Article ; Online: Association of carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis with the HLA-B75 serotype or HLA-B*15:21 allele in Filipino patients.
2020 Volume 20, Issue 3, Page(s) 533–541
Abstract: A case-control study was conducted to investigate the association of HLA-A alleles, HLA-B alleles including HLA-B*15:02 and HLA-B75 serotype with carbamazepine-induced SJS/TEN in Filipino patients. A retrospective review of medical records was performed. ...
| Abstract | A case-control study was conducted to investigate the association of HLA-A alleles, HLA-B alleles including HLA-B*15:02 and HLA-B75 serotype with carbamazepine-induced SJS/TEN in Filipino patients. A retrospective review of medical records was performed. Pertinent clinical data were collected. Eight (8) carbamazepine-induced SJS/TEN cases and 32 tolerant controls were recruited. Genomic DNA was extracted from the saliva samples and genotyping was performed by employing allele-specific polymerase chain reaction. Data were analyzed using the Fisher's exact test, Mann-Whitney U test, univariate logistic regression, and multivariate logistic regression. Single allele association analysis was done. The strength of association was expressed as odds ratio with 95% confidence interval. Positive predictive value, negative predictive value, sensitivity, and specificity were computed. Of all the alleles tested, the HLA-B75 serotype (p = 0.007, OR = 23.25, 95% CI = 2.33-232.21) and HLA-B*15:21 (p = 0.026, OR = 7.53, 95% CI = 1.27-44.79) were significantly associated with carbamazepine-induced SJS/TEN. The HLA-B75 serotype or HLA-B*15:21 allele may be used as a genetic risk assessment prior to prescription for prevention of carbamazepine-induced SJS/TEN in Filipino patients. |
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| MeSH term(s) | Adult ; Alleles ; Anticonvulsants/adverse effects ; Asian Continental Ancestry Group/genetics ; Carbamazepine/adverse effects ; Case-Control Studies ; Female ; HLA-B Antigens/genetics ; Humans ; Male ; Middle Aged ; Philippines/epidemiology ; Serogroup ; Stevens-Johnson Syndrome/epidemiology ; Stevens-Johnson Syndrome/genetics ; Young Adult |
| Chemical Substances | Anticonvulsants ; HLA-B Antigens ; HLA-B75 antigen ; Carbamazepine (33CM23913M) |
| Language | English |
| Publishing date | 2020-01-03 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2106831-8 |
| ISSN | 1473-1150 ; 1470-269X |
| ISSN (online) | 1473-1150 |
| ISSN | 1470-269X |
| DOI | 10.1038/s41397-019-0143-8 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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