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Book ; Online: Building the gateway to consciousness - about the development of the thalamus

Scholpp, Steffen / Shimogori, Tomomi

2015

Abstract: Since years, patterning and function of some brain parts such as the cortex in the forebrain and the optical tectum or cerebellum in the midbrain/hindbrain region are under strong investigation. Interestingly the diencephalon located in the caudal ... ...

Abstract	Since years, patterning and function of some brain parts such as the cortex in the forebrain and the optical tectum or cerebellum in the midbrain/hindbrain region are under strong investigation. Interestingly the diencephalon located in the caudal forebrain has been ignored for decades. Consequently, the existing knowledge from the development of this region to function in the mature brain is very fragmented. The central part of the diencephalon is the thalamus. This central relay station plays a crucial role in distributing incoming sensory information to appropriate regions of the cortex. The thalamus develops in the posterior part of the embryonic forebrain, where early cell fate decisions are controlled by local signaling centers. In this Research Topic we discuss recent achievements elucidating thalamic neurogenesis - from neural progenitor cells to highly specialized neurons with cortical target cells in great distance. In parallel, we highlight developmental aspects leading from the early thalamic anlage to the late the organization of the complex relay station of the brain
Keywords	Neurosciences. Biological psychiatry. Neuropsychiatry ; Science (General)
Size	1 electronic resource (107 p.)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020091039
ISBN	9782889194704 ; 2889194701
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Introduction: in vivo cell biology in zebrafish.

Scholpp, Steffen

Histochemistry and cell biology

2020 Volume 154, Issue 5, Page(s) 457–461

MeSH term(s)	Animals ; Cell Biology ; Zebrafish
Language	English
Publishing date	2020-10-29
Publishing country	Germany
Document type	Editorial ; Introductory Journal Article
ZDB-ID	1222930-1
ISSN	1432-119X ; 0301-5564 ; 0948-6143
ISSN (online)	1432-119X
ISSN	0301-5564 ; 0948-6143
DOI	10.1007/s00418-020-01931-4
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Article ; Online: Transport and gradient formation of Wnt and Fgf in the early zebrafish gastrula.

Cooper, Emma J / Scholpp, Steffen

Current topics in developmental biology

2023 Volume 157, Page(s) 125–153

Abstract: Within embryonic development, the occurrence of gastrulation is critical in the formation of multiple germ layers with many differentiative abilities. These cells are instructed through exposure to signalling molecules called morphogens. The secretion of ...

Abstract	Within embryonic development, the occurrence of gastrulation is critical in the formation of multiple germ layers with many differentiative abilities. These cells are instructed through exposure to signalling molecules called morphogens. The secretion of morphogens from a source tissue creates a concentration gradient that allows distinct pattern formation in the receiving tissue. This review focuses on the morphogens Wnt and Fgf in zebrafish development. Wnt has been shown to have critical roles throughout gastrulation, including in anteroposterior patterning and neural posterisation. Fgf is also a vital signal, contributing to involution and mesodermal specification. Both morphogens have also been found to work in finely balanced synergy for processes such as neural induction. Thus, the signalling range of Wnts and Fgfs must be strictly controlled to target the correct target cells. Fgf and Wnts signal to local cells as well as to cells in the distance in a highly regulated way, requiring specific dissemination mechanisms that allow efficient and precise signalling over short and long distances. Multiple transportation mechanisms have been discovered to aid in producing a stable morphogen gradient, including short-range diffusion, filopodia-like extensions called cytonemes and extracellular vesicles, mainly exosomes. These mechanisms are specific to the morphogen that they transport and the intended signalling range. This review article discusses how spreading mechanisms in these two morphogenetic systems differ and the consequences on paracrine signalling, hence tissue patterning.
MeSH term(s)	Animals ; Zebrafish ; Gastrula ; Wnt Proteins ; Signal Transduction ; Zebrafish Proteins/genetics ; Body Patterning
Chemical Substances	Wnt Proteins ; Zebrafish Proteins
Language	English
Publishing date	2023-12-27
Publishing country	United States
Document type	Review ; Journal Article
ISSN	1557-8933 ; 0070-2153
ISSN (online)	1557-8933
ISSN	0070-2153
DOI	10.1016/bs.ctdb.2023.12.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Vertebrate Wnt5a - At the crossroads of cellular signalling.

Rogers, Sally / Scholpp, Steffen

Seminars in cell & developmental biology

2021 Volume 125, Page(s) 3–10

Abstract: Wnt signalling is an essential pathway in embryogenesis, differentiation, cell motility, development, and adult tissue homeostasis in vertebrates. The Wnt signalling network can activate several downstream pathways such as the β-catenin-dependent TCF/LEF ...

Abstract	Wnt signalling is an essential pathway in embryogenesis, differentiation, cell motility, development, and adult tissue homeostasis in vertebrates. The Wnt signalling network can activate several downstream pathways such as the β-catenin-dependent TCF/LEF transcription, the Wnt/planar cell polarity (PCP) pathway, and the Wnt/Calcium pathway. Wnt5a is a vertebrate Wnt ligand that is most often associated with the Wnt/PCP signalling pathway. Wnt5a/PCP signalling has a well-described role in embryogenesis via binding to a receptor complex of Frizzled and its co-receptors to initiate downstream activation of the c-Jun N-terminal kinase (JNK) signalling cascade and the Rho and Rac GTPases, Rho-Kinase (ROCK). This activation results in the cytoskeletal remodelling required for cell polarity, migration, and subsequently, tissue re-arrangement and organ formation. This review will focus on more recent work that has revealed new roles for Wnt5a ligands and consequently, an emerging broader function. This is partly due to our growing understanding of the crosstalk between the Wnt/PCP pathway with both the Wnt/β-catenin pathway and other signalling pathways, and in part due to the identification of novel atypical receptors for Wnt5a that demonstrate a far broader role for this ligand.
MeSH term(s)	Animals ; Cell Differentiation ; Cell Polarity/physiology ; Vertebrates/metabolism ; Wnt Proteins/genetics ; Wnt Proteins/metabolism ; Wnt Signaling Pathway/physiology
Chemical Substances	Wnt Proteins
Language	English
Publishing date	2021-10-20
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2021.10.002
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Zs.A 2918: Show issues

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Article ; Online: Cytoneme-mediated transport of active Wnt5b-Ror2 complexes in zebrafish.

Zhang, Chengting / Brunt, Lucy / Ono, Yosuke / Rogers, Sally / Scholpp, Steffen

Nature

2023 Volume 625, Issue 7993, Page(s) 126–133

Abstract: Chemical signalling is the primary means by which cells communicate in the embryo. The underlying principle refers to a group of ligand-producing cells and a group of cells that respond to this signal because they express the appropriate ... ...

Abstract	Chemical signalling is the primary means by which cells communicate in the embryo. The underlying principle refers to a group of ligand-producing cells and a group of cells that respond to this signal because they express the appropriate receptors
MeSH term(s)	Animals ; Gastrula/cytology ; Gastrula/embryology ; Gastrula/metabolism ; Ligands ; Wnt Proteins/metabolism ; Wnt Signaling Pathway/physiology ; Zebrafish/embryology ; Zebrafish/metabolism ; Cell Polarity ; Cell Movement ; Pseudopodia/metabolism ; Receptor Tyrosine Kinase-like Orphan Receptors/metabolism ; Paracrine Communication
Chemical Substances	Ligands ; Wnt Proteins ; Wnt5a protein, zebrafish ; Ror2 protein, zebrafish ; Receptor Tyrosine Kinase-like Orphan Receptors (EC 2.7.10.1)
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-06850-7
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Zs.MG 9: Show issues
Zs.MO 244: Show issues

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Article ; Online: Preserving Cytonemes for Immunocytochemistry of Cultured Adherent Cells.

Rogers, Sally / Scholpp, Steffen

Methods in molecular biology (Clifton, N.J.)

2020 Volume 2346, Page(s) 183–190

Abstract: Cytonemes are specialized signalling filopodia that have a role in development and cellular differentiation. However, they are not well preserved by standard fixation techniques to study protein localization and interactions. A recent methodological ... ...

Abstract	Cytonemes are specialized signalling filopodia that have a role in development and cellular differentiation. However, they are not well preserved by standard fixation techniques to study protein localization and interactions. A recent methodological advance has yielded improvements in cytoneme preservation using glutaraldehyde fixation and sodium borohydride treatment to reduce background. We herein describe a safer method for effective blocking using glycine following glutaraldehyde fixation of cytonemes on cultured adherent cells and demonstrate its effectiveness in immunocytochemistry.
MeSH term(s)	Borohydrides/chemistry ; Cell Adhesion ; Cell Communication ; Cells, Cultured ; Glutaral/chemistry ; Humans ; Immunohistochemistry ; Pseudopodia/metabolism
Chemical Substances	Borohydrides ; sodium borohydride (87L0B9CPPA) ; Glutaral (T3C89M417N)
Keywords	covid19
Language	English
Publishing date	2020-08-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/7651_2020_305
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish.

Sutton, Gemma / Kelsh, Robert N / Scholpp, Steffen

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 782445

Abstract: The neural crest (NC) is a multipotent cell population in vertebrate embryos with extraordinary migratory capacity. The NC is crucial for vertebrate development and forms a myriad of cell derivatives throughout the body, including pigment cells, neuronal ...

Abstract	The neural crest (NC) is a multipotent cell population in vertebrate embryos with extraordinary migratory capacity. The NC is crucial for vertebrate development and forms a myriad of cell derivatives throughout the body, including pigment cells, neuronal cells of the peripheral nervous system, cardiomyocytes and skeletogenic cells in craniofacial tissue. NC induction occurs at the end of gastrulation when the multipotent population of NC progenitors emerges in the ectodermal germ layer in the neural plate border region. In the process of NC fate specification, fate-specific markers are expressed in multipotent progenitors, which subsequently adopt a specific fate. Thus, NC cells delaminate from the neural plate border and migrate extensively throughout the embryo until they differentiate into various cell derivatives. Multiple signalling pathways regulate the processes of NC induction and specification. This review explores the ongoing role of the Wnt/β-catenin signalling pathway during NC development, focusing on research undertaken in the Teleost model organism, zebrafish (
Language	English
Publishing date	2021-11-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.782445
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Article ; Online: Cytonemes in development.

Zhang, Chengting / Scholpp, Steffen

Current opinion in genetics & development

2019 Volume 57, Page(s) 25–30

Abstract: Cell-cell communication is essential during the development of multicellular organisms. Specialized cell protrusions called cytonemes have been identified to exchange signals between cells that are vital for tissue development. Cytonemes can carry ... ...

Abstract	Cell-cell communication is essential during the development of multicellular organisms. Specialized cell protrusions called cytonemes have been identified to exchange signals between cells that are vital for tissue development. Cytonemes can carry signalling components between distant cells and thus regulate the activity levels of the corresponding signalling pathways across entire tissues. This review summarizes the key findings on the formation and function of cytonemes in tissue development.
MeSH term(s)	Animals ; Bone Morphogenetic Proteins/genetics ; Cell Communication/genetics ; Embryonic Development/genetics ; Hedgehog Proteins/genetics ; Humans ; Protein Transport/genetics ; Signal Transduction/genetics ; Wnt Proteins/genetics
Chemical Substances	Bone Morphogenetic Proteins ; Hedgehog Proteins ; Wnt Proteins
Language	English
Publishing date	2019-08-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1077312-5
ISSN	1879-0380 ; 0959-437X
ISSN (online)	1879-0380
ISSN	0959-437X
DOI	10.1016/j.gde.2019.06.005
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Zs.A 3240: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Mechanisms of intercellular Wnt transport.

Routledge, Daniel / Scholpp, Steffen

Development (Cambridge, England)

2019 Volume 146, Issue 10

Abstract: Wnt proteins are secreted glycoproteins that regulate multiple processes crucial to the development and tissue homeostasis of multicellular organisms, including tissue patterning, proliferation, cell fate specification, cell polarity and migration. To ... ...

Abstract	Wnt proteins are secreted glycoproteins that regulate multiple processes crucial to the development and tissue homeostasis of multicellular organisms, including tissue patterning, proliferation, cell fate specification, cell polarity and migration. To elicit these effects, Wnts act as autocrine as well as paracrine signalling molecules between Wnt-producing and Wnt-receiving cells. More than 40 years after the discovery of the Wg/Wnt pathway, it is still unclear how they are transported to fulfil their paracrine signalling functions. Several mechanisms have been proposed to mediate intercellular Wnt transport, including Wnt-binding proteins, lipoproteins, exosomes and cytonemes. In this Review, we describe the evidence for each proposed mechanism, and discuss how they may contribute to Wnt dispersal in tissue-specific and context-dependent manners, to regulate embryonic development precisely and maintain the internal steady state within a defined tissue.
MeSH term(s)	Animals ; Biological Transport/genetics ; Biological Transport/physiology ; Humans ; Wnt Proteins/genetics ; Wnt Proteins/metabolism ; Wnt Signaling Pathway/genetics ; Wnt Signaling Pathway/physiology
Chemical Substances	Wnt Proteins
Language	English
Publishing date	2019-05-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.176073
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Zs.MG 91: Show issues

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Article ; Online: Emerging role of contact-mediated cell communication in tissue development and diseases.

Mattes, Benjamin / Scholpp, Steffen

Histochemistry and cell biology

2018 Volume 150, Issue 5, Page(s) 431–442

Abstract: Cells of multicellular organisms are in continuous conversation with the neighbouring cells. The sender cells signal the receiver cells to influence their behaviour in transport, metabolism, motility, division, and growth. How cells communicate with each ...

Abstract	Cells of multicellular organisms are in continuous conversation with the neighbouring cells. The sender cells signal the receiver cells to influence their behaviour in transport, metabolism, motility, division, and growth. How cells communicate with each other can be categorized by biochemical signalling processes, which can be characterised by the distance between the sender cell and the receiver cell. Existing classifications describe autocrine signals as those where the sender cell is identical to the receiver cell. Complementary to this scenario, paracrine signalling describes signalling between a sender cell and a different receiver cell. Finally, juxtacrine signalling describes the exchange of information between adjacent cells by direct cell contact, whereas endocrine signalling describes the exchange of information, e.g., by hormones between distant cells or even organs through the bloodstream. In the last two decades, however, an unexpected communication mechanism has been identified which uses cell protrusions to exchange chemical signals by direct contact over long distances. These signalling protrusions can deliver signals in both ways, from sender to receiver and vice versa. We are starting to understand the morphology and function of these signalling protrusions in many tissues and this accumulation of findings forces us to revise our view of contact-dependent cell communication. In this review, we will focus on the two main categories of signalling protrusions, cytonemes and tunnelling nanotubes. These signalling protrusions emerge as essential structural components of a vibrant communication network in the development and tissue homeostasis of any multicellular organism.
MeSH term(s)	Animals ; Cell Communication ; Disease ; Embryonic Development ; Homeostasis ; Humans
Language	English
Publishing date	2018-09-25
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1222930-1
ISSN	1432-119X ; 0301-5564 ; 0948-6143
ISSN (online)	1432-119X
ISSN	0301-5564 ; 0948-6143
DOI	10.1007/s00418-018-1732-3
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