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  1. Article ; Online: Erratum to: Cohen-Cutler S, Wong K, Mena V, et al. Hearing Loss Risk in Pediatric Patients Treated with Cranial Irradiation and Cisplatin-Based Chemotherapy. Int J Radiat Oncol Biol Phys 2021:110(5);1488-1495.

    Cohen-Cutler, Sally / Wong, Kenneth / Mena, Victoria / Sianto, Kevin / Wright, Michael A / Olch, Arthur / Orgel, Etan

    International journal of radiation oncology, biology, physics

    2021  Volume 112, Issue 3, Page(s) 838–839

    Language English
    Publishing date 2021-12-21
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2021.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1218: Show issues Location:
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  2. Article ; Online: POIROT: a powerful test for parent-of-origin effects in unrelated samples leveraging multiple phenotypes.

    Head, S Taylor / Leslie, Elizabeth J / Cutler, David J / Epstein, Michael P

    Bioinformatics (Oxford, England)

    2023  Volume 39, Issue 4

    Abstract: Motivation: There is widespread interest in identifying genetic variants that exhibit parent-of-origin effects (POEs) wherein the effect of an allele on phenotype expression depends on its parental origin. POEs can arise from different phenomena ... ...

    Abstract Motivation: There is widespread interest in identifying genetic variants that exhibit parent-of-origin effects (POEs) wherein the effect of an allele on phenotype expression depends on its parental origin. POEs can arise from different phenomena including genomic imprinting and have been documented for many complex traits. Traditional tests for POEs require family data to determine parental origins of transmitted alleles. As most genome-wide association studies (GWAS) sample unrelated individuals (where allelic parental origin is unknown), the study of POEs in such datasets requires sophisticated statistical methods that exploit genetic patterns we anticipate observing when POEs exist. We propose a method to improve discovery of POE variants in large-scale GWAS samples that leverages potential pleiotropy among multiple correlated traits often collected in such studies. Our method compares the phenotypic covariance matrix of heterozygotes to homozygotes based on a Robust Omnibus Test. We refer to our method as the Parent of Origin Inference using Robust Omnibus Test (POIROT) of multiple quantitative traits.
    Results: Through simulation studies, we compared POIROT to a competing univariate variance-based method which considers separate analysis of each phenotype. We observed POIROT to be well-calibrated with improved power to detect POEs compared to univariate methods. POIROT is robust to non-normality of phenotypes and can adjust for population stratification and other confounders. Finally, we applied POIROT to GWAS data from the UK Biobank using BMI and two cholesterol phenotypes. We identified 338 genome-wide significant loci for follow-up investigation.
    Availability and implementation: The code for this method is available at https://github.com/staylorhead/POIROT-POE.
    MeSH term(s) Genome-Wide Association Study/methods ; Phenotype ; Genetic Testing ; Genomic Imprinting ; Computer Simulation ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btad199
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    Zs.A 2374: Show issues Location:
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  3. Article: Development and evaluation of mouse anti-Ara h 1 and Ara h 3 IgE monoclonal antibodies for advancing peanut allergy research.

    Waritani, Takaki / Lomax, Sidney / Cutler, Dawn / Chang, Jessica

    MethodsX

    2023  Volume 11, Page(s) 102470

    Abstract: Immediate hypersensitivity reactions to peanuts are a considerable public health concern due to the acute and severe IgE mediated reactions. To conduct research on the pathogenesis and therapeutics of peanut allergies, it is imperative to have mouse anti- ...

    Abstract Immediate hypersensitivity reactions to peanuts are a considerable public health concern due to the acute and severe IgE mediated reactions. To conduct research on the pathogenesis and therapeutics of peanut allergies, it is imperative to have mouse anti-crude peanut extract (CPE) IgE monoclonal antibodies (mAbs) for both
    Language English
    Publishing date 2023-11-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2830212-6
    ISSN 2215-0161
    ISSN 2215-0161
    DOI 10.1016/j.mex.2023.102470
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  4. Article ; Online: Chemical Approaches for Improving Plant Water Use.

    Vaidya, Aditya S / Cutler, Sean R

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2462, Page(s) 221–230

    Abstract: Agricultural productivity in rain-fed crops has been threatened in recent decades due to increased instances of drought and diminishing freshwater resources. This has led to the development of novel chemical and genetic approaches for improving plant ... ...

    Abstract Agricultural productivity in rain-fed crops has been threatened in recent decades due to increased instances of drought and diminishing freshwater resources. This has led to the development of novel chemical and genetic approaches for improving plant water use efficiency. Agrochemical water-banking with the aid of synthetic mimics of phytohormone abscisic acid (ABA) is one such approach, whereby plant transpiration can be chemically tuned to ensure water availability during critical stages of growth. Here, we describe the use of infrared thermography, a noninvasive quantitative technique to evaluate antitranspirant efficacy of existing ABA receptor agonists in crops such as wheat and tomato.
    MeSH term(s) Abscisic Acid/pharmacology ; Droughts ; Gene Expression Regulation, Plant ; Lycopersicon esculentum/metabolism ; Plants/metabolism ; Water/metabolism
    Chemical Substances Water (059QF0KO0R) ; Abscisic Acid (72S9A8J5GW)
    Language English
    Publishing date 2022-02-13
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2156-1_17
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  5. Article ; Online: Identifying latent genetic interactions in genome-wide association studies using multiple traits.

    Bass, Andrew J / Bian, Shijia / Wingo, Aliza P / Wingo, Thomas S / Cutler, David J / Epstein, Michael P

    Genome medicine

    2024  Volume 16, Issue 1, Page(s) 62

    Abstract: The "missing" heritability of complex traits may be partly explained by genetic variants interacting with other genes or environments that are difficult to specify, observe, and detect. We propose a new kernel-based method called Latent Interaction ... ...

    Abstract The "missing" heritability of complex traits may be partly explained by genetic variants interacting with other genes or environments that are difficult to specify, observe, and detect. We propose a new kernel-based method called Latent Interaction Testing (LIT) to screen for genetic interactions that leverages pleiotropy from multiple related traits without requiring the interacting variable to be specified or observed. Using simulated data, we demonstrate that LIT increases power to detect latent genetic interactions compared to univariate methods. We then apply LIT to obesity-related traits in the UK Biobank and detect variants with interactive effects near known obesity-related genes (URL: https://CRAN.R-project.org/package=lit ).
    MeSH term(s) Humans ; Genome-Wide Association Study ; Obesity/genetics ; Epistasis, Genetic ; Quantitative Trait, Heritable ; Quantitative Trait Loci ; Models, Genetic ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease ; Genetic Pleiotropy ; Phenotype ; Multifactorial Inheritance
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2484394-5
    ISSN 1756-994X ; 1756-994X
    ISSN (online) 1756-994X
    ISSN 1756-994X
    DOI 10.1186/s13073-024-01329-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Refugee crisis and re-emergence of forgotten infections in Europe.

    Cutler, S J

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2016  Volume 22, Issue 1, Page(s) 8–9

    MeSH term(s) Animals ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/transmission ; Emigration and Immigration ; Europe/epidemiology ; Humans ; Ornithodoros/growth & development ; Refugees ; Relapsing Fever/epidemiology ; Relapsing Fever/pathology ; Relapsing Fever/transmission
    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Editorial
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2015.10.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
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    Zs.MO 284: Show issues

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  7. Article: MITRAL REGURGITATION IN SADDLE-BILLED STORKS (

    Torres, Rodrigo S Garcés / Vilá, Jorge / MacLean, Robert A / Cutler, Daniel C

    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians

    2024  Volume 54, Issue 4, Page(s) 845–854

    Abstract: The asymptomatic and slow progressive nature of cardiopathies represents a risk to the welfare of avian species in human care. Diagnosis and treatment of cardiac disease in birds pose a challenge due to unique anatomic and physiologic characteristics. ... ...

    Abstract The asymptomatic and slow progressive nature of cardiopathies represents a risk to the welfare of avian species in human care. Diagnosis and treatment of cardiac disease in birds pose a challenge due to unique anatomic and physiologic characteristics. Comprehensive cardiac assessments with diagnostic tools such as echocardiography, color-Doppler, the biomarker cardiac troponin I (cTn1), and cholesterol serum concentrations have been utilized in different bird species with varying success. Saddle-billed storks (
    MeSH term(s) Animals ; Humans ; Mitral Valve Insufficiency/diagnosis ; Mitral Valve Insufficiency/veterinary ; Birds ; Echocardiography/veterinary ; Digoxin ; Cholesterol
    Chemical Substances Digoxin (73K4184T59) ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2174930-9
    ISSN 1937-2825 ; 1042-7260
    ISSN (online) 1937-2825
    ISSN 1042-7260
    DOI 10.1638/2023-0039
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  8. Article ; Online: Digital Health to Patient-Facing Artificial Intelligence: Ethical Implications and Threats to Dignity for Patients With Cancer.

    Kelkar, Amar H / Hantel, Andrew / Koranteng, Erica / Cutler, Corey S / Hammer, Marilyn J / Abel, Gregory A

    JCO oncology practice

    2023  Volume 20, Issue 3, Page(s) 314–317

    Abstract: Ethical considerations for patient-facing AI for oncology: dignity, autonomy, safety, equity, inclusivity. ...

    Abstract Ethical considerations for patient-facing AI for oncology: dignity, autonomy, safety, equity, inclusivity.
    MeSH term(s) Humans ; Artificial Intelligence ; Digital Health ; Respect ; Neoplasms ; Medical Oncology
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.23.00412
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  9. Article ; Online: Neglected zoonoses: forgotten infections among disregarded populations.

    Cutler, S J

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2015  Volume 21, Issue 5, Page(s) 392–393

    MeSH term(s) Animals ; Humans ; Neglected Diseases/epidemiology ; Neglected Diseases/prevention & control ; Zoonoses/epidemiology ; Zoonoses/prevention & control
    Keywords covid19
    Language English
    Publishing date 2015-05-08
    Publishing country England
    Document type Editorial
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2015.04.023
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  10. Article ; Online: Assessment of climate change effects on vegetation and river hydrology in a semi-arid river basin.

    Ougahi, Jamal Hassan / E J Cutler, Mark / J Cook, Simon

    PloS one

    2022  Volume 17, Issue 8, Page(s) e0271991

    Abstract: Climate change plays a key role in changing vegetation productivity dynamics, which ultimately affect the hydrological cycle of a watershed through evapotranspiration (ET). Trends and correlation analysis were conducted to investigate vegetation ... ...

    Abstract Climate change plays a key role in changing vegetation productivity dynamics, which ultimately affect the hydrological cycle of a watershed through evapotranspiration (ET). Trends and correlation analysis were conducted to investigate vegetation responses across the whole Upper Jhelum River Basin (UJRB) in the northeast of Pakistan using the normalized difference vegetation index (NDVI), climate variables, and river flow data at inter-annual/monthly scales between 1982 and 2015. The spatial variability in trends calculated with the Mann-Kendall (MK) trend test on NDVI and climate data was assessed considering five dominant land use/cover types. The inter-annual NDVI in four out of five vegetation types showed a consistent increase over the 34-year study period; the exception was for herbaceous vegetation (HV), which increased until the end of the 1990s and then decreased slightly in subsequent years. In spring, significant (p<0.05) increasing trends were found in the NDVI of all vegetation types. Minimum temperature (Tmin) showed a significant increase during spring, while maximum temperature (Tmax) decreased significantly during summer. Average annual increase in Tmin (1.54°C) was much higher than Tmax (0.37°C) over 34 years in the UJRB. Hence, Tmin appears to have an enhancing effect on vegetation productivity over the UJRB. A significant increase in NDVI, Tmin and Tmax during spring may have contributed to reductions in spring river flow by enhancing evapotranspiration observed in the watershed of UJRB. These findings provide valuable information to improve our knowledge and understanding about the interlinkages between vegetation, climate and river flow at a watershed scale.
    MeSH term(s) China ; Climate Change ; Ecosystem ; Environmental Monitoring ; Hydrology ; Rivers ; Seasons ; Temperature
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0271991
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