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  1. Article ; Online: Radiation Exposure of Interventional Echocardiographers: Protecting and Nurturing a New Subspecialty.

    Kam, Kevin Ka-Ho / Lee, Alex Pui-Wai

    JACC. Asia

    2023  Volume 3, Issue 2, Page(s) 310–311

    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2772-3747
    ISSN (online) 2772-3747
    DOI 10.1016/j.jacasi.2023.01.003
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  2. Article ; Online: The diagnostic dilemma of fungal keratitis.

    Kam, Ka Wai / Rao, Srinivas K / Young, Alvin L

    Eye (London, England)

    2022  Volume 37, Issue 3, Page(s) 386–387

    MeSH term(s) Humans ; Corneal Ulcer ; Keratitis/diagnosis ; Eye Infections, Fungal/microbiology ; Antifungal Agents
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2022-08-13
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-022-02202-3
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  3. Article ; Online: Corneal nerve changes in herpes zoster ophthalmicus: a prospective longitudinal in vivo confocal microscopy study.

    Mok, Eugenie / Kam, Ka Wai / Young, Alvin L

    Eye (London, England)

    2023  Volume 37, Issue 14, Page(s) 3033–3040

    Abstract: Purpose: To study the changes in corneal nerves and corneal sensitivity over a 6-month period in patients with herpes zoster ophthalmicus (HZO) compared with healthy subjects.: Methods: This was a prospective longitudinal study on patients with newly ...

    Abstract Purpose: To study the changes in corneal nerves and corneal sensitivity over a 6-month period in patients with herpes zoster ophthalmicus (HZO) compared with healthy subjects.
    Methods: This was a prospective longitudinal study on patients with newly diagnosed HZO. In vivo confocal microscopy (IVCM) corneal nerve parameters and corneal sensitivity were measured and compared between eyes with HZO, contralateral eyes and controls at baseline, 2 and 6 months.
    Results: Fifteen subjects with HZO and 15 healthy age and sex matched controls were recruited. HZO eyes revealed a reduction in corneal nerve branch density (CNBD) from baseline to 2 months (9.65 ± 5.75 vs. 5.90 ± 6.87/mm
    Conclusion: Corneal denervation was present at 2 months in HZO eyes, with an observed recovery by 6 months. HZO fellow eyes demonstrated increased corneal nerve parameters at 2 months, which could represent a proliferative response to nerve degeneration. IVCM is useful in monitoring corneal nerve changes, and is more sensitive in detecting nerve alterations than esthesiometry.
    MeSH term(s) Humans ; Herpes Zoster Ophthalmicus ; Longitudinal Studies ; Prospective Studies ; Cornea/innervation ; Microscopy, Confocal/methods
    Language English
    Publishing date 2023-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-023-02469-0
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  4. Article ; Online: Pterygium: Surgical Techniques and Choices.

    Young, Alvin L / Kam, Ka Wai

    Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

    2019  Volume 8, Issue 6, Page(s) 422–423

    MeSH term(s) Humans ; Ophthalmologic Surgical Procedures/methods ; Pterygium/surgery
    Language English
    Publishing date 2019-11-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2756329-7
    ISSN 2162-0989 ; 2162-0989
    ISSN (online) 2162-0989
    ISSN 2162-0989
    DOI 10.1097/APO.0000000000000269
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  5. Article ; Online: Plug and Clip: Percutaneous Repair of a Perforated Mitral Valve Complicating Severe Functional Mitral Regurgitation.

    Lai, Leo Kar Lok / So, Chak-Yu / Chui, Ka-Lung / Kam, Kevin Ka-Ho / Kwok, Ka-Wai / Wong, Randolph Hung-Leung / Cheung, Gary Shing-Him / Lam, Yat-Yin / Lee, Alex Pui-Wai

    JACC. Cardiovascular interventions

    2022  Volume 15, Issue 4, Page(s) e41–e43

    MeSH term(s) Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/etiology ; Mitral Valve Insufficiency/surgery ; Surgical Instruments ; Treatment Outcome
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2021.12.009
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  6. Article ; Online: Correction to: Nicotinamide riboside as a neuroprotective therapy for glaucoma: study protocol for a randomized, double-blind, placebo-control trial.

    Leung, Christopher Kai Shun / Ren, Seraph Tianmin / Chan, Poemen Pui Man / Wan, Kelvin Ho Nam / Kam, Aziz Ka Wai / Lai, Gilda Wing Ki / Chiu, Vivian Sheung Man / Ko, Match Wai Lun / Yiu, Cedric Ka Fai / Yu, Marco Chak Yan

    Trials

    2022  Volume 23, Issue 1, Page(s) 134

    Language English
    Publishing date 2022-02-10
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-022-06079-1
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  7. Article ; Online: Cellular zinc metabolism and zinc signaling

    Bonan Chen / Peiyao Yu / Wai Nok Chan / Fuda Xie / Yigan Zhang / Li Liang / Kam Tong Leung / Kwok Wai Lo / Jun Yu / Gary M. K. Tse / Wei Kang / Ka Fai To

    Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-

    from biological functions to diseases and therapeutic targets

    2024  Volume 41

    Abstract: Abstract Zinc metabolism at the cellular level is critical for many biological processes in the body. A key observation is the disruption of cellular homeostasis, often coinciding with disease progression. As an essential factor in maintaining cellular ... ...

    Abstract Abstract Zinc metabolism at the cellular level is critical for many biological processes in the body. A key observation is the disruption of cellular homeostasis, often coinciding with disease progression. As an essential factor in maintaining cellular equilibrium, cellular zinc has been increasingly spotlighted in the context of disease development. Extensive research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells, despite its low tissue concentration. This has led to a growing body of literature investigating zinc’s cellular metabolism, particularly the functions of zinc transporters and storage mechanisms during cancer progression. Zinc transportation is under the control of two major transporter families: SLC30 (ZnT) for the excretion of zinc and SLC39 (ZIP) for the zinc intake. Additionally, the storage of this essential element is predominantly mediated by metallothioneins (MTs). This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression, with a special focus on cancer. We also compile a summary of clinical trials involving zinc ions. Given the main localization of zinc transporters at the cell membrane, the potential for targeted therapies, including small molecules and monoclonal antibodies, offers promising avenues for future exploration.
    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Shift in Tissue-Specific Immune Niches and CD137 Expression in Tuberculoma of Pembrolizumab-Treated Nasopharyngeal Carcinoma Patients.

    Kam, Ngar Woon / Lo, Anthony Wing Ip / Hung, Desmond Tae Yang / Ko, Ho / Wu, Ka Chun / Kwong, Dora Lai Wan / Lam, Ka On / Leung, To Wai / Che, Chi Ming / Lee, Victor Ho Fun

    Cancers

    2024  Volume 16, Issue 2

    Abstract: The use of immune checkpoint inhibitors (ICIs) in cancer treatment has shown promise but can also have unintended consequences, such as reactivating latent tuberculosis (TB). To develop treatments that address ICIs-related adverse events, it is essential ...

    Abstract The use of immune checkpoint inhibitors (ICIs) in cancer treatment has shown promise but can also have unintended consequences, such as reactivating latent tuberculosis (TB). To develop treatments that address ICIs-related adverse events, it is essential to understand cellular heterogeneity across healthy and pathological tissues. We performed cross-tissue multiplexed staining analysis on samples from two patients with TB reactivation during pembrolizumab treatment for metastatic nasopharyngeal carcinoma. CD8+ T cells, rather than CD4+ T cells, accumulated preferentially in the tuberculoma and were associated with increased production of IFNγ and expression of CD137. Additionally, CD137 enrichment played a role in the spatial organization of the tuberculoma, with specific interaction limited to spatial proximal cells between IFNγ+ CD137+ CD8+ T cells and IL12+ CD137+ type-1 macrophages. This unique feature was not observed in non-tumoral or tumoral tissues. Our analysis of public transcriptomic datasets supported the notion that this cellular interaction was more prominent in patients with durable ICI responses compared to those with non-ICI-related TB. We suggest that shifts towards CD137-rich immune niches are correlated with both off-target immune-related adverse events and anti-tumor efficacy. Targeting the tumor microenvironment through conditional activation of anti-CD137 signaling in combination with ICIs can modulate the reactivity of T cells and macrophages for localized tumor killing without the potential off-target immune-related risks associated with ICIs alone.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16020268
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  9. Article ; Online: Importance of parental involvement in paediatric palliative care in Hong Kong: qualitative case study.

    Wong, Frances Kam Yuet / Ho, Jacqueline Mei Chi / Lai, Tsz Chui / Lee, Lilian Po Yee / Ho, Eva Ka Yan / Lee, Susanna Wai Yee / Chan, Stephan C W / Fung, Cheuk Wing / Ho, Assunta Chi Hang / Li, Chak-Ho / Li, Chi Kong / Chiu, Annie Ting Gee / Tsui, Kwing Wan / Lam, Katherine Ka Wai

    Archives of disease in childhood

    2024  Volume 109, Issue 2, Page(s) 130–137

    Abstract: Objective: To compare and contrast the perceived care needs of children with life-limiting conditions (CLLC) from the perspectives of the children, parents and healthcare providers.: Design: A qualitative case study method using semistructured ... ...

    Abstract Objective: To compare and contrast the perceived care needs of children with life-limiting conditions (CLLC) from the perspectives of the children, parents and healthcare providers.
    Design: A qualitative case study method using semistructured interviews was employed with a within-case and across-case analysis. Themes and subthemes emerging from the cases were compared and contrasted in the across-case analysis to explore the similarities and variations in participant perceptions.
    Setting/participants: The setting was the paediatric departments of five regional hospitals in Hong Kong. Twenty-five sets of informants (CLLC-parent-healthcare provider) were recruited, with 65 individual interviews conducted.
    Results: A total of 3784 units of analysis were identified, resulting in three themes with subthemes. 'Living with the disease' (55.8%) occupied the largest proportion, followed by 'information and understanding about the disease' (27.4%), and 'care support and palliative care' (16.8%). Healthcare provider support mainly focused on physical concerns. Family and social support were present, but carer stress created tension between couples. Doctors were the primary source of medical information, but the parents had to seek further information via the internet and support from patient groups. There was a perceived need for better coordination and collaboration of care. The palliative care approach coordinated by nurses was seen as helpful in addressing the care needs of the CLLC.
    Conclusions: This original study identified the importance of palliative care with active engagement of parents which can address the service gap for CLLC.
    MeSH term(s) Child ; Humans ; Palliative Care ; Hong Kong ; Parents ; Social Support ; Qualitative Research
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2023-325810
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  10. Article ; Online: Effects of Oat β-Glucan and Inulin on Alleviation of Nonalcoholic Steatohepatitis Aggravated by Circadian Disruption in C57BL/6J Mice.

    Kei, Nelson / Cheung, Kam Kuen / Ma, Ka Lee / Yau, Tsz Kwan / Lauw, Susana / Wong, Vincent Wai Sun / You, Lijun / Cheung, Peter Chi Keung

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 7, Page(s) 3520–3535

    Abstract: This was the first study that examined the effects of oat β-glucan and inulin on diet-induced nonalcoholic steatohepatitis (NASH) in circadian-disrupted (CD)-male C57BL/6J mice. CD intensified NASH, significantly increasing alanine aminotransferase and ... ...

    Abstract This was the first study that examined the effects of oat β-glucan and inulin on diet-induced nonalcoholic steatohepatitis (NASH) in circadian-disrupted (CD)-male C57BL/6J mice. CD intensified NASH, significantly increasing alanine aminotransferase and upregulating hepatic tumor necrosis factor α (TNFα) and transforming growth factor β 1 (TGFβ1). However, these observations were significantly alleviated by oat β-glucan and inulin treatments. Compared to CD NASH mice, oat β-glucan significantly decreased the liver index, aspartate aminotransferase (AST), and insulin. In prebiotic-treated and CD NASH mice, significant negative correlations were found between enrichment of
    MeSH term(s) Male ; Mice ; Animals ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Inulin/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Mice, Inbred C57BL ; Liver/metabolism ; beta-Glucans
    Chemical Substances Inulin (9005-80-5) ; beta-glucan, (1-3)(1-4)- (55965-23-6) ; Tumor Necrosis Factor-alpha ; beta-Glucans
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c08028
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