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  1. Article ; Online: Moving Safely to Phase 2 of the COVID-19 Pandemic: What Is More Pressing, Dates or Data?

    Werba, José Pablo / Veglia, Fabrizio

    Global heart

    2020  Volume 15, Issue 1, Page(s) 39

    Abstract: An in-depth analysis of gathered data collected in several countries on the pre-infectious characteristics of patients who have developed severe forms of COVID-19 disease could be the basis for developing tools to estimate individual risk and tailor ... ...

    Abstract An in-depth analysis of gathered data collected in several countries on the pre-infectious characteristics of patients who have developed severe forms of COVID-19 disease could be the basis for developing tools to estimate individual risk and tailor protective measures for a safer route through the Phase 2 of the pandemic.
    MeSH term(s) COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Data Interpretation, Statistical ; Female ; Humans ; Male ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Risk Assessment ; Risk Factors ; Time Factors
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2629633-0
    ISSN 2211-8179 ; 2211-8160
    ISSN (online) 2211-8179
    ISSN 2211-8160
    DOI 10.5334/gh.813
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  2. Article ; Online: Moving Safely to Phase 2 of the COVID-19 Pandemic

    José Pablo Werba / Fabrizio Veglia

    Global Heart, Vol 15, Iss

    What Is More Pressing, Dates or Data?

    2020  Volume 1

    Abstract: An in-depth analysis of gathered data collected in several countries on the pre-infectious characteristics of patients who have developed severe forms of COVID-19 disease could be the basis for developing tools to estimate individual risk and tailor ... ...

    Abstract An in-depth analysis of gathered data collected in several countries on the pre-infectious characteristics of patients who have developed severe forms of COVID-19 disease could be the basis for developing tools to estimate individual risk and tailor protective measures for a safer route through the Phase 2 of the pandemic.
    Keywords covid-19 ; cardiovascular ; risk factors ; algorithm ; prevention ; health policy ; comorbidities ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Public aspects of medicine ; RA1-1270 ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Ubiquity Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Moving Safely to Phase 2 of the COVID-19 Pandemic: What Is More Pressing, Dates or Data?

    Werba, José Pablo / Veglia, Fabrizio

    Glob Heart

    Abstract: An in-depth analysis of gathered data collected in several countries on the pre-infectious characteristics of patients who have developed severe forms of COVID-19 disease could be the basis for developing tools to estimate individual risk and tailor ... ...

    Abstract An in-depth analysis of gathered data collected in several countries on the pre-infectious characteristics of patients who have developed severe forms of COVID-19 disease could be the basis for developing tools to estimate individual risk and tailor protective measures for a safer route through the Phase 2 of the pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #761018
    Database COVID19

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  4. Article ; Online: A machine learning based approach to identify carotid subclinical atherosclerosis endotypes.

    Chen, Qiao Sen / Bergman, Otto / Ziegler, Louise / Baldassarre, Damiano / Veglia, Fabrizio / Tremoli, Elena / Strawbridge, Rona J / Gallo, Antonio / Pirro, Matteo / Smit, Andries J / Kurl, Sudhir / Savonen, Kai / Lind, Lars / Eriksson, Per / Gigante, Bruna

    Cardiovascular research

    2024  Volume 119, Issue 16, Page(s) 2594–2606

    Abstract: Aims: To define endotypes of carotid subclinical atherosclerosis.: Methods and results: We integrated demographic, clinical, and molecular data (n = 124) with ultrasonographic carotid measurements from study participants in the IMPROVE cohort (n = ... ...

    Abstract Aims: To define endotypes of carotid subclinical atherosclerosis.
    Methods and results: We integrated demographic, clinical, and molecular data (n = 124) with ultrasonographic carotid measurements from study participants in the IMPROVE cohort (n = 3340). We applied a neural network algorithm and hierarchical clustering to identify carotid atherosclerosis endotypes. A measure of carotid subclinical atherosclerosis, the c-IMTmean-max, was used to extract atherosclerosis-related features and SHapley Additive exPlanations (SHAP) to reveal endotypes. The association of endotypes with carotid ultrasonographic measurements at baseline, after 30 months, and with the 3-year atherosclerotic cardiovascular disease (ASCVD) risk was estimated by linear (β, SE) and Cox [hazard ratio (HR), 95% confidence interval (CI)] regression models. Crude estimates were adjusted by common cardiovascular risk factors, and baseline ultrasonographic measures. Improvement in ASCVD risk prediction was evaluated by C-statistic and by net reclassification improvement with reference to SCORE2, c-IMTmean-max, and presence of carotid plaques. An ensemble stacking model was used to predict endotypes in an independent validation cohort, the PIVUS (n = 1061). We identified four endotypes able to differentiate carotid atherosclerosis risk profiles from mild (endotype 1) to severe (endotype 4). SHAP identified endotype-shared variables (age, biological sex, and systolic blood pressure) and endotype-specific biomarkers. In the IMPROVE, as compared to endotype 1, endotype 4 associated with the thickest c-IMT at baseline (β, SE) 0.36 (0.014), the highest number of plaques 1.65 (0.075), the fastest c-IMT progression 0.06 (0.013), and the highest ASCVD risk (HR, 95% CI) (1.95, 1.18-3.23). Baseline and progression measures of carotid subclinical atherosclerosis and ASCVD risk were associated with the predicted endotypes in the PIVUS. Endotypes consistently improved measures of ASCVD risk discrimination and reclassification in both study populations.
    Conclusions: We report four replicable subclinical carotid atherosclerosis-endotypes associated with progression of atherosclerosis and ASCVD risk in two independent populations. Our approach based on endotypes can be applied for precision medicine in ASCVD prevention.
    MeSH term(s) Humans ; Risk Factors ; Carotid Artery Diseases/diagnostic imaging ; Atherosclerosis/diagnostic imaging ; Plaque, Atherosclerotic ; Carotid Arteries ; Cardiovascular Diseases
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvad106
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    Zs.A 565: Show issues Location:
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  5. Article: Determinants of Carotid Wall Echolucency in a Cohort of European High Cardiovascular Risk Subjects: A Cross-Sectional Analysis of IMPROVE Baseline Data.

    Frigerio, Beatrice / Coggi, Daniela / Bonomi, Alice / Amato, Mauro / Capra, Nicolò / Colombo, Gualtiero I / Sansaro, Daniela / Ravani, Alessio / Savonen, Kai / Giral, Philippe / Gallo, Antonio / Pirro, Matteo / Gigante, Bruna / Eriksson, Per / Strawbridge, Rona J / Mulder, Douwe J / Tremoli, Elena / Veglia, Fabrizio / Baldassarre, Damiano

    Biomedicines

    2024  Volume 12, Issue 4

    Abstract: Echolucency, a measure of plaque instability associated with increased cardiovascular risk, can be assessed in both the carotid plaque and the plaque-free common carotid intima-media (IM) complex as a gray-scale median (plaque-GSM and IM-GSM, ... ...

    Abstract Echolucency, a measure of plaque instability associated with increased cardiovascular risk, can be assessed in both the carotid plaque and the plaque-free common carotid intima-media (IM) complex as a gray-scale median (plaque-GSM and IM-GSM, respectively). The impact of specific vascular risk factors on these two phenotypes remains uncertain, including the nature and extent of their influence. This study aims to seek the determinants of plaque-GSM and IM-GSM. Plaque-GSM and IM-GSM were measured in subjects from the IMPROVE study cohort (aged 54-79, 46% men) recruited in five European countries. Plaque-GSM was measured in subjects who had at least one IMT
    Language English
    Publishing date 2024-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12040737
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  6. Article ; Online: Examination of the best cut-off points of PHQ-2 and GAD-2 for detecting depression and anxiety in Italian cardiovascular inpatients.

    Giuliani, Mattia / Gorini, Alessandra / Barbieri, Simone / Veglia, Fabrizio / Tremoli, Elena

    Psychology & health

    2020  Volume 36, Issue 9, Page(s) 1088–1101

    Abstract: Objective: Despite the frequent association between anxiety, depression and cardiovascular diseases (CVD), cardiovascular inpatients are not usually screened for these psychopathological conditions. To fill this gap, especially in hospital environments, ...

    Abstract Objective: Despite the frequent association between anxiety, depression and cardiovascular diseases (CVD), cardiovascular inpatients are not usually screened for these psychopathological conditions. To fill this gap, especially in hospital environments, there is the need of brief screening instruments that provide reliable information in a very short time. According to this need, the aim of this study was to examine the best cut-off points of two brief and easy-to-use questionnaires in a sample of Italian cardiovascular inpatients: the 2-item Patient Health Questionnaire (PHQ-2) and the 2-item Generalized Anxiety Disorder (GAD-2).
    Design: 3500 cardiovascular inpatients were recruited and completed both the 9-item Patient Health Questionnaire (PHQ-9) and the 7-item Generalized Anxiety Disorder (GAD-7). PHQ-2 and GAD-2 were then obtained extracting the first two item from PHQ-9 and GAD-7.
    Main outcome measures: The PHQ-2 and GAD-2 psychometric properties were calculated comparing them with PHQ-9 and GAD-7, respectively.
    Results: The PHQ-2 threshold of ≥ 2 and the GAD-2 threshold of ≥ 3 are the best solutions in balancing between sensitivity and specificity, also providing acceptable rates of false positives and false negatives.
    Conclusions: the PHQ-2 and GAD-2 Italian versions showed good diagnostic features for measuring depression and anxiety in CVD patients.
    MeSH term(s) Anxiety ; Anxiety Disorders/diagnosis ; Anxiety Disorders/epidemiology ; Depression/diagnosis ; Depression/epidemiology ; Humans ; Inpatients ; Italy/epidemiology ; Patient Health Questionnaire ; Surveys and Questionnaires
    Language English
    Publishing date 2020-10-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 625255-2
    ISSN 1476-8321 ; 0887-0446
    ISSN (online) 1476-8321
    ISSN 0887-0446
    DOI 10.1080/08870446.2020.1830093
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2856: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Plasma FA composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans.

    Pavanello, Chiara / Ossoli, Alice / Strazzella, Arianna / Risè, Patrizia / Veglia, Fabrizio / Lhomme, Marie / Parini, Paolo / Calabresi, Laura

    Journal of lipid research

    2022  Volume 63, Issue 7, Page(s) 100232

    Abstract: Mutations in the LCAT gene cause familial LCAT deficiency (Online Mendelian Inheritance in Man ID: #245900), a very rare metabolic disorder. LCAT is the only enzyme able to esterify cholesterol in plasma, whereas sterol O-acyltransferases 1 and 2 are the ...

    Abstract Mutations in the LCAT gene cause familial LCAT deficiency (Online Mendelian Inheritance in Man ID: #245900), a very rare metabolic disorder. LCAT is the only enzyme able to esterify cholesterol in plasma, whereas sterol O-acyltransferases 1 and 2 are the enzymes esterifying cellular cholesterol in cells. Despite the complete lack of LCAT activity, patients with familial LCAT deficiency exhibit circulating cholesteryl esters (CEs) in apoB-containing lipoproteins. To analyze the origin of these CEs, we investigated 24 carriers of LCAT deficiency in this observational study. We found that CE plasma levels were significantly reduced and highly variable among carriers of two mutant LCAT alleles (22.5 [4.0-37.8] mg/dl) and slightly reduced in heterozygotes (218 [153-234] mg/dl). FA distribution in CE (CEFA) was evaluated in whole plasma and VLDL in a subgroup of the enrolled subjects. We found enrichment of C16:0, C18:0, and C18:1 species and a depletion in C18:2 and C20:4 species in the plasma of carriers of two mutant LCAT alleles. No changes were observed in heterozygotes. Furthermore, plasma triglyceride-FA distribution was remarkably similar between carriers of LCAT deficiency and controls. CEFA distribution in VLDL essentially recapitulated that of plasma, being mainly enriched in C16:0 and C18:1, while depleted in C18:2 and C20:4. Finally, after fat loading, chylomicrons of carriers of two mutant LCAT alleles showed CEs containing mainly saturated FAs. This study of CEFA composition in a large cohort of carriers of LCAT deficiency shows that in the absence of LCAT-derived CEs, CEs present in apoB-containing lipoproteins are derived from hepatic and intestinal sterol O-acyltransferase 2.
    MeSH term(s) Apolipoproteins B ; Cholesterol/metabolism ; Cholesterol Esters ; Humans ; Lecithin Cholesterol Acyltransferase Deficiency/genetics ; Lipoproteins ; Phosphatidylcholine-Sterol O-Acyltransferase/genetics ; Phosphatidylcholine-Sterol O-Acyltransferase/metabolism ; Sterol O-Acyltransferase/metabolism ; Sterol O-Acyltransferase 2
    Chemical Substances Apolipoproteins B ; Cholesterol Esters ; Lipoproteins ; Cholesterol (97C5T2UQ7J) ; Sterol O-Acyltransferase (EC 2.3.1.26) ; LCAT protein, human (EC 2.3.1.43) ; Phosphatidylcholine-Sterol O-Acyltransferase (EC 2.3.1.43)
    Language English
    Publishing date 2022-05-19
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1016/j.jlr.2022.100232
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    Zs.A 175: Show issues Location:
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  8. Article ; Online: Uptake and effectiveness of a primary cardiovascular prevention program in an underserved multiethnic urban community.

    Werba, José P / Giroli, Monica G / Simonelli, Niccolò / Vigo, Lorenzo / Gorini, Alessandra / Bonomi, Alice / Veglia, Fabrizio / Tremoli, Elena

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2022  Volume 32, Issue 5, Page(s) 1110–1120

    Abstract: Background and aims: Cardiometabolic risk is increased among disadvantaged people and ethnic minorities. Paradoxically, their uptake of primary cardiovascular prevention is relatively low. New strategies are needed to tackle this public health problem. ... ...

    Abstract Background and aims: Cardiometabolic risk is increased among disadvantaged people and ethnic minorities. Paradoxically, their uptake of primary cardiovascular prevention is relatively low. New strategies are needed to tackle this public health problem. Aims of this study were to assess the uptake (as well as its determinants) and effectiveness of a primary cardiovascular prevention program for communities devised to facilitate access of disadvantaged and inclusion of ethnic minorities in addition to providing a state-of-the-art interdisciplinary personalized care.
    Methods and results: Single center, hospital-based, open study. All the residents in an underserved multiethnic urban community aged 40-65 years (n = 1646, 43.6% immigrants) were proactively invited by post mail to participate in a cardiovascular prevention program and different approaches were adopted to promote accessibility and inclusiveness. Program uptake was 23% and individual features independently associated with program uptake were status of immigrant (OR [CI 95%]: 3.6 [2.6-5.1]), higher educational level (3.6 [2.8-4.7]), and female gender (1.6 [1.2-2.1]). Retention was 82% at 6 months and 69% at 12 months. A predefined outcome of global cardiovascular risk improvement at 12 months in subjects with glycaemia >126 mg/dl, LDL-C >115 mg/dl, systolic blood pressure ≥140 mmHg or BMI >28 at baseline was reached in 35%, 33%, 37% and 7% of the patients, respectively. 20% of smokers quitted and significant favorable changes were reported in diet quality, anxiety, depression and physical activity.
    Conclusion: Access inequalities to effective prevention may be counteracted, but increasing global uptake requires further upstream sensitization and awareness actions. REGISTERED IN CLINICALTRIALS.GOV: NCT03129165.
    MeSH term(s) Adult ; Aged ; Blood Glucose ; Blood Pressure ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Diet ; Exercise ; Female ; Humans ; Male ; Middle Aged ; Primary Prevention
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2022-01-16
    Publishing country Netherlands
    Document type Clinical Study ; Journal Article
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2022.01.013
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    Zs.A 3149: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Modulation of soluble receptor for advanced glycation end products isoforms and advanced glycation end products in long-living individuals.

    Scavello, Francesco / Tedesco, Calogero C / Castiglione, Stefania / Maciag, Anna / Sangalli, Elena / Veglia, Fabrizio / Spinetti, Gaia / Puca, Annibale A / Raucci, Angela

    Biomarkers in medicine

    2021  Volume 15, Issue 11, Page(s) 785–796

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Receptor for Advanced Glycation End Products
    Chemical Substances Receptor for Advanced Glycation End Products
    Language English
    Publishing date 2021-07-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm-2020-0856
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    Zs.A 6985: Show issues Location:
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  10. Article ; Online: Apolipoprotein E isoforms differentially affect LCAT-dependent cholesterol esterification.

    Vitali, Cecilia / Pavanello, Chiara / Turri, Marta / Lund-Katz, Sissel / Phillips, Michael C / Catapano, Alberico Luigi / Baragetti, Andrea / Norata, Giuseppe Danilo / Veglia, Fabrizio / Calabresi, Laura

    Atherosclerosis

    2023  Volume 382, Page(s) 117266

    Abstract: Background and aims: LCAT esterifies cholesterol in both HDL (α-activity) and apoB-containing lipoproteins (β-activity). The main activator of LCAT β-activity is apoE, which in humans exists in 3 main different isoforms (E2, E3 and E4). Here, to gather ... ...

    Abstract Background and aims: LCAT esterifies cholesterol in both HDL (α-activity) and apoB-containing lipoproteins (β-activity). The main activator of LCAT β-activity is apoE, which in humans exists in 3 main different isoforms (E2, E3 and E4). Here, to gather insights into the potential role of LCAT in apoB-containing lipoprotein metabolism, we investigated the ability of apoE isoforms to promote LCAT-mediated cholesterol esterification.
    Methods: We evaluated the plasma cholesterol esterification rate (CER) in 311 individuals who express functional LCAT and either apoE2, apoE3, or apoE4 and in 28 individuals who also carried LCAT mutations causing selective loss of LCAT α-activity (Fish-Eye Disease (FED)-causing mutations). The association of carrier status with CER was determined using an adjusted linear regression model. The kinetic of LCAT activity towards reconstituted HDLs (rHDLs) containing each apoE isoform was determined using the Michaelis-Menten model.
    Results: Plasma CER was ∼20% higher in apoE2 carriers compared to apoE3 carriers, and ∼30% higher in apoE2 carriers compared to apoE4 carriers. After adjusting for age, sex, total cholesterol, HDL-C, apoA-I, apoB, chronic kidney disease diagnosis, zygosity, and LCAT concentration, CER remained significantly different among carriers of the three apoE isoforms. The same trend was observed in carriers of FED-causing mutations. rHDLs containing apoE2 were associated with a lower affinity but higher maximal esterification rate, compared to particles containing apoE3 or apoE4.
    Conclusion: The present results suggest that the apoE2 isoform is associated with a higher LCAT-mediated cholesterol esterification. This observation may contribute to the characterization of the peculiar functional properties of apoE2.
    Language English
    Publishing date 2023-08-30
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2023.117266
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