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Article ; Online: Experimental Evidence for Seed Metabolic Allometry in Barrel Medic (

Domergue, Jean-Baptiste / Lalande, Julie / Beucher, Daniel / Satour, Pascale / Abadie, Cyril / Limami, Anis M / Tcherkez, Guillaume

International journal of molecular sciences

2022 Volume 23, Issue 15

Abstract: Seed size is often considered to be an important trait for seed quality, i.e., vigour and germination performance. It is believed that seed size reflects the quantity of reserve material and thus the C and N sources available for post-germinative ... ...

Abstract	Seed size is often considered to be an important trait for seed quality, i.e., vigour and germination performance. It is believed that seed size reflects the quantity of reserve material and thus the C and N sources available for post-germinative processes. However, mechanisms linking seed size and quality are poorly documented. In particular, specific metabolic changes when seed size varies are not well-known. To gain insight into this aspect, we examined seed size and composition across different accessions of barrel medic (
MeSH term(s)	Amino Acids/metabolism ; Lipids ; Medicago truncatula/genetics ; Seeds/metabolism
Chemical Substances	Amino Acids ; Lipids
Language	English
Publishing date	2022-07-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23158484
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Experimental Evidence for Seed Metabolic Allometry in Barrel Medic ( Medicago truncatula Gaertn.)

Jean-Baptiste Domergue / Julie Lalande / Daniel Beucher / Pascale Satour / Cyril Abadie / Anis M. Limami / Guillaume Tcherkez

International Journal of Molecular Sciences, Vol 23, Iss 8484, p

2022 Volume 8484

Abstract	Seed size is often considered to be an important trait for seed quality, i.e., vigour and germination performance. It is believed that seed size reflects the quantity of reserve material and thus the C and N sources available for post-germinative processes. However, mechanisms linking seed size and quality are poorly documented. In particular, specific metabolic changes when seed size varies are not well-known. To gain insight into this aspect, we examined seed size and composition across different accessions of barrel medic ( Medicago truncatula Gaertn.) from the genetic core collection. We conducted multi-elemental analyses and isotope measurements, as well as exact mass GC–MS metabolomics. There was a systematic increase in N content (+0.17% N mg −1 ) and a decrease in H content (–0.14% H mg −1 ) with seed size, reflecting lower lipid and higher S-poor protein quantity. There was also a decrease in 2 H natural abundance (δ 2 H), due to the lower prevalence of 2 H-enriched lipid hydrogen atoms that underwent isotopic exchange with water during seed development. Metabolomics showed that seed size correlates with free amino acid and hexoses content, and anticorrelates with amino acid degradation products, disaccharides, malic acid and free fatty acids. All accessions followed the same trend, with insignificant differences in metabolic properties between them. Our results show that there is no general, proportional increase in metabolite pools with seed size. Seed size appears to be determined by metabolic balance (between sugar and amino acid degradation vs. utilisation for storage), which is in turn likely determined by phloem source metabolite delivery during seed development.
Keywords	seed ; metabolomics ; isotope ; elemental composition ; size ; fluxes ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	580
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Constraining Plateau Uplift in Southern Africa by Combining Thermochronology, Sediment Flux, Topography, and Landscape Evolution Modeling

Stanley, Jessica R. / Braun, Jean / Baby, Guillaume / Guillocheau, François / Robin, Cécile / Flowers, Rebecca M. / Brown, Roderick / Wildman, Mark / Beucher, Romain

Journal of geophysical research. 2021 July, v. 126, no. 7

2021

Abstract: The uplift of the southern African Plateau with its average elevations of ∼1,000 m is often attributed to mantle processes, but there are conflicting theories for the timing and drivers of topographic development. Evidence for most proposed plateau ... ...

Abstract	The uplift of the southern African Plateau with its average elevations of ∼1,000 m is often attributed to mantle processes, but there are conflicting theories for the timing and drivers of topographic development. Evidence for most proposed plateau development histories is derived from continental erosion histories, marine stratigraphic architecture, or landscape morphology. Here we use a landscape evolution model to integrate a large data set of low‐temperature thermochronometry, sediment flux rates to surrounding marine basins, and current topography for southern Africa. We explore three main hypotheses for surface uplift: (a) southern Africa was already elevated by the Early Cretaceous before Gondwana breakup, (b) uplift and continental tilting occurred during the mid‐Cretaceous, or (c) uplift occurred during the mid to late Cenozoic. We test which of these three intervals of plateau development are plausible by using an inversion method to constrain the range in erosional and uplift model parameters that can best reproduce the observed data. Results indicate four regions of parameter space that fall into two families of uplift histories are most compatible with the data. Both uplift families have limited initial topography with some topographic uplift and continental tilting starting at ∼90–100 Ma. In one acceptable scenario, nearly all of the topography, >1,300 m, is created at this time with little Cenozoic uplift. In the other acceptable scenario, ∼400–800 m of uplift occurs in the mid‐Cretaceous with another ∼500–1,000 m of uplift in the mid‐Cenozoic. The two model scenarios have different geodynamic implications, which we compare to geodynamic models.
Keywords	Cenozoic era ; Early Cretaceous epoch ; data collection ; geophysics ; landscapes ; models ; research ; sediments ; thermochronology ; topography ; Southern Africa
Language	English
Dates of publication	2021-07
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ISSN	2169-9313
DOI	10.1029/2020JB021243
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Bronchial epithelia from adults and children: SARS-CoV-2 spread via syncytia formation and type III interferon infectivity restriction.

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 28, Page(s) e2202370119

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections initiate in the bronchi of the upper respiratory tract and are able to disseminate to the lower respiratory tract, where infections can cause an acute respiratory distress syndrome ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections initiate in the bronchi of the upper respiratory tract and are able to disseminate to the lower respiratory tract, where infections can cause an acute respiratory distress syndrome with a high degree of mortality in elderly patients. We used reconstituted primary bronchial epithelia from adult and child donors to follow the SARS-CoV-2 infection dynamics. We show that, in epithelia from adult donors, infections initiate in multiciliated cells and spread within 24 to 48 h throughout the whole epithelia. Syncytia formed of ciliated and basal cells appeared at the apical side of the epithelia within 3 to 4 d and were released into the apical lumen, where they contributed to the transmittable virus dose. A small number of reconstituted epithelia were intrinsically more resistant to virus infection, limiting virus spread to different degrees. This phenotype was more frequent in epithelia derived from children versus adults and correlated with an accelerated release of type III interferon. Treatment of permissive adult epithelia with exogenous type III interferon restricted infection, while type III interferon gene knockout promoted infection. Furthermore, a transcript analysis revealed that the inflammatory response was specifically attenuated in children. Taken together, our findings suggest that apical syncytia formation is an underappreciated source of virus propagation for tissue or environmental dissemination, whereas a robust type III interferon response such as commonly seen in young donors restricted SARS-CoV-2 infection. Thus, the combination of interferon restriction and attenuated inflammatory response in children might explain the epidemiological observation of age-related susceptibility to COVID-19.
MeSH term(s)	Aged ; Bronchi/immunology ; Bronchi/virology ; COVID-19/immunology ; COVID-19/virology ; Child ; Disease Susceptibility ; Giant Cells/immunology ; Giant Cells/virology ; Humans ; Interferons/immunology ; Respiratory Mucosa/immunology ; Respiratory Mucosa/virology ; SARS-CoV-2/immunology
Chemical Substances	interferon type III ; Interferons (9008-11-1)
Language	English
Publishing date	2022-06-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2202370119
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Article ; Online: Cervical ripening in prolonged pregnancies by silicone double balloon catheter versus vaginal dinoprostone slow release system: The MAGPOP randomised controlled trial.

Diguisto, Caroline / Le Gouge, Amélie / Arthuis, Chloé / Winer, Norbert / Parant, Olivier / Poncelet, Christophe / Chauleur, Celine / Hannigsberg, Jacob / Ducarme, Guillaume / Gallot, Denis / Gabriel, Rene / Desbriere, Raoul / Beucher, Gael / Faraguet, Cyrille / Isly, Helene / Rozenberg, Patrick / Giraudeau, Bruno / Perrotin, Franck

PLoS medicine

2021 Volume 18, Issue 2, Page(s) e1003448

Abstract: Background: Prolonged pregnancies are a frequent indication for induction of labour. When the cervix is unfavourable, cervical ripening before oxytocin administration is recommended to increase the likelihood of vaginal delivery, but no particular ... ...

Abstract	Background: Prolonged pregnancies are a frequent indication for induction of labour. When the cervix is unfavourable, cervical ripening before oxytocin administration is recommended to increase the likelihood of vaginal delivery, but no particular method is currently recommended for cervical ripening of prolonged pregnancies. This trial evaluates whether the use of mechanical cervical ripening with a silicone double balloon catheter for induction of labour in prolonged pregnancies reduces the cesarean section rate for nonreassuring fetal status compared with pharmacological cervical ripening by a vaginal pessary for the slow release of dinoprostone (prostaglandin E2). Methods and findings: This is a multicentre, superiority, open-label, parallel-group, randomised controlled trial conducted in 15 French maternity units. Women with singleton pregnancies, a vertex presentation, ≥41+0 and ≤42+0 weeks' gestation, a Bishop score <6, intact membranes, and no history of cesarean delivery for whom induction of labour was decided were randomised to either mechanical cervical ripening with a Cook Cervical Ripening Balloon or pharmacological cervical ripening by a Propess vaginal pessary serving as a prostaglandin E2 slow-release system. The primary outcome was the rate of cesarean for nonreassuring fetal status, with an independent endpoint adjudication committee determining whether the fetal heart rate was nonreassuring. Secondary outcomes included delivery (time from cervical ripening to delivery, number of patients requiring analgesics), maternal and neonatal outcomes. Between January 2017 and December 2018, 1,220 women were randomised in a 1:1 ratio, 610 allocated to a silicone double balloon catheter, and 610 to the Propess vaginal pessary for the slow release of dinoprostone. The mean age of women was 31 years old, and 80% of them were of white ethnicity. The cesarean rates for nonreassuring fetal status were 5.8% (35/607) in the mechanical ripening group and 5.3% (32/609) in the pharmacological ripening group (proportion difference: 0.5%; 95% confidence interval (CI) -2.1% to 3.1%, p = 0.70). Time from cervical ripening to delivery was shorter in the pharmacological ripening group (23 hours versus 32 hours, median difference 6.5 95% CI 5.0 to 7.9, p < 0.001), and fewer women required analgesics in the mechanical ripening group (27.5% versus 35.4%, difference in proportion -7.9%, 95% CI -13.2% to -2.7%, p = 0.003). There were no statistically significant differences between the 2 groups for other delivery, maternal, and neonatal outcomes. A limitation was a low observed rate of cesarean section. Conclusions: In this study, we observed no difference in the rates of cesarean deliveries for nonreassuring fetal status between mechanical ripening with a silicone double balloon catheter and pharmacological cervical ripening with a pessary for the slow release of dinoprostone. Trial registration: ClinicalTrials.gov NCT02907060.
MeSH term(s)	Adult ; Cervical Ripening/drug effects ; Cervical Ripening/physiology ; Cesarean Section/methods ; Delivery, Obstetric/methods ; Dinoprostone/administration & dosage ; Dinoprostone/pharmacology ; Female ; Humans ; Labor, Induced/methods ; Oxytocics/administration & dosage ; Oxytocics/pharmacology ; Pessaries ; Pregnancy ; Pregnancy, Prolonged/drug therapy ; Silicones/pharmacology
Chemical Substances	Oxytocics ; Silicones ; Dinoprostone (K7Q1JQR04M)
Language	English
Publishing date	2021-02-11
Publishing country	United States
Document type	Journal Article ; Pragmatic Clinical Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2185925-5
ISSN	1549-1676 ; 1549-1277
ISSN (online)	1549-1676
ISSN	1549-1277
DOI	10.1371/journal.pmed.1003448
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Agomelatine-induced thrombocytopenic purpura, a possible new adverse effect.

Bourneau-Martin, Delphine / Blanchard, Renaud / Beucher, Anne-Bérangère / Drablier, Guillaume / Lagarce, Laurence / Lainé-Cessac, Pascale

Therapie

2016 Volume 72, Issue 3, Page(s) 401–402

MeSH term(s)	Acetamides/adverse effects ; Female ; Humans ; Hypnotics and Sedatives/adverse effects ; Middle Aged ; Purpura, Thrombocytopenic/chemically induced
Chemical Substances	Acetamides ; Hypnotics and Sedatives ; agomelatine (137R1N49AD)
Language	English
Publishing date	2016-11-11
Publishing country	France
Document type	Case Reports ; Letter
ZDB-ID	603474-3
ISSN	1958-5578 ; 0040-5957
ISSN (online)	1958-5578
ISSN	0040-5957
DOI	10.1016/j.therap.2016.09.006
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Article ; Online: Minisci-Photoredox-Mediated α-Heteroarylation of N-Protected Secondary Amines: Remarkable Selectivity of Azetidines.

Bosset, Cyril / Beucher, Hélène / Bretel, Guillaume / Pasquier, Elisabeth / Queguiner, Laurence / Henry, Cyril / Vos, Ann / Edwards, James P / Meerpoel, Lieven / Berthelot, Didier

Organic letters

2018 Volume 20, Issue 19, Page(s) 6003–6006

Abstract: The development of a general, mild, and functional-group-tolerant direct functionalization of N-heteroarenes by C-H functionalization with N-protected amines, including azetidines under Minisci-mediated photoredox conditions, is reported. A broad scope ... ...

Abstract	The development of a general, mild, and functional-group-tolerant direct functionalization of N-heteroarenes by C-H functionalization with N-protected amines, including azetidines under Minisci-mediated photoredox conditions, is reported. A broad scope of substituted azetidines, including spirocyclic derivatives, and heterocycles were explored. This reaction enables the production of sp3-rich complex druglike structures in one step from unactivated feedstock amines and heterocycles.
Language	English
Publishing date	2018-09-25
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.8b00991
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Minisci-Photoredox-Mediated α-Heteroarylation of N-Protected Secondary Amines: Remarkable Selectivity of Azetidines

Bosset, Cyril / Ann Vos / Cyril Henry / Didier Berthelot / Elisabeth Pasquier / Guillaume Bretel / Hélène Beucher / James P. Edwards / Laurence Queguiner / Lieven Meerpoel

Organic letters. 2018 Sept. 25, v. 20, no. 19

2018

Abstract: The development of a general, mild, and functional-group-tolerant direct functionalization of N-heteroarenes by C–H functionalization with N-protected amines, including azetidines under Minisci-mediated photoredox conditions, is reported. A broad scope ... ...

Abstract	The development of a general, mild, and functional-group-tolerant direct functionalization of N-heteroarenes by C–H functionalization with N-protected amines, including azetidines under Minisci-mediated photoredox conditions, is reported. A broad scope of substituted azetidines, including spirocyclic derivatives, and heterocycles were explored. This reaction enables the production of sp3-rich complex druglike structures in one step from unactivated feedstock amines and heterocycles.
Keywords	carbon-hydrogen bond activation ; chemical structure ; feedstocks ; redox reactions ; secondary amines
Language	English
Dates of publication	2018-0925
Size	p. 6003-6006.
Publishing place	American Chemical Society
Document type	Article
ISSN	1523-7052
DOI	10.1021/acs.orglett.8b00991
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Cervical ripening in prolonged pregnancies by silicone double balloon catheter versus vaginal dinoprostone slow release system

Caroline Diguisto / Amélie Le Gouge / Chloé Arthuis / Norbert Winer / Olivier Parant / Christophe Poncelet / Celine Chauleur / Jacob Hannigsberg / Guillaume Ducarme / Denis Gallot / Rene Gabriel / Raoul Desbriere / Gael Beucher / Cyrille Faraguet / Helene Isly / Patrick Rozenberg / Bruno Giraudeau / Franck Perrotin / Groupe de Recherche en Obstétrique et Gynécologie (GROG)

PLoS Medicine, Vol 18, Iss 2, p e

The MAGPOP randomised controlled trial.

2021 Volume 1003448

Abstract: Background Prolonged pregnancies are a frequent indication for induction of labour. When the cervix is unfavourable, cervical ripening before oxytocin administration is recommended to increase the likelihood of vaginal delivery, but no particular method ... ...

Abstract	Background Prolonged pregnancies are a frequent indication for induction of labour. When the cervix is unfavourable, cervical ripening before oxytocin administration is recommended to increase the likelihood of vaginal delivery, but no particular method is currently recommended for cervical ripening of prolonged pregnancies. This trial evaluates whether the use of mechanical cervical ripening with a silicone double balloon catheter for induction of labour in prolonged pregnancies reduces the cesarean section rate for nonreassuring fetal status compared with pharmacological cervical ripening by a vaginal pessary for the slow release of dinoprostone (prostaglandin E2). Methods and findings This is a multicentre, superiority, open-label, parallel-group, randomised controlled trial conducted in 15 French maternity units. Women with singleton pregnancies, a vertex presentation, ≥41+0 and ≤42+0 weeks' gestation, a Bishop score <6, intact membranes, and no history of cesarean delivery for whom induction of labour was decided were randomised to either mechanical cervical ripening with a Cook Cervical Ripening Balloon or pharmacological cervical ripening by a Propess vaginal pessary serving as a prostaglandin E2 slow-release system. The primary outcome was the rate of cesarean for nonreassuring fetal status, with an independent endpoint adjudication committee determining whether the fetal heart rate was nonreassuring. Secondary outcomes included delivery (time from cervical ripening to delivery, number of patients requiring analgesics), maternal and neonatal outcomes. Between January 2017 and December 2018, 1,220 women were randomised in a 1:1 ratio, 610 allocated to a silicone double balloon catheter, and 610 to the Propess vaginal pessary for the slow release of dinoprostone. The mean age of women was 31 years old, and 80% of them were of white ethnicity. The cesarean rates for nonreassuring fetal status were 5.8% (35/607) in the mechanical ripening group and 5.3% (32/609) in the pharmacological ripening group ...
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SARS-CoV-2 transmission via apical syncytia release from primary bronchial epithelia and infectivity restriction in children epithelia

bioRxiv

Abstract: The beta-coronavirus SARS-CoV-2 is at the origin of a persistent worldwide pandemic. SARS-CoV-2 infections initiate in the bronchi of the upper respiratory tract and are able to disseminate to the lower respiratory tract eventually causing acute severe ... ...

Abstract	The beta-coronavirus SARS-CoV-2 is at the origin of a persistent worldwide pandemic. SARS-CoV-2 infections initiate in the bronchi of the upper respiratory tract and are able to disseminate to the lower respiratory tract eventually causing acute severe respiratory syndrome with a high degree of mortality in the elderly. Here we use reconstituted primary bronchial epithelia from adult and children donors to follow the infection dynamic following infection with SARS-CoV-2. We show that in bronchial epithelia derived from adult donors, infections initiate in multi-ciliated cells. Then, infection rapidly spread within 24-48h throughout the whole epithelia. Within 3-4 days, large apical syncytia form between multi-ciliated cells and basal cells, which dissipate into the apical lumen. We show that these syncytia are a significant source of the released infectious dose. In stark contrast to these findings, bronchial epithelia reconstituted from children donors are intrinsically more resistant to virus infection and show active restriction of virus spread. This restriction is paired with accelerated release of IFN compared to adult donors. Taken together our findings reveal apical syncytia formation as an underappreciated source of infectious virus for either local dissemination or release into the environment. Furthermore, we provide direct evidence that children bronchial epithelia are more resistant to infection with SARS-CoV-2 providing experimental support for epidemiological observations that SARS-CoV-2 cases fatality is linked to age.
Keywords	covid19
Language	English
Publishing date	2021-05-28
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2021.05.28.446159
Database	COVID19

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