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Article ; Online: The COVID-19 pandemic as a long-term school crisis: Impact, risk, resilience, and crisis management.

Nickerson, Amanda B / Sulkowski, Michael L

School psychology (Washington, D.C.)

2021 Volume 36, Issue 5, Page(s) 271–276

Abstract: ... virus, crisis management practices for other crisis (e.g., natural disasters, technological disasters ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic presents school communities across the United States and world with an unpresented challenge. Virtually, all members of school communities have been impacted and the long-term ramifications of the pandemic remain unknown. However, despite being a novel virus, crisis management practices for other crisis (e.g., natural disasters, technological disasters, unexpected deaths) have utility for school safety promotion and helping affected individuals cope effectively with the monumental challenges they face during the pandemic. Such practices can reduce risk while fostering resilience concomitantly. This special issue,
MeSH term(s)	Adaptation, Psychological ; Adolescent ; Adult ; COVID-19 ; Child ; Humans ; Psychology, Educational ; Resilience, Psychological ; Risk ; Safety Management ; Schools ; Vulnerable Populations
Language	English
Publishing date	2021-09-30
Publishing country	United States
Document type	Introductory Journal Article
ISSN	2578-4226
ISSN (online)	2578-4226
DOI	10.1037/spq0000470
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Article ; Online: Sexual Victimization in Adolescence: Pathways of Risk from Sexual Harassment via Risky Alcohol Use and Delinquency Among U.S. Adolescents.

Livingston, Jennifer A / Wang, Weijun / Nickerson, Amanda B / Testa, Maria

Archives of sexual behavior

2023 Volume 52, Issue 7, Page(s) 2823–2834

Abstract: ... in life (e.g., child sexual abuse) can increase risk of future sexual assault victimization ...

Abstract	Sexual harassment is a common, yet understudied form of peer victimization experienced by adolescents during a critical period in the development of sexual identity. Adverse sexual experiences early in life (e.g., child sexual abuse) can increase risk of future sexual assault victimization; however, it is unclear as to whether sexual harassment victimization is also a risk factor for sexual assault. We examined the prospective association between peer sexual harassment and experiencing sexual victimization in the following year among a community sample of 13-15-year-old adolescents (N = 800, 57% female) from the northeastern USA. We also examined whether risky alcohol use and delinquency mediated the association between sexual harassment and sexual assault victimization, as well as whether the paths differed by gender. Results indicated that sexual harassment victimization prospectively predicted later sexual victimization for both girls and boys. Using a parallel mediation path model, we determined that for girls, sexual harassment victimization predicted both risky alcohol use and delinquency, but only risky alcohol use was predictive of sexual victimization. For boys, sexual harassment victimization predicted delinquency but not risky alcohol use. Risky alcohol use was not associated with sexual victimization for boys. Findings indicate that sexual harassment victimization increases risk of later sexual victimization in adolescence, but the pathways differ by gender.
MeSH term(s)	Male ; Child ; Humans ; Adolescent ; Female ; Sexual Harassment ; Surveys and Questionnaires ; Crime Victims ; Bullying ; Peer Group
Language	English
Publishing date	2023-03-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	184221-3
ISSN	1573-2800 ; 0004-0002
ISSN (online)	1573-2800
ISSN	0004-0002
DOI	10.1007/s10508-023-02582-x
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Article ; Online: Gallium arsenide optical phased array photonic integrated circuit.

Nickerson, Michael / Song, Bowen / Brookhyser, Jim / Erwin, Gregory / Kleinert, Jan / Klamkin, Jonathan

Optics express

2023 Volume 31, Issue 17, Page(s) 27106–27122

Abstract: A 16-channel optical phased array is fabricated on a gallium arsenide photonic integrated circuit platform with a low-complexity process. Tested with a 1064 nm external laser, the array demonstrates 0.92° beamwidth, 15.3° grating-lobe-free steering range, ...

Abstract	A 16-channel optical phased array is fabricated on a gallium arsenide photonic integrated circuit platform with a low-complexity process. Tested with a 1064 nm external laser, the array demonstrates 0.92° beamwidth, 15.3° grating-lobe-free steering range, and 12 dB sidelobe level. Based on a reverse biased p-i-n structure, component phase modulators are 3 mm long with DC power consumption of less than 5 µW and greater than 770 MHz electro-optical bandwidth. Separately fabricated 4-mm-long phase modulators based on the same structure demonstrate single-sided V
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.492556
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Article ; Online: The impact of sexual scripts in brand-generated cannabis social media posts on sex-related cannabis expectancies: Does body appreciation moderate effects?

Willoughby, Jessica Fitts / Hust, Stacey J T / Couto, Leticia / Li, Jiayu / Kang, Soojung / Nickerson, Christina Griselda / Price, Ron / Tlachi-Munoz, Sandy

Drug and alcohol review

2023 Volume 43, Issue 1, Page(s) 122–131

Abstract: ... sexually objectified women or recreational appeals (e.g., sitting by a firepit). We conducted regressions ... enhancement scripts (b = 0.34, p < 0.01), which was associated with increased cannabis sex enhancement ... expectancies (b = 0.34, p < 0.001) and decreased cannabis sexual risk expectancies (b = -0.16, p < 0.001 ...

Abstract	Introduction: Cannabis messaging on digital media may include sexualised portrayals. We examined whether exposure to and perceptions of cannabis posts that included sexual objectification impacted two types of sex-related cannabis expectancies-sexual risk and sexual enhancement-and whether body appreciation moderated these relationships. Methods: We conducted an online experiment with college students in Washington state. Participants viewed three brand-generated cannabis Instagram posts that either included sexually objectified women or recreational appeals (e.g., sitting by a firepit). We conducted regressions, using the PROCESS macro, to examine the hypothesized model and potential mediation and moderation. Results: Exposure to sexualised advertisements was associated with increased perceptions of cannabis sex enhancement scripts (b = 0.34, p < 0.01), which was associated with increased cannabis sex enhancement expectancies (b = 0.34, p < 0.001) and decreased cannabis sexual risk expectancies (b = -0.16, p < 0.001); exposure to such advertisements were also associated with increased perceptions of cannabis sexual risk scripts (b = 0.61, p < 0.001), which was associated with increased cannabis sexual risk expectancies (b = 0.53, p < 0.001). Body appreciation was associated with increased cannabis sex enhancement expectancies (b = 0.13, p < 0.01) and moderated the relationship between exposure to sexualised ads and cannabis sex enhancement expectancies (b = -0.21, p < 0.01). Discussion and conclusions: Practitioners may want to consider how to increase critical consumption of cannabis content on digital media. Researchers should consider the possible role of body appreciation as it relates to cannabis and sex enhancement expectancies.
MeSH term(s)	Humans ; Female ; Cannabis ; Social Media ; Internet ; Sexual Behavior ; Washington
Language	English
Publishing date	2023-03-18
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1080442-0
ISSN	1465-3362 ; 0959-5236
ISSN (online)	1465-3362
ISSN	0959-5236
DOI	10.1111/dar.13642
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Zs.A 5621: Show issues

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Article ; Online: Legal Performance-enhancing Drugs Alter Course and Treatment of Rhabdomyolysis-induced Acute Kidney Injury.

Hebert, Jessica F / Eiwaz, Mahaba B / Nickerson, Megan N / Munhall, Adam C / Pai, Akash A / Groat, Tahnee / Andeen, Nicole K / Hutchens, Michael P

Military medicine

2023 Volume 188, Issue Suppl 6, Page(s) 346–353

Abstract: ... administration greatly worsened RIAKI (GFR 14.3 ± 19.5 vs. 577.4 ± 454.6 µL/min/100 g in control, UOP 0.5 ± 0.4 ...

Abstract	Introduction: Rhabdomyolysis-induced acute kidney injury (RIAKI) can interrupt physical training and increase mortality in injured warfighters. The legal performance-enhancing drugs caffeine and ibuprofen, which can cause renal injury, are widely used by service members. Whether caffeine or ibuprofen affects RIAKI is unknown. Cilastatin treatment was recently identified as an experimental treatment to prevent RIAKI at injury. To determine potential interacting factors in RIAKI treatment, we test the hypothesis that caffeine and ibuprofen worsen RIAKI and interfere with treatment. Materials and methods: In mice, RIAKI was induced by glycerol intramuscular injection. Simultaneously, mice received caffeine (3 mg/kg), ibuprofen (10 mg/kg), or vehicle. A second cohort received volume resuscitation (PlasmaLyte, 20 mL/kg) in addition to caffeine or ibuprofen. In a third cohort, cilastatin (200 mg/kg) was administered concurrently with drug and glycerol administration. Glomerular filtration rate (GFR), blood urea nitrogen (BUN), urine output (UOP), renal pathology, and renal immunofluorescence for kidney injury molecule 1 were quantified after 24 hours. Results: Caffeine did not worsen RIAKI; although BUN was modestly increased by caffeine administration, 24-hour GFR, UOP, and renal histopathology were similar between vehicle-treated, caffeine-treated, and caffeine + PlasmaLyte-treated mice. Ibuprofen administration greatly worsened RIAKI (GFR 14.3 ± 19.5 vs. 577.4 ± 454.6 µL/min/100 g in control, UOP 0.5 ± 0.4 in ibuprofen-treated mice vs. 2.7 ± 1.7 mL/24 h in control, and BUN 264 ± 201 in ibuprofen-treated mice vs. 66 ± 21 mg/dL in control, P < .05 for all); PlasmaLyte treatment did not reverse this effect. Cilastatin with or without PlasmaLyte did not reverse the deleterious effect of ibuprofen in RIAKI. Conclusions: Caffeine does not worsen RIAKI. The widely used performance-enhancing drug ibuprofen greatly worsens RIAKI in mice. Standard or experimental treatment of RIAKI including the addition of cilastatin to standard resuscitation is ineffective in mice with RIAKI exacerbated by ibuprofen. These findings may have clinical implications for the current therapy of RIAKI and for translational studies of novel treatment.
MeSH term(s)	Humans ; Mice ; Animals ; Ibuprofen/pharmacology ; Ibuprofen/therapeutic use ; Performance-Enhancing Substances/therapeutic use ; Caffeine/pharmacology ; Caffeine/therapeutic use ; Glycerol/therapeutic use ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/etiology ; Cilastatin/pharmacology ; Cilastatin/therapeutic use ; Rhabdomyolysis/complications ; Rhabdomyolysis/drug therapy
Chemical Substances	Ibuprofen (WK2XYI10QM) ; Performance-Enhancing Substances ; Caffeine (3G6A5W338E) ; Glycerol (PDC6A3C0OX) ; Cilastatin (141A6AMN38)
Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usad142
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Article ; Online: Profiles of post-migration stressors and mental health in refugees: A latent class analysis.

Byrow, Yulisha / Liddell, Belinda / O'Donnell, Meaghan / Mau, Vicki / McMahon, Tadgh / Bryant, Richard / Benson, Greg / Nickerson, Angela

Psychiatry research

2022 Volume 311, Page(s) 114494

Abstract: ... identified distinct psychological symptom profiles using person centred statistical techniques (e.g., latent ...

Abstract	Studies have documented the mental health effects of pre-migration trauma on resettled refugees and identified distinct psychological symptom profiles using person centred statistical techniques (e.g., latent class analysis; LCA). These techniques have advanced our understanding of the complex presentation of trauma and psychopathology in refugees. The current study employs LCA to examine patterns of exposure to stressors including post-migration stressors, allowing us to identify patterns of post-migration stress exposure and their association with mental health outcomes. Participants were 1085 Arabic, Farsi, Tamil, or English speaking adult refugees. Pre-migration trauma, post-migration stressors, PTSD, depression, anger, and functional impairment was measured. LCA was conducted to identify distinct classes of post-migration stressors and associations with mental health and adjustment in the resettlement environment. Latent class analysis revealed 5 classes of participants: high difficulties class (7.2%), immigration fear class (14.4%), social disconnection class (17.3%), moderate difficulties class (28.9%) and a low difficulties class (32.3%). Each of the five classes shared commonalities in addition to key differences associated with specific demographic characteristics and psychopathology. Post-migration stressors appear to map onto distinct profiles, which uniquely contribute to functional impairment and mental health outcomes in refugees. These findings have substantial implications for public health and social services working with resettled refugee communities.
MeSH term(s)	Adult ; Humans ; India ; Latent Class Analysis ; Mental Health ; Refugees/psychology ; Stress Disorders, Post-Traumatic/psychology
Language	English
Publishing date	2022-03-06
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2022.114494
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Article: Snowball ICA: A Model Order Free Independent Component Analysis Strategy for Functional Magnetic Resonance Imaging Data.

Hu, Guoqiang / Waters, Abigail B / Aslan, Serdar / Frederick, Blaise / Cong, Fengyu / Nickerson, Lisa D

Frontiers in neuroscience

2020 Volume 14, Page(s) 569657

Abstract: In independent component analysis (ICA), the selection of model order (i.e., number of components to be extracted) has crucial effects on functional magnetic resonance imaging (fMRI) brain network analysis. Model order selection (MOS) algorithms have ... ...

Abstract	In independent component analysis (ICA), the selection of model order (i.e., number of components to be extracted) has crucial effects on functional magnetic resonance imaging (fMRI) brain network analysis. Model order selection (MOS) algorithms have been used to determine the number of estimated components. However, simulations show that even when the model order equals the number of simulated signal sources, traditional ICA algorithms may misestimate the spatial maps of the signal sources. In principle, increasing model order will consider more potential information in the estimation, and should therefore produce more accurate results. However, this strategy may not work for fMRI because large-scale networks are widely spatially distributed and thus have increased mutual information with noise. As such, conventional ICA algorithms with high model orders may not extract these components at all. This conflict makes the selection of model order a problem. We present a new strategy for model order free ICA, called Snowball ICA, that obviates these issues. The algorithm collects all information for each network from fMRI data without the limitations of network scale. Using simulations and
Language	English
Publishing date	2020-09-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2020.569657
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Article ; Online: Saliva and Lung Microbiome Associations with Electronic Cigarette Use and Smoking.

Ying, Kevin L / Brasky, Theodore M / Freudenheim, Jo L / McElroy, Joseph P / Nickerson, Quentin A / Song, Min-Ae / Weng, Daniel Y / Wewers, Mark D / Whiteman, Noah B / Mathe, Ewy A / Shields, Peter G

Cancer prevention research (Philadelphia, Pa.)

2022 Volume 15, Issue 7, Page(s) 435–446

Abstract: The microbiome has increasingly been linked to cancer. Little is known about the lung and oral cavity microbiomes in smokers, and even less for electronic cigarette (EC) users, compared with never-smokers. In a cross-sectional study (n = 28) of smokers, ... ...

Abstract	The microbiome has increasingly been linked to cancer. Little is known about the lung and oral cavity microbiomes in smokers, and even less for electronic cigarette (EC) users, compared with never-smokers. In a cross-sectional study (n = 28) of smokers, EC users, and never-smokers, bronchoalveolar lavage and saliva samples underwent metatranscriptome profiling to examine associations with lung and oral microbiomes. Pairwise comparisons assessed differentially abundant bacteria species. Total bacterial load was similar between groups, with no differences in bacterial diversity across lung microbiomes. In lungs, 44 bacteria species differed significantly (FDR < 0.1) between smokers/never-smokers, with most decreased in smokers. Twelve species differed between smokers/EC users, all decreased in smokers of which Neisseria sp. KEM232 and Curvibacter sp. AEP1-3 were observed. Among the top five decreased species in both comparisons, Neisseria elongata, Neisseria sicca, and Haemophilus parainfluenzae were observed. In the oral microbiome, 152 species were differentially abundant for smokers/never-smokers, and 17 between smokers/electronic cigarette users, but only 21 species were differentially abundant in both the lung and oral cavity. EC use is not associated with changes in the lung microbiome compared with never-smokers, indicating EC toxicity does not affect microbiota. Statistically different bacteria in smokers compared with EC users and never-smokers were almost all decreased, potentially due to toxic effects of cigarette smoke. The low numbers of overlapping oral and lung microbes suggest that the oral microbiome is not a surrogate for analyzing smoking-related effects in the lung. Prevention relevance: The microbiome affects cancer and other disease risk. The effects of e-cig usage on the lung microbiome are essentially unknown. Given the importance of lung microbiome dysbiosis populated by oral species which have been observed to drive lung cancer progression, it is important to study effects of e-cig use on microbiome.
MeSH term(s)	Bacteria ; Cross-Sectional Studies ; Electronic Nicotine Delivery Systems ; Lung ; Microbiota ; Saliva ; Vaping
Language	English
Publishing date	2022-06-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Intramural
ZDB-ID	2434717-6
ISSN	1940-6215 ; 1940-6207
ISSN (online)	1940-6215
ISSN	1940-6207
DOI	10.1158/1940-6207.CAPR-21-0601
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Article: A Three-Dimensional Cell Culture Model To Study Enterovirus Infection of Polarized Intestinal Epithelial Cells.

Drummond, Coyne G / Nickerson, Cheryl A / Coyne, Carolyn B

mSphere

2015 Volume 1, Issue 1

Abstract: Despite serving as the primary entry portal for coxsackievirus B (CVB), little is known about CVB ... of enterovirus-host interactions in intestinal epithelial cells. IMPORTANCE Coxsackievirus B (CVB), a member ...

Abstract	Despite serving as the primary entry portal for coxsackievirus B (CVB), little is known about CVB infection of the intestinal epithelium, owing at least in part to the lack of suitable in vivo models and the inability of cultured cells to recapitulate the complexity and structure associated with the gastrointestinal (GI) tract. Here, we report on the development of a three-dimensional (3-D) organotypic cell culture model of Caco-2 cells to model CVB infection of the gastrointestinal epithelium. We show that Caco-2 cells grown in 3-D using the rotating wall vessel (RWV) bioreactor recapitulate many of the properties of the intestinal epithelium, including the formation of well-developed tight junctions, apical-basolateral polarity, brush borders, and multicellular complexity. In addition, transcriptome analyses using transcriptome sequencing (RNA-Seq) revealed the induction of a number of genes associated with intestinal epithelial differentiation and/or intestinal processes in vivo when Caco-2 cells were cultured in 3-D. Applying this model to CVB infection, we found that although the levels of intracellular virus production were similar in two-dimensional (2-D) and 3-D Caco-2 cell cultures, the release of infectious CVB was enhanced in 3-D cultures at early stages of infection. Unlike CVB, the replication of poliovirus (PV) was significantly reduced in 3-D Caco-2 cell cultures. Collectively, our studies show that Caco-2 cells grown in 3-D using the RWV bioreactor provide a cell culture model that structurally and transcriptionally represents key aspects of cells in the human GI tract and can thus be used to expand our understanding of enterovirus-host interactions in intestinal epithelial cells. IMPORTANCE Coxsackievirus B (CVB), a member of the enterovirus family of RNA viruses, is associated with meningitis, pericarditis, diabetes, dilated cardiomyopathy, and myocarditis, among other pathologies. CVB is transmitted via the fecal-oral route and encounters the epithelium lining the gastrointestinal tract early in infection. The lack of suitable in vivo and in vitro models to study CVB infection of the gastrointestinal epithelium has limited our understanding of the events that surround infection of these specialized cells. Here, we report on the development of a three-dimensional (3-D) organotypic cell culture model of human intestinal epithelial cells that better models the gastrointestinal epithelium in vivo. By applying this 3-D model, which recapitulates many aspects of the gastrointestinal epithelium in vivo, to the study of CVB infection, our work provides a new cell system to model the mechanisms by which CVB infects the intestinal epithelium, which may have a profound impact on CVB pathogenesis. Podcast: A podcast concerning this article is available.
Language	English
Publishing date	2015-11-18
Publishing country	United States
Document type	Journal Article
ISSN	2379-5042
ISSN	2379-5042
DOI	10.1128/mSphere.00030-15
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Article ; Online: Anxiety moderates the effects of stressor controllability and cognitive reappraisal on distress following aversive exposure: An experimental investigation.

Le, Lillian / Moulds, Michelle / Nickerson, Angela

Journal of behavior therapy and experimental psychiatry

2018 Volume 60, Page(s) 87–94

Abstract: ... reappraisal (CR) depends on different factors, including the individual's psychological wellbeing (e.g., level ... of anxiety) and the context in which the strategy is used (e.g., stressor controllability). The present study ... to a condition in which they had (a) control or (b) no control over the viewing duration of distressing film ...

Abstract	Background and objectives: Emerging evidence suggests that the effectiveness of cognitive reappraisal (CR) depends on different factors, including the individual's psychological wellbeing (e.g., level of anxiety) and the context in which the strategy is used (e.g., stressor controllability). The present study aimed to investigate the emotional (negative affect) and physiological (skin conductance levels) effects of emotion regulation following exposure to controllable versus uncontrollable stress. Methods: Ninety-five undergraduate students completed measures assessing anxiety, and were randomly assigned to a condition in which they had (a) control or (b) no control over the viewing duration of distressing film clips, and were then instructed to either (a) cognitively reappraise or (b) ruminate about the clips. Results: There were no significant interactions between controllability, emotion regulation, and pre-post changes in responses. However, individual differences in anxiety moderated the effects of controllability and emotion regulation on distress responses. For participants low in anxiety, CR was related to smaller increases in distress following uncontrollable than controllable stress. This pattern was not observed for those high in anxiety following stress exposure. Limitations: This study used a non-clinical sample, limiting the generalizability of the findings. Conclusions: These findings indicate that the utility of CR may depend upon contextual factors such as stressor controllability, and individual differences in psychological symptoms.
MeSH term(s)	Adolescent ; Adult ; Anxiety/physiopathology ; Emotions/physiology ; Female ; Humans ; Judgment/physiology ; Male ; Random Allocation ; Rumination, Cognitive/physiology ; Self-Control ; Stress, Psychological/physiopathology ; Young Adult
Language	English
Publishing date	2018-05-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	280250-8
ISSN	1873-7943 ; 0005-7916
ISSN (online)	1873-7943
ISSN	0005-7916
DOI	10.1016/j.jbtep.2018.05.001
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