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  1. Article ; Online: Low Velocity Impact Monitoring of Composite Tubes Based on FBG Sensors.

    Huan, Shengsheng / Lu, Linjiao / Shen, Tao / Du, Jianke

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 4

    Abstract: Carbon fiber reinforced composites (CFRP) are susceptible to hidden damage from low velocity external impacts during their service life. To ensure the proper monitoring of the state of the composites, it is crucial to predict the location of an impact ... ...

    Abstract Carbon fiber reinforced composites (CFRP) are susceptible to hidden damage from low velocity external impacts during their service life. To ensure the proper monitoring of the state of the composites, it is crucial to predict the location of an impact event. In this paper, fiber Bragg grating (FBG) sensors are affixed to the surface of a carbon fiber composite tube, and an optical sensing interrogator is used to capture the central wavelength shift of the FBG sensors due to low-velocity impacts. A discrete wavelet transform is used for noise reduction in the response signals. Then, the differences in the captured response signals of the FBG sensors at different locations of the impact were analyzed. Moreover, two methods were implemented to predict the location of low-velocity impacts, according to the differences in the captured response signals. The BP neural network-based method utilized three data sets to train the neural network, resulting in an average localization error of 20.68 mm. In contrast, the method based on error outliers selected a specific data set as the reference dataset, achieving an average localization error of 13.98 mm. The comparison of the predicted results shows that the latter approach has a higher predictive accuracy and does not require a significant amount of data.
    Language English
    Publishing date 2024-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24041279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: How Tongxie-Yaofang Regulates Intestinal Synaptic Plasticity by Activating Enteric Glial Cells and NGF/TrkA Pathway in Diarrhea-Predominant Irritable Bowel Syndrome Rats.

    Lu, Xiaofang / Zhang, Shengsheng

    Drug design, development and therapy

    2023  Volume 17, Page(s) 2969–2983

    Abstract: Purpose: Diarrhea-predominant irritable bowel syndrome (D-IBS) is a frequent functional gastrointestinal disease that affects health and quality of life owing to its high incidence and recurrence rate. Tongxie-Yaofang (TXYF) is a traditional Chinese ... ...

    Abstract Purpose: Diarrhea-predominant irritable bowel syndrome (D-IBS) is a frequent functional gastrointestinal disease that affects health and quality of life owing to its high incidence and recurrence rate. Tongxie-Yaofang (TXYF) is a traditional Chinese medicine prescribed for D-IBS. However, the therapeutic mechanism of TXYF has not been fully elucidated. This study aimed to investigate the effects of TXYF on visceral hypersensitivity in stress-induced D-IBS rats and the underlying mechanisms.
    Methods: Electromyographic (EMG) activity of the external oblique muscles and the abdominal withdrawal reflex (AWR) score captured by Barostat were used to quantify the effect of TXYF on visceral sensitivity. Transmission electron microscopy (TEM) was used to observe the ultrastructure of the enteric nervous system (ENS). For molecular detection, the colonic expression of enteric glial cell's (EGC's) activation markers, glial fibrillary acidic protein (GFAP) and calcium-binding protein S100β, NGF, TrkA, synaptic plasticity-related factors, synaptophysin (SYN) and postsynaptic density-95 (PSD-95), glutamate, glutamate receptors α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR), and N-methyl-D-aspartate receptor (NMDAR) were detected by immunohistochemistry, enzyme-linked immunosorbent assay, and real-time PCR. An ex vivo experiment was conducted to measure the EGC-induced NGF release.
    Results: TXYF decreased the EMG activity and AWR scores in rats with D-IBS. Under TEM, TXYF improved the dense and irregular nerve arrangement, narrowed the synaptic cleft, and decreased the number of synaptic vesicles in D-IBS rats. In addition, TXYF decreased the expression of GFAP, S100β, SYN, and PSD-95; down-regulated the levels of NGF, TrkA, and glutamate; and reduced the mRNA expression of AMPAR1, NMDAR1, and NMDAR2B. In an ex vivo experiment, TXYF decreased NGF release in D-IBS rats, and this trend disappeared under EGC inhibition.
    Conclusion: TXYF alleviated visceral hypersensitivity in D-IBS rats possibly by improving synaptic plasticity through inhibiting the activity of EGCs and the NGF/TrkA signaling pathway in the colon.
    MeSH term(s) Rats ; Animals ; Irritable Bowel Syndrome/drug therapy ; Quality of Life ; Glutamic Acid ; Diarrhea/drug therapy ; Neuroglia/metabolism ; Neuronal Plasticity
    Chemical Substances tongxie-yaofang ; Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2023-09-27
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S423333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sesquiterpenoids isolated from feces-residing

    Lu, Shengsheng / Hu, Jianan / Xie, Xi / Huang, Ruifeng / He, Jian

    Natural product research

    2022  Volume 36, Issue 24, Page(s) 6286–6296

    Abstract: Five metabolites ( ...

    Abstract Five metabolites (
    MeSH term(s) Animals ; Streptomyces/chemistry ; Influenza A virus ; Sesquiterpenes/chemistry ; Feces ; Antiviral Agents/pharmacology ; Ursidae ; Molecular Structure
    Chemical Substances Sesquiterpenes ; Antiviral Agents
    Language English
    Publishing date 2022-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2033740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Houpo paiqi mixture promotes intestinal motility in constipated rats by modulating gut microbiota and activating 5-HT-cAMP-PKA signal pathway.

    Wang, Ruixin / Lu, Xiaofang / Zhao, Luqing / Zhang, Weixi / Zhang, Shengsheng

    Journal of applied microbiology

    2023  Volume 134, Issue 8

    Abstract: Aims: Constipation is a common functional gastrointestinal disorder, which needs more effective treatment approaches. Houpo Paiqi Mixture (HPPQM) is a type of Chinese patent medicine developed from a classical formula that has been widely applied to the ...

    Abstract Aims: Constipation is a common functional gastrointestinal disorder, which needs more effective treatment approaches. Houpo Paiqi Mixture (HPPQM) is a type of Chinese patent medicine developed from a classical formula that has been widely applied to the treatment of intestinal motility disorder. Here we aim to assess the effectiveness of HPPQM in the treatment of constipation in rat models and its potential mechanism.
    Methods and results: UPLC-MS/MS was performed to investigate the chemical component of HPPQM. Rats were randomly divided into normal control, constipation model (CM), HPPQM (low, middle and high dose) and mosapride groups. Loperamide 8 mg/kg was given orally to induce CM. The small intestine motility, colonic contraction, rectum propulsion, and histological feature of the colon were significantly improved in HPPQM group, compared with CM group (P < 0.05). Results of 16S rRNA sequencing revealed that HPPQM treatment strikingly restructured intestinal microbiota in constipated rats by increasing the relative abundances of Bacteroides and Akkermansia and decreasing the relative abundances of Prevotella and Lactobacillus. The levels of GPR43, 5-HT, 5-HT4R, cAMP, PKA were decreased while SERT was increased in constipated rats (P < 0.05), which could be restored to normal levels by treatment with HPPQM (P < 0.05). Differences in amplitude between experimental CLSMs (with HPPQM added) and control CLSMs were discovered, starting at the concentration of 40 nL/mL (P < 0.05). It was found that GLPG0974 and GR113808 could significantly reduce this reactivity (P < 0.05).
    Conclusions: HPPQM manifested a curative effect in constipated rats by promoting intestinal motility. The underlying mechanisms might be related to modulating gut microbiota and activating 5-HT-cAMP-PKA signal pathway.
    MeSH term(s) Rats ; Animals ; Gastrointestinal Microbiome ; Serotonin/pharmacology ; Serotonin/therapeutic use ; RNA, Ribosomal, 16S ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Constipation/drug therapy ; Gastrointestinal Motility ; Signal Transduction
    Chemical Substances Serotonin (333DO1RDJY) ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1358023-1
    ISSN 1365-2672 ; 1364-5072
    ISSN (online) 1365-2672
    ISSN 1364-5072
    DOI 10.1093/jambio/lxad153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A subregion-based RadioFusionOmics model discriminates between grade 4 astrocytoma and glioblastoma on multisequence MRI.

    Wei, Ruili / Lu, Songlin / Lai, Shengsheng / Liang, Fangrong / Zhang, Wanli / Jiang, Xinqing / Zhen, Xin / Yang, Ruimeng

    Journal of cancer research and clinical oncology

    2024  Volume 150, Issue 2, Page(s) 73

    Abstract: Purpose: To explore a subregion-based RadioFusionOmics (RFO) model for discrimination between adult-type grade 4 astrocytoma and glioblastoma according to the 2021 WHO CNS5 classification.: Methods: 329 patients (40 grade 4 astrocytomas and 289 ... ...

    Abstract Purpose: To explore a subregion-based RadioFusionOmics (RFO) model for discrimination between adult-type grade 4 astrocytoma and glioblastoma according to the 2021 WHO CNS5 classification.
    Methods: 329 patients (40 grade 4 astrocytomas and 289 glioblastomas) with histologic diagnosis was retrospectively collected from our local institution and The Cancer Imaging Archive (TCIA). The volumes of interests (VOIs) were obtained from four multiparametric MRI sequences (T
    Results: The two best VOIs were manual VOI
    Conclusion: The performance of subregions defined by clustering was comparable to that of subregions that were manually defined. Fusion of features from the edematous subregions of multiple MRI sequences by the RFO model resulted in differentiation between grade 4 astrocytoma and glioblastoma.
    MeSH term(s) Adult ; Humans ; Glioblastoma/diagnostic imaging ; Glioblastoma/genetics ; Retrospective Studies ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/genetics ; Magnetic Resonance Imaging/methods ; Edema
    Language English
    Publishing date 2024-02-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-023-05603-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mogroside V alleviates the heat stress-induced disruption of the porcine oocyte in vitro maturation.

    Peng, Ke / Cui, Kexin / Li, Pan / Liu, Xinxin / Du, Ya / Xu, Huiyan / Yang, Xiaogan / Lu, Shengsheng / Liang, Xingwei

    Theriogenology

    2024  Volume 217, Page(s) 37–50

    Abstract: Heat stress (HS) is a stressor that negatively affect female reproduction. Specially, oocytes are very sensitive to HS. It has been demonstrated that some active compounds can protect oocyte from HS. We previously found that Mogroside V (MV), extracted ... ...

    Abstract Heat stress (HS) is a stressor that negatively affect female reproduction. Specially, oocytes are very sensitive to HS. It has been demonstrated that some active compounds can protect oocyte from HS. We previously found that Mogroside V (MV), extracted from Siraitia grosvenorii (Luo Han Guo), can protect oocyte from many kinds of stresses. However, how MV alleviates HS-induced disruption of oocyte maturation remains unknown. In this study, we treated the HS-induced porcine oocytes with MV to examine their maturation and quality. Our findings demonstrate that MV can effectively alleviate HS-induced porcine oocyte abnormal cumulus cell expansion, decrease of first polar body extrusion rate, spindle assembly and chromosome separation abnormalities, indicating MV attenuates oocyte mature defects. We further observed that MV can effectively alleviate HS-induced cortical granule distribution abnormality and decrease of blastocyst formation rate after parthenogenesis activation. In addition, MV treatment reversed mitochondrial dysfunction and lipid droplet content decrease, reduced reactive oxygen species levels, early apoptosis and DNA damage in porcine oocytes after HS. Collectively, this study suggests that MV can effectively protect porcine oocytes from HS.
    MeSH term(s) Swine ; Female ; Animals ; In Vitro Oocyte Maturation Techniques/veterinary ; Oocytes ; Oogenesis ; Reactive Oxygen Species/pharmacology ; Heat-Shock Response ; Triterpenes
    Chemical Substances mogroside V (88901-36-4) ; Reactive Oxygen Species ; Triterpenes
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189232-0
    ISSN 1879-3231 ; 0093-691X
    ISSN (online) 1879-3231
    ISSN 0093-691X
    DOI 10.1016/j.theriogenology.2024.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: New sesquiterpene from a soil fungus of

    Huang, Ruifeng / Zhou, Runhong / Zhou, Shaofen / Lin, Haixing / Lu, Shengsheng / Qiu, Jingnan / He, Jian

    Natural product research

    2022  Volume 38, Issue 9, Page(s) 1562–1569

    Abstract: Sixteen secondary metabolites, including one new sesquiterpene ( ...

    Abstract Sixteen secondary metabolites, including one new sesquiterpene (
    MeSH term(s) Trichoderma/chemistry ; Magnetic Resonance Spectroscopy ; Polyketides/pharmacology ; Polyketides/metabolism ; Sesquiterpenes/chemistry ; Molecular Structure
    Chemical Substances Polyketides ; Sesquiterpenes
    Language English
    Publishing date 2022-12-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2159398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: MnO

    Lu, Yi / Pan, Xinni / Cao, Cheng / Fan, Shanshan / Tan, Haisong / Cui, Shengsheng / Liu, Yanlei / Cui, Daxiang

    Advanced healthcare materials

    2023  Volume 12, Issue 22, Page(s) e2300163

    Abstract: As one of the most widely used drugs, acetaminophen, is the leading cause of acute liver injury. In addition, acetaminophen-induced liver injury (AILI) has a strong relationship with the overproduced reactive oxygen species, which can be effectively ... ...

    Abstract As one of the most widely used drugs, acetaminophen, is the leading cause of acute liver injury. In addition, acetaminophen-induced liver injury (AILI) has a strong relationship with the overproduced reactive oxygen species, which can be effectively eliminated by nanozymes. To address these challenges, mesoporous PdPt@MnO
    MeSH term(s) Humans ; Acetaminophen/pharmacology ; Reactive Oxygen Species ; Chemical and Drug Induced Liver Injury, Chronic/pathology ; Manganese Compounds ; Oxides ; Liver
    Chemical Substances Acetaminophen (362O9ITL9D) ; Reactive Oxygen Species ; Manganese Compounds ; Oxides
    Language English
    Publishing date 2023-05-25
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202300163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Calibration and analysis of discrete element simulation parameters of Chinese cabbage seeds.

    Shengsheng Wang / Lu Mengqing / Xingyi Liu / Jiangtao Ji / Pan Chen

    PLoS ONE, Vol 17, Iss 6, p e

    2022  Volume 0270415

    Abstract: Objective To improve the accuracy of parameters used in discrete element simulation test of Chinese cabbage seeds harvesting process. Methods Firstly, the key physical parameters of Chinese cabbage seeds were measured. According to the results, the ... ...

    Abstract Objective To improve the accuracy of parameters used in discrete element simulation test of Chinese cabbage seeds harvesting process. Methods Firstly, the key physical parameters of Chinese cabbage seeds were measured. According to the results, the discrete element simulation model was established and the value range of simulation test parameters was determined. Then, the actual repose angle of Chinese cabbage seeds was obtained by physical accumulation test using bottomless conical cylinder lifting method. Plackett-Burman test, steepest climb test, Box-Behnken test and parameter optimization test were carried out in sequence with the actual angle of repose as the response value. Finally, the obtained parameters are verified. Results 1. The Plackett-Burman test showed that the seed-seed rolling friction coefficient, the seed-steel rolling friction coefficient, the seed-seed static friction coefficient, and the seed-steel static friction coefficient had significant effects on the repose angle of Chinese cabbage seeds (P<0.05). 2. The optimization test showed that the seed-seed rolling friction coefficient was 0.08, the seed-steel rolling friction coefficient was 0.109, the seed-seed static friction coefficient was 0.496, and the seed-steel static friction coefficient was 0.415. 3. The validation test showed that the repose angle of Chinese cabbage seeds under such parameter was 23.62°, and the error with the repose angle of the physical test was 0.73%. Conclusion The study show that the discrete element simulation parameters of Chinese cabbage seeds model and calibration are reliable, which can provide reference for the discrete element simulation of Chinese cabbage seeds.
    Keywords Medicine ; R ; Science ; Q
    Subject code 600
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Elesclomol Loaded Copper Oxide Nanoplatform Triggers Cuproptosis to Enhance Antitumor Immunotherapy.

    Lu, Xufeng / Chen, Xiaodong / Lin, Chengyin / Yi, Yongdong / Zhao, Shengsheng / Zhu, Bingzi / Deng, Wenhai / Wang, Xiang / Xie, Zuoliang / Rao, Shangrui / Ni, Zhonglin / You, Tao / Li, Liyi / Huang, Yingpeng / Xue, Xiangyang / Yu, Yaojun / Sun, Weijian / Shen, Xian

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  , Page(s) e2309984

    Abstract: The induction of cuproptosis, a recently identified form of copper-dependent immunogenic cell death, is a promising approach for antitumor therapy. However, sufficient accumulation of intracellular copper ions ( ... ...

    Abstract The induction of cuproptosis, a recently identified form of copper-dependent immunogenic cell death, is a promising approach for antitumor therapy. However, sufficient accumulation of intracellular copper ions (Cu
    Language English
    Publishing date 2024-03-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202309984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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