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Article ; Online: In-vitro antioxidant and anti-inflammatory potential along with p.o. pharmacokinetic profile of key bioactive phytocompounds of Snow Mountain Garlic: a comparative analysis vis-à-vis normal garlic.

Kaur, Bhupinder / Kumar, Nitish / Kumari, Laxmi / Gupta, Ajai P / Sharma, Rajni / Chopra, Kanwaljit / Saxena, Shweta

2024

Abstract: Snow mountain garlic (SMG) is a trans-Himalayan medicinal plant used in the traditional medicine system for several ailments, including inflammatory arthritis. Research studies are insufficient to validate its folk medicinal applications. In the present ... ...

Abstract	Snow mountain garlic (SMG) is a trans-Himalayan medicinal plant used in the traditional medicine system for several ailments, including inflammatory arthritis. Research studies are insufficient to validate its folk medicinal applications. In the present study, the comparative abundance of its key bioactive phytocompounds, viz., S-allyl-L-cysteine (SAC), alliin, and S-methyl-L-cysteine (SMC) against normal garlic were assessed using the LC-MS/MS-MRM method. In addition, the study also explored the antioxidant and anti-inflammatory potency of crude extract of SMG and purified signature phytocompounds (i.e., SMC, SAC, and alliin) in comparison with normal garlic and dexamethasone in LPS-stimulated RAW264.7 macrophage cells. The LC-MS/MS-MRM study revealed significant differences among SMG and normal garlic, viz., alliin 22.8-fold higher in SMG, and SMC could be detected only in SMG. In the bioassays, SMG extract and purified signature phytocompounds significantly downregulated oxidative damage in activated macrophages, boosting endogenous antioxidants' activity. SMG extract-treated macrophages significantly suppressed NF-κB expression and related inflammatory indicators such as cytokines, COX-2, iNOS, and NO. Notably, the observed anti-inflammatory and antioxidant bioactivities of SMG extract were comparable to signature phytocompounds and dexamethasone. In addition, SAC being uniformly found in SMG and normal garlic, its comparative pharmacokinetics was studied to validate the pharmacodynamic superiority of SMG over normal garlic. Significantly higher plasma concentrations (Cmax), half-life (t1/2), and area under curve (AUC) of SAC following SMG extract administration than normal garlic validated the proposed hypothesis. Thus, the abundance of bioactive phytocompounds and their better pharmacokinetics in SMG extract might be underlying its medicinal merits over normal garlic.
Language	English
Publishing date	2024-04-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-024-01435-w
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Article ; Online: Hierarchical Nanoflowers of MgFe 2 O 4 , Bentonite and B-,P- Co-Doped Graphene Oxide as Adsorbent and Photocatalyst

Manpreet Kaur Ubhi / Manpreet Kaur / Dhanwinder Singh / Mohammed Javed / Aderbal C. Oliveira / Vijayendra Kumar Garg / Virender K. Sharma

International Journal of Molecular Sciences, Vol 23, Iss 9678, p

Optimization of Parameters by Box–Behnken Methodology

2022 Volume 9678

Abstract: ... synthesized by ultra-sonication approach. HNFs were ternary composite of MgFe 2 O 4 and bentonite with boron ... on the MgFe 2 O 4 -bentonite surface, resulting in a porous flower-like morphology. The red-shift in XPS ... binding energies of HNFs as compared to MgFe 2 O 4 -bentoniteand BPGO revealed the presence of strong ...

Abstract	In the present study, nanocomposites having hierarchical nanoflowers (HNFs) -like morphology were synthesized by ultra-sonication approach. HNFs were ternary composite of MgFe 2 O 4 and bentonite with boron-, phosphorous- co-doped graphene oxide (BPGO). The HNFs were fully characterized using different analytical tools viz . X-ray photoelectron spectroscopy, scanning electron microscopy, energy dispersion spectroscopy, transmission electron microscopy, X-ray diffraction, vibrating sample magnetometry and Mössbauer analysis. Transmission electron micrographs showed that chiffon-like BPGO nanosheets were wrapped on the MgFe 2 O 4 -bentonite surface, resulting in a porous flower-like morphology. The red-shift in XPS binding energies of HNFs as compared to MgFe 2 O 4 -bentoniteand BPGO revealed the presence of strong interactions between the two materials. Box–Behnken statistical methodology was employed to optimize adsorptive and photocatalytic parameters using Pb(II) and malathion as model pollutants, respectively. HNFs exhibited excellent adsorption ability for Pb(II) ions, with the Langmuir adsorption capacity of 654 mg g −1 at optimized pH 6.0 and 96% photocatalytic degradation of malathion at pH 9.0 as compared to MgFe 2 O 4 -bentonite and BPGO. Results obtained in this study clearly indicate that HNFs are promising nanocomposite for the removal of inorganic and organic contaminants from the aqueous solutions.
Keywords	hierarchical nanoflower ; nanocomposite ; boron and phosphorus doped GO ; magnesium ferrite-bentonite ; adsorbent ; photocatalyst ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	669
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Ruthenium(IV) complexes featuring P,O-chelating ligands: regioselective substitution directly from allylic alcohols.

Sundararaju, Basker / Achard, Mathieu / Demerseman, Bernard / Toupet, Loic / Sharma, Gangavaram V M / Bruneau, Christian

Angewandte Chemie (International ed. in English)

2010 Volume 49, Issue 15, Page(s) 2782–2785

Language	English
Publishing date	2010-04-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.200907034
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Article ; Online: Antibodies to protein tyrosine phosphatase receptor type O (PTPro) increase glomerular albumin permeability (P(alb)).

Charba, Deane S / Wiggins, Roger C / Goyal, Meera / Wharram, Bryan L / Wiggins, Jocelyn E / McCarthy, Ellen T / Sharma, Ram / Sharma, Mukut / Savin, Virginia J

American journal of physiology. Renal physiology

2009 Volume 297, Issue 1, Page(s) F138–44

Abstract: ... junctions of glomerular podocytes. Protein tyrosine phosphatase receptor-O (PTPro) is a transmembrane ... required to maintain glomerular macromolecular permeability, albumin permeability (P(alb)) was studied ... 4C3, specific to the amino acid core of PTPro, decreased its phosphatase activity and increased P(alb ...

Abstract	Glomerular capillary filtration barrier characteristics are determined in part by the slit-pore junctions of glomerular podocytes. Protein tyrosine phosphatase receptor-O (PTPro) is a transmembrane protein expressed on the apical surface of podocyte foot processes. Tyrosine phosphorylation of podocyte proteins including nephrin may control the filtration barrier. To determine whether PTPro activity is required to maintain glomerular macromolecular permeability, albumin permeability (P(alb)) was studied after incubation of glomeruli from normal animals with a series of monoclonal (mAb) and polyclonal antibodies. Reagents included mAbs to rabbit and rat PTPro and polyclonal rabbit immune IgG to rat PTPro. mAb 4C3, specific to the amino acid core of PTPro, decreased its phosphatase activity and increased P(alb) of rabbit glomeruli in a time- and concentration-dependent manner. In contrast, mAb P8E7 did not diminish phosphatase activity and did not alter P(alb). Preincubation of 4C3 with PTPro extracellular domain fusion protein blocked glomerular binding and abolished permeability activity. In parallel experiments, P(alb) of rat glomeruli was increased by two mAbs (1B4 and 1D1) or by polyclonal anti-rat PTPro. We conclude that PTPro interaction with specific antibodies acutely increases P(alb). The identity of the normal ligand for PTPro and of its substrate, as well as the mechanism by which phosphatase activity of this receptor affects the filtration barrier, remain to be determined.
MeSH term(s)	Albumins/metabolism ; Albuminuria/metabolism ; Animals ; Antibodies, Monoclonal/pharmacology ; Cell Membrane Permeability/drug effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Glomerular Filtration Rate/drug effects ; Kidney Glomerulus/drug effects ; Kidney Glomerulus/metabolism ; Podocytes/drug effects ; Podocytes/metabolism ; Protein Binding ; Protein Structure, Tertiary/drug effects ; Rabbits ; Rats ; Receptor-Like Protein Tyrosine Phosphatases, Class 3/immunology ; Receptor-Like Protein Tyrosine Phosphatases, Class 3/metabolism ; Time Factors
Chemical Substances	Albumins ; Antibodies, Monoclonal ; Receptor-Like Protein Tyrosine Phosphatases, Class 3 (EC 3.1.3.48)
Language	English
Publishing date	2009-04-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00122.2008
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Article: P-type Cu--Ti--O nanotube arrays and their use in self-biased heterojunction photoelectrochemical diodes for hydrogen generation.

Mor, Gopal K / Varghese, Oomman K / Wilke, Rudeger H T / Sharma, Sanjeev / Shankar, Karthik / Latempa, Thomas J / Choi, Kyoung-Shin / Grimes, Craig A

Nano letters

2008 Volume 8, Issue 7, Page(s) 1906–1911

Abstract: ... of vertically oriented p-type Cu-Ti-O nanotube array films by anodization of copper rich (60% to 74%) Ti metal ... splitting photoelectrochemical pn-junction diodes are fabricated using p-type Cu-Ti-O nanotube array films ... incident upon the UV absorbing n-TiO 2 side, with the visible light passing to the p-Cu-Ti-O side ...

Abstract	Copper and titanium remain relatively plentiful in the earth's crust; hence, their use for large-scale solar energy conversion technologies is of significant interest. We describe fabrication of vertically oriented p-type Cu-Ti-O nanotube array films by anodization of copper rich (60% to 74%) Ti metal films cosputtered onto fluorine doped tin oxide (FTO) coated glass. Cu-Ti-O nanotube array films 1 mum thick exhibit external quantum efficiencies up to 11%, with a spectral photoresponse indicating that the complete visible spectrum, 380 to 885 nm, contributes significantly to the photocurrent generation. Water-splitting photoelectrochemical pn-junction diodes are fabricated using p-type Cu-Ti-O nanotube array films in combination with n-type TiO 2 nanotube array films. With the glass substrates oriented back-to-back, light is incident upon the UV absorbing n-TiO 2 side, with the visible light passing to the p-Cu-Ti-O side. In a manner analogous to photosynthesis, photocatalytic reactions are powered only by the incident light to generate fuel with oxygen evolved from the n-TiO 2 side of the diode and hydrogen from the p-Cu-Ti-O side. To date, we find under global AM 1.5 illumination that such photocorrosion-stable diodes generate a photocurrent of approximately 0.25 mA/cm (2), at a photoconversion efficiency of 0.30%.
MeSH term(s)	Copper/chemistry ; Hydrogen/chemistry ; Lasers, Semiconductor ; Microscopy, Electron, Scanning ; Nanotubes/chemistry ; Nanotubes/ultrastructure ; Photochemistry ; Titanium/chemistry ; X-Ray Diffraction
Chemical Substances	Copper (789U1901C5) ; Hydrogen (7YNJ3PO35Z) ; Titanium (D1JT611TNE)
Language	English
Publishing date	2008-06-10
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1530-6984
ISSN	1530-6984
DOI	10.1021/nl080572y
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Article: Growth and physiological response of Arthrobacter protophormiae RKJ100 toward higher concentrations of o-nitrobenzoate and p-hydroxybenzoate.

Sharma, Narinder K / Pandey, Janmejay / Gupta, Nisha / Jain, Rakesh K

FEMS microbiology letters

2007 Volume 271, Issue 1, Page(s) 65–70

Abstract: ... viz. o-nitrobenzoate (ONB) and p-hydroxybenzoate (PHB). Arthrobacter protophormiae RKJ100 ...

Abstract	Bioremediation of sites that are heavily contaminated with pollutant chemicals is a challenge as most of the microorganisms cannot tolerate higher concentrations of toxic compounds. Only a few strains of the genus Pseudomonas have been studied for their tolerance toward the higher concentrations of aromatic pollutant compounds, a phenomenon that is accompanied by various physiological changes. In the present study we have characterized the growth response and physiological changes (adaptations) of a Gram-positive bacterium, Arthrobacter protophormiae RKJ100, toward the higher concentrations of two aromatic compounds, viz. o-nitrobenzoate (ONB) and p-hydroxybenzoate (PHB). Arthrobacter protophormiae RKJ100 could utilize 30 mM ONB and 50 mM PHB as sole sources of carbon and energy. It was capable of growth on higher concentrations of ONB (up to 200 mM) and PHB (up to 150 mM) when the cells were pre-exposed to lower concentrations of these compounds. The adaptive responses shown by the organism during growth on higher concentrations of these compounds were evident from significant changes in cellular fatty acid profiles. In addition, Bacterial Adhesion To Hydrocarbon (BATH) assay and scanning electron microscopy showed substantial increase in cell surface hydrophobicity and decrease in cell size of A. protophormiae RKJ100 when grown on ONB and PHB as compared to succinate-grown cells.
MeSH term(s)	Adaptation, Physiological ; Arthrobacter/cytology ; Arthrobacter/drug effects ; Arthrobacter/growth & development ; Arthrobacter/metabolism ; Bacterial Adhesion/drug effects ; Carbon/metabolism ; Drug Tolerance ; Energy Metabolism ; Fatty Acids/metabolism ; Hydrophobic and Hydrophilic Interactions ; Microscopy, Electron, Scanning ; Nitrobenzoates/metabolism ; Nitrobenzoates/pharmacology ; Parabens/metabolism ; Parabens/pharmacology ; Succinic Acid/metabolism
Chemical Substances	2-nitrobenzoate ; Fatty Acids ; Nitrobenzoates ; Parabens ; Carbon (7440-44-0) ; Succinic Acid (AB6MNQ6J6L) ; 4-hydroxybenzoic acid (JG8Z55Y12H)
Language	English
Publishing date	2007-06
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752343-9
ISSN	1574-6968 ; 0378-1097
ISSN (online)	1574-6968
ISSN	0378-1097
DOI	10.1111/j.1574-6968.2007.00697.x
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Article: Ruthenium(IV) Complexes Featuring P,O-Chelating Ligands: Regioselective Substitution Directly from Allylic Alcohols

Sundararaju, Basker / Achard, Mathieu / Demerseman, Bernard / Toupet, Loic / Sharma, Gangavaram V.M / Bruneau, Christian

Angewandte Chemie. 2010 Apr. 01, v. 49, no. 15

2010

Language	English
Dates of publication	2010-0401
Size	p. 2782-2785.
Publishing place	Wiley-VCH Verlag
Document type	Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.200907034
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Article ; Online: Volumetric, Viscometric and Excess Properties of Binary Mixtures of 1-Iodobutane with Benzene, Toluene, o-Xylene, m-Xylene, p-Xylene, and Mesitylene at Temperatures from 303.15 to 313.15 K

Sangita Sharma / Khushbu Thakkar / Paras Patel / Madhuresh Makavana

Advances in Physical Chemistry, Vol

2013 Volume 2013

Abstract: ... toluene, o-xylene, m-xylene, p-xylene, and mesitylene at 303.15, 308.15, and 313.15 K for the entire ...

Abstract	Densities and viscosities have been determined for binary mixtures of 1-iodobutane with benzene, toluene, o-xylene, m-xylene, p-xylene, and mesitylene at 303.15, 308.15, and 313.15 K for the entire composition range at atmospheric pressure. The excess molar volumes, , deviations in viscosity, Δη, and excess Gibbs’ free energy of activation flow, Δ have been calculated from the experimental values. The experimental data were fitted to Redlich-Kister polynomial equation. The variations of these parameters with composition of the mixtures and temperature have been discussed in terms of molecular interactions occurring in these mixtures. Further, the viscosities of these binary mixtures were calculated theoretically from their corresponding pure component data by using empirical relations like Bingham, Arrhenius and Eyring, Kendall and Munroe, Hind, Katti and Chaudhari, Grunberg and Nissan, and Tamura and Kurata. Comparison of various interaction parameters has been expressed to explain the intermolecular interactions between iodobutane and selected hydrocarbons.
Keywords	Physical and theoretical chemistry ; QD450-801
Subject code	541
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
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Article: Growth and physiological response of Arthrobacter protophormiae RKJ100 toward higher concentrations of o-nitrobenzoate and p-hydroxybenzoate

Sharma, Narinder K / Pandey, Janmejay / Gupta, Nisha / Jain, Rakesh K

FEMS microbiology letters. 2007 June, v. 271, no. 1

2007

Abstract: ... viz. o-nitrobenzoate (ONB) and p-hydroxybenzoate (PHB). Arthrobacter protophormiae RKJ100 ...

Abstract	Bioremediation of sites that are heavily contaminated with pollutant chemicals is a challenge as most of the microorganisms cannot tolerate higher concentrations of toxic compounds. Only a few strains of the genus Pseudomonas have been studied for their tolerance toward the higher concentrations of aromatic pollutant compounds, a phenomenon that is accompanied by various physiological changes. In the present study we have characterized the growth response and physiological changes (adaptations) of a Gram-positive bacterium, Arthrobacter protophormiae RKJ100, toward the higher concentrations of two aromatic compounds, viz. o-nitrobenzoate (ONB) and p-hydroxybenzoate (PHB). Arthrobacter protophormiae RKJ100 could utilize 30 mM ONB and 50 mM PHB as sole sources of carbon and energy. It was capable of growth on higher concentrations of ONB (up to 200 mM) and PHB (up to 150 mM) when the cells were pre-exposed to lower concentrations of these compounds. The adaptive responses shown by the organism during growth on higher concentrations of these compounds were evident from significant changes in cellular fatty acid profiles. In addition, Bacterial Adhesion To Hydrocarbon (BATH) assay and scanning electron microscopy showed substantial increase in cell surface hydrophobicity and decrease in cell size of A. protophormiae RKJ100 when grown on ONB and PHB as compared to succinate-grown cells.
Keywords	fatty acids
Language	English
Dates of publication	2007-06
Size	p. 65-70.
Publisher	Blackwell Publishing Ltd
Publishing place	Oxford, UK
Document type	Article
ZDB-ID	752343-9
ISSN	1574-6968 ; 0378-1097
ISSN (online)	1574-6968
ISSN	0378-1097
DOI	10.1111/j.1574-6968.2007.00697.x
Database	NAL-Catalogue (AGRICOLA)

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Article: Tuberculosis in elderly persons.

Sharma, O P

The Indian journal of tuberculosis

2022 Volume 69 Suppl 2, Page(s) S196–S197

MeSH term(s)	Humans ; Aged ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/epidemiology
Language	English
Publishing date	2022-10-30
Publishing country	India
Document type	Editorial
ZDB-ID	603129-8
ISSN	0019-5707 ; 0019-5705
ISSN	0019-5707 ; 0019-5705
DOI	10.1016/j.ijtb.2022.10.005
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