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Article: Lung Cancer Screening: Review and 2021 Update.

Ramaswamy, Anuradha

Current pulmonology reports

2022 Volume 11, Issue 1, Page(s) 15–28

Abstract: Purpose of review: Lung cancer screening with low-dose CT (LDCT) scans has been widely accepted within the last decade. Our knowledge and ability to implement screening has greatly increased because of significant research efforts and guidelines from ... ...

Abstract	Purpose of review: Lung cancer screening with low-dose CT (LDCT) scans has been widely accepted within the last decade. Our knowledge and ability to implement screening has greatly increased because of significant research efforts and guidelines from multiple professional societies. The purpose of this review is to summarize some of the significant findings pertaining to lung cancer screening. Recent findings: Screening with LDCT decreases lung cancer mortality in multiple studies. Use of validated risk prediction calculators can improve patient selection and screening efficiency. Shared decision making and smoking cessation counseling are essential screening components. Multidisciplinary involvement is required for the success of a screening program. Summary: Lung cancer screening is complex, and implementation of a successful program requires multidisciplinary expertise. Further prospective studies are required to determine optimal patient selection, screening intervals, and strategies to maximize benefit while further decreasing harms.'
Language	English
Publishing date	2022-04-02
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2199-2428
ISSN	2199-2428
DOI	10.1007/s13665-021-00283-1
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Article: Effect of Soluble Solids and High Pressure Treatment on Rheological Properties of Protein Enriched Mango Puree.

Ramaswamy, Hosahalli S / Gundurao, Anuradha

Foods (Basel, Switzerland)

2019 Volume 8, Issue 1

Abstract: The effects of high pressure treatment on the rheological properties of protein enriched mango puree were evaluated. In the first part, the original soluble solids in mango puree (28° Brix) was lowered to 26, 23 and 20° Brix, and each was supplemented ... ...

Abstract	The effects of high pressure treatment on the rheological properties of protein enriched mango puree were evaluated. In the first part, the original soluble solids in mango puree (28° Brix) was lowered to 26, 23 and 20° Brix, and each was supplemented with 2, 5 and 8% of whey protein to assess the influence of added protein. The samples were then evaluated by dynamic rheology. Pressure treatment resulted in a progressive increase in elastic (G') and viscous modulii (G″) as well as complex viscosity (η*). Values of G' were higher than G″ demonstrating that the product behaved more like a gel. Additional tests were carried out by simultaneously varying protein and soluble solids contents, and keeping the total solids at 28%. In this case, the effects of pressure levels and holding times were similar to previous results. However, the positive effects of higher protein were negated by the negative effects of lower soluble solids, resulting in an overall decreasing effect on rheology. The developed models effectively predicted the combined influence of protein and soluble solid concentrations on rheological parameters (R2 > 0.85). Sensory evaluation of 2% and 5% protein supplemented and pressure treated (500 MPa/3 min) mango puree yielded acceptable sensory qualities, resulting in a product with enriched protein content.
Language	English
Publishing date	2019-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods8010039
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Article: Bronchoscopic lung volume reduction: recent updates.

Ramaswamy, Anuradha / Puchalski, Jonathan

Journal of thoracic disease

2018 Volume 10, Issue 4, Page(s) 2519–2527

Abstract: Emphysema causes significant morbidity and mortality, incurring both financial and psychosocial costs. Alternatives to medical therapy and surgical lung volume reduction surgery (LVRS) have increased interest in bronchoscopic techniques. Bronchoscopic ... ...

Abstract	Emphysema causes significant morbidity and mortality, incurring both financial and psychosocial costs. Alternatives to medical therapy and surgical lung volume reduction surgery (LVRS) have increased interest in bronchoscopic techniques. Bronchoscopic lung volume reduction (BLVR) is still in its infancy and additional trials and follow-up are critical. However, several new randomized clinical trials (RCTs) have demonstrated improvement in lung function, quality of life and exercise capacity in select patients receiving endobronchial valves and coil therapy. This article highlights recent data regarding bronchoscopic treatment of emphysema.
Language	English
Publishing date	2018-05-23
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd.2018.02.72
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Article: Effect of Soluble Solids and High Pressure Treatment on Rheological Properties of Protein Enriched Mango Puree

Ramaswamy, Hosahalli S / Gundurao, Anuradha

Foods. 2019 Jan. 21, v. 8, no. 1

2019

Abstract	The effects of high pressure treatment on the rheological properties of protein enriched mango puree were evaluated. In the first part, the original soluble solids in mango puree (28° Brix) was lowered to 26, 23 and 20° Brix, and each was supplemented with 2, 5 and 8% of whey protein to assess the influence of added protein. The samples were then evaluated by dynamic rheology. Pressure treatment resulted in a progressive increase in elastic (G′) and viscous modulii (G″) as well as complex viscosity (η*). Values of G′ were higher than G″ demonstrating that the product behaved more like a gel. Additional tests were carried out by simultaneously varying protein and soluble solids contents, and keeping the total solids at 28%. In this case, the effects of pressure levels and holding times were similar to previous results. However, the positive effects of higher protein were negated by the negative effects of lower soluble solids, resulting in an overall decreasing effect on rheology. The developed models effectively predicted the combined influence of protein and soluble solid concentrations on rheological parameters (R2 > 0.85). Sensory evaluation of 2% and 5% protein supplemented and pressure treated (500 MPa/3 min) mango puree yielded acceptable sensory qualities, resulting in a product with enriched protein content.
Keywords	brix ; fruit puree ; gels ; high pressure treatment ; models ; protein content ; rheology ; sensory evaluation ; sensory properties ; total soluble solids ; viscosity ; whey protein
Language	English
Dates of publication	2019-0121
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods8010039
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: An analysis of psychological problems in older Indian patients with cancer.

Journal of geriatric oncology

2024 , Page(s) 101744

Language	English
Publishing date	2024-03-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2556813-9
ISSN	1879-4076 ; 1879-4068
ISSN (online)	1879-4076
ISSN	1879-4068
DOI	10.1016/j.jgo.2024.101744
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Article ; Online: Sex-specific differences in systemic immune responses in MIS-C children.

Rajamanickam, Anuradha / Kumar, Nathella Pavan / Venkataraman, Aishwarya / Varadarjan, Poovazhagi / Selladurai, Elilarasi / Sankaralingam, Thangavelu / Thiruvengadam, Kannan / Selvam, Ramya / Thimmaiah, Akshith / Natarajan, Suresh / Ramaswamy, Ganesh / Putlibai, Sulochana / Sadasivam, Kalaimaran / Sundaram, Balasubramanian / Hissar, Syed / Ranganathan, Uma Devi / Babu, Subash

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1720

Abstract: Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare manifestation of Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2) infection that can result in increased morbidity and mortality. Mounting evidence describes sex disparities in ... ...

Abstract	Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare manifestation of Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2) infection that can result in increased morbidity and mortality. Mounting evidence describes sex disparities in the clinical outcomes of coronavirus disease 2019 (COVID-19). However, there is a lack of information on sex-specific differences in immune responses in MIS-C. This study is an observational and cross-sectional study and we wanted to examine immune parameters such as cytokines, chemokines, acute phase proteins (APPs), growth factors, microbial translocation markers (MTMs), complement components and matrix metalloproteinases (MMPs) in MIS-C children, based on sex. Male children were associated with heightened levels of pro-inflammatory cytokines-IFNγ, IL-2, TNFα, IL-1α, IL-1β, IL-6, IL-12, G-CSF and GM-CSF, chemokines-CCL2, CCL11, CXCL1, CXCL8 and CXCL10, acute phase proteins-α-2M, CRP, growth factors VEGF and TGFα, microbial translocation markers- iFABP, LBP, EndoCAb, complement components-C1q, MBL and C3 and matrix metalloproteinases MMP-8 and MMP-9 compared to female children with MIS-C. These results indicate that the heightened immune response in males is a characteristic feature of MIS-C. These findings might explain the differential disease pathogenesis in males compared to females with MIS-C and facilitate a deeper understanding of this disease.
MeSH term(s)	Child ; Humans ; Male ; Female ; Cross-Sectional Studies ; SARS-CoV-2 ; Cytokines ; Acute-Phase Proteins ; Systemic Inflammatory Response Syndrome ; Immunity ; Matrix Metalloproteinases ; COVID-19/complications
Chemical Substances	Cytokines ; Acute-Phase Proteins ; Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Observational Study ; Case Reports ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52116-1
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Article ; Online: Recurrent Tracheal Stenosis: A Novel Presentation of Silicosis.

Ramaswamy, Anuradha / Panchabhai, Tanmay S / Farver, Carol / Mehta, Atul C

Annals of the American Thoracic Society

2016 Volume 13, Issue 7, Page(s) 1184–1187

MeSH term(s)	Humans ; Recurrence ; Silicosis/complications ; Silicosis/diagnosis ; Trachea ; Tracheal Stenosis/etiology
Language	English
Publishing date	2016-07-04
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.201512-827LE
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Article: The prevalence of cognitive impairment in older Indian persons with cancer and brain metastases.

Dhanawat, Aditya / Noronha, Vanita / Ramaswamy, Anant / Gattani, Shreya / Castelino, Renita / Dhekale, Ratan / Mahajan, Sarika / Patil, Vijay / Menon, Nandini / Daptardar, Anuradha / Gota, Vikram / Banavali, Shripad / Badwe, Rajendra / Prabhash, Kumar

Ecancermedicalscience

2022 Volume 16, Page(s) 1372

Abstract: Background: Older patients with cancer are more vulnerable to the effects of cognitive impairment affecting their functional status, quality of life, compliance to treatment and ultimately survival. Cancer-related cognitive impairment may be due to the ... ...

Abstract	Background: Older patients with cancer are more vulnerable to the effects of cognitive impairment affecting their functional status, quality of life, compliance to treatment and ultimately survival. Cancer-related cognitive impairment may be due to the cancer itself or due to the treatment of cancer. There are no data regarding the prevalence of cognitive impairment in older persons with cancer and brain metastasis. Methods: This retrospective analysis was conducted on a prospectively collected data set of patients who attended the geriatric oncology clinic at a tertiary care comprehensive cancer centre in India from June 2018 to July 2021. Patients aged 60 years and above with malignancy were included. Cognition was assessed with the mini-mental status examination (MMSE); the Hindi MMSE was used for illiterate patients. A score of ≤23 on the MMSE was considered abnormal. Correlation between the presence of cognitive impairment and brain metastasis was tested using the chi-square test. Results: A total of 597 patients were included, of which 462 (77.4%) were male. The median age was 69 years (range: 60-100 years). All patients had solid tumours; 244 (40.9%) had lung, 189 (31.7%) had gastrointestinal and 75 (12.6%) had head and neck malignancies. Forty-one (6.9%) patients had brain metastases, of which 10 (24.4%) had solitary, 30 (73.2%) had multiple lesions and 1 (2.4%) had leptomeningeal metastases. Cognitive impairment was noted in 11 (26.8%) of the 41 patients with brain metastases and 91 (16.4%) of the 556 patients without brain metastases. There was no significant correlation between the presence of brain metastases and cognitive impairment, Conclusion: Older persons with cancer and brain metastases were not found to have a higher occurrence of cognitive impairment than those without brain metastases in this study. The next step is to understand whether older persons with brain metastases are at a higher risk for cognitive decline as a result of therapeutic interventions such as cranial radiotherapy and chemotherapy.
Language	English
Publishing date	2022-04-07
Publishing country	England
Document type	Journal Article
ISSN	1754-6605
ISSN	1754-6605
DOI	10.3332/ecancer.2022.1372
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Article ; Online: Caregiver burden in older Indian patients with cancer- Experience from a tertiary care center.

Menon, Nandini / Patil, Vijay M / Ramaswamy, Anant / Gattani, Shreya / Castelino, Renita / Dhekale, Ratan / Gota, Vikram / Sekar, Anbarasan / Deodhar, Jayita / Mahajan, Sarika G / Daptardar, Anuradha / Prabhash, Kumar / Banavali, Shripad D / Badwe, Rajendra A / Noronha, Vanita

Journal of geriatric oncology

2022 Volume 13, Issue 7, Page(s) 970–977

Abstract: Introduction: Most of the long-term care for older adults with chronic or debilitating illnesses is provided by unpaid family members or informal caregivers. There is limited information on caregiver burden among caregivers of older patients with cancer ...

Abstract	Introduction: Most of the long-term care for older adults with chronic or debilitating illnesses is provided by unpaid family members or informal caregivers. There is limited information on caregiver burden among caregivers of older patients with cancer in India. Hence, we assessed the prevalence and severity of caregiver burden among caregivers of older Indian patients with cancer. Materials and methods: This was an observational study conducted at the geriatric oncology clinic at Tata Memorial Centre, Mumbai, India. Caregivers of patients aged 60 years and over with a diagnosis of cancer were assessed for caregiver burden using the Zarit Burden Interview. Descriptive statistics were used for demographic and clinical variables. Factors impacting caregiver burden were analyzed using multiple linear regression analysis. Results: Caregiver burden was assessed among 127 caregivers of older Indian patients with cancer. The median patient age was 69 years (range 60-90). Most patients were men (75.6%). There were 33 female caregivers (26%), and 94 male caregivers (74%). The median caregiver burden score was 12 (IQR 6-20). Caregiver burden was "little/none" in 97 (76.4%), "mild-moderate" in 25 (19.7%), "moderate-severe" in four (3.1%) and "severe" in one (0.8%) of the caregivers assessed. On multivariate analysis, factors that significantly impacted caregiver burden scores were the presence of psychological issues in the patient and the caregiver's educational level. Discussion: Caregiver burden was low among caregivers of older Indian patients with cancer seen at a single center. Caregivers of patients with psychological disorders, and those who had less schooling reported higher caregiver burden.
MeSH term(s)	Aged ; Aged, 80 and over ; Caregiver Burden ; Caregivers/psychology ; Cost of Illness ; Female ; Humans ; Male ; Middle Aged ; Neoplasms/therapy ; Tertiary Care Centers
Language	English
Publishing date	2022-06-22
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	2556813-9
ISSN	1879-4076 ; 1879-4068
ISSN (online)	1879-4076
ISSN	1879-4068
DOI	10.1016/j.jgo.2022.05.008
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Article: Crizotinib induces Par-4 secretion from normal cells and GRP78 expression on the cancer cell surface for selective tumor growth inhibition.

Burikhanov, Ravshan / Ganguly, Saptadwipa / Ellingson, Sally / Sviripa, Vitaliy M / Araujo, Nathalia / Li, Shunqiang / Venkatraman, Prasanna / Rao, Mahadev / Choughule, Anuradha / Brainson, Christine F / Zhan, Chang-Guo / Spielmann, H Peter / Watt, David S / Govindan, Ramaswamy / Rangnekar, Vivek M

American journal of cancer research

2023 Volume 13, Issue 3, Page(s) 976–991

Abstract: Lung cancer is the leading cause of cancer-related deaths. Lung cancer cells develop resistance to apoptosis by suppressing the secretion of the tumor suppressor Par-4 protein (also known as PAWR) and/or down-modulating the Par-4 receptor GRP78 on the ... ...

Abstract	Lung cancer is the leading cause of cancer-related deaths. Lung cancer cells develop resistance to apoptosis by suppressing the secretion of the tumor suppressor Par-4 protein (also known as PAWR) and/or down-modulating the Par-4 receptor GRP78 on the cell surface (csGRP78). We sought to identify FDA-approved drugs that elevate csGRP78 on the surface of lung cancer cells and induce Par-4 secretion from the cancer cells and/or normal cells in order to inhibit cancer growth in an autocrine or paracrine manner. In an unbiased screen, we identified crizotinib (CZT), an inhibitor of activated ALK/MET/ROS1 receptor tyrosine kinase, as an inducer of csGRP78 expression in ALK-negative, KRAS or EGFR mutant lung cancer cells. Elevation of csGRP78 in the lung cancer cells was dependent on activation of the non-receptor tyrosine kinase SRC by CZT. Inhibition of SRC activation in the cancer cells prevented csGRP78 translocation but promoted Par-4 secretion by CZT, implying that activated SRC prevented Par-4 secretion. In normal cells, CZT did not activate SRC and csGRP78 elevation but induced Par-4 secretion. Consequently, CZT induced Par-4 secretion from normal cells and elevated csGRP78 in the ALK-negative tumor cells to cause paracrine apoptosis in cancer cell cultures and growth inhibition of tumor xenografts in mice. Thus, CZT induces differential activation of SRC in normal and cancer cells to trigger the pro-apoptotic Par-4-GRP78 axis. As csGRP78 is a targetable receptor, CZT can be repurposed to elevate csGRP78 for inhibition of ALK-negative lung tumors.
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2589522-9
ISSN	2156-6976
ISSN	2156-6976
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