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  1. Article ; Online: ESR Essentials: diagnosis of hepatocellular carcinoma-practice recommendations by ESGAR.

    Cannella, Roberto / Zins, Marc / Brancatelli, Giuseppe

    European radiology

    2024  Volume 34, Issue 4, Page(s) 2127–2139

    Abstract: Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy and a leading cause of cancer related death worldwide. Current guidelines for the noninvasive diagnosis of HCC are provided by the European Association for the Study of the ... ...

    Abstract Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy and a leading cause of cancer related death worldwide. Current guidelines for the noninvasive diagnosis of HCC are provided by the European Association for the Study of the Liver (EASL), the American Association for the Study of Liver Diseases (AASLD) which endorsed the Liver Imaging Reporting and Data System (LI-RADS) algorithm, the Korean Liver Cancer Association-National Cancer Center (KLCA-NCC), and the Asian-Pacific Association for the Study of the Liver (APASL). These allow the diagnosis of HCC in high-risk patients in the presence of typical imaging features on contrast-enhanced CT, MRI, or contrast-enhanced ultrasound. Size, non-rim arterial phase hyperenhancement, non-peripheral washout, enhancing capsule, and growth are major imaging features and they should be combined for the diagnosis of HCC. This article provides concise and relevant practice recommendations aimed at general radiologist audience, summarizing the best practice and informing on the essential imaging criteria for the diagnosis of HCC, while also discussing the high-risk population criteria, imaging modalities, and imaging features according to the current guidelines. KEY POINTS: • Noninvasive diagnosis of hepatocellular carcinoma (HCC) can be provided only in patients at high risk. • Contrast-enhanced CT or MRI are the first-line imaging exams for the diagnosis of HCC. • Major imaging features should be combined to provide the diagnosis of definitive HCC.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Tomography, X-Ray Computed/methods ; Contrast Media ; Magnetic Resonance Imaging/methods ; Retrospective Studies ; Sensitivity and Specificity
    Chemical Substances Contrast Media
    Language English
    Publishing date 2024-02-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-024-10606-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: CT and MR Imaging of Retroperitoneal Sarcomas: A Practical Guide for the Radiologist.

    Porrello, Giorgia / Cannella, Roberto / Randazzo, Angelo / Badalamenti, Giuseppe / Brancatelli, Giuseppe / Vernuccio, Federica

    Cancers

    2023  Volume 15, Issue 11

    Abstract: Primary retroperitoneal sarcomas (RPS) represent around 10-16% of all sarcomas, with liposarcomas and leiomyosarcomas being the most common subtypes. RPS have some peculiar characteristics, imaging appearances, worse prognosis, and complications compared ...

    Abstract Primary retroperitoneal sarcomas (RPS) represent around 10-16% of all sarcomas, with liposarcomas and leiomyosarcomas being the most common subtypes. RPS have some peculiar characteristics, imaging appearances, worse prognosis, and complications compared to other locations of sarcoma. Commonly, RPS primarily present as large masses, progressively encasing adjacent structures, causing mass effect, and complications. RPS diagnosis is often challenging, and these tumors may be overlooked; however, failure to recognize RPS characteristics leads to a worse prognosis for the patients. Surgery is the only recognized curative treatment, but the anatomical constraints of the retroperitoneum limit the ability to achieve wide resection margins; therefore, these tumors have a high rate of recurrence, and require long-term follow-up. The radiologist has an important role in the diagnosis of RPS, the definition of their extent, and their follow-up. Specific knowledge of the main imaging findings is required to reach an early diagnosis, and, ultimately, to guarantee the best patient management. This article provides an overview of the current knowledge regarding cross-sectional imaging features of patients with retroperitoneal sarcomas, presenting tips and tricks to improve imaging diagnosis of RPS.
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15112985
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  3. Article ; Online: Influence of H-bond competitors on the solvent-dependent structures of an octaurea-calix[4]tube.

    Milone, Marco / Pisagatti, Ilenia / Gattuso, Giuseppe / Notti, Anna / Parisi, Melchiorre F / Brancatelli, Giovanna / Hickey, Neal / Geremia, Silvano

    RSC advances

    2024  Volume 14, Issue 7, Page(s) 4448–4455

    Abstract: A novel octaurea-calix[4]tube (UC4T) has been synthesized in three steps from the original Beer' ... ...

    Abstract A novel octaurea-calix[4]tube (UC4T) has been synthesized in three steps from the original Beer's
    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra08764f
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  4. Article: The Neoplastic Side of the Abdominal Wall: A Comprehensive Pictorial Essay of Benign and Malignant Neoplasms.

    Porrello, Giorgia / Cannella, Roberto / Alvarez-Hornia Pérez, Eduardo / Brancatelli, Giuseppe / Vernuccio, Federica

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 2

    Abstract: Abdominal wall neoplasms are usually benign and, in the majority of these cases, no further work-up or treatment is indicated. The percentage of malignant abdominal neoplasms, however, is not negligible. Radiologists play a pivotal role in identifying ... ...

    Abstract Abdominal wall neoplasms are usually benign and, in the majority of these cases, no further work-up or treatment is indicated. The percentage of malignant abdominal neoplasms, however, is not negligible. Radiologists play a pivotal role in identifying imaging features that should favor malignancy, including larger lesion size, edema, neurovascular involvement, and peripheral or inhomogeneous dynamic enhancement, thus indicating to the clinician the need for further work-up. Histopathology is the reference standard for the characterization of abdominal wall neoplasms. In patients undergoing surgery, radiological assessment is needed to guide the surgeon by providing a comprehensive anatomic guide of the tumor extension. We present a pictorial review of benign and malignant abdominal wall neoplasms that can be encountered on radiological examinations, with a main focus on CT and MRI features that help in narrowing the differential diagnosis.
    Language English
    Publishing date 2023-01-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13020315
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  5. Article: Liver imaging and pregnancy: what to expect when your patient is expecting.

    Porrello, Giorgia / Cannella, Roberto / Bernuau, Jacques / Agman, Antoine / Brancatelli, Giuseppe / Dioguardi Burgio, Marco / Vilgrain, Valérie

    Insights into imaging

    2024  Volume 15, Issue 1, Page(s) 66

    Abstract: Liver diseases in pregnancy can be specific to gestation or only coincidental. In the latter case, the diagnosis can be difficult. Rapid diagnosis of maternal-fetal emergencies and situations requiring specialized interventions are crucial to preserve ... ...

    Abstract Liver diseases in pregnancy can be specific to gestation or only coincidental. In the latter case, the diagnosis can be difficult. Rapid diagnosis of maternal-fetal emergencies and situations requiring specialized interventions are crucial to preserve the maternal liver and guarantee materno-fetal survival. While detailed questioning of the patient and a clinical examination are highly important, imaging is often essential to reach a diagnosis of these liver diseases and lesions. Three groups of liver diseases may be observed during pregnancy: (1) diseases related to pregnancy: intrahepatic cholestasis of pregnancy, pre-eclampsia, eclampsia, hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome, and acute fatty liver of pregnancy; (2) liver diseases that are more frequent during or exacerbated by pregnancy: acute herpes simplex hepatitis, Budd-Chiari syndrome, hemorrhagic hereditary telangiectasia, hepatocellular adenoma, portal vein thrombosis, and cholelithiasis; (3) coincidental conditions, including acute hepatitis, incidental focal liver lesions, metabolic dysfunction-associated steatotic liver disease, cirrhosis, hepatocellular carcinoma, liver abscesses and parasitosis, and liver transplantation. Specific knowledge of the main imaging findings is required to reach an early diagnosis, for adequate follow-up, and to avoid adverse consequences in both the mother and the fetus.Critical relevance statement Pregnancy-related liver diseases are the most important cause of liver dysfunction in pregnant patients and, in pregnancy, even common liver conditions can have an unexpected turn. Fear of radiations should never delay necessary imaging studies in pregnancy.Key points• Pregnancy-related liver diseases are the most frequent cause of liver dysfunction during gestation.• Fear of radiation should never delay necessary imaging studies.• Liver imaging is important to assess liver emergencies and for the diagnosis and follow-up of any other liver diseases.• Common liver conditions and lesions may take an unexpected turn during pregnancy.• Pregnancy-specific diseases such as pre-eclampsia and HELLP syndrome must be rapidly identified. However, imaging should never delay delivery when it is considered to be urgent for maternal-fetal survival.
    Language English
    Publishing date 2024-02-27
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2543323-4
    ISSN 1869-4101
    ISSN 1869-4101
    DOI 10.1186/s13244-024-01622-x
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  6. Article ; Online: Changes in the ultrasound presentation of hepatocellular carcinoma: a center's three decades of experience.

    Giannitrapani, Lydia / Amodeo, Simona / Mirarchi, Luigi / Terranova, Antonino / Seidita, Aurelio / Mozzini, Chiara / Cabibi, Daniela / Brancatelli, Giuseppe / Licata, Anna / Soresi, Maurizio

    Journal of ultrasound

    2024  

    Abstract: Purpose: Ultrasound (US) surveillance is a cornerstone for early diagnosis of HCC, anyway US presentation has undergone significant changes. With the aim of evaluating the effects of US surveillance program in the real-world clinical practice, we wanted ...

    Abstract Purpose: Ultrasound (US) surveillance is a cornerstone for early diagnosis of HCC, anyway US presentation has undergone significant changes. With the aim of evaluating the effects of US surveillance program in the real-world clinical practice, we wanted to evaluate US presentation of HCCs over the last 30 years and the differences of HCCs presentation according to etiology.
    Methods: 174 patients diagnosed between 1993 and 98 (G1), 96 between 2003 and 08 (G2), 102 between 2013 and 18 (G3), were compared. US patterns were: single, multiple or diffuse nodules. The echo-patterns: iso-, hypo-, hyper-echoic, or mixed. In G1, the HCC diagnosis was mainly histologic; in G2 by EASL 2001 and AASLD 2005, in G3 AASLD 2011, EASL 2012, and AISF 2013 guidelines.
    Results: HCV was the most frequent etiology, dropping between G1 (81%) and G3 (66%) (P < 0.01), metabolic increased between G1 (5%) and G3 (14%) (P < 0.01). Single HCC was more prevalent in G3 vs G1 (65.6% vs 40%) (P < 0.0001), multiple nodules in G1 (50%) vs G3 (33.3%) (P < 0.02) and diffuse in G1 (16%) vs G2 (2%) and vs G3 (1%) (P < 0.001). The most frequent echo-pattern was hypo-echoic G1 (50%) vs G2 (79%) and G1 vs G3 (65%) (P < 0.01). Iso-echoic pattern was the least frequent (7-12%). Mixed pattern decreased from G1 (28%) to G3 (12%) (P < 0.002). In G3 there were more multiple or diffuse HCCs in metabolic (P < 0.03).
    Conclusion: US presentation became less severe due to surveillance programs. HCV remains the most frequent cause, an increase in metabolic etiology has been shown throughout the decades.
    Language English
    Publishing date 2024-04-07
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2365426-0
    ISSN 1876-7931 ; 1971-3495
    ISSN (online) 1876-7931
    ISSN 1971-3495
    DOI 10.1007/s40477-024-00888-7
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  7. Article: The Benign Side of the Abdominal Wall: A Pictorial Review of Non-Neoplastic Diseases.

    Porrello, Giorgia / Vernuccio, Federica / Alvarez-Hornia Pérez, Eduardo / Brancatelli, Giuseppe / Cannella, Roberto

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 12

    Abstract: The abdominal wall is the location of a wide spectrum of pathological conditions, from benign to malignant ones. Imaging is often recommended for the evaluation of known palpable abdominal masses. However, abdominal wall pathologies are often ... ...

    Abstract The abdominal wall is the location of a wide spectrum of pathological conditions, from benign to malignant ones. Imaging is often recommended for the evaluation of known palpable abdominal masses. However, abdominal wall pathologies are often incidentally discovered and represent a clinical and diagnostic challenge. Knowledge of the possible etiologies and complications, combined with clinical history and laboratory findings, is crucial for the correct management of these conditions. Specific imaging clues can help the radiologist narrow the differential diagnosis and distinguish between malignant and benign processes. In this pictorial review, we will focus on the non-neoplastic benign masses and processes that can be encountered on the abdominal wall on cross-sectional imaging, with a particular focus on their management. Distinctive sonographic imaging clues, compared with computed tomography (CT) and magnetic resonance (MR) findings will be highlighted, together with clinical and practical tips for reaching the diagnosis and guiding patient management, to provide a complete diagnostic guide for the radiologist.
    Language English
    Publishing date 2022-12-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12123211
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  8. Article ; Online: "Nodule-in-nodule" architecture of hepatocellular carcinoma.

    Giambelluca, Dario / Cannella, Roberto / Caruana, Giovanni / Brancatelli, Giuseppe

    Abdominal radiology (New York)

    2019  Volume 44, Issue 7, Page(s) 2671–2673

    MeSH term(s) Carcinoma, Hepatocellular/diagnostic imaging ; Humans ; Liver/diagnostic imaging ; Liver Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2019-03-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2839786-1
    ISSN 2366-0058 ; 2366-004X
    ISSN (online) 2366-0058
    ISSN 2366-004X
    DOI 10.1007/s00261-019-02001-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1262: Show issues Location:
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  9. Article ; Online: Reply to "Oxaliplatin-Induced Liver Changes on Gadoxetate Disodium-Enhanced Liver MRI".

    Furlan, Alessandro / Brancatelli, Giuseppe / Vilgrain, Valerie

    AJR. American journal of roentgenology

    2018  Volume 211, Issue 2, Page(s) W134

    MeSH term(s) Focal Nodular Hyperplasia ; Gadolinium DTPA ; Humans ; Liver ; Magnetic Resonance Imaging ; Oxaliplatin
    Chemical Substances gadolinium ethoxybenzyl DTPA ; Oxaliplatin (04ZR38536J) ; Gadolinium DTPA (K2I13DR72L)
    Language English
    Publishing date 2018-08-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.18.19786
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  10. Article: Spectrum of liver lesions hyperintense on hepatobiliary phase: an approach by clinical setting.

    Vernuccio, Federica / Gagliano, Domenico Salvatore / Cannella, Roberto / Ba-Ssalamah, Ahmed / Tang, An / Brancatelli, Giuseppe

    Insights into imaging

    2021  Volume 12, Issue 1, Page(s) 8

    Abstract: Hepatobiliary MRI contrast agents are increasingly being used for liver imaging. In clinical practice, most focal liver lesions do not uptake hepatobiliary contrast agents. Less commonly, hepatic lesions may show variable signal characteristics on ... ...

    Abstract Hepatobiliary MRI contrast agents are increasingly being used for liver imaging. In clinical practice, most focal liver lesions do not uptake hepatobiliary contrast agents. Less commonly, hepatic lesions may show variable signal characteristics on hepatobiliary phase. This pictorial essay reviews a broad spectrum of benign and malignant focal hepatic observations that may show hyperintensity on hepatobiliary phase in various clinical settings. In non-cirrhotic patients, focal hepatic observations that show hyperintensity in the hepatobiliary phase are usually benign and typically include focal nodular hyperplasia. In patients with primary or secondary vascular disorders, focal nodular hyperplasia-like lesions arise as a local hyperplastic response to vascular alterations and tend to be iso- or hyperintense in the hepatobiliary phase. In oncologic patients, metastases and cholangiocarcinoma are hypointense lesions in the hepatobiliary phase; however, occasionally they may show a diffuse, central and inhomogeneous hepatobiliary paradoxical uptake with peripheral rim hypointensity. Post-chemotherapy focal nodular hyperplasia-like lesions may be tricky, and their typical hyperintense rim in the hepatobiliary phase is very helpful for the differential diagnosis with metastases. In cirrhotic patients, hepatocellular carcinoma may occasionally appear hyperintense on hepatobiliary phase.
    Language English
    Publishing date 2021-01-12
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2543323-4
    ISSN 1869-4101
    ISSN 1869-4101
    DOI 10.1186/s13244-020-00928-w
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