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Article ; Online: Does the M-Phase Promoting Factor (MPF) Activate a Major Ca

Labbe, Jean Claude / Picard, André / Doree, Marcel

2023 Volume 30, Issue 2, Page(s) 197–207

Abstract: In starfish, the activity of a major ... ...

Abstract	In starfish, the activity of a major Ca
Language	English
Publishing date	2023-06-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	280433-5
ISSN	1440-169X ; 0012-1592
ISSN (online)	1440-169X
ISSN	0012-1592
DOI	10.1111/j.1440-169X.1988.00197.x
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Article: Myriopteris grusziae: A New Species from Texas and Oklahoma Segregated from the Chihuahuan Desert Taxon M. scabra (Pteridaceae)

Windham, Michael D. / Picard, Kathryn T. / Pryer, Kathleen M.

Systematic botany. 2022 Sept. 16, v. 47, no. 3

2022

Abstract: ... nature of M. scabra, published chromosome counts indicate that collections assigned to this taxon ... as a new species, M. grusziae, which completely supplants diploid M. scabra in the northeastern portion ... of its range (central Texas and south-central Oklahoma). This presumed allotetraploid is most like M. scabra ...

Abstract	Myriopteris scabra (until recently called Cheilanthes horridula) is a xeric-adapted fern species, endemic to the southwestern United States and northern Mexico. It is one of the most recognizable ferns in North America due to the unusual nature of the indument present on its adaxial leaf surfaces. This consists of rigid, multicellular trichomes with glassy, needle-like apices and compact conical bodies that are partially embedded in the leaf surface to form swollen, pustulate bases. Despite the seemingly distinctive nature of M. scabra, published chromosome counts indicate that collections assigned to this taxon encompass both diploids (n = 29) and tetraploids (n = 58). Here we investigate this case of cryptic diversity by integrating data from cytogenetic and spore analyses, observations of sporophyte morphology, and geographic distributions. Myriopteris scabra s.l. is shown to comprise two genetically disparate, morphologically recognizable taxa that exhibit little or no geographic overlap. The tetraploid taxon is described as a new species, M. grusziae, which completely supplants diploid M. scabra in the northeastern portion of its range (central Texas and south-central Oklahoma). This presumed allotetraploid is most like M. scabra but differs in having ultimate segments with adaxial trichomes that are longer, more flexible, mostly linear, and superficially attached. In addition, tetraploid M. grusziae has larger, more abundant scales that largely conceal the dark, sclerified leaf rachises, and it produces consistently larger spores than diploid M. scabra. We hypothesize that M. grusziae is an allotetraploid hybrid that acquired half of its chromosomes from M. scabra. However, the identity of the other diploid parent has yet to be resolved.
Keywords	Cheilanthes ; allotetraploidy ; chromosomes ; diploidy ; ferns and fern allies ; hybrids ; leaves ; new species ; spores ; sporophytes ; tetraploidy ; trichomes ; Chihuahuan Desert ; Mexico ; Oklahoma ; Texas
Language	English
Dates of publication	2022-0916
Size	p. 876-886.
Publishing place	American Society of Plant Toxonomists
Document type	Article
ZDB-ID	2052625-8
ISSN	1548-2324 ; 0363-6445
ISSN (online)	1548-2324
ISSN	0363-6445
DOI	10.1600/036364422X16573022073590
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Article ; Online: Effect of genetic polymorphisms in CYP3A4, CYP3A5, and m-TOR on everolimus blood exposure and clinical outcomes in cancer patients.

Bonnet, Stéphanie / Falkowski, Sabrina / Deppenweiler, Marine / Monchaud, Caroline / Arnion, Hélène / Picard, Nicolas / Woillard, Jean-Baptiste

The pharmacogenomics journal

2020 Volume 20, Issue 5, Page(s) 647–654

Abstract: Genetic variations in CYP3A4, CYP3A5, and m-TOR could contribute to interpatient variability ... regarding m-TOR inhibitors pharmacokinetics or cellular effects. The purpose of this study was to evaluate ... in genes related to everolimus pharmacokinetics (CYP3A4*22 and CYP3A5*3) or pharmacodynamics (m-TOR ...

Abstract	Genetic variations in CYP3A4, CYP3A5, and m-TOR could contribute to interpatient variability regarding m-TOR inhibitors pharmacokinetics or cellular effects. The purpose of this study was to evaluate the influence of selected candidate variations in these genes on everolimus pharmacokinetics, efficacy, and toxicity in cancer patients. Thirty-four patients receiving everolimus for breast (n = 22) or renal (n = 10) cancers, or neuroendocrine tumors of pancreatic origin (n = 2) were included in the study. Six variants in genes related to everolimus pharmacokinetics (CYP3A422 and CYP3A53) or pharmacodynamics (m-TOR rs2295079, rs2295080, rs2024627 and rs1057079) were genotyped. Associations with trough concentrations (C
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/blood ; Antineoplastic Agents/pharmacokinetics ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Disease Progression ; Drug Monitoring ; Everolimus/adverse effects ; Everolimus/blood ; Everolimus/pharmacokinetics ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Neoplasms/blood ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/mortality ; Pharmacogenetics ; Pharmacogenomic Variants ; Phenotype ; Polymorphism, Single Nucleotide ; Progression-Free Survival ; Retrospective Studies ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Antineoplastic Agents ; Everolimus (9HW64Q8G6G) ; CYP3A5 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; CYP3A4 protein, human (EC 1.14.14.55) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1)
Language	English
Publishing date	2020-02-04
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2106831-8
ISSN	1473-1150 ; 1470-269X
ISSN (online)	1473-1150
ISSN	1470-269X
DOI	10.1038/s41397-020-0152-7
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Article ; Online: Effect of age and carcass weight on quality traits of m. rectus abdominis from Charolais heifers.

Ellies-Oury, M P / Dumont, R / Perrier, G / Roux, M / Micol, D / Picard, B

Animal : an international journal of animal bioscience

2017 Volume 11, Issue 4, Page(s) 720–727

Abstract: ... expected to increase overall meat quality of m. rectus abdominis of Charolais heifers. Totally, 40 heifers ... 397±6 and 451±9 kg). The m. rectus abdominis was excised 24 h postmortem to determine metabolic ...

Abstract	In practice cattle may be slaughtered at different combinations of age and weight. As each of these factors could affect meat quality traits, the present work aimed to identify which combination can be expected to increase overall meat quality of m. rectus abdominis of Charolais heifers. Totally, 40 heifers were slaughtered either at 26±1 or at 36±1 months of age. Young heifers were sampled at two different carcass weights (349±12 and 394±8 kg). Old heifers were also sampled at two different carcass weights (397±6 and 451±9 kg). The m. rectus abdominis was excised 24 h postmortem to determine metabolic enzyme activities, myosin heavy-chain isoform proportions, lipid contents, collagen content and collagen solubility. Shear force measurements were evaluated on raw and broiled meat after 14 days of ageing. Meat quality traits scored between 0 and 10 by sensory analysis. Increasing slaughter age from 26 to 36 months had no impact on either raw/broiled shear force (0.31⩽P⩽0.47) and/or meat quality traits (0.62⩽P⩽0.91) or on physicochemical properties of heifer's meat samples. Increasing carcass weight for a similar slaughter age of 26 months had also impact neither on meat quality traits (0.52⩽P⩽0.91) nor on muscular properties. On the contrary, increasing carcass weight for a similar slaughter age of 36 months had induced a decrease of muscular shear force (raw muscle; P=0.009) and a concomitant decrease of total collagen content (P=0.03). Nevertheless, no significant impact on meat quality traits was revealed by the sensorial panel (0.13⩽P⩽0.49). Metabolic enzyme activities (0.13⩽P⩽0.86) and myosin heavy-chain proportions (0.13⩽P⩽0.96) were not significantly impacted by slaughter age and carcass weight. Thus, the impact of increasing carcass weight and/or slaughter age in young Charolais heifers has a limited impact on meat quality traits and associated muscular characteristics. Modulating heifer's cycles (age and/or carcass weight in the studied range) appears to be a way to answer to the numerous marketing chains, without penalising meat quality traits.
MeSH term(s)	Age Factors ; Animals ; Body Composition ; Cattle/growth & development ; Cattle/physiology ; Female ; Muscle Development ; Phenotype ; Rectus Abdominis/growth & development ; Rectus Abdominis/physiology ; Red Meat/standards
Language	English
Publishing date	2017-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2257920-5
ISSN	1751-732X ; 1751-7311
ISSN (online)	1751-732X
ISSN	1751-7311
DOI	10.1017/S1751731116001907
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Article ; Online: Quantification of the radiative impact of light-absorbing particles during two contrasted snow seasons at Col du Lautaret (2058 m a.s.l., French Alps)

F. Tuzet / M. Dumont / G. Picard / M. Lamare / D. Voisin / P. Nabat / M. Lafaysse / F. Larue / J. Revuelto / L. Arnaud

The Cryosphere, Vol 14, Pp 4553-

2020 Volume 4579

Abstract: ... snow metamorphism. First, a unique dataset collected at Col du Lautaret (2058 m a.s.l., above sea level ...

Abstract	The presence of light-absorbing particles (LAPs) in snow leads to a decrease in short-wave albedo affecting the surface energy budget. However, the understanding of the impacts of LAPs is hampered by the lack of dedicated datasets, as well as the scarcity of models able to represent the interactions between LAPs and snow metamorphism. The present study aims to address both these limitations by introducing a survey of LAP concentrations over two snow seasons in the French Alps and an estimation of their impacts based on the Crocus snowpack model that represents the complex interplays between LAP dynamics and snow metamorphism. First, a unique dataset collected at Col du Lautaret (2058 m a.s.l., above sea level, French Alps) for the two snow seasons 2016–2017 and 2017–2018 is presented. This dataset consists of spectral albedo measurements, vertical profiles of snow specific surface area (SSA), density and concentrations of different LAP species. Spectral albedos are processed to estimate SSA and LAP absorption-equivalent concentrations near the surface of the snowpack. These estimates are then compared to chemical measurements of LAP concentrations and SSA measurements. Our dataset highlights, among others, large discrepancies between two measurement techniques of black carbon (BC) concentrations in snow (namely thermal-optical and laser-induced incandescence). Second, we present ensemble snowpack simulations of the multi-physics version of the detailed snowpack model Crocus, forced with in situ meteorological data, as well as dust and BC deposition fluxes from an atmospheric model. The temporal variations of near-surface LAP concentrations and SSA are most of the time correctly simulated. The simulated seasonal radiative forcing of LAPs is 33 % higher for the 2017–2018 snow season than for the 2016–2017 one, highlighting a strong variability between these two seasons. However, the shortening of the snow season caused by LAPs is similar with 10 ± 5 and 11 ± 1 d for the first and the second snow seasons, ...
Keywords	Environmental sciences ; GE1-350 ; Geology ; QE1-996.5
Subject code	551
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Quantification of the radiative impact of light-absorbing particles during two contrasted snow seasons at Col du Lautaret (2058 m a.s.l., French Alps)

Tuzet, François / Dumont, Marie / Picard, Ghislain / Lamare, Maxim / Voisin, Didier / Nabat, Pierre / Lafaysse, Mathieu / Larue, Fanny / Revuelto, Jesus / Arnaud, Laurent

eISSN: 1994-0424

2020

Abstract: ... snow metamorphism. First, a unique dataset collected at Col du Lautaret (2058 m a.s.l., above sea level ...

Abstract	The presence of light-absorbing particles (LAPs) in snow leads to a decrease in short-wave albedo affecting the surface energy budget. However, the understanding of the impacts of LAPs is hampered by the lack of dedicated datasets, as well as the scarcity of models able to represent the interactions between LAPs and snow metamorphism. The present study aims to address both these limitations by introducing a survey of LAP concentrations over two snow seasons in the French Alps and an estimation of their impacts based on the Crocus snowpack model that represents the complex interplays between LAP dynamics and snow metamorphism. First, a unique dataset collected at Col du Lautaret (2058 m a.s.l., above sea level, French Alps) for the two snow seasons 2016–2017 and 2017–2018 is presented. This dataset consists of spectral albedo measurements, vertical profiles of snow specific surface area (SSA), density and concentrations of different LAP species. Spectral albedos are processed to estimate SSA and LAP absorption-equivalent concentrations near the surface of the snowpack. These estimates are then compared to chemical measurements of LAP concentrations and SSA measurements. Our dataset highlights, among others, large discrepancies between two measurement techniques of black carbon (BC) concentrations in snow (namely thermal-optical and laser-induced incandescence). Second, we present ensemble snowpack simulations of the multi-physics version of the detailed snowpack model Crocus, forced with in situ meteorological data, as well as dust and BC deposition fluxes from an atmospheric model. The temporal variations of near-surface LAP concentrations and SSA are most of the time correctly simulated. The simulated seasonal radiative forcing of LAPs is 33 % higher for the 2017–2018 snow season than for the 2016–2017 one, highlighting a strong variability between these two seasons. However, the shortening of the snow season caused by LAPs is similar with 10 ± 5 and 11 ± 1 d for the first and the second snow seasons, respectively. This counter-intuitive result is attributed to two small snowfalls at the end of the first season and highlights the importance in accounting for meteorological conditions to correctly predict the impact of LAPs. The strong variability of season shortening caused by LAPs in the multi-physics ensemble for the first season (10 ± 5 d) also points out the sensitivity of model-based estimations of LAP impact on modelling uncertainties of other processes. Finally, the indirect impact of LAPs (i.e. the enhancement of energy absorption due to the acceleration of the metamorphism by LAPs) is negligible for the 2 years considered here, which is contrary to what was found in previous studies for other sites.
Subject code	551
Language	English
Publishing date	2020-12-15
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High occurrence of new particle formation events at the Maïdo high-altitude observatory (2150 m), Réunion (Indian Ocean)

B. Foucart / K. Sellegri / P. Tulet / C. Rose / J.-M. Metzger / D. Picard

Atmospheric Chemistry and Physics, Vol 18, Pp 9243-

2018 Volume 9261

Abstract: ... observed at the Maïdo observatory, Réunion, a Southern Hemisphere site located at 2150 m (a.s.l.) and ...

Abstract	This study aims to report and characterise the frequent new particle formation (NPF) events observed at the Maïdo observatory, Réunion, a Southern Hemisphere site located at 2150 m (a.s.l.) and surrounded by the Indian Ocean. From May 2014 to December 2015, continuous aerosol measurements were made using both a differential mobility particle sizer (DMPS) and an air ion spectrometer (AIS) to characterise the NPF events down to the lowest particle-size scale. Carbon monoxide (CO) and black carbon (BC) concentrations were monitored, as well as meteorological parameters, in order to identify the conditions that were favourable to the occurrence of nucleation in this specific environment. We point out that the annual NPF frequency average (65 %) is one of the highest reported so far. Monthly averages show a bimodal variation in the NPF frequency, with a maximum observed during transition periods (autumn and spring). A high yearly median particle growth rate (GR) of 15.16 nm h −1 is also measured showing a bimodal seasonal variation with maxima observed in July and November. Yearly medians of 2 and 12 nm particle formation rates ( J 2 and J 12 ) are 0.858 and 0.508 cm −3 s −1 , respectively, with a seasonal variation showing a maximum during winter, that correspond to low temperature and RH typical of the dry season, but also to high BC concentrations. We show that the condensation sink exceeds a threshold value (1.04×10 −3 s −1 ) with a similar seasonal variation than the one of the NPF event frequency, suggesting that the occurrence of the NPF process might be determined by the availability of condensable vapours, which are likely to be transported together with pre-existing particles from lower altitudes.
Keywords	Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	333
Language	English
Publishing date	2018-07-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chemical composition and structural characteristics of Arabian camel (Camelus dromedarius) m. longissimus thoracis.

Al-Owaimer, A N / Suliman, G M / Sami, A S / Picard, B / Hocquette, J F

Meat science

2014 Volume 96, Issue 3, Page(s) 1233–1241

Abstract: Saudi Arabian camels of four breeds (6 animals per breed) were used to evaluate characteristics and quality of their meat. Chemical composition, fibre cross sectional area, collagen content, muscle metabolism, cooking loss, pH at 24 h post mortem, colour ...

Abstract	Saudi Arabian camels of four breeds (6 animals per breed) were used to evaluate characteristics and quality of their meat. Chemical composition, fibre cross sectional area, collagen content, muscle metabolism, cooking loss, pH at 24 h post mortem, colour values (except redness) and shear force of Longissimus thoracis (LT) muscle did not differ between the breeds. Elevated pH values and short sarcomeres reduced overall tenderisation, with a difference between myofibril fragmentation index (P<0.001) and sarcomere length (P<0.05) between breeds. A positive correlation was observed between the activities of the mitochondrial enzymes (r>0.49), between the glycolytic activities (PFK and LDH) (r=0.61) and between Myosin Heavy Chain IIa and LDH activity. The intramuscular fat content was positively associated with redness and muscle oxidative metabolism, whereas shear force had a slight positive association with collagen content and muscle glycolytic metabolism and a negative association with muscle oxidative metabolism and muscle fibre area.
MeSH term(s)	Adipose Tissue/chemistry ; Animals ; Breeding ; Camelus ; Collagen/chemistry ; Color ; Cooking ; Food Quality ; Glycolysis ; Hydrogen-Ion Concentration ; Male ; Meat/analysis ; Muscle, Skeletal/chemistry ; Myosin Heavy Chains/chemistry ; Sarcomeres/chemistry ; Saudi Arabia
Chemical Substances	Collagen (9007-34-5) ; Myosin Heavy Chains (EC 3.6.4.1)
Language	English
Publishing date	2014-03
Publishing country	England
Document type	Journal Article
ZDB-ID	753319-6
ISSN	1873-4138 ; 0309-1740
ISSN (online)	1873-4138
ISSN	0309-1740
DOI	10.1016/j.meatsci.2013.10.025
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Article: Effect of age and carcass weight on quality traits of m. rectus abdominis from Charolais heifers

Ellies-Oury, M. P / Dumont, R / Perrier, G / Roux, M / Micol, D / Picard, B

Animal. 2017 Apr., v. 11, no. 4

2017

Abstract	In practice cattle may be slaughtered at different combinations of age and weight. As each of these factors could affect meat quality traits, the present work aimed to identify which combination can be expected to increase overall meat quality of m. rectus abdominis of Charolais heifers. Totally, 40 heifers were slaughtered either at 26±1 or at 36±1 months of age. Young heifers were sampled at two different carcass weights (349±12 and 394±8 kg). Old heifers were also sampled at two different carcass weights (397±6 and 451±9 kg). The m. rectus abdominis was excised 24 h postmortem to determine metabolic enzyme activities, myosin heavy-chain isoform proportions, lipid contents, collagen content and collagen solubility. Shear force measurements were evaluated on raw and broiled meat after 14 days of ageing. Meat quality traits scored between 0 and 10 by sensory analysis. Increasing slaughter age from 26 to 36 months had no impact on either raw/broiled shear force (0.31⩽P⩽0.47) and/or meat quality traits (0.62⩽P⩽0.91) or on physicochemical properties of heifer’s meat samples. Increasing carcass weight for a similar slaughter age of 26 months had also impact neither on meat quality traits (0.52⩽P⩽0.91) nor on muscular properties. On the contrary, increasing carcass weight for a similar slaughter age of 36 months had induced a decrease of muscular shear force (raw muscle; P=0.009) and a concomitant decrease of total collagen content (P=0.03). Nevertheless, no significant impact on meat quality traits was revealed by the sensorial panel (0.13⩽P⩽0.49). Metabolic enzyme activities (0.13⩽P⩽0.86) and myosin heavy-chain proportions (0.13⩽P⩽0.96) were not significantly impacted by slaughter age and carcass weight. Thus, the impact of increasing carcass weight and/or slaughter age in young Charolais heifers has a limited impact on meat quality traits and associated muscular characteristics. Modulating heifer’s cycles (age and/or carcass weight in the studied range) appears to be a way to answer to the numerous marketing chains, without penalising meat quality traits.
Keywords	Charolais ; age at slaughter ; carcass weight ; collagen ; enzyme activity ; heifers ; lipids ; marketing ; meat ; meat quality ; muscles ; myosin heavy chains ; sensory evaluation ; solubility
Language	English
Dates of publication	2017-04
Size	p. 720-727.
Publishing place	Cambridge University Press
Document type	Article
ZDB-ID	2257920-5
ISSN	1751-732X ; 1751-7311
ISSN (online)	1751-732X
ISSN	1751-7311
DOI	10.1017/S1751731116001907
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Recent Advances in OMICs Technologies and Application for Ensuring Meat Quality, Safety and Authenticity

Gagaoua, Mohammed / Picard, Brigitte

2023

Keywords	Research & information: general ; Biology, life sciences ; Biochemistry ; sea bream ; fish ; spoilage ; metabolomics ; multivariate analysis ; biomarkers ; meat tenderness ; fat ; proteomics ; proteins ; enzymes ; quantification ; biological pathways ; chemometrics ; wooden breast ; myopathy ; feed efficiency ; upstream regulator analysis ; foodomics ; beef tenderness ; bovine biomarkers ; muscle ; proteome ; liquid chromatography-tandem mass spectrometry (LC-MS/MS) ; septuple PCR ; adulteration ; meat species ; mitochondrial genes ; multiplex PCR ; cellular compartments ; protein extractability ; sarcoplasmic proteins ; myofibrillar proteins ; meat quality biomarkers ; DFD meat ; oxidative stress ; certified reference material ; digital PCR ; duck interleukin 2 ; mitochondrial gene ; meat adulteration ; ovine ; color stability ; enzyme ; bioinformatics ; intensive management ; extensive management ; mixing unfamiliar animals ; pre-slaughter stress ; protein biomarkers ; sheep ; tenderness ; novel isoforms ; alternative splicing ; CTCF ; Iso-seq ; ChIP-seq ; DNA metabarcoding ; animal species ; species identification ; NGS ; food adulteration ; validation ; interlaboratory ring trial ; n/a
Language	English
Size	1 electronic resource (220 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030383429
ISBN	9783036556666 ; 3036556664
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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