSCM) and molecular docking analysis were subsequently implemented to identify Pyruvate Kinase M2 (PKM2) as a potential interacting protein of SelW. Meanwhile, SelW modulated PKM2 translocation into the nucleus to trigger transactivation of the HIF-1α, in further mediating mitochondrial apoptosis, eventually resulting in mitochondrial damage, ROS excessive production and mtDNA leakage. Additionally, mito-ROS accumulation induced the activation of the NLRP3 inflammasome-mediated pyroptosis, thereby facilitating extracellular leakage of mtDNA. The escaped mtDNA then evokes the cGAS-STING signaling pathway in macrophage, thus inducing a shift in macrophage phenotype. Together, our results suggest SelW promotes hepatocyte apoptosis and pyroptosis by regulating metabolic reprogramming to activate cGAS/STING signaling of macrophages, thereby exacerbating the progression of NAFLD.
MeSH term(s)	Animals ; Humans ; Mice ; Diet, High-Fat ; DNA, Mitochondrial/metabolism ; Liver/metabolism ; Mice, Inbred C57BL ; Molecular Docking Simulation ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/metabolism ; Nucleotidyltransferases/metabolism ; Reactive Oxygen Species/metabolism ; Selenoprotein W/metabolism
Chemical Substances	DNA, Mitochondrial ; Nucleotidyltransferases (EC 2.7.7.-) ; Reactive Oxygen Species ; Selenoprotein W ; SELENOW protein, human
Language	English
Publishing date	2024-03-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2024.103114
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Article ; Online: Mandibular Gorham-Stout Disease With Implanted Fibular Resorption.

Miao, Cheng / Cao, Yubin / Li, Chunjie

The Journal of craniofacial surgery

2024

Abstract: Gorham-Stout disease is an extremely rare disease characterized by progressive massive osteolysis with different clinical manifestations. The pathology is characterized by vascular proliferation, leading to destruction and resorption of the bone matrix, ... ...

Abstract	Gorham-Stout disease is an extremely rare disease characterized by progressive massive osteolysis with different clinical manifestations. The pathology is characterized by vascular proliferation, leading to destruction and resorption of the bone matrix, but the exact etiology is unknown. It can occur in any part of the body, with few reports of cases involving the maxillofacial region. Herein, the authors report a case of Gorham-Stout disease of the mandible, which started by affecting the alveolar bone and progressed to the mandibular marginal branches and even to the implanted vascularized free fibula.
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000009928
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Article ; Online: The complete chloroplast genome sequence of

Yao, Zhangliang / Miao, Jiashun / Xu, Weidong / Cao, Liangliang / Lu, Qiang

Mitochondrial DNA. Part B, Resources

2024 Volume 9, Issue 2, Page(s) 277–280

Abstract: Zuili' is a distinguished plum ( ...

Abstract	'Zuili' is a distinguished plum (
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ISSN	2380-2359
ISSN (online)	2380-2359
DOI	10.1080/23802359.2024.2316068
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Article ; Online: Computational chemistry for water-splitting electrocatalysis.

Miao, Licheng / Jia, Wenqi / Cao, Xuejie / Jiao, Lifang

Chemical Society reviews

2024 Volume 53, Issue 6, Page(s) 2771–2807

Abstract: Electrocatalytic water splitting driven by renewable electricity has attracted great interest in recent years for producing hydrogen with high-purity. However, the practical applications of this technology are limited by the development of ... ...

Abstract	Electrocatalytic water splitting driven by renewable electricity has attracted great interest in recent years for producing hydrogen with high-purity. However, the practical applications of this technology are limited by the development of electrocatalysts with high activity, low cost, and long durability. In the search for new electrocatalysts, computational chemistry has made outstanding contributions by providing fundamental laws that govern the electron behavior and enabling predictions of electrocatalyst performance. This review delves into theoretical studies on electrochemical water-splitting processes. Firstly, we introduce the fundamentals of electrochemical water electrolysis and subsequently discuss the current advancements in computational methods and models for electrocatalytic water splitting. Additionally, a comprehensive overview of benchmark descriptors is provided to aid in understanding intrinsic catalytic performance for water-splitting electrocatalysts. Finally, we critically evaluate the remaining challenges within this field.
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472875-8
ISSN	1460-4744 ; 0306-0012
ISSN (online)	1460-4744
ISSN	0306-0012
DOI	10.1039/d2cs01068b
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Article ; Online: Effect of comprehensive nursing intervention on improving cognitive level and quality of life of patients with senile dementia.

Cao, Ruili / Miao, Dongrui

Minerva surgery

2022 Volume 78, Issue 4, Page(s) 444–446

MeSH term(s)	Humans ; Alzheimer Disease ; Quality of Life/psychology ; Cognition
Language	English
Publishing date	2022-01-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3067899-7
ISSN	2724-5438
ISSN (online)	2724-5438
DOI	10.23736/S2724-5691.21.09384-9
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Article ; Online: Deoxynivalenol Induces Intestinal Epithelial Barrier Damage through RhoA/ROCK Pathway-Mediated Apoptosis and F-Actin-Associated Tight Junction Disruption.

Miao, Chenjiao / Wu, Zuoyao / Sun, Yafei / Cao, Zheng

Journal of agricultural and food chemistry

2024

Abstract: Deoxynivalenol (DON) poses a serious global food safety risk due to its high toxicity and contamination rate. It disrupts the intestinal epithelial barrier, allowing exogenous toxins to enter the circulation and resulting in sepsis and systemic toxicity. ...

Abstract	Deoxynivalenol (DON) poses a serious global food safety risk due to its high toxicity and contamination rate. It disrupts the intestinal epithelial barrier, allowing exogenous toxins to enter the circulation and resulting in sepsis and systemic toxicity. In this research, 32 male Kunming mice and Porcine Small Intestinal Epithelial (IPEC-J2) cells were treated with DON at 0-4.8 mg/kg (7 d) and 0-12 μM (24 h), respectively. Histopathological results revealed that DON disrupted the intestinal epithelial barrier, causing apoptosis and tight junction (TJ) injury. Immunofluorescence and protein expression results showed that DON-induced p53-dependent mitochondrial pathway apoptosis and fibrillar actin (F-actin)-associated TJ injury and that the RhoA/ROCK pathway were activated in mice jejunal tissue and IPEC-J2 cells. Pretreatment with RhoA or ROCK inhibitors (Rosin or Y-27632) maintained DON-induced apoptosis and F-actin-associated TJ injury in IPEC-J2 cells. Thus, DON induces damage to the intestinal epithelial barrier through the RhoA/ROCK pathway-mediated apoptosis and F-actin-associated TJ disruption.
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.4c02091
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Article ; Online: Association between ethylene oxide exposure and periodontitis: a cross-sectional study from NHANES 2013-2014.

Miao, Di / Zhao, Lina / Cao, Ruoyan

BMC public health

2024 Volume 24, Issue 1, Page(s) 195

Abstract: Background: Exposure to ethylene oxide (EO) induces inflammation and oxidative stress, which are the main mechanisms of periodontitis. However, the effect of EO on periodontal health is not unclear. In this study, we aimed to explore the relationship ... ...

Abstract	Background: Exposure to ethylene oxide (EO) induces inflammation and oxidative stress, which are the main mechanisms of periodontitis. However, the effect of EO on periodontal health is not unclear. In this study, we aimed to explore the relationship between EO exposure and the risk of periodontitis in general US adults. Methods: Data used in our study from the National Health and Nutritional Examination Survey (NHANES) 2013-2014. The EO biomarker, hemoglobin adduct of EO (HbEO), was measured in blood samples utilizing high-performance liquid chromatography-tandem mass spectrometry. Periodontitis category was defined by the CDC/AAP according to clinical periodontal parameters. Natural cubic spline, weight multivariable logistic regression analyses and subgroup analysis were used to explore the association between EO exposure and the risk of periodontitis. Results: A total of 1497 participants over the age of 30 were included in our study. A non-linear positive association with periodontitis was identified for HbEO levels. Participants in the highest tertile of HbEO levels were more likely to have poorer periodontal health compared to the lowest tertile (OR Conclusions: HbEO levels are positively associated with poor periodontal health in US adults. Additional longitudinal studies are necessary to further enhance our comprehension of the impact of exposure to EO on periodontal status.
MeSH term(s)	Adult ; Humans ; Ethylene Oxide ; Cross-Sectional Studies ; Nutrition Surveys ; Periodontitis/epidemiology ; Longitudinal Studies
Chemical Substances	Ethylene Oxide (JJH7GNN18P)
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-17735-3
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