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  1. Article: Dr. Tetsuro Fujiwara-My Memories from the Early Days of Dr. Fujiwara's Research.

    Jobe, Alan H

    Biomedicines

    2024  Volume 12, Issue 1

    Abstract: This brief commentary honors Dr. Tesuro Fujiwara, the first person to treat infants with respiratory distress syndrome by instilling surfactant into their trachea. In the 1960s, mortality from RDS, which could only be treated with oxygen, was about 50 ... ...

    Abstract This brief commentary honors Dr. Tesuro Fujiwara, the first person to treat infants with respiratory distress syndrome by instilling surfactant into their trachea. In the 1960s, mortality from RDS, which could only be treated with oxygen, was about 50 percent. Based on the physiology Fujiwara learned that lung immaturity could be treated with doses of surfactant from animals in sheep models. He then made a surfactant from cow lungs called Servanta and treated 10 infants with RDS, who all had a large improvement in oxygenation. Other new therapies, such as continuous positive airway pressure and newer infant ventilators-in combination with surfactant therapy have decreased infant mortality to less than 1% from RDS in the most recent US infant death statistics.
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12010218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 50 Years ago in The Journal of Pediatrics: Respiratory distress syndrome of newborn infants: I. Diagnosis and incidence Miller H. J Pediatr 1962;61:2-8. Respiratory Distress Syndrome of Newborn Infants: II. Clinical Study of Pathogenesis Miller H. J Pediatr 1962;61:9-16.

    Jobe, Alan H

    The Journal of pediatrics

    2012  Volume 161, Issue 1, Page(s) 93

    MeSH term(s) Humans ; Incidence ; Infant, Newborn ; Respiratory Distress Syndrome, Newborn/diagnosis ; Respiratory Distress Syndrome, Newborn/epidemiology
    Language English
    Publishing date 2012-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2012.01.070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Three Existential Challenges in Optimizing the Lifelong Health of Infants Born Preterm.

    Jobe, Alan H

    The Journal of pediatrics

    2022  Volume 252, Page(s) 188–190

    MeSH term(s) Infant, Newborn ; Infant ; Humans ; Female ; Infant, Premature ; Premature Birth
    Language English
    Publishing date 2022-09-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2022.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: 50 Years Ago in TheJournalofPediatrics: Respiratory Distress Syndrome Versus Cyanotic Congenital Heart Disease in Infants Who Are Newborns.

    Jobe, Alan H

    The Journal of pediatrics

    2022  Volume 248, Page(s) 65

    MeSH term(s) Cyanosis ; Heart Defects, Congenital/complications ; Humans ; Infant ; Infant, Newborn ; Respiratory Distress Syndrome ; Respiratory Distress Syndrome, Newborn
    Language English
    Publishing date 2022-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2022.07.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Neonatal Network Data Based‒Associations Based on Large Numbers that May Be Spurious.

    Jobe, Alan H

    The Journal of pediatrics

    2021  Volume 235, Page(s) 18–19

    MeSH term(s) Brain Injuries ; Gestational Age ; Humans ; Indomethacin ; Infant, Newborn
    Chemical Substances Indomethacin (XXE1CET956)
    Language English
    Publishing date 2021-04-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2021.04.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: 50 Years Ago in TheJournalofPediatrics: My… how things have changed!

    Jobe, Alan H

    The Journal of pediatrics

    2021  Volume 240, Page(s) 109

    MeSH term(s) History, 20th Century ; History, 21st Century ; Humans ; Hyaline Membrane Disease/diagnosis ; Pediatrics/history ; Periodicals as Topic/history ; Publishing
    Language English
    Publishing date 2021-12-24
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2021.10.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Fetal and neonatal lung development

    Jobe, Alan H. / Whitsett, Jeffrey A. / Abman, Steven H.

    clinical correlates and technologies for the future

    (Lung growth, development, and disease)

    2016  

    Author's details edited by Alan H. Jobe, Jeffrey A. Whitsett, Steven H. Abman
    Series title Lung growth, development, and disease
    Keywords Lung / embryology ; Infant, Newborn ; Lung / growth & development ; Lung Diseases ; Lungs/Growth ; Pediatric respiratory diseases
    Language English
    Size ix, 324 Seiten, Illustrationen
    Publisher Cambridge University Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT019201294
    ISBN 978-1-107-07209-1 ; 1-107-07209-3
    Database Catalogue ZB MED Medicine, Health

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  8. Article ; Online: Preterm lung and brain responses to mechanical ventilation and corticosteroids.

    Hillman, Noah H / Jobe, Alan H

    Journal of perinatology : official journal of the California Perinatal Association

    2023  Volume 43, Issue 10, Page(s) 1222–1229

    Abstract: Mechanical ventilation is necessary to maintain oxygenation and ventilation in many preterm infants. Unfortunately, even short periods of mechanical ventilation can cause lung and airway injury, and initiate the lung inflammation that contributes to the ... ...

    Abstract Mechanical ventilation is necessary to maintain oxygenation and ventilation in many preterm infants. Unfortunately, even short periods of mechanical ventilation can cause lung and airway injury, and initiate the lung inflammation that contributes to the development of bronchopulmonary dysplasia (BPD). The mechanical stretch leads to airway cell differentiation and simplification of the alveoli, and releases cytokines that cause systemic response in other organs. Mechanical ventilation also leads to brain injury (IVH, white and gray matter) and neuronal inflammation that can affect the neurodevelopment of preterm infants. In efforts to decrease BPD, corticosteroids have been used for both prevention and treatment of lung inflammation. Corticosteroids have also been demonstrated to cause neuronal injury, so the clinician must balance the negative effects of both mechanical ventilation and steroids on the brain and lungs. Predictive models for BPD can help assess the infants who will benefit most from corticosteroid exposure. This review describes the lung and brain injury from mechanical ventilation in the delivery room and chronic mechanical ventilation in animal models. It provides updates on the current guidelines for use of postnatal corticosteroids (dexamethasone, hydrocortisone, budesonide, budesonide with surfactant) for the prevention and treatment of BPD, and the effects the timing of each steroid regimen has on neurodevelopment.
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645021-0
    ISSN 1476-5543 ; 0743-8346
    ISSN (online) 1476-5543
    ISSN 0743-8346
    DOI 10.1038/s41372-023-01692-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Other causes of fetal brain injury.

    Jobe, Alan H

    American journal of obstetrics and gynecology

    2020  Volume 223, Issue 2, Page(s) 301

    MeSH term(s) Brain Injuries ; Female ; Fetus ; Humans ; Pregnancy ; Prenatal Care
    Language English
    Publishing date 2020-03-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2020.03.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A striking result from antenatal exposure to N-acetylcysteine.

    Jobe, Alan H

    Pediatric research

    2020  Volume 89, Issue 1, Page(s) 14–15

    MeSH term(s) Acetylcysteine ; Female ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases ; Inflammation ; Pregnancy
    Chemical Substances Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2020-09-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-020-01168-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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