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Article: Total Antioxidant Potential, Total Phenolic Profile and Cytotoxic Activity Against Brain Cancer: Melocan and Galdirik

Al Yassine, Diaa / El Massri, Nourhane / Demircan, Gunnur / Bulut, Gulay / Akin, Demet / Tacer-Caba, Zeynep

2024 Volume 61, Issue 4, Page(s) 475–484

Abstract: Research background: Brain cancer is known to be one of the most difficult types of cancer to cure. It has a serious impact on the lives of diagnosed people due to the insufficient treatment options and their side effects. The search for new alternative ...

Abstract	Research background: Brain cancer is known to be one of the most difficult types of cancer to cure. It has a serious impact on the lives of diagnosed people due to the insufficient treatment options and their side effects. The search for new alternative treatments is therefore ongoing. Melocan ( Experimental approach: The aim of this study is to determine the antioxidant and cytotoxic activity of Results and conclusions: According to the results, the water extracts of Novelty and scientific contribution: This is the first study that aims to evaluate the potential cytotoxic activity of two local Turkish plants,
Language	English
Publishing date	2024-01-09
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	1340467-2
ISSN	1330-9862
ISSN	1330-9862
DOI	10.17113/ftb.61.04.23.8071
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Article ; Online: Efficacy of a care bundle to prevent multiple infections in the intensive care unit: A quasi-experimental pretest-posttest design study.

Yazici, Gulay / Bulut, Hulya

Applied nursing research : ANR

2017 Volume 39, Page(s) 4–10

Abstract: Background: Healthcare-associated infections extend hospitalization time, increase treatment costs and increase morbidity-mortality rates.: Objectives: To evaluate the efficacy of a care bundle aimed at preventing three most frequent intensive care ... ...

Abstract	Background: Healthcare-associated infections extend hospitalization time, increase treatment costs and increase morbidity-mortality rates. Objectives: To evaluate the efficacy of a care bundle aimed at preventing three most frequent intensive care unit-acquired infections. Materials and method: This quasi-experimental study occurred in an 18-bed tertiary care intensive care unit at a university hospital in Turkey. The sample consisted of 120 patients older than 18years and receiving invasive mechanical ventilation therapy, or had a central venous catheter or urinary catheter. The study comprised three stages. In stage one, the intensive care unit nurses were trained in infection measures, VAP, CA-UTIs and CLABSIs sections of the care bundle. In stage two, the trained nurses applied the care bundle and received feedback on any problematic issues. In stage three, the nurses' compatibility and efficacy of the infection prevention care bundle on the infection rates of VAP, CA-UTIs and CLABSIs were evaluated over three 3-month periods. Results: Over 1000 ventilation days, ventilator-associated pneumonia infection rates were 23.4, 12.6, and 11.5, during January-March, April-June and July-September, respectively, with January-March and April-June showing a significant decrease (χ Conclusions: The infection rates decreased with increased compatibility of the care bundle prepared from evidence-based guidelines.
MeSH term(s)	Adult ; Catheter-Related Infections/prevention & control ; Critical Care Nursing/methods ; Critical Care Nursing/statistics & numerical data ; Cross Infection/prevention & control ; Female ; Hospitals, University/statistics & numerical data ; Humans ; Infection Control/methods ; Infection Control/statistics & numerical data ; Male ; Patient Care Bundles ; Pneumonia, Ventilator-Associated/prevention & control ; Tertiary Care Centers/statistics & numerical data ; Turkey ; Young Adult
Language	English
Publishing date	2017-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1027369-4
ISSN	1532-8201 ; 0897-1897
ISSN (online)	1532-8201
ISSN	0897-1897
DOI	10.1016/j.apnr.2017.10.009
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Article ; Online: Perceived learning environment and academic motivation: An explanatory mixed methods study in a Molecular Biology and Genetics program.

Yurtseven, Nihal / Atay, Derin / Bulut, Gülay

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

2021 Volume 50, Issue 1, Page(s) 21–28

Abstract: Lack of motivation of students is a major concern for the instructors and administration in universities, and it is in their interest to address these issues in the most effective and efficient way. The purpose of this explanatory sequential mixed-method ...

Abstract	Lack of motivation of students is a major concern for the instructors and administration in universities, and it is in their interest to address these issues in the most effective and efficient way. The purpose of this explanatory sequential mixed-method study is to examine the predictive power of the learning environment on student academic motivation and to learn students' opinions on this issue. One hundred twenty students enrolled at the Molecular Biology and Genetics program completed the Academic Motivation and Learning Environment Perception scales, Quantitative findings indicated that only the activities dimension of the learning environment has a predictive power on academic motivation. Focus group interviews conducted with 16 students validated the quantitative findings. Students particularly drew attention to activities that foster active participation in the learning process, emphasizing the vitality of being engaged and of having real-life experiences in their learning environment.
MeSH term(s)	Humans ; Learning ; Molecular Biology ; Motivation ; Students ; Universities
Language	English
Publishing date	2021-10-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2039717-3
ISSN	1539-3429 ; 1470-8175
ISSN (online)	1539-3429
ISSN	1470-8175
DOI	10.1002/bmb.21581
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Article ; Online: Role of Systemic Inflammatory Markers in Pediatric Kidney Transplantation.

Taner, Sevgin / Goktepe, Berk / Zaman, Ece Irem / Asci, Gulay / Bulut, Ipek Kaplan / Toz, Huseyin / Sarsik, Banu / Firat, Ozgur / Kizilkaya, Ali Ekber / Kabasakal, Caner / Keskinoğlu, Ahmet

Transplantation proceedings

2023 Volume 55, Issue 5, Page(s) 1152–1155

Abstract: Background: Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII = N × P/L), and neutrophil percentage-albumin ratio (NPAR) have become accepted markers of inflammation in recent years. These ... ...

Abstract	Background: Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII = N × P/L), and neutrophil percentage-albumin ratio (NPAR) have become accepted markers of inflammation in recent years. These indices are used as indicators of disease activity, mortality, and morbidity in many diseases. This study evaluated the relationship between inflammatory indices and graft function in pediatric kidney transplant recipients. Methods: Medical records of pediatric patients who underwent kidney transplantation at Ege University between 1995 and 2020 were reviewed retrospectively. Demographic, clinical, and laboratory data were recorded during the third month, first year, and fifth year of transplantation and at the last visit. Results: The median age of the 119 patients (60 boys/59 girls) at the time of transplantation was 154 months, and the median follow-up period was 101 months. According to Spearman correlation analysis, patients' final creatinine levels were positively correlated with NLR (r = 0.319), PLR (r = 0.219), SII (r = 0.214), and NPAR (r = 0.347) of the last visit; final estimate glomerular filtration rate levels were negatively correlated with NLR (P = .010, r = -0.250) and NPAR (P = .004, r = -0.277). The median NPAR of the patients with chronic allograft dysfunction at the last visit was found to be statistically significantly higher than without (P = .032). Conclusion: NLR, PLR, SII, and NPAR values are correlated with creatinine levels after 5 years of kidney transplantation. The NPAR and final creatinine levels had the highest correlation coefficient among these inflammatory markers. These results suggest that inflammatory markers, especially NPAR, may be a candidate to be an indicator of ongoing inflammation in the graft.
MeSH term(s)	Male ; Female ; Humans ; Child ; Kidney Transplantation/adverse effects ; Retrospective Studies ; Creatinine ; Inflammation ; Lymphocytes ; Neutrophils ; Albumins
Chemical Substances	Creatinine (AYI8EX34EU) ; Albumins
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2023.03.030
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Article: Ulcerated giant labial acrochordon in a child.

Ozkol, Hatice Uce / Bulut, Gulay / Gumus, Sibel / Calka, Omer

Indian dermatology online journal

2015 Volume 6, Issue 1, Page(s) 60–61

Language	English
Publishing date	2015-01-22
Publishing country	India
Document type	Journal Article
ZDB-ID	2585814-2
ISSN	2249-5673 ; 2229-5178
ISSN (online)	2249-5673
ISSN	2229-5178
DOI	10.4103/2229-5178.148955
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Article: Biochemical and histopathologic assessment of effects of acitretin on epiphyseal growth plate in rats.

Onder, Sevda / Bilgili, Serap Gunes / Bulut, Gulay / Celik, Huseyin Tugrul / Oguztuzun, Serpil / Onder, Hacı / Calka, Omer / Karadag, Ayse Serap

Postepy dermatologii i alergologii

2020 Volume 37, Issue 3, Page(s) 346–352

Abstract: Introduction: Acitretin is a commonly used retinoid in dermatology. Although there are generally known side effects, the effects on the epiphyseal plaque and bone metabolism are not clear in the literature.: Aim: To histopathologically investigate ... ...

Abstract	Introduction: Acitretin is a commonly used retinoid in dermatology. Although there are generally known side effects, the effects on the epiphyseal plaque and bone metabolism are not clear in the literature. Aim: To histopathologically investigate the effects on the epiphyseal plate and assess variations in bone metabolism caused by acitretin. Material and methods: Three groups were formed with 10 rats in each group. The 1 Results: Staining with haematoxylin-eosin found reductions in the epiphyseal plate in the 1 Conclusions: Our data show that though acitretin caused degeneration of the epiphyseal plate, it did not cause clear thinning and we identified no significant variations in bone metabolism markers.
Language	English
Publishing date	2020-07-16
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596142-1
ISSN	1642-395X
ISSN	1642-395X
DOI	10.5114/ada.2020.95983
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Article ; Online: Biochemical and histopathologic assessment of effects of acitretin on epiphyseal growth plate in rats

Sevda Onder / Serap Bilgili / Gulay Bulut / Huseyin Tugrul Celik / Serpil Oguztuzun / Hacı Onder / Omer Calka / Ayse Karadag

Advances in Dermatology and Allergology, Vol 37, Iss 3, Pp 346-

2020 Volume 352

Keywords	acitretin ; epiphyseal plate ; bone metabolism ; rat ; Dermatology ; RL1-803 ; Internal medicine ; RC31-1245
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Termedia Publishing House
Document type	Article ; Online
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Article ; Online: Chemotherapy-induced acral erythema with involvement of the face and neck: A case report.

Ozkol, Hatice Uce / Calka, Omer / Bulut, Gulay

Toxicology and industrial health

2016 Volume 32, Issue 5, Page(s) 791–794

Abstract: Chemotherapy-induced acral erythema (CIAE) is a cutaneous response to diverse chemotherapeutic drug administration. These drugs cause symmetrical and painful erythema of palmoplantar surfaces. Bulla formation, desquamation, and subsequent ... ...

Abstract	Chemotherapy-induced acral erythema (CIAE) is a cutaneous response to diverse chemotherapeutic drug administration. These drugs cause symmetrical and painful erythema of palmoplantar surfaces. Bulla formation, desquamation, and subsequent reepithelialization may occur. Commonly, the lesions slowly resolve over 7-15 days, through desquamation, followed by regeneration of the skin. Here, we described a case of CIAE, with involvement of face and neck in a patient treated for breast cancer using a number of chemotherapeutic agents. Face involvement in CIAE has not been previously reported in the literature.
MeSH term(s)	Antineoplastic Agents/adverse effects ; Breast Neoplasms/drug therapy ; Cyclophosphamide/adverse effects ; Cyclophosphamide/therapeutic use ; Dose-Response Relationship, Drug ; Epirubicin/adverse effects ; Epirubicin/therapeutic use ; Face/pathology ; Female ; Hand-Foot Syndrome/diagnosis ; Hand-Foot Syndrome/drug therapy ; Humans ; Neck/pathology ; Pyridoxine/pharmacology ; Skin/drug effects ; Skin/pathology ; Taxoids/adverse effects ; Taxoids/therapeutic use ; Trastuzumab/adverse effects ; Trastuzumab/therapeutic use ; Vitamin B Complex/pharmacology ; Young Adult
Chemical Substances	Antineoplastic Agents ; Taxoids ; Vitamin B Complex (12001-76-2) ; docetaxel (15H5577CQD) ; Epirubicin (3Z8479ZZ5X) ; Cyclophosphamide (8N3DW7272P) ; Pyridoxine (KV2JZ1BI6Z) ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2016-05
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	56831-4
ISSN	1477-0393 ; 0748-2337
ISSN (online)	1477-0393
ISSN	0748-2337
DOI	10.1177/0748233713511514
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Article: Tonsillar solitary fibrous tumour: A interesting rare case.

Bulut, Gulay / Erten, Remzi / Almali, Ayse Oter / Bulut, Mehmet Deniz / Bayram, Irfan

JPMA. The Journal of the Pakistan Medical Association

2017 Volume 67, Issue 3, Page(s) 476–479

Abstract: A solitary fibrous tumour (SFT) is a rare mesenchymal tumour that frequently originates in the mesothelium-covered surfaces, such as the pleura and peritoneum. It may develop in various body parts, including the head and neck. These tumours may arise in ... ...

Abstract	A solitary fibrous tumour (SFT) is a rare mesenchymal tumour that frequently originates in the mesothelium-covered surfaces, such as the pleura and peritoneum. It may develop in various body parts, including the head and neck. These tumours may arise in several different patterns, which results in difficulties in diagnosing them. This case is a solitary tumour developing from the palatine tonsil in a 17-year-old male patient; it is the second case in the literature. The tumour has the histopathological characteristics of a patternless pattern, a slight pleomorphism, and a composition of hypercellular and hypocellular sites. Immunohistochemically, the tumour cells showed a strong positive staining with CD34, Bcl-2, and vimentin. No recurrence developed in the patient's approximately 18-month-long follow-up period.
MeSH term(s)	Adolescent ; Diagnosis, Differential ; Humans ; Magnetic Resonance Imaging ; Male ; Palatine Tonsil/chemistry ; Palatine Tonsil/diagnostic imaging ; Palatine Tonsil/pathology ; Solitary Fibrous Tumors/chemistry ; Solitary Fibrous Tumors/diagnostic imaging ; Solitary Fibrous Tumors/pathology
Language	English
Publishing date	2017-03-16
Publishing country	Pakistan
Document type	Case Reports ; Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
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Article ; Online: Bronchogenic cyst mimicking an adrenal mass in the retroperitoneal region: report of a rare case.

Bulut, Gulay / Bulut, Mehmet Deniz / Bahadır, Inci / Kotan, Çetin

Indian journal of pathology & microbiology

2015 Volume 58, Issue 1, Page(s) 96–98

Abstract: We report the surgical excision of a retroperitoneal bronchogenic cyst that presented as a nonfunctioning left adrenal mass in a 25-year-old woman with continuous pain in the left flank. Preoperative biochemical testing confirmed that the mass was ... ...

Abstract	We report the surgical excision of a retroperitoneal bronchogenic cyst that presented as a nonfunctioning left adrenal mass in a 25-year-old woman with continuous pain in the left flank. Preoperative biochemical testing confirmed that the mass was nonfunctional. Bronchogenic cysts are mostly benign congenital abnormalities that originate from the remnants of the primitive foregut and typically occur in the lung. Subdiaphragmatic and especially, retroperitoneal locations are rare. Despite the rarity of this pathologic entity, bronchogenic cysts should be considered in the differential diagnosis of retroperitoneal cystic lesions. Diagnosis must be definitively confirmed by histology.
MeSH term(s)	Adrenal Gland Neoplasms/pathology ; Adult ; Bronchogenic Cyst/diagnosis ; Bronchogenic Cyst/pathology ; Bronchogenic Cyst/surgery ; DNA-Binding Proteins/analysis ; Diagnosis, Differential ; Female ; Histocytochemistry ; Humans ; Immunohistochemistry ; Microscopy ; Radiography, Abdominal ; Retroperitoneal Neoplasms/diagnosis ; Retroperitoneal Neoplasms/pathology ; Retroperitoneal Neoplasms/surgery ; Tomography, X-Ray Computed ; Transcription Factors
Chemical Substances	DNA-Binding Proteins ; TTF1 protein, human ; Transcription Factors
Language	English
Publishing date	2015-01
Publishing country	India
Document type	Case Reports ; Journal Article
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
DOI	10.4103/0377-4929.151200
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