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  1. Article ; Online: The clinical spectrum of thymoma-associated immunodeficiency: Good syndrome and beyond.

    Wang, Chen / Shi, Yiyun / Lim, Xin Rong / Walter, Jolan E

    European journal of internal medicine

    2024  

    Language English
    Publishing date 2024-04-13
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2024.04.006
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    Zs.A 2608: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Precision Medicine in Allergy and Immunology Through the Lens of Immunogenomics.

    Phillips, Elizabeth J / Walter, Jolan E

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 7, Page(s) 1776–1777

    MeSH term(s) Allergy and Immunology ; Humans ; Hypersensitivity/therapy ; Precision Medicine
    Language English
    Publishing date 2022-07-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.05.025
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    Zs.A 7086: Show issues Location:
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  3. Article ; Online: Introducing a New Epoch in Inborn Errors of Immunity.

    Arkwright, Peter D / Walter, Jolan E

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 2, Page(s) 660–662

    MeSH term(s) High-Throughput Nucleotide Sequencing ; Humans ; Infant, Newborn ; Neonatal Screening
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.11.022
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    Zs.A 7086: Show issues Location:
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  4. Article ; Online: Autoantibodies in immunodeficiency syndromes: The Janus faces of immune dysregulation.

    Wang, Chen / Walter, Jolan E

    Blood reviews

    2022  Volume 55, Page(s) 100948

    Abstract: Immunodeficiency syndromes represent a diverse group of inherited and acquired disorders, characterized by a spectrum of clinical manifestations, including recurrent infections, autoimmunity, lymphoproliferation and malignancy. Autoantibodies against ... ...

    Abstract Immunodeficiency syndromes represent a diverse group of inherited and acquired disorders, characterized by a spectrum of clinical manifestations, including recurrent infections, autoimmunity, lymphoproliferation and malignancy. Autoantibodies against various self-antigens reflect the immune dysregulation underlying these disorders, and could contribute to certain clinical findings, such as susceptibility to opportunistic infections, cytopenia of different hematopoietic lineages, and organ-specific autoimmune diseases. The mechanism of autoantibody production in the context of immunodeficiency remains largely unknown but is likely shaped by both intrinsic genetic aberrations and extrinsic exposures to possible infectious agents. These autoantibodies if harbor neutralizing activities and reach certain levels in the circulation, could disrupt the biological functions of their targets, resulting in specific clinical manifestations. Herein, we reviewed the prevalence of autoantibodies against cytokines, hematopoietic cells and organ-specific antigens in immunodeficiency syndromes and examined their associations with certain clinical findings. Moreover, the potential mechanism of autoantibody production was also discussed. These may shed light on the development of mechanism-based therapies to reset the dysregulated immune system in immunodeficient patients.
    MeSH term(s) Autoantibodies ; Autoimmune Diseases/etiology ; Autoimmunity ; Cytokines ; Humans ; Syndrome
    Chemical Substances Autoantibodies ; Cytokines
    Language English
    Publishing date 2022-03-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2022.100948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Editorial: Mechanisms of dysregulated antibody responses in inborn errors of immunity.

    Min, Qing / Walter, Jolan E / Schroeder, Harry W / Burrows, Peter D / Wang, Ji-Yang

    Frontiers in immunology

    2023  Volume 14, Page(s) 1335217

    MeSH term(s) Antibody Formation ; Immune System Diseases
    Language English
    Publishing date 2023-11-21
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1335217
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  6. Article ; Online: CMV-Seropositive Mothers of SCID: To Breastfeed or Not?

    Walter, Jolan E / Heimall, Jennifer

    The journal of allergy and clinical immunology. In practice

    2020  Volume 7, Issue 8, Page(s) 2866–2867

    MeSH term(s) Cytomegalovirus ; Cytomegalovirus Infections ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Infant ; Mothers ; Severe Combined Immunodeficiency
    Language English
    Publishing date 2020-02-10
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2019.08.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7086: Show issues Location:
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  7. Article ; Online: The new quest in CTLA-4 insufficiency: How to immune modulate effectively?

    Westermann-Clark, Emma / Ballow, Mark / Walter, Jolan E

    The Journal of allergy and clinical immunology

    2021  Volume 149, Issue 2, Page(s) 543–546

    MeSH term(s) Abatacept ; B7-2 Antigen ; CTLA-4 Antigen ; Humans
    Chemical Substances B7-2 Antigen ; CTLA-4 Antigen ; Abatacept (7D0YB67S97)
    Language English
    Publishing date 2021-12-13
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2021.11.020
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    Uh III Zs.92: Show issues Location:
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  8. Article ; Online: Evolving Approach to Clinical Cytometry for Immunodeficiencies and Other Immune Disorders.

    Sadighi Akha, Amir A / Csomós, Krisztián / Ujházi, Boglárka / Walter, Jolán E / Kumánovics, Attila

    Clinics in laboratory medicine

    2023  Volume 43, Issue 3, Page(s) 467–483

    Abstract: Primary immunodeficiencies were initially identified on the basis of recurrent, severe or unusual infections. Subsequently, it was noted that these diseases can also manifest with autoimmunity, autoinflammation, allergy, lymphoproliferation and ... ...

    Abstract Primary immunodeficiencies were initially identified on the basis of recurrent, severe or unusual infections. Subsequently, it was noted that these diseases can also manifest with autoimmunity, autoinflammation, allergy, lymphoproliferation and malignancy, hence a conceptual change and their renaming as inborn errors of immunity. Ongoing advances in flow cytometry provide the opportunity to expand or modify the utility and scope of existing laboratory tests in this field to mirror this conceptual change. Here we have used the B cell subset, variably known as CD21low B cells, age-associated B cells and T-bet+ B cells, as an example to demonstrate this possibility.
    MeSH term(s) Humans ; Immune System Diseases/diagnosis ; Immunologic Deficiency Syndromes/diagnosis ; B-Lymphocyte Subsets ; B-Lymphocytes ; Flow Cytometry
    Language English
    Publishing date 2023-06-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604580-7
    ISSN 1557-9832 ; 0272-2712
    ISSN (online) 1557-9832
    ISSN 0272-2712
    DOI 10.1016/j.cll.2023.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1695: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Advances and Challenges of the Decade: The Ever-Changing Clinical and Genetic Landscape of Immunodeficiency.

    Walter, Jolan E / Ziegler, John B / Ballow, Mark / Cunningham-Rundles, Charlotte

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 1, Page(s) 107–115

    Abstract: In the past 10 years, we have witnessed major advances in clinical immunology. Newborn screening for severe combined immunodeficiency has become universal in the United States and screening programs are being extended to severe combined immunodeficiency ... ...

    Abstract In the past 10 years, we have witnessed major advances in clinical immunology. Newborn screening for severe combined immunodeficiency has become universal in the United States and screening programs are being extended to severe combined immunodeficiency and other inborn errors of immunity globally. Early genetic testing is becoming the norm for many of our patients and allows for informed selection of targeted therapies including biologics repurposed from other specialties. During the COVID-19 pandemic, our understanding of essential immune responses expanded and the discovery of immune gene defects continued. Immunoglobulin products, the backbone of protection for antibody deficiency syndromes, came into use to minimize side effects. New polyclonal and monoclonal antibody products emerged with increasing options to manage respiratory viral agents such as SARS-CoV-2 and respiratory syncytial virus. Against these advances, we still face major challenges. Atypical is becoming typical as phenotypes of distinct genetic disease overlap whereas the clinical spectrum of the same genetic defect widens. Therefore, clinical judgment needs to be paired with repeated deep immune phenotyping and upfront genetic testing, as technologies rapidly evolve, and clinical disease often progresses with age. Managing patients with organ damage resulting from immune dysregulation poses a special major clinical challenge and management often lacks standardization, from autoimmune cytopenias, granulomatous interstitial lung disease, enteropathy, and liver disease to endocrine, rheumatologic, and neurologic complications. Clinical, translational, and basic science networks will continue to advance the field; however, cross-talk and education with practicing allergists/immunologists are essential to keep up with the ever-changing clinical and genetic landscape of inborn errors of immunity.
    MeSH term(s) Humans ; Severe Combined Immunodeficiency ; Pandemics ; COVID-19/complications ; SARS-CoV-2 ; Immunologic Deficiency Syndromes/genetics
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.11.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The WHIM Syndrome Is No Longer a Whim.

    Walter, Jolan E / Ballow, Mark

    The journal of allergy and clinical immunology. In practice

    2019  Volume 7, Issue 5, Page(s) 1578–1579

    MeSH term(s) Humans ; Lung Diseases ; Neoplasms ; Papillomavirus Infections ; Primary Immunodeficiency Diseases ; Warts
    Language English
    Publishing date 2019-05-02
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2019.03.001
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