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  1. Article: Single Dose of Ivermectin is not Useful in Patients with Hematological Disorders and COVID-19 Illness: A Phase II B Open Labelled Randomized Controlled Trial.

    George, Biju / Moorthy, Mahesh / Kulkarni, Uday / Selvarajan, Sushil / Rupali, Priscilla / Christopher, D J / Balamugesh, T / Rose, Winsley / Lakshmi, Kavitha M / Devasia, Anup J / Fouzia, N A / Korula, Anu / Lionel, Sharon / Abraham, Aby / Mathews, Vikram

    Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

    2022  Volume 38, Issue 4, Page(s) 615–622

    Abstract: Repurposed drugs may reduce morbidity and mortality in patients with hematological disorders who develop COVID-19 illness. 112 patients with predominantly hematological illnesses were randomized to receive standard of care, ivermectin 12 mg [Iv 12] or 24  ...

    Abstract Repurposed drugs may reduce morbidity and mortality in patients with hematological disorders who develop COVID-19 illness. 112 patients with predominantly hematological illnesses were randomized to receive standard of care, ivermectin 12 mg [Iv 12] or 24 mg [Iv24] for asymptomatic, mild, or moderate COVID 19 illness. Serial respiratory samples for rRT-PCR samples were sent on Day 3, 5 and 7. rRT-PCR negativity and ≥ 2 log
    Language English
    Publishing date 2022-05-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 2422370-0
    ISSN 0974-0449 ; 0971-4502
    ISSN (online) 0974-0449
    ISSN 0971-4502
    DOI 10.1007/s12288-022-01546-w
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  2. Article: Corrigendum: Increase in pediatric recurrent fever evaluations during the first year of the COVID-19 pandemic in North America.

    Mansfield, Leanne M / Lapidus, Sivia K / Romero, Samira Nazzar / Moorthy, Lakshmi N / Adler-Shohet, Felice C / Hollander, Matthew / Cherian, Julie / Twilt, Marinka / Lionetti, Geraldina / Mohan, Smriti / DeLaMora, Patricia A / Durrant, Karen L / Muskardin, Theresa Wampler / Correia Marques, Mariana / Onel, Karen B / Dedeoglu, Fatma / Gutierrez, Maria J / Schulert, Grant

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1323946

    Abstract: This corrects the article DOI: 10.3389/fped.2023.1240242.]. ...

    Abstract [This corrects the article DOI: 10.3389/fped.2023.1240242.].
    Language English
    Publishing date 2023-11-06
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1323946
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  3. Article: Increase in pediatric recurrent fever evaluations during the first year of the COVID-19 pandemic in North America.

    Mansfield, Leanne M / Lapidus, Sivia K / Romero, Samira Nazzar / Moorthy, Lakshmi N / Adler-Shohet, Felice C / Hollander, Matthew / Cherian, Julie / Twilt, Marinka / Lionetti, Geraldina / Mohan, Smriti / DeLaMora, Patricia A / Durrant, Karen L / Muskardin, Theresa Wampler / Correia Marques, Mariana / Onel, Karen B / Dedeoglu, Fatma / Gutierrez, Maria J / Schulert, Grant

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1240242

    Abstract: The impact of the COVID-19 pandemic on new diagnoses of recurrent fevers and autoinflammatory diseases is largely unknown. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) PFAPA/AID Working Group aimed to investigate the impact of the ... ...

    Abstract The impact of the COVID-19 pandemic on new diagnoses of recurrent fevers and autoinflammatory diseases is largely unknown. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) PFAPA/AID Working Group aimed to investigate the impact of the COVID-19 pandemic on the number of pediatric patients evaluated for recurrent fevers and autoinflammatory diseases in North America. The absolute number of new outpatient visits and the proportion of these visits attributed to recurrent fever diagnoses during the pre-pandemic period (1 March 2019-29 February 2020) and the first year of the COVID-19 pandemic (1 March 2020-28 February 2021) were examined. Data were collected from 27 sites in the United States and Canada. Our results showed an increase in the absolute number of new visits for recurrent fever evaluations in 21 of 27 sites during the COVID-19 pandemic compared to the pre-pandemic period. The increase was observed across different geographic regions in North America. Additionally, the proportion of new visits to these centers for recurrent fever in relation to all new patient evaluations was significantly higher during the first year of the pandemic, increasing from 7.8% before the pandemic to 10.9% during the pandemic year (
    Language English
    Publishing date 2023-08-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1240242
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  4. Article ; Online: Case 1: Alopecia in a Healthy 9-year-old Girl.

    Magrini, Danielle / Li, Suzanne C / Bhise, Vikram / Weiss, Pamela F / Moorthy, Lakshmi N

    Pediatrics in review

    2015  Volume 36, Issue 11, Page(s) 503–505

    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Alopecia/etiology ; Child ; Dermatologic Agents/therapeutic use ; Diagnosis, Differential ; Female ; Humans ; Methotrexate/therapeutic use ; Scleroderma, Localized/complications ; Scleroderma, Localized/diagnosis ; Scleroderma, Localized/drug therapy
    Chemical Substances Adrenal Cortex Hormones ; Dermatologic Agents ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 774515-1
    ISSN 1526-3347 ; 0191-9601
    ISSN (online) 1526-3347
    ISSN 0191-9601
    DOI 10.1542/pir.36-11-503
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  5. Article ; Online: Abdominal pain, rash, and arthritis.

    Parlow, Brittany / Mohiuddin, Adil / Chou, Theodore / Cato-Varlack, Janice / Boneparth, Alexis / Moorthy, Lakshmi N

    Clinical pediatrics

    2015  Volume 54, Issue 5, Page(s) 498–500

    MeSH term(s) Abdominal Pain/etiology ; Adolescent ; Anti-Inflammatory Agents/therapeutic use ; Antirheumatic Agents/therapeutic use ; Arthritis/etiology ; Azathioprine/therapeutic use ; Cyclophosphamide/therapeutic use ; Diagnosis, Differential ; Exanthema/etiology ; Female ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis ; Granulomatosis with Polyangiitis/therapy ; Hemoptysis/etiology ; Humans ; Immunosuppressive Agents/therapeutic use ; Methylprednisolone Hemisuccinate/therapeutic use ; Plasmapheresis ; Prednisone/therapeutic use ; Rituximab/therapeutic use
    Chemical Substances Anti-Inflammatory Agents ; Antirheumatic Agents ; Immunosuppressive Agents ; Rituximab (4F4X42SYQ6) ; Methylprednisolone Hemisuccinate (5GMR90S4KN) ; Cyclophosphamide (8N3DW7272P) ; Azathioprine (MRK240IY2L) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Clinical Conference ; Journal Article
    ZDB-ID 207678-0
    ISSN 1938-2707 ; 0009-9228
    ISSN (online) 1938-2707
    ISSN 0009-9228
    DOI 10.1177/0009922814554502
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  6. Article ; Online: Successful Treatment of Henoch-Schönlein Purpura With Recurrent Gastrointestinal Involvement With Mycophenolate Mofetil: A Brief Report.

    Chou, Theodore / Louissant, Valerie R / Adams, Alexa / Gurkan, Sevgi / Chefitz, Dalya / Weller, Alan S / Moorthy, Lakshmi N

    Clinical pediatrics

    2015  Volume 54, Issue 9, Page(s) 900–903

    MeSH term(s) Abdominal Pain/etiology ; Child ; Diarrhea/etiology ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Mycophenolic Acid/analogs & derivatives ; Mycophenolic Acid/therapeutic use ; Purpura, Schoenlein-Henoch/complications ; Purpura, Schoenlein-Henoch/drug therapy ; Recurrence ; Treatment Outcome
    Chemical Substances Immunosuppressive Agents ; Mycophenolic Acid (HU9DX48N0T)
    Language English
    Publishing date 2015-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207678-0
    ISSN 1938-2707 ; 0009-9228
    ISSN (online) 1938-2707
    ISSN 0009-9228
    DOI 10.1177/0009922814568288
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  7. Article: Quality of life measures and psychiatric symptoms in adolescents with systemic lupus erythematosus and familial Mediterranean fever.

    Düzçeker, Yasemin / Kanbur, Nuray Ö / Demirkaya, Erkan / Derman, Orhan / Moorthy, Lakshmi N / Ozen, Seza

    International journal of adolescent medicine and health

    2014  Volume 26, Issue 4, Page(s) 541–549

    Abstract: ... the perceptions of parents and adolescents.: Methods: This study included 51 adolescents diagnosed with SLE (n ... 25) and FMF (n=26), and 51 healthy adolescents. The Health Related QL (HRQL) of SLE patients was ...

    Abstract Purpose: To describe the relation between global Quality of Life (QL) and psychiatric symptoms in adolescents with systemic lupus erythematosus (SLE) and familial Mediterranean fever (FMF), and to analyze the perceptions of parents and adolescents.
    Methods: This study included 51 adolescents diagnosed with SLE (n=25) and FMF (n=26), and 51 healthy adolescents. The Health Related QL (HRQL) of SLE patients was rated by parents and adolescents using the Simple Measurement of Impact of Lupus Erythematosus in Youngsters© (SMILEY©). The global QL of FMF patients and healthy adolescents was rated by the response given to the first question of the SMILEY© by each parent and adolescent. All participants completed the Brief Symptom Inventory (BSI), which measures psychiatric symptoms.
    Results: In total, 92.3% with FMF, 56% with SLE and 76.5% of healthy adolescents reported their global QL as good and very good using the first question of the SMILEY©. The global QL perceptions of adolescents and their parents did not correlate (FMF, p=0.94; SLE, p=0.16). SLE patients had the highest rate of depression (54.2%), whereas hostility was detected among 54.9% of healthy adolescents. Significant relations were detected between BSI and SMILEY© scores.
    Conclusion: The global QL perceptions of adolescents with FMF were better than those of healthy adolescents, which may be explained by their perceived relief of anguish they suffer during their short-lived attacks. The global QL perceptions of adolescents with SLE were the worst, most probably due to the chronic course resulting in an awareness of limitations and intense treatment. Adolescents with SLE had similar psychopathological symptom scores when compared with FMF patients and healthy adolescents. This could be explained by developing resilience. Differences in the perception of adolescents versus their parents regarding global QL emphasized the importance of adolescent-specific interviews for chronic illnesses and multidisciplinary follow-up with adolescent medicine.
    MeSH term(s) Adolescent ; Familial Mediterranean Fever/psychology ; Female ; Humans ; Lupus Erythematosus, Systemic/psychology ; Male ; Mental Health ; Parents ; Quality of Life ; Severity of Illness Index
    Language English
    Publishing date 2014
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639287-8
    ISSN 2191-0278 ; 0334-0139
    ISSN (online) 2191-0278
    ISSN 0334-0139
    DOI 10.1515/ijamh-2013-0332
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  8. Article ; Online: Dietary Sugar Exposure and Oral Health Status in Children with Autism Spectrum Disorder: A Case-control Study.

    Moorthy, Lakshmi / Dixit, Uma B / Kole, Rachita C / Gajre, Mona P

    Journal of autism and developmental disorders

    2021  Volume 52, Issue 6, Page(s) 2523–2534

    Abstract: ... with and without Autism Spectrum Disorder (ASD), aged 5-12 years (n = 136, each). Data regarding socio ...

    Abstract This case-control study compared dietary sugar exposure and oral health status between children with and without Autism Spectrum Disorder (ASD), aged 5-12 years (n = 136, each). Data regarding socio-demographics, child's oral hygiene practices and behavior, diet-related behavior, oral habits and dental trauma were obtained. Child's diet on the previous day was recorded using 24-h recall method and sugar exposure was calculated using Dental Diet Diary (D3) mobile application. Oral Hygiene Index-Simplified (OHI-S), deft and DMFT were recorded. Results showed no significant differences in sugar exposure, deft and DMFT between the groups. Although oral hygiene practices were significantly better in children with ASD, their OHI-S was significantly worse. Significantly more children with ASD reported mouth-breathing, bruxism and self-injurious habits.
    MeSH term(s) Autism Spectrum Disorder/epidemiology ; Case-Control Studies ; Child ; Cross-Sectional Studies ; Dietary Sugars/adverse effects ; Humans ; Oral Health ; Oral Hygiene ; Sugars
    Chemical Substances Dietary Sugars ; Sugars
    Language English
    Publishing date 2021-07-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-021-05151-0
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  9. Article: Knockdown of human telomerase reverse transcriptase induces apoptosis in cervical cancer cell line.

    Nagapoosanam, Anantha Lakshmi / Ganesan, Nithya / Umapathy, Devan / Moorthy, Rajesh Kannan / Arockiam, Antony Joseph Velanganni

    The Indian journal of medical research

    2019  Volume 149, Issue 3, Page(s) 345–353

    Abstract: Background & objectives: : Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of telomerase enzyme that maintains telomere ends by the addition of telomeric repeats to the ends of chromosomal DNA, and that may generate immortal ... ...

    Abstract Background & objectives: : Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of telomerase enzyme that maintains telomere ends by the addition of telomeric repeats to the ends of chromosomal DNA, and that may generate immortal cancer cells. Hence, the activity of telomerase is raised in cancer cells including cervical cancer. The present study aimed to validate the unique siRNA loaded chitosan coated poly-lactic-co-glycolic acid (PLGA) nanoparticle targeting hTERT mRNA to knock down the expression of hTERT in HeLa cells.
    Methods: : The siRNA loaded chitosan coated polylactic-co-glycolic acid (PLGA) nanoparticles were synthesized by double emulsion solvent diffusion method. The characterization of nano-formulation was done to determine efficient siRNA delivery. MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay, reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot were performed to evaluate silencing efficiency of nano-formulation.
    Results: :Size, zeta potential and encapsulation efficiency of nanoparticles were 249.2 nm, 12.4 mV and 80.5 per cent, respectively. Sustained release of siRNA from prepared nanoparticle was studied for 72 h by ultraviolet method. Staining assays were performed to confirm senescence and apoptosis. Silencing of hTERT mRNA and protein expression were analyzed in HeLa cells by RT-PCR and Western blot.
    Interpretation & conclusions: : The findings showed that biodegradable chitosan coated PLGA nanoparticles possessed an ability for efficient and successful siRNA delivery. The siRNA-loaded PLGA nanoparticles induced apoptosis in HeLa cells. Further studies need to be done with animal model.
    MeSH term(s) Apoptosis/genetics ; Cell Proliferation/genetics ; Chitosan/chemistry ; Chitosan/pharmacology ; Female ; Gene Knockdown Techniques ; Gene Silencing ; HeLa Cells ; Humans ; Nanoparticles/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/pharmacology ; RNA, Messenger/antagonists & inhibitors ; RNA, Small Interfering/chemistry ; RNA, Small Interfering/genetics ; RNA, Small Interfering/pharmacology ; Telomerase/antagonists & inhibitors ; Telomerase/genetics ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/pathology
    Chemical Substances RNA, Messenger ; RNA, Small Interfering ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Chitosan (9012-76-4) ; TERT protein, human (EC 2.7.7.49) ; Telomerase (EC 2.7.7.49)
    Language English
    Publishing date 2019-06-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_1676_16
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  10. Article ; Online: Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus.

    Walters, Heather M / Pan, Nancy / Moorthy, Lakshmi N / Ward, Mary J / Peterson, Margaret G / Lehman, Thomas J

    Pediatric rheumatology online journal

    2012  Volume 10, Issue 1, Page(s) 22

    Language English
    Publishing date 2012-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2279468-2
    ISSN 1546-0096 ; 1546-0096
    ISSN (online) 1546-0096
    ISSN 1546-0096
    DOI 10.1186/1546-0096-10-22
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