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  1. Book ; Online: Femmes et droit public

    Humbert, Marion / Martins, Maverick / Routier, Romain

    Liberté, égalité, sororité

    (Schol@ ; 2)

    2023  

    Series title Schol@ ; 2
    Keywords Political control & freedoms ; Law ; Public law ; Feminism ; Sorority ; Genital mutilation ; Claims ; Equality ; Menstrual precariousness ; Inclusiveness ; Clothing ; Parity ; Body ; Bioethics ; Positive discrimination ; Inclusive writing ; Gender and sexual violence ; Sexist Contempt ; Students ; Sexism ; Constitutional law ; Administrative law ; International law ; Criminal law ; Comparative law ; Harassment ; Freedom
    Language fra
    Size 1 electronic resource (137 pages)
    Publisher Presses universitaires de Pau et des Pays de l'Adour
    Publishing place Pau
    Document type Book ; Online
    Note French
    HBZ-ID HT030381923
    ISBN 9782353111564 ; 2353111564
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Characterization of pulmonary arterial hypertension patients walking more than 450 m in 6 min at diagnosis.

    Degano, Bruno / Sitbon, Olivier / Savale, Laurent / Garcia, Gilles / O'Callaghan, Dermot S / Jaïs, Xavier / Humbert, Marc / Simonneau, Gérald

    Chest

    2010  Volume 137, Issue 6, Page(s) 1297–1303

    Abstract: ... to have a "near-normal" 6-min walk distance (6MWD) (ie, > 450 m). Because they are generally excluded ... treatment responses of 49 consecutive patients with a 6MWD > 450 m at the time of newly diagnosed PAH. Data ... from this cohort were then compared with data from hemodynamically matched patients with a 6MWD < or = 450 m ...

    Abstract Background: At diagnosis of pulmonary arterial hypertension (PAH), some patients are considered to have a "near-normal" 6-min walk distance (6MWD) (ie, > 450 m). Because they are generally excluded from randomized controlled trials, little is known about these patients.
    Methods: We analyzed the baseline characteristics and treatment responses of 49 consecutive patients with a 6MWD > 450 m at the time of newly diagnosed PAH. Data from this cohort were then compared with data from hemodynamically matched patients with a 6MWD < or = 450 m.
    Results: Patients with a 6MWD > 450 m were either in World Health Organization (WHO) functional class (FC) II (n = 23) or III (n = 26) at baseline. Compared with patients in FC II, those in FC III had more severe hemodynamic impairment (ie, a lower cardiac index and higher pulmonary vascular pressures and resistance) but similar 6MWD. At first evaluation after initiation of PAH-specific treatment (3-6 months), FC improved (FC I-II: n = 38; FC III: n = 11, P < .005) and cardiac index increased. However, 6MWD remained unchanged. Compared with matched patients with a 6MWD < or = 450 m (n = 98), individuals with a 6MWD > 450 m were approximately 9 years younger (P = .0006) and had a lower BMI (P = .0009).
    Conclusions: Anthropometric characteristics such as younger age and lower BMI may explain higher 6MWD in some PAH patients. In the cohort of patients with a 6MWD > 450 m, hemodynamic indices and WHO FC were more sensitive than 6MWD in detecting changes secondary to PAH-specific treatments.
    MeSH term(s) Adult ; Age Factors ; Analysis of Variance ; Antihypertensive Agents/therapeutic use ; Body Mass Index ; Case-Control Studies ; Chi-Square Distribution ; Exercise Test ; Exercise Tolerance/physiology ; Female ; Hemodynamics/physiology ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/physiopathology ; Linear Models ; Male ; Middle Aged ; Registries ; Respiratory Function Tests ; Retrospective Studies ; Risk Factors ; Walking/physiology
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2010-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.09-2060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  3. Article ; Online: Viewpoint: activin signalling inhibitors for the treatment of pulmonary arterial hypertension.

    Humbert, Marc

    The European respiratory journal

    2023  Volume 62, Issue 5

    MeSH term(s) Humans ; Pulmonary Arterial Hypertension/drug therapy ; Activins ; Familial Primary Pulmonary Hypertension ; Hypertension, Pulmonary/drug therapy
    Chemical Substances Activins (104625-48-1)
    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01726-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 292: Show issues

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  4. Article ; Online: Restraint of the G2/M transition by the SR/RRM family mRNA shuttling binding protein SNXAHRB1 in Aspergillus nidulans.

    James, Steven W / Banta, Travis / Barra, James / Ciraku, Lorela / Coile, Clifford / Cuda, Zach / Day, Ryan / Dixit, Cheshil / Eastlack, Steven / Giang, Anh / Goode, James / Guice, Alexis / Huff, Yulon / Humbert, Sara / Kelliher, Christina / Kobie, Julie / Kohlbrenner, Emily / Mwambutsa, Faustin / Orzechowski, Amanda /
    Shingler, Kristin / Spell, Casey / Anglin, Sarah Lea

    Genetics

    2014  Volume 198, Issue 2, Page(s) 617–633

    Abstract: Control of the eukaryotic G2/M transition by CDC2/CYCLINB is tightly regulated by protein-protein ... ribonucleoprotein-M, a spliceosomal component involved in pre-mRNA processing and alternative splicing. snxA(Hrb) (1 ...

    Abstract Control of the eukaryotic G2/M transition by CDC2/CYCLINB is tightly regulated by protein-protein interactions, protein phosphorylations, and nuclear localization of CDC2/CYCLINB. We previously reported a screen, in Aspergillus nidulans, for extragenic suppressors of nimX2(cdc2) that resulted in the identification of the cold-sensitive snxA1 mutation. We demonstrate here that snxA1 suppresses defects in regulators of the CDK1 mitotic induction pathway, including nimX2(cdc) (2), nimE6(cyclinB), and nimT23(cdc) (25), but does not suppress G2-arresting nimA1/nimA5 mutations, the S-arresting nimE10(cyclinB) mutation, or three other G1/S phase mutations. snxA encodes the A. nidulans homolog of Saccharomyces cerevisiae Hrb1/Gbp2; nonessential shuttling messenger RNA (mRNA)-binding proteins belonging to the serine-arginine-rich (SR) and RNA recognition motif (RRM) protein family; and human heterogeneous ribonucleoprotein-M, a spliceosomal component involved in pre-mRNA processing and alternative splicing. snxA(Hrb) (1) is nonessential, its deletion phenocopies the snxA1 mutation, and its overexpression rescues snxA1 and ΔsnxA mutant phenotypes. snxA1 and a second allele isolated in this study, snxA2, are hypomorphic mutations that result from decreased transcript and protein levels, suggesting that snxA acts normally to restrain cell cycle progression. SNXA(HRB1) is predominantly nuclear, but is not retained in the nucleus during the partially closed mitosis of A. nidulans. We show that the snxA1 mutation does not suppress nimX2 by altering NIMX2(CDC2)/NIME(CYCLINB) kinase activity and that snxA1 or ΔsnxA alter localization patterns of NIME(CYCLINB) at the restrictive temperatures for snxA1 and nimX2. Together, these findings suggest a novel and previously unreported role of an SR/RRM family protein in cell cycle regulation, specifically in control of the CDK1 mitotic induction pathway.
    MeSH term(s) Aspergillus nidulans/cytology ; Aspergillus nidulans/metabolism ; CDC2 Protein Kinase/metabolism ; Cell Nucleus/metabolism ; Cyclin B/metabolism ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; G2 Phase ; Gene Expression ; Interphase ; Mutation ; Nucleocytoplasmic Transport Proteins/genetics ; Nucleocytoplasmic Transport Proteins/metabolism ; Protein Transport
    Chemical Substances Cyclin B ; Fungal Proteins ; Nucleocytoplasmic Transport Proteins ; CDC2 Protein Kinase (EC 2.7.11.22)
    Language English
    Publishing date 2014-08-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1534/genetics.114.167445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 767: Show issues Location:
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  5. Book: The right ventricle in pulmonary arterial hypertension

    Humbert, Marc

    (The American journal of cardiology ; 110,6S = Suppl.)

    2012  

    Author's details guest ed.: Marc Humbert
    Series title The American journal of cardiology ; 110,6S = Suppl.
    Collection
    Language English
    Size VII, 51S S. : Ill., graph. Darst.
    Publisher Excerpta Medica
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT017437881
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Ui IV Zs 73 -110,6S- verfügbar in Königswinter Königswinter

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  6. Article ; Online: The Long March to a Cure for Pulmonary Hypertension.

    Humbert, Marc

    JACC. Asia

    2022  Volume 2, Issue 3, Page(s) 215–217

    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Editorial
    ISSN 2772-3747
    ISSN (online) 2772-3747
    DOI 10.1016/j.jacasi.2022.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Pulmonary hypertension

    Humbert, Marc

    (Lung biology in health and disease ; 236)

    2009  

    Author's details ed. by Marc Humbert
    Series title Lung biology in health and disease ; 236
    Collection
    Keywords Hypertension, Pulmonary ; Pulmonary hypertension
    Subject code 616.24
    Language English
    Size XXII, 497 S., [16] Bl. : Ill., graph. Darst., Kt., 24 cm
    Publisher Informa Healthcare
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Formerly CIP Uk. - Includes bibliographical references and index
    HBZ-ID HT016103771
    ISBN 978-1-4200-9475-6 ; 1-4200-9475-0
    Database Catalogue ZB MED Medicine, Health

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    2009 A 5863 order for loan Magazin

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  8. Book ; Conference proceedings: Proceedings of the 4th World Symposium on Pulmonary Hypertension

    Humbert, Marc

    [11 - 14, 2008 at Dana Point, California]

    (Journal of the American College of Cardiology ; 54,1, Suppl. S)

    2009  

    Event/congress World Symposium on Pulmonary Hypertension (4., 2008, DanaPointCalif.)
    Author's details guest ed.: Marc Humbert
    Series title Journal of the American College of Cardiology ; 54,1, Suppl. S
    Collection
    Language English
    Size S117 S. : Ill.
    Publisher Elsevier
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT016007434
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1846 -54,Suppl.S- not available for loan Zeitschriften-Lesesaal

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  9. Article ; Online: Monographic Issue on Pulmonary Hypertension.

    Barberà, Joan Albert / Humbert, Marc

    Seminars in respiratory and critical care medicine

    2023  Volume 44, Issue 6, Page(s) 719–720

    MeSH term(s) Humans ; Hypertension, Pulmonary/therapy
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0043-1772751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The European reference network on rare lung diseases (ERN-LUNG) ambition to offer better lung health for all.

    Humbert, Marc / Wagner, Thomas

    Presse medicale (Paris, France : 1983)

    2023  Volume 52, Issue 3, Page(s) 104172

    Language English
    Publishing date 2023-09-10
    Publishing country France
    Document type Editorial
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2023.104172
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