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  1. Article ; Online: Time to consider catheter ablation as an alternative to implantable cardioverter-defibrillator therapy in high-risk patients with Brugada syndrome?

    Conte, Giulio / Probst, Vincent

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2023  Volume 25, Issue 12

    MeSH term(s) Humans ; Defibrillators, Implantable/adverse effects ; Brugada Syndrome/diagnosis ; Brugada Syndrome/therapy ; Brugada Syndrome/physiopathology ; Atrial Appendage/surgery ; Electrocardiography ; Vascular Diseases/etiology ; Punctures ; Catheter Ablation/adverse effects
    Language English
    Publishing date 2023-11-10
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/euad338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5434: Show issues Location:
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  2. Article ; Online: Is right ventricular outflow tract epicardial substrate ablation the standard of care in high-risk Brugada syndrome?

    Behr, Elijah R / Conte, Giulio / Wilde, Arthur

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2024  Volume 26, Issue 1

    MeSH term(s) Humans ; Brugada Syndrome/diagnosis ; Brugada Syndrome/surgery ; Brugada Syndrome/complications ; Defibrillators, Implantable ; Standard of Care ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/surgery ; Heart Ventricles/physiopathology ; Arrhythmias, Cardiac/physiopathology ; Catheter Ablation/adverse effects
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/euae020
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  3. Article ; Online: Letter to the Editor-Electrophysiological study in women with Brugada Syndrome.

    Belhassen, Bernard / Conte, Giulio

    Heart rhythm

    2021  Volume 18, Issue 6, Page(s) 1039

    MeSH term(s) Brugada Syndrome/diagnosis ; Electrocardiography ; Female ; Heart Ventricles ; Humans
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2021.03.021
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  4. Article ; Online: Family History of Sudden Cardiac Death in the Young and Inherited Arrhythmia Syndromes: Awareness and Attitudes of General Practitioners and Private Practice Cardiologists.

    Piciacchia, Flavia / Auricchio, Angelo / Behr, Elijah R / Wilde, Arthur A M / Conte, Giulio

    Circulation. Genomic and precision medicine

    2023  Volume 16, Issue 1, Page(s) e003913

    MeSH term(s) Humans ; Syndrome ; Cardiologists ; General Practitioners ; Arrhythmias, Cardiac/genetics ; Death, Sudden, Cardiac ; Private Practice ; Attitude
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ISSN 2574-8300
    ISSN (online) 2574-8300
    DOI 10.1161/CIRCGEN.122.003913
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  5. Article ; Online: Management of ventricular tachycardias: insights on centre settings, procedural workflow, endpoints, and implementation of guidelines-results from an EHRA survey.

    Sultan, Arian / Futyma, Piotr / Metzner, Andreas / Anic, Ante / Richter, Sergio / Roten, Laurent / Badertscher, Patrick / Conte, Giulio / Chun, Julian K R

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2024  Volume 26, Issue 2

    Abstract: Ventricular tachycardia (VT), and its occurrence, is still one of the main reasons for sudden cardiac death and, therefore, for increased mortality and morbidity foremost in patients with structural heart [Kahle A-K, Jungen C, Alken F-A, Scherschel K, ... ...

    Abstract Ventricular tachycardia (VT), and its occurrence, is still one of the main reasons for sudden cardiac death and, therefore, for increased mortality and morbidity foremost in patients with structural heart [Kahle A-K, Jungen C, Alken F-A, Scherschel K, Willems S, Pürerfellner H et al. Management of ventricular tachycardia in patients with ischaemic cardiomyopathy: contemporary armamentarium. Europace 2022;24:538-51]. Catheter ablation has become a safe and effective treatment option in patients with recurrent VT [Cronin EM, Bogun FM, Maury P, Peichl P, Chen M, Namboodiri N et al. 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias. Heart Rhythm 2020;17:e2-154]. Previous and current guidelines provide guidance on indication for VT ablation and risk assessment and evaluation of underlying disease. However, no uniform recommendation is provided regarding procedural strategies, timing of ablation, and centre setting. Therefore, these specifics seem to differ largely, and recent data are sparse. This physician-based European Heart Rhythm Association survey aims to deliver insights on not only infrastructural settings but also procedural specifics, applied technologies, ablation strategies, and procedural endpoints. Therefore, these findings might deliver a real-world scenario of VT management and potentially are of guidance for other centres.
    MeSH term(s) Humans ; Workflow ; Tachycardia, Ventricular/diagnosis ; Tachycardia, Ventricular/surgery ; Arrhythmias, Cardiac/surgery ; Treatment Outcome ; Myocardial Ischemia ; Catheter Ablation/methods
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/euae030
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  6. Article ; Online: Cognitive Reserve Potential: Capturing Cognitive Resilience Capability in Adolescence.

    Conte, Federica / Rinaldi, Luca / Gerosa, Tiziano / Mondini, Sara / Costantini, Giulio / Girelli, Luisa

    Assessment

    2023  , Page(s) 10731911231183363

    Abstract: Cognitive reserve (CR) represents the adaptive response of the cognitive system responsible for preserving normal functioning in the face of brain damage. Experiential factors such as education, occupation, and leisure activities influence the ... ...

    Abstract Cognitive reserve (CR) represents the adaptive response of the cognitive system responsible for preserving normal functioning in the face of brain damage. Experiential factors such as education, occupation, and leisure activities influence the development of CR. Theoretically, such factors build up from childhood and across adulthood. Thus, appropriate tools to define and measure CR as early as adolescence are essential to understand its developmental processes. To this aim, we introduce the construct of "Cognitive Reserve Potential" (CRP) and its corresponding index of experiential factors tailored to youth. We investigated prototypical youth exposures potentially associated with the lifelong development of CR (e.g., sport practice, musical experiences, cultural activities, and relationships with peers and family). Principal component analysis and confirmatory factor analysis identified and replicated the CRP factor structure on two independent samples of Italian students:
    Language English
    Publishing date 2023-07-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1362144-0
    ISSN 1552-3489 ; 1073-1911
    ISSN (online) 1552-3489
    ISSN 1073-1911
    DOI 10.1177/10731911231183363
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    Zs.A 4650: Show issues Location:
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  7. Article ; Online: Adjusted Unit Value Transfer as a Tool for Raising Awareness on Ecosystem Services Provided by Constructed Wetlands for Water Pollution Control: An Italian Case Study.

    Rizzo, Anacleto / Conte, Giulio / Masi, Fabio

    International journal of environmental research and public health

    2021  Volume 18, Issue 4

    Abstract: Constructed wetlands (CWs) are nature-based solutions (NBS) for water pollution control that can also be designed to be multipurpose in terms of additional ecosystem services (ESs), such as biodiversity support and social benefits. Awareness about ... ...

    Abstract Constructed wetlands (CWs) are nature-based solutions (NBS) for water pollution control that can also be designed to be multipurpose in terms of additional ecosystem services (ESs), such as biodiversity support and social benefits. Awareness about additional ESs of CWs can be raised with value transfer (VT) methods for ESs monetization, in particular, the simplified adjusted unit VT method. A multi-criteria analysis (MCA) was performed to compare grey and green infrastructure alternatives for the management of a combined sewer overflow in the Buccinasco town (Italy), in which the criteria related to ESs were monetized with an adjusted VT method (B£ST software). The results highlighted the potential interest in the implementation of the green infrastructure in a new urban park, due to the activation of additional ESs of interest, such as health and recreational aspects. The results were also confirmed by a sensitivity analysis, which simulated the variation of preferences among different stakeholder groups (e.g., citizens, environmentalists). In conclusion, this work provided a transparent methodology to support decisions regarding green and grey infrastructure, allowing to evaluate additional ESs from the beginning of the decision stage with low cost and efforts.
    MeSH term(s) Cities ; Conservation of Natural Resources ; Ecosystem ; Italy ; Water Pollution/prevention & control ; Wetlands
    Language English
    Publishing date 2021-02-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18041531
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  8. Article ; Online: Adjusted Unit Value Transfer as a Tool for Raising Awareness on Ecosystem Services Provided by Constructed Wetlands for Water Pollution Control

    Anacleto Rizzo / Giulio Conte / Fabio Masi

    International Journal of Environmental Research and Public Health, Vol 18, Iss 1531, p

    An Italian Case Study

    2021  Volume 1531

    Abstract: Constructed wetlands (CWs) are nature-based solutions (NBS) for water pollution control that can also be designed to be multipurpose in terms of additional ecosystem services (ESs), such as biodiversity support and social benefits. Awareness about ... ...

    Abstract Constructed wetlands (CWs) are nature-based solutions (NBS) for water pollution control that can also be designed to be multipurpose in terms of additional ecosystem services (ESs), such as biodiversity support and social benefits. Awareness about additional ESs of CWs can be raised with value transfer (VT) methods for ESs monetization, in particular, the simplified adjusted unit VT method. A multi-criteria analysis (MCA) was performed to compare grey and green infrastructure alternatives for the management of a combined sewer overflow in the Buccinasco town (Italy), in which the criteria related to ESs were monetized with an adjusted VT method (B£ST software). The results highlighted the potential interest in the implementation of the green infrastructure in a new urban park, due to the activation of additional ESs of interest, such as health and recreational aspects. The results were also confirmed by a sensitivity analysis, which simulated the variation of preferences among different stakeholder groups (e.g., citizens, environmentalists). In conclusion, this work provided a transparent methodology to support decisions regarding green and grey infrastructure, allowing to evaluate additional ESs from the beginning of the decision stage with low cost and efforts.
    Keywords constructed wetland ; treatment wetland ; ecosystem service ; value transfer ; nature-based solution ; green-blue infrastructure ; Medicine ; R
    Subject code 710
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Induction of Autophagy Promotes Clearance of RHO

    Intartaglia, Daniela / Giamundo, Giuliana / Naso, Federica / Nusco, Edoardo / Di Giulio, Simona / Salierno, Francesco Giuseppe / Polishchuk, Elena / Conte, Ivan

    Frontiers in aging neuroscience

    2022  Volume 14, Page(s) 878958

    Abstract: Autophagy is a critical metabolic process that acts as a major self-digestion and recycling pathway contributing to maintain cellular homeostasis. An emerging field of research supports the therapeutic modulation of autophagy for treating human ... ...

    Abstract Autophagy is a critical metabolic process that acts as a major self-digestion and recycling pathway contributing to maintain cellular homeostasis. An emerging field of research supports the therapeutic modulation of autophagy for treating human neurodegenerative disorders, in which toxic aggregates are accumulated in neurons. Our previous study identified Ezrin protein as an inhibitor of autophagy and lysosomal functions in the retina; thus, in turn, identifying it as a potential pharmacological target for increasing retinal cell clearance to treat inherited retinal dystrophies in which misfolded proteins have accumulated. This study aimed to verify the therapeutic inhibition of Ezrin to induce clearance of toxic aggregates in a mouse model for a dominant form of retinitis pigmentosa (i.e., RHO
    Language English
    Publishing date 2022-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2022.878958
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  10. Article ; Online: Deep Generative Models: The winning key for large and easily accessible ECG datasets?

    Monachino, Giuliana / Zanchi, Beatrice / Fiorillo, Luigi / Conte, Giulio / Auricchio, Angelo / Tzovara, Athina / Faraci, Francesca Dalia

    Computers in biology and medicine

    2023  Volume 167, Page(s) 107655

    Abstract: Large high-quality datasets are essential for building powerful artificial intelligence (AI) algorithms capable of supporting advancement in cardiac clinical research. However, researchers working with electrocardiogram (ECG) signals struggle to get ... ...

    Abstract Large high-quality datasets are essential for building powerful artificial intelligence (AI) algorithms capable of supporting advancement in cardiac clinical research. However, researchers working with electrocardiogram (ECG) signals struggle to get access and/or to build one. The aim of the present work is to shed light on a potential solution to address the lack of large and easily accessible ECG datasets. Firstly, the main causes of such a lack are identified and examined. Afterward, the potentials and limitations of cardiac data generation via deep generative models (DGMs) are deeply analyzed. These very promising algorithms have been found capable not only of generating large quantities of ECG signals but also of supporting data anonymization processes, to simplify data sharing while respecting patients' privacy. Their application could help research progress and cooperation in the name of open science. However several aspects, such as a standardized synthetic data quality evaluation and algorithm stability, need to be further explored.
    MeSH term(s) Humans ; Artificial Intelligence ; Electrocardiography ; Heart ; Algorithms ; Data Accuracy
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2023.107655
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