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  1. Book ; Online: DNA Replication Origins in Microbial Genomes, Volume 2

    Gao, Feng / Leonard, Alan C.

    2019  

    Keywords Science: general issues ; Medical microbiology & virology ; Microbiology (non-medical) ; bacteria ; yeast ; replication origin ; DNA replication ; replication regulation ; replication licensing ; orisome ; replisome ; secondary chromosome ; population genomics
    Size 1 electronic resource (140 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230091
    ISBN 9782889632459 ; 2889632458
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Recollections of a Helmstetter Disciple.

    Leonard, Alan C

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 5

    Abstract: Nearly fifty years ago, it became possible to ... ...

    Abstract Nearly fifty years ago, it became possible to construct
    Language English
    Publishing date 2023-04-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13051114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Blocking, Bending, and Binding: Regulation of Initiation of Chromosome Replication During the

    Grimwade, Julia E / Leonard, Alan C

    Frontiers in microbiology

    2021  Volume 12, Page(s) 732270

    Abstract: Genome duplication is a critical event in the reproduction cycle of every cell. Because all daughter cells must inherit a complete genome, chromosome replication is tightly regulated, with multiple mechanisms focused on controlling when chromosome ... ...

    Abstract Genome duplication is a critical event in the reproduction cycle of every cell. Because all daughter cells must inherit a complete genome, chromosome replication is tightly regulated, with multiple mechanisms focused on controlling when chromosome replication begins during the cell cycle. In bacteria, chromosome duplication starts when nucleoprotein complexes, termed orisomes, unwind replication origin (
    Language English
    Publishing date 2021-09-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.732270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: DNA Replication Origins in Microbial Genomes, Volume 2.

    Gao, Feng / Leonard, Alan C

    Frontiers in microbiology

    2019  Volume 10, Page(s) 2416

    Language English
    Publishing date 2019-10-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2019.02416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Programmed Pore-Shape Fixing in a Soft Porous Molecular Crystal-Navigating the Phase Interconversion Landscape.

    Eaby, Alan C / Loots, Leigh / Basson, Jeanice L / Esterhuysen, Catharine / Barbour, Leonard J

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 32, Page(s) e202304152

    Abstract: Pore-shape fixing effects (PSFEs) in soft porous crystals are a relatively unexplored area of materials chemistry. We report the PSFE in the prototypical dynamic van der Waals solid p-tert-butylcalix[4]arene (TBC4). Starting with the high-density guest- ... ...

    Abstract Pore-shape fixing effects (PSFEs) in soft porous crystals are a relatively unexplored area of materials chemistry. We report the PSFE in the prototypical dynamic van der Waals solid p-tert-butylcalix[4]arene (TBC4). Starting with the high-density guest-free phase, two porous shape-fixed phases were programmed using the stimuli of CO
    Language English
    Publishing date 2023-06-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202304152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Benzonatate Safety and Effectiveness: A Systematic Review of the Literature.

    Costantino, Ryan C / Leonard, James / Gorman, Emily F / Ventura, Davide / Baltz, Alan / Gressler, Laura Elisabeth

    The Annals of pharmacotherapy

    2023  Volume 57, Issue 10, Page(s) 1221–1236

    Abstract: Objective: To review the available literature regarding the treatment effects and efficacy of benzonatate needed to better inform patients, providers, and regulators evaluating its role in modern medical therapies.: Data sources: Comprehensive ... ...

    Abstract Objective: To review the available literature regarding the treatment effects and efficacy of benzonatate needed to better inform patients, providers, and regulators evaluating its role in modern medical therapies.
    Data sources: Comprehensive literature searches were conducted in PubMed, Embase (Elsevier), Cochrane Library, and Scopus for original research articles evaluating the effectiveness, tolerability, and safety profile of benzonatate from January 1956 through August 2022.
    Study selection and data extraction: The identified studies were screened for relevance and then assessed for inclusion through a full-text review, data extraction, and quality assessment by multiple reviewers using the online software Covidence.
    Data synthesis: The selection process resulted in 37 articles consisting of 21 cohort studies, 5 experimental studies, and 11 case studies and series. Initial clinical studies exploring potential therapeutic benefits collected data from very small populations and limited clinical settings. Safety is primarily assessed in terms of toxicity due to overdose or inappropriate use. Quality assessment raised concerns for high degrees of biases primarily related to the limited sample size, data collection, generalizability, and study design.
    Relevance to patient care and clinical practice: This review reveals substantial limitations within existing evidence pertaining to the safety and clinical effectiveness of benzonatate and thus, a need for large observational studies or randomized trials to better characterize its role and value in modern medical practice.
    Conclusions: Rising safety concerns should bring closer scrutiny upon the prescription of benzonatate whose approval is founded upon evidence that would not stand up to current regulatory review.
    MeSH term(s) Humans ; Butylamines ; Drug Overdose ; Text Messaging
    Chemical Substances benzonatate (5P4DHS6ENR) ; Butylamines
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1177/10600280221135750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Dehydration of a crystal hydrate at subglacial temperatures.

    Eaby, Alan C / Myburgh, Dirkie C / Kosimov, Akmal / Kwit, Marcin / Esterhuysen, Catharine / Janiak, Agnieszka M / Barbour, Leonard J

    Nature

    2023  Volume 616, Issue 7956, Page(s) 288–292

    Abstract: Water is one of the most important substances on our ... ...

    Abstract Water is one of the most important substances on our planet
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-05749-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  8. Article: Blocking the Trigger: Inhibition of the Initiation of Bacterial Chromosome Replication as an Antimicrobial Strategy.

    Grimwade, Julia E / Leonard, Alan C

    Antibiotics (Basel, Switzerland)

    2019  Volume 8, Issue 3

    Abstract: All bacterial cells must duplicate their genomes prior to dividing into two identical daughter cells. Chromosome replication is triggered when a nucleoprotein complex, termed the orisome, assembles, unwinds the duplex DNA, and recruits the proteins ... ...

    Abstract All bacterial cells must duplicate their genomes prior to dividing into two identical daughter cells. Chromosome replication is triggered when a nucleoprotein complex, termed the orisome, assembles, unwinds the duplex DNA, and recruits the proteins required to establish new replication forks. Obviously, the initiation of chromosome replication is essential to bacterial reproduction, but this process is not inhibited by any of the currently-used antimicrobial agents. Given the urgent need for new antibiotics to combat drug-resistant bacteria, it is logical to evaluate whether or not unexploited bacterial processes, such as orisome assembly, should be more closely examined for sources of novel drug targets. This review will summarize current knowledge about the proteins required for bacterial chromosome initiation, as well as how orisomes assemble and are regulated. Based upon this information, we discuss current efforts and potential strategies and challenges for inhibiting this initiation pharmacologically.
    Language English
    Publishing date 2019-08-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics8030111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Targeting the Bacterial Orisome in the Search for New Antibiotics.

    Grimwade, Julia E / Leonard, Alan C

    Frontiers in microbiology

    2017  Volume 8, Page(s) 2352

    Abstract: There is an urgent need for new antibiotics to combat drug resistant bacteria. Existing antibiotics act on only a small number of proteins and pathways in bacterial cells, and it seems logical that expansion of the target set could lead to development of ...

    Abstract There is an urgent need for new antibiotics to combat drug resistant bacteria. Existing antibiotics act on only a small number of proteins and pathways in bacterial cells, and it seems logical that expansion of the target set could lead to development of novel antimicrobial agents. One essential process, not yet exploited for antibiotic discovery, is the initiation stage of chromosome replication, mediated by the bacterial orisome. In all bacteria, orisomes assemble when the initiator protein, DnaA, as well as accessory proteins, bind to a DNA scaffold called the origin of replication (
    Language English
    Publishing date 2017-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2017.02352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Changing Perspectives on the Role of DnaA-ATP in Orisome Function and Timing Regulation.

    Leonard, Alan C / Rao, Prassanna / Kadam, Rohit P / Grimwade, Julia E

    Frontiers in microbiology

    2019  Volume 10, Page(s) 2009

    Abstract: Bacteria, like all cells, must precisely duplicate their genomes before they divide. Regulation of this critical process focuses on forming a pre-replicative nucleoprotein complex, termed the orisome. Orisomes perform two essential mechanical tasks that ... ...

    Abstract Bacteria, like all cells, must precisely duplicate their genomes before they divide. Regulation of this critical process focuses on forming a pre-replicative nucleoprotein complex, termed the orisome. Orisomes perform two essential mechanical tasks that configure the unique chromosomal replication origin,
    Language English
    Publishing date 2019-08-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2019.02009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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