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Article ; Online: Maternal High-Fat Diet Controls Offspring Kidney Health and Disease.

Liu, Hsi-Yun / Lee, Chen-Hao / Hsu, Chien-Ning / Tain, You-Lin

2023 Volume 15, Issue 12

Abstract: A balanced diet during gestation is critical for fetal development, and excessive intake of saturated fats during gestation and lactation is related to an increased risk of offspring kidney disease. Emerging evidence indicates that a maternal high-fat ... ...

Abstract	A balanced diet during gestation is critical for fetal development, and excessive intake of saturated fats during gestation and lactation is related to an increased risk of offspring kidney disease. Emerging evidence indicates that a maternal high-fat diet influences kidney health and disease of the offspring via so-called renal programming. This review summarizes preclinical research documenting the connection between a maternal high-fat diet during gestation and lactation and offspring kidney disease, as well as the molecular mechanisms behind renal programming, and early-life interventions to offset adverse programming processes. Animal models indicate that offspring kidney health can be improved via perinatal polyunsaturated fatty acid supplementation, gut microbiota changes, and modulation of nutrient-sensing signals. These findings reinforce the significance of a balanced maternal diet for the kidney health of offspring.
MeSH term(s)	Rats ; Animals ; Pregnancy ; Female ; Humans ; Diet, High-Fat/adverse effects ; Hypertension/etiology ; Rats, Sprague-Dawley ; Kidney ; Fatty Acids ; Maternal Nutritional Physiological Phenomena ; Prenatal Exposure Delayed Effects
Chemical Substances	Fatty Acids
Language	English
Publishing date	2023-06-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15122698
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Article ; Online: Sonoelectrochemical exfoliation of defective black phosphorus nanosheet with black phosphorus quantum dots as a uric acid sensor.

Wang, Tzu-Pei / Cheng, Tain-Kei / Chen, Po-Yu / Lee, Chien-Liang

Ultrasonics sonochemistry

2024 Volume 104, Page(s) 106814

Abstract: To maintain human health, the development of rapid uric acid (UA) sensing is crucial. In this study, defective black phosphorus nanosheets with black phosphorus quantum dots (dBPN/BPQDs) were successfully and rapidly prepared by sonoelectrochemical ... ...

Abstract	To maintain human health, the development of rapid uric acid (UA) sensing is crucial. In this study, defective black phosphorus nanosheets with black phosphorus quantum dots (dBPN/BPQDs) were successfully and rapidly prepared by sonoelectrochemical exfoliation. In this process, the intercalation of phosphate ions into the black phosphorus working electrode was improved by coupling ultrasonic radiation with a high intercalating potential (8 V vs. Ag/AgCl/3M). The dBPN/BPQDs with various vacancies (5-9 defects, 5-7-7-5 defects, and 5-8-5 defect vacancies) exhibited a remarkable mass activity (j
Language	English
Publishing date	2024-02-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1208333-1
ISSN	1873-2828 ; 1350-4177
ISSN (online)	1873-2828
ISSN	1350-4177
DOI	10.1016/j.ultsonch.2024.106814
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Zs.A 4441: Show issues

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Article ; Online: Evaluation of the Feasibility of In Vitro Metabolic Interruption of Trimethylamine with Resveratrol Butyrate Esters and Its Purified Monomers.

Huang, Ping-Hsiu / Chen, De-Quan / Chen, Yu-Wei / Shih, Ming-Kuei / Lee, Bao-Hong / Tain, You-Lin / Hsieh, Chang-Wei / Hou, Chih-Yao

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 2

Abstract: Resveratrol (RSV), obtained from dietary sources, has been shown to reduce trimethylamine oxide (TMAO) levels in humans, and much research indicates that TMAO is recognized as a risk factor for cardiovascular disease. Therefore, this study investigated ... ...

Abstract	Resveratrol (RSV), obtained from dietary sources, has been shown to reduce trimethylamine oxide (TMAO) levels in humans, and much research indicates that TMAO is recognized as a risk factor for cardiovascular disease. Therefore, this study investigated the effects of RSV and RSV-butyrate esters (RBE) on the proliferation of co-cultured bacteria and HepG2 cell lines, respectively, and also investigated the changes in trimethylamine (TMA) and TMOA content in the medium and flavin-containing monooxygenase-3 (FMO3) gene expression. This study revealed that 50 µg/mL of RBE could increase the population percentage of
MeSH term(s)	Humans ; Butyrates/pharmacology ; Feasibility Studies ; Resveratrol/pharmacology ; Esters ; Methylamines
Chemical Substances	Butyrates ; trimethylamine (LHH7G8O305) ; trimethyloxamine (FLD0K1SJ1A) ; Resveratrol (Q369O8926L) ; Esters ; Methylamines
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29020429
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Article ; Online: Exogenous BMP7 administration attenuated vascular calcification and improved bone disorders in chronic uremic rats.

Lee, Chien-Te / Kuo, Wei-Hung / Tain, You-Lin / Wang, Yi / Lee, Wen-Chin

Biochemical and biophysical research communications

2022 Volume 621, Page(s) 8–13

Abstract: Vascular calcification is commonly observed in chronic kidney disease (CKD) and is associated with increased morbidity and mortality. This study examined whether exogenous BMP7 administration can modulate disturbed CKD-MBD in adenine-induced chronic ... ...

Abstract	Vascular calcification is commonly observed in chronic kidney disease (CKD) and is associated with increased morbidity and mortality. This study examined whether exogenous BMP7 administration can modulate disturbed CKD-MBD in adenine-induced chronic uremic rats. After an adenine diet for 4 weeks, the animals were injected with BMP7 for 2 weeks. Biochemical data, kidney tissue, bony structure, and vascular calcification of the thoracic aorta were examined and compared. Reduced renal function, hyperphosphatemia, and hyperparathyroidism with low 1,25(OH)2 vitamin D levels were observed in the adenine group. MicroCT revealed reduced bone mineral density (BMD), decreased bone and tissue volume ratio (BV/TV), and decreased trabecular number with increased separation. Marked vascular calcification was observed in adenine-fed animals, and immunohistochemical analysis showed increased expression of BMP2, RUNX2, vitamin D receptor (VDR), and Pit1 in aortic tissue. Treatment with BMP7 was associated with reduced serum phosphate, intact parathyroid hormone, FGF23, sclerostin, and DKK1 levels. BMP7 administration was accompanied with improvements in BMD and BV/TV. The increase in BMP2, RUNX2, VDR, and Pit1 was reversed by BMP7. In conclusion, exogenous BMP7 administration improved hyperphosphatemia and hyperparathyroidism in adenine-induced CKD. This treatment also attenuated vascular calcification and modulated structural abnormalities in the skeletal system.
MeSH term(s)	Adenine ; Animals ; Bone Morphogenetic Protein 7/therapeutic use ; Core Binding Factor Alpha 1 Subunit ; Hyperphosphatemia/complications ; Rats ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Vascular Calcification/drug therapy ; Vascular Calcification/metabolism
Chemical Substances	Bmp7 protein, rat ; Bone Morphogenetic Protein 7 ; Core Binding Factor Alpha 1 Subunit ; Adenine (JAC85A2161)
Language	English
Publishing date	2022-07-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.06.101
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Zs.A 116: Show issues

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Article ; Online: Sources, Degradation, Ingestion and Effects of Microplastics on Humans: A Review.

Lin, Yan-Duan / Huang, Ping-Hsiu / Chen, Yu-Wei / Hsieh, Chang-Wei / Tain, You-Lin / Lee, Bao-Hong / Hou, Chih-Yao / Shih, Ming-Kuei

Toxics

2023 Volume 11, Issue 9

Abstract: Celluloid, the predecessor to plastic, was synthesized in 1869, and due to technological advancements, plastic products appear to be ubiquitous in daily life. The massive production, rampant usage, and inadequate disposal of plastic products have led to ... ...

Abstract	Celluloid, the predecessor to plastic, was synthesized in 1869, and due to technological advancements, plastic products appear to be ubiquitous in daily life. The massive production, rampant usage, and inadequate disposal of plastic products have led to severe environmental pollution. Consequently, reducing the employment of plastic has emerged as a pressing concern for governments globally. This review explores microplastics, including their origins, absorption, and harmful effects on the environment and humans. Several methods exist for breaking down plastics, including thermal, mechanical, light, catalytic, and biological processes. Despite these methods, microplastics (MPs, between 1 and 5 mm in size) continue to be produced during degradation. Acknowledging the significant threat that MPs pose to the environment and human health is imperative. This form of pollution is pervasive in the air and food and infiltrates our bodies through ingestion, inhalation, or skin contact. It is essential to assess the potential hazards that MPs can introduce. There is evidence suggesting that MPs may have negative impacts on different areas of human health. These include the respiratory, gastrointestinal, immune, nervous, and reproductive systems, the liver and organs, the skin, and even the placenta and placental barrier. It is encouraging to see that most of the countries have taken steps to regulate plastic particles. These measures aim to reduce plastic usage, which is essential today. At the same time, this review summarizes the degradation mechanism of plastics, their impact on human health, and plastic reduction policies worldwide. It provides valuable information for future research on MPs and regulatory development.
Language	English
Publishing date	2023-09-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics11090747
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Article: A Higher Abundance of

Yu, Hong-Ren / Tsai, Ching-Chang / Chan, Julie Y H / Lee, Wei-Chia / Wu, Kay L H / Tain, You-Lin / Hsu, Te-Yao / Cheng, Hsin-Hsin / Huang, Hsin-Chun / Huang, Cheng-Hsieh / Pan, Wen-Harn / Yeh, Yao-Tsung

Microorganisms

2023 Volume 11, Issue 5

Abstract: Preterm birth is a major challenge in pregnancy worldwide. Prematurity is the leading cause of death in infants and may result in severe complications. Nearly half of preterm births are spontaneous, but do not have recognizable causes. This study ... ...

Abstract	Preterm birth is a major challenge in pregnancy worldwide. Prematurity is the leading cause of death in infants and may result in severe complications. Nearly half of preterm births are spontaneous, but do not have recognizable causes. This study investigated whether the maternal gut microbiome and associated functional pathways might play a key role in spontaneous preterm birth (sPTB). Two hundred eleven women carrying singleton pregnancies were enrolled in this mother-child cohort study. Fecal samples were freshly collected at 24-28 weeks of gestation before delivery, and the 16S ribosomal RNA gene was sequenced. Microbial diversity and composition, core microbiome, and associated functional pathways were then statistically analyzed. Demographic characteristics were collected using records from the Medical Birth Registry and questionnaires. The result showed that the gut microbiome of mothers with over-weight (BMI ≥ 24) before pregnancy have lower alpha diversity than those with normal BMI before pregnancy. A higher abundance of
Language	English
Publishing date	2023-04-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11051171
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Article ; Online: Maternal Fructose Intake Exacerbates Cardiac Remodeling in Offspring with Ventricular Pressure Overload.

Leu, Steve / Wu, Kay L H / Lee, Wei-Chia / Tain, You-Lin / Chan, Julie Y H

Nutrients

2021 Volume 13, Issue 9

Abstract: Recent studies demonstrated that metabolic syndrome and cardiovascular diseases could be elicited by developmental programming, which is regulated by prenatal nutritional and environmental stress. In this study, we utilized a rat model to examine the ... ...

Abstract	Recent studies demonstrated that metabolic syndrome and cardiovascular diseases could be elicited by developmental programming, which is regulated by prenatal nutritional and environmental stress. In this study, we utilized a rat model to examine the effect of excessive maternal fructose intake during pregnancy and lactation on cardiac development and progression of pressure overload-induced cardiac hypertrophy in offspring. Transverse aortic constriction (TAC) was performed on 3-month-old male offspring to induce ventricular pressure overload. Four weeks post-TAC, echocardiographic assessment as well as histopathological and biochemical examinations were performed on the myocardium of the offspring. Echocardiographic and gross examinations showed that heart weight, interventricular septal thickness in diastole (IVD; d), and left ventricular posterior wall thickness in diastole (LVPW; d) were elevated in offspring with TAC and further increased by maternal fructose exposure (MFE). However, the left ventricular ejection function was not significantly affected. Myocardial histopathological examination revealed that the indices of fibrosis and oxidative stress were higher in offspring with MFE and TAC than those in animals receiving either treatment. Molecular examinations on the myocardium demonstrated an MFE-induced upregulation of p38-MAPK signaling. Next generation sequence (NGS) analysis indicated a modulation of the expression levels of several cardiac hypertrophy-associated genes, including GPR22, Myh7, Nppa, P2RX4, and Npy by MFE. Subsequent RT-PCR indicated that MFE regulated the expression levels of genes responsive to cardiac hypertrophy (i.e., Myh-7, ANP) and oxidative stress (i.e., GR, GPx, and NQO-1). In conclusion, MFE during pregnancy and lactation modulated myocardial gene expression, increased oxidative stress, and exacerbated ventricular pressure overload-induced cardiac remodeling in rat offspring.
MeSH term(s)	Animals ; Aorta ; Cardiomegaly/etiology ; Cardiomegaly/genetics ; Constriction ; Female ; Fructose/administration & dosage ; Fructose/adverse effects ; Gene Expression ; Heart/drug effects ; Heart/embryology ; Heart/growth & development ; Lactation ; Male ; Myocardium/metabolism ; Myocardium/pathology ; Oxidative Stress ; Pregnancy ; Prenatal Exposure Delayed Effects ; Rats ; Ventricular Pressure/physiology
Chemical Substances	Fructose (30237-26-4)
Language	English
Publishing date	2021-09-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13093267
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Article: Vinpocetine Ameliorates Metabolic-Syndrome-Associated Bladder Overactivity in Fructose-Fed Rats by Restoring Succinate-Modulated cAMP Levels and Exerting Anti-Inflammatory Effects in the Bladder Detrusor Muscle.

Lee, Wei-Chia / Yu, Hong-Ren / Tain, You-Lin / Wu, Kay L H / Chuang, Yao-Chi / Chan, Julie Y H

Biomedicines

2022 Volume 10, Issue 11

Abstract: Succinate and its receptor, the G protein-coupled receptor 91 (GPR91), have pathological implications in metabolic syndrome (MetS) and its associated bladder dysfunction, particularly in decreasing bladder cAMP levels and promoting proinflammation. Using ...

Abstract	Succinate and its receptor, the G protein-coupled receptor 91 (GPR91), have pathological implications in metabolic syndrome (MetS) and its associated bladder dysfunction, particularly in decreasing bladder cAMP levels and promoting proinflammation. Using fructose-fed rats (FFRs), a rat model of MetS, we investigate the effects of vinpocetine (a phosphodiesterase-1 inhibitor) and celecoxib (a selective cyclooxygenase-2 inhibitor) on MetS-associated bladder overactivity. Phenotypes of the overactive bladder, including increased micturition frequency and a shortened intercontractile interval in cystometry, were observed in FFRs, together with elevated succinate levels in the liver and serum and the downregulation of GPR91 in the liver and urinary bladder. Treatments with vinpocetine and celecoxib improved tissue fibrosis and ameliorated the overexpression of the inflammatory cytokines, such as IL-1β, in the liver and bladder. In bladder organ bath studies, vinpocetine, but not celecoxib, treatment restored the contraction and relaxation responses of the detrusor muscle strip in response to KCl, carbachol, and forskolin stimulation. At a molecular level, vinpocetine and celecoxib treatments modulated the downstream messengers of GPR91 (i.e., ERK1/2 and JNK), suppressed NF-κB and IL-1β expressions in the bladder, and prevented the fibrogenesis observed in FFRs. The exogenous application of succinate to a bladder organ bath significantly reduced the forskolin-induced cAMP production by the detrusor muscle, which was notably restored in the presence of vinpocetine. Together, these results suggest that vinpocetine may alleviate the MetS-associated bladder overactivity by restoring the succinate-modulated detrusor cAMP production and exerting the anti-inflammatory effects in the bladder detrusor muscle.
Language	English
Publishing date	2022-10-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10112716
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Article ; Online: Protection by -Biotics against Hypertension Programmed by Maternal High Fructose Diet: Rectification of Dysregulated Expression of Short-Chain Fatty Acid Receptors in the Hypothalamic Paraventricular Nucleus of Adult Offspring.

Chao, Yung-Mei / Tain, You-Lin / Lee, Wei-Chia / Wu, Kay L H / Yu, Hong-Ren / Chan, Julie Y H

Nutrients

2022 Volume 14, Issue 20

Abstract: The role of short-chain fatty acids (SCFAs) in the brain on the developmental programming of hypertension is poorly understood. The present study explored dysregulated tissue levels of SCFAs and expression of SCFA-sensing receptors in the hypothalamic ... ...

Abstract	The role of short-chain fatty acids (SCFAs) in the brain on the developmental programming of hypertension is poorly understood. The present study explored dysregulated tissue levels of SCFAs and expression of SCFA-sensing receptors in the hypothalamic paraventricular nucleus (PVN), a key forebrain region engaged in neural regulation of blood pressure of offspring to maternal high fructose diet (HFD) exposure. We further investigated the engagement of SCFA-sensing receptors in PVN in the beneficial effects of -biotics (prebiotic, probiotic, synbiotic, and postbiotic) on programmed hypertension. Maternal HFD during gestation and lactation significantly reduced circulating butyrate, along with decreased tissue level of butyrate and increased expression of SCFA-sensing receptors, GPR41 and olfr78, and tissue oxidative stress and neuroinflammation in PVN of HFD offspring that were rectified by oral supplement with -biotics. Gene silencing of
MeSH term(s)	Animals ; Rats ; Female ; Humans ; Paraventricular Hypothalamic Nucleus/metabolism ; Fructose/adverse effects ; Fructose/metabolism ; Antioxidants/metabolism ; Rats, Sprague-Dawley ; Hypertension/prevention & control ; Hypertension/genetics ; Fatty Acids, Volatile/metabolism ; Diet ; Anti-Inflammatory Agents/metabolism ; RNA, Messenger/metabolism ; Butyrates/metabolism
Chemical Substances	Fructose (30237-26-4) ; Antioxidants ; Fatty Acids, Volatile ; Anti-Inflammatory Agents ; RNA, Messenger ; Butyrates
Language	English
Publishing date	2022-10-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14204306
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Article ; Online: The Impact of Gut Microbiome on Maternal Fructose Intake-Induced Developmental Programming of Adult Disease.

Hsu, Chien-Ning / Yu, Hong-Ren / Chan, Julie Y H / Wu, Kay L H / Lee, Wei-Chia / Tain, You-Lin

Nutrients

2022 Volume 14, Issue 5

Abstract: Excessive or insufficient maternal nutrition can influence fetal development and the susceptibility of offspring to adult disease. As eating a fructose-rich diet is becoming more common, the effects of maternal fructose intake on offspring health is of ... ...

Abstract	Excessive or insufficient maternal nutrition can influence fetal development and the susceptibility of offspring to adult disease. As eating a fructose-rich diet is becoming more common, the effects of maternal fructose intake on offspring health is of increasing relevance. The gut is required to process fructose, and a high-fructose diet can alter the gut microbiome, resulting in gut dysbiosis and metabolic disorders. Current evidence from animal models has revealed that maternal fructose consumption causes various components of metabolic syndrome in adult offspring, while little is known about how gut microbiome is implicated in fructose-induced developmental programming and the consequential risks for developing chronic disease in offspring. This review will first summarize the current evidence supporting the link between fructose and developmental programming of adult diseases. This will be followed by presenting how gut microbiota links to common mechanisms underlying fructose-induced developmental programming. We also provide an overview of the reprogramming effects of gut microbiota-targeted therapy on fructose-induced developmental programming and how this approach may prevent adult-onset disease. Using gut microbiota-targeted therapy to prevent maternal fructose diet-induced developmental programming, we have the potential to mitigate the global burden of fructose-related disorders.
MeSH term(s)	Animals ; Diet ; Female ; Fructose/adverse effects ; Gastrointestinal Microbiome ; Humans ; Maternal Nutritional Physiological Phenomena ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Fructose (30237-26-4)
Language	English
Publishing date	2022-02-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14051031
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