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  1. Book ; Online: Education, Economy and Identity : Ten years of Educational Reform in Thailand

    Chupradit, Supat / Baron-Gutty, Audrey

    2009  

    Abstract: Modern education in Thailand started at the end of the nineteenth century under the impulse of King Chulalongkorn. Many scholars tracing back the evolution from traditional education to a modern education system emphasized the feeling of necessity that ... ...

    Abstract Modern education in Thailand started at the end of the nineteenth century under the impulse of King Chulalongkorn. Many scholars tracing back the evolution from traditional education to a modern education system emphasized the feeling of necessity that motivated this transformation. Wyatt (1969), Mead (2004) and Watson (1982) underlined the need for a modern administration, to handle the Siamese nation-state "as" the Western states, and in that respect, the key role played by education to structure the new Siam and to appear to the eyes of the world as civilized (Peleggi 2002). The shaping of a new education took place amidst strong political struggles. Siam needed to stand firm within the regional arena, swept by the winds of Western colonialism. Internally, King Chulalongkorn had to legitimize his power and to unify the kingdom by integrating satellite kingdoms into a wider space, the Siamese nation state. Education was vital for this mission as it would contribute not only to bringing state power into the provinces through state-paid teachers and government officials, but also to transmitting a whole nation-related imagery to the young generations. Giving rise to Thai-ness among the populations located at the margins of the kingdom was a tremendous ordeal. In the Southern part of the kingdom, population was mainly Muslim, spoke Malay and felt culturally closer to the Malay state (Dulyakasem 1991). In the Northern part, incorporating the Lanna kingdom and hill tribe populations into Siam proved not to be easy. Ideological, social and national values were introduced into education delivered to students, and with the implementation of the Compulsory Education Act of 1921, school attendance tied children and parents to the nation state and made them liable to it
    Keywords Political science (General)
    Size 1 electronic resource ( pages)
    Publisher Institut de recherche sur l'Asie du Sud-Est contemporaine
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020321692
    ISBN 9782355960000 ; 2355960003
    DOI 10.4000/books.irasec.723
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Pulmonary hypertension in sickle cell disease.

    Al Kahf, Salma / Roche, Anne / Baron, Audrey / Chantalat-Auger, Christelle / Savale, Laurent

    Presse medicale (Paris, France : 1983)

    2023  Volume 52, Issue 4, Page(s) 104209

    Abstract: Sickle cell disease (SCD) is a complex genetic disorder that has long challenged both patients and healthcare professionals. One of its chronic and debilitating complications is pulmonary hypertension (PH). SCD-associated PH is often post-capillary, ... ...

    Abstract Sickle cell disease (SCD) is a complex genetic disorder that has long challenged both patients and healthcare professionals. One of its chronic and debilitating complications is pulmonary hypertension (PH). SCD-associated PH is often post-capillary, secondary to left heart disease. It can also sometimes be pre-capillary with multiple and often interrelated mechanisms including obstructive remodeling of the pulmonary vascular bed secondary to hemolysis, endothelial dysfunction, thrombosis, hypoxia, or associated risk factors like portal hypertension. Screening symptomatic patients with echocardiographic signs of PH is crucial to determine those who should undergo right heart catheterization, the cornerstone exam to diagnose and categorize patients with PH. The workup following the diagnosis relies on identifying the cause of PH to personalize treatment. Ongoing efforts are made to treat this complex condition, starting with treating the underlying disease with hydroxyurea or chronic blood exchange transfusion. Robust data on the efficacy of PAH-specific therapies are lacking in this specific population. Initiation of such therapies must be made by an expert center after a case-by-case assessment of the benefit-risk ratio according to the phenotype and the mechanisms involved in the development of PH. Efforts are also poured into studying the interventional and medical therapies used on chronic thromboembolic PH for patients presenting with a thrombotic form. The management of those patients requires a multidisciplinary approach, with conjoint efforts from PH and SCD specialists.
    MeSH term(s) Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/therapy ; Anemia, Sickle Cell/complications ; Echocardiography ; Heart Diseases/complications ; Hydroxyurea/therapeutic use
    Chemical Substances Hydroxyurea (X6Q56QN5QC)
    Language English
    Publishing date 2023-11-14
    Publishing country France
    Document type Journal Article
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2023.104209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Management of Acutely Decompensated Pulmonary Hypertension.

    Savale, Laurent / Kularatne, Mithum / Roche, Anne / Pichon, Jérémie / Baron, Audrey / Boucly, Athenaïs / Sitbon, Olivier / Humbert, Marc

    Seminars in respiratory and critical care medicine

    2023  Volume 44, Issue 6, Page(s) 762–770

    Abstract: Pulmonary arterial hypertension is a severe life-threatening condition associated with increased pulmonary vascular resistance and resulting right heart dysfunction. Admission to intensive care unit with acutely decompensated right heart failure is a ... ...

    Abstract Pulmonary arterial hypertension is a severe life-threatening condition associated with increased pulmonary vascular resistance and resulting right heart dysfunction. Admission to intensive care unit with acutely decompensated right heart failure is a significant negative prognostic event with a high risk of multisystem organ dysfunction and death. Presentations are heterogenous and may combine signs of both diastolic and systolic dysfunction complicating management. Renal dysfunction is often present, but other organ systems can be involved resulting in findings such as acute hepatic dysfunction or bowel wall congestion and ischemia. The goals of therapy are to rapidly reverse ventriculo-arterial decoupling and reduce right ventricular afterload to prevent progression to refractory or irreversible right heart failure. Triggering events must be investigated for and addressed urgently if identified. Volume status management is critical and both noninvasive and invasive testing can aid in prognostication and guide management, including the use of inotropes and vasopressors. In cases of refractory right heart dysfunction, consideration of urgent lung transplantation and mechanical circulatory support is necessary. These patients should be managed at expert centers in an intensive care setting with a multidisciplinary team of practitioners experienced in the management of right heart dysfunction given the high short- and long-term mortality resulting from acute decompensated right heart failure.
    MeSH term(s) Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/therapy ; Hypertension, Pulmonary/complications ; Intensive Care Units ; Lung Transplantation/adverse effects ; Critical Care/methods ; Heart Failure/therapy ; Ventricular Dysfunction, Right/therapy ; Ventricular Dysfunction, Right/etiology
    Language English
    Publishing date 2023-06-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0043-1770119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cross-reactivity among and between macrolides, lincosamides, and streptogramins: Study on the French pharmacovigilance database.

    Le Baron, Quentin / Bourneau-Martin, Delphine / Babin, Marina / Gouraud, Aurore / Tauber, Marie / Fresse, Audrey / Lebrun-Vignes, Bénédicte / Delaunay, Juliette / Morisset, Martine / Briet, Marie

    Fundamental & clinical pharmacology

    2024  

    Abstract: Background: Hypersensitivity reactions (HSR) are reported for the macrolides, lincosamides, and streptogramins (MLS) antibiotic family. Data about cross-reactivity among and between MLS remain scarce or controversial.: Objectives: The aim of this ... ...

    Abstract Background: Hypersensitivity reactions (HSR) are reported for the macrolides, lincosamides, and streptogramins (MLS) antibiotic family. Data about cross-reactivity among and between MLS remain scarce or controversial.
    Objectives: The aim of this study was to provide an overview of hypersensitivity cross-reactions among MLSs based on data extracted from the French National Pharmacovigilance Database (FPVD).
    Methods: Cases of HSR to MLSs reported between January 1985 and December 2019 were extracted from the FPVD using standardized MedDRA queries (SMQ). Cases including an allergological test involving multiple MLSs and giving at least one positive result were included.
    Results: Of the 8394 cases reviewed, 149 were included. HSR mainly involved pristinamycin (n = 83; 53.2%) and spiramycin (n = 31; 19.9%). HSR to MLS was immediate in 54 cases and delayed in 94 cases. Skin tests represented the majority of the allergological tests performed (n = 728; 84.7%), followed by reintroduction tests (n = 79; 9.2%). Eighty-six cross-reactivities among MLS were identified in 62 cases (41.6%). All the 25 explorations performed for streptogramins showed cross-reactivities, but only 30/253 among macrolides (11.9%). Cross-reactivities between the three MLS were observed in 31/322 (9.6%) of the allergological explorations.
    Conclusion: This study highlights the possibility of cross-reactivity among and between MLSs. Dermatologists and allergologists managing patients with HSR to MLSs should be aware of a risk of cross-reactivity among the macrolides and between the different classes of MLS and to perform MLSs allergological testing before recommending an alternative antibiotic, especially in severe drug hypersensitivity from the MLS family.
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 639134-5
    ISSN 1472-8206 ; 0767-3981
    ISSN (online) 1472-8206
    ISSN 0767-3981
    DOI 10.1111/fcp.13005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome.

    Robert, Fabien / Certain, Marie-Caroline / Baron, Audrey / Thuillet, Raphaël / Duhaut, Léa / Ottaviani, Mina / Kamel Chelgham, Mustapha / Normand, Corinne / Berrebeh, Nihel / Ricard, Nicolas / Furlan, Valerie / Desroches-Castan, Agnès / Gonzales, Emmanuel / Jacquemin, Emmanuel / Sitbon, Olivier / Humbert, Marc / Bailly, Sabine / Coilly, Audrey / Guignabert, Christophe /
    Tu, Ly / Savale, Laurent

    American journal of respiratory and critical care medicine

    2024  

    Abstract: Rationale: Hepatopulmonary syndrome (HPS) is a severe complication of liver diseases characterized by abnormal dilatation of pulmonary vessels, resulting in impaired oxygenation. Recent research highlights the pivotal role of liver-produced bone ... ...

    Abstract Rationale: Hepatopulmonary syndrome (HPS) is a severe complication of liver diseases characterized by abnormal dilatation of pulmonary vessels, resulting in impaired oxygenation. Recent research highlights the pivotal role of liver-produced bone morphogenetic protein (BMP)-9 in maintaining pulmonary vascular integrity.
    Objectives: This study aimed to investigate the involvement of BMP-9 in human and experimental HPS.
    Methods: Circulating BMP-9 levels were measured in 63 healthy controls and 203 cirrhotic patients, with or without HPS. Two animal models of portal hypertension were employed: common bile duct ligation (CBDL) with cirrhosis and long-term partial portal vein ligation (PPVL) without cirrhosis. Additionally, the therapeutic effect of low-dose BMP activator FK506 was investigated, and the pulmonary vascular phenotype of BMP-9 knockout rats was analyzed.
    Measurements and main results: Patients with HPS related to compensated cirrhosis demonstrated lower levels of circulating BMP-9 compared to patients without HPS. Severe cirrhosis patients exhibited consistently low levels of BMP-9. In animal models, HPS characteristics, including intrapulmonary vascular dilations (IPVDs) and alveolo-arterial gradient enlargement, were observed. HPS development in both rat models correlated with reduced intrahepatic BMP-9 expression, decreased circulating BMP-9 level and activity, and impaired pulmonary BMP-9 endothelial pathway. Daily treatment with FK506 for 2-weeks restored BMP pathway in the lungs, alleviating IPVDs, and improving gas exchange impairment. Furthermore, BMP-9 knockout rats displayed a pulmonary HPS phenotype, supporting its role in disease progression.
    Conclusion: The study findings suggest that portal hypertension-induced loss of BMP-9 signaling contributes to HPS development.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202307-1289OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pyoderma gangrenosum et hémopathies chez la personne âgée.

    Gay, Pierre / Villain, Cédric / Kottler, Diane / Rouet, Audrey / Tomeo, Charlotte / Baron, Marine / Choquet, Sylvain / Barete, Stéphane / Minaud, Alix / Barrou, Zina / Verny, Marc

    Geriatrie et psychologie neuropsychiatrie du vieillissement

    2023  Volume 21, Issue 1, Page(s) 31–36

    Abstract: Pyoderma gangrenosum (PG) belongs to neutrophilic dermatoses. PG can have different clinical presentations (ulcerated, bullous, pustular), is often painful, and preferentially affects the lower limbs. The diagnosis can be challenging, and a cutaneous ... ...

    Title translation Pyoderma gangrenosum and hemopathies in older patients.
    Abstract Pyoderma gangrenosum (PG) belongs to neutrophilic dermatoses. PG can have different clinical presentations (ulcerated, bullous, pustular), is often painful, and preferentially affects the lower limbs. The diagnosis can be challenging, and a cutaneous biopsy is often necessary, which shows an aseptic cutaneous infiltrate of neutrophils. The association with inflammatory or hematologic conditions is frequent, especially in older patients. The hematologic diseases the most frequently associated with PG are myelodysplastic syndrome, followed by monoclonal gammopathy of undetermined significance. Because of the strong impact of its treatment, recognition of PG is crucial. The treatment is based on first-line corticosteroids and topical or systemic immunosuppressive drugs and most often leads to a favourable outcome. The management of an acute hematologic disease would further improve the prognosis of PG. The singularity of geriatric patients encourages to thoroughly balance the risks and benefits of the recommended drugs and to consider associated non-drug measures. Here, we propose a review of the scientific literature about the association between PG and hematologic diseases, with a special focus on older patients, accompanied by the report of two cases in geriatric ward.
    MeSH term(s) Humans ; Aged ; Pyoderma Gangrenosum/drug therapy ; Pyoderma Gangrenosum/diagnosis ; Pyoderma Gangrenosum/pathology ; Adrenal Cortex Hormones/therapeutic use
    Chemical Substances Adrenal Cortex Hormones
    Language French
    Publishing date 2023-04-28
    Publishing country France
    Document type Case Reports ; Review ; English Abstract ; Journal Article
    ISSN 2115-7863
    ISSN (online) 2115-7863
    DOI 10.1684/pnv.2023.1087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Management of Acutely Decompensated Pulmonary Hypertension

    Savale, Laurent / Kularatne, Mithum / Roche, Anne / Pichon, Jérémie / Baron, Audrey / Boucly, Athenaïs / Sitbon, Olivier / Humbert, Marc

    Seminars in Respiratory and Critical Care Medicine

    (Pulmonary Hypertension)

    2023  Volume 44, Issue 06, Page(s) 762–770

    Abstract: Pulmonary arterial hypertension is a severe life-threatening condition associated with increased pulmonary vascular resistance and resulting right heart dysfunction. Admission to intensive care unit with acutely decompensated right heart failure is a ... ...

    Series title Pulmonary Hypertension
    Abstract Pulmonary arterial hypertension is a severe life-threatening condition associated with increased pulmonary vascular resistance and resulting right heart dysfunction. Admission to intensive care unit with acutely decompensated right heart failure is a significant negative prognostic event with a high risk of multisystem organ dysfunction and death. Presentations are heterogenous and may combine signs of both diastolic and systolic dysfunction complicating management. Renal dysfunction is often present, but other organ systems can be involved resulting in findings such as acute hepatic dysfunction or bowel wall congestion and ischemia. The goals of therapy are to rapidly reverse ventriculo-arterial decoupling and reduce right ventricular afterload to prevent progression to refractory or irreversible right heart failure. Triggering events must be investigated for and addressed urgently if identified. Volume status management is critical and both noninvasive and invasive testing can aid in prognostication and guide management, including the use of inotropes and vasopressors. In cases of refractory right heart dysfunction, consideration of urgent lung transplantation and mechanical circulatory support is necessary. These patients should be managed at expert centers in an intensive care setting with a multidisciplinary team of practitioners experienced in the management of right heart dysfunction given the high short- and long-term mortality resulting from acute decompensated right heart failure.
    Keywords pulmonary hypertension ; right heart failure ; intensive care unit ; lung transplantation ; vasopressor
    Language English
    Publishing date 2023-06-27
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0043-1770119
    Database Thieme publisher's database

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  8. Article ; Online: Pubertal development of transfusion-dependent thalassemia patients in the era of oral chelation with deferasirox: results from the French registry.

    Broccia, Mathilde Veneziano / Vergier, Julia / Benoit, Audrey / Huguenin, Yoann / Lambilliotte, Anne / Castex, Marie Pierre / Gourdon, Stephanie / Ithier, Ghislaine / Kebaili, Kamila / Rohrlich, Pierre / Pondarre, Corinne / Chamouine, Abdourahim / Simon, Pauline / Kpati, Kokou Placide Agbo / Allali, Slimane / Baron-Joly, Sandrine / Bayart, Sophie / Billaud, Nicolas / Brousse, Valentine /
    Dumesnil, Cecile / Garnier, Nathalie / Guichard, Isabelle / Joseph, Laure / Kamdem, Annie / Maitre, Julie / Mathey, Catherine / Paillard, Catherine / Phulpin, Aurelie / Renard, Cecile / Stoven, Cecile / Touati, Mohamed / Trochu, Capucine / Nafissi, Suzanne Mathieu / Badens, Catherine / Szepetowski, Sarah / Thuret, Isabelle

    Haematologica

    2024  

    Abstract: Not available. ...

    Abstract Not available.
    Language English
    Publishing date 2024-02-22
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.283610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impact of Fast SARS-CoV-2 Molecular Point-Of-Care Testing on Patients' Length of Stay in an Emergency Department.

    Baron, Audrey / Peyrony, Olivier / Salmona, Maud / Mahjoub, Nadia / Ellouze, Sami / Anastassiou, Maud / Delaugerre, Constance / Fontaine, Jean-Paul / Chevret, Sylvie / LeGoff, Jerome / Feghoul, Linda

    Microbiology spectrum

    2022  Volume 10, Issue 4, Page(s) e0063622

    Abstract: The ID NOW COVID-19 system (IDNOW) is a point-of-care test (POCT) providing results within 15 min. We evaluated the impact of IDNOW use on patient length of stay (LOS) in an emergency department (ED). In the ED of Saint-Louis Hospital, Paris, France, ... ...

    Abstract The ID NOW COVID-19 system (IDNOW) is a point-of-care test (POCT) providing results within 15 min. We evaluated the impact of IDNOW use on patient length of stay (LOS) in an emergency department (ED). In the ED of Saint-Louis Hospital, Paris, France, adult patients requiring a rapid diagnosis of SARS-CoV-2 were tested with Cepheid Xpert Xpress SARS-CoV-2 or FilmArray respiratory panel RP2 in the virology laboratory between 18 October and 3 November 2020 (period 1) and with IDNOW between 4 November and 30 November 2020 (period 2). A total of 676 patients participated in the study, 337 during period 1 and 339 during period 2. The median LOS in ED was significantly higher in period 1 than in period 2 (276 versus 208 min,
    MeSH term(s) Adult ; COVID-19/diagnosis ; Emergency Service, Hospital ; Humans ; Length of Stay ; Pandemics ; Point-of-Care Testing ; SARS-CoV-2/genetics
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00636-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Patient-Derived Xenograft and Cell Line Models of Human Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type.

    Prochazkova-Carlotti, Martina / Gros, Audrey / Richard, Elodie / Cherrier, Floriane / Laharanne, Elodie / Idrissi, Yamina / Baron, Camille / Poglio, Sandrine / Ducharme, Océane / Menguy, Sarah / Pham-Ledard, Anne / Beylot-Barry, Marie / Merlio, Jean-Philippe / Bresson-Bepoldin, Laurence

    The Journal of investigative dermatology

    2022  Volume 143, Issue 2, Page(s) 340–344.e6

    MeSH term(s) Humans ; Animals ; Leg ; Heterografts ; Skin Neoplasms/genetics ; Lymphoma, Large B-Cell, Diffuse/genetics ; Cell Line ; Disease Models, Animal
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2022.08.043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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