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  1. Article ; Online: Regulatory Evolution of the

    Valdespino-Díaz, Marcos A / Rosales-Reyes, Roberto / De la Cruz, Miguel A / Bustamante, Víctor H

    Journal of bacteriology

    2022  Volume 204, Issue 5, Page(s) e0058521

    Abstract: One important event for the divergence of Salmonella from Escherichia coli was the acquisition by horizontal transfer of ... ...

    Abstract One important event for the divergence of Salmonella from Escherichia coli was the acquisition by horizontal transfer of the
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression Regulation, Bacterial ; Phosphates/metabolism ; Salmonella typhimurium/metabolism ; Serogroup ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances Bacterial Proteins ; Phosphates ; Transcription Factors
    Language English
    Publishing date 2022-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.00585-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Significance of Molecular Identification of Genomic Variants of Pseudomonas aeruginosa in Children with Cystic Fibrosis.

    Rosales-Reyes, Roberto / Flores-Vega, Verónica Roxana / Lezana-Fernández, José Luis / Santos-Preciado, José Ignacio

    Archives of medical research

    2022  Volume 53, Issue 6, Page(s) 641–642

    Abstract: Pseudomonas aeruginosa is a significant cause of lung infections in patients with cystic fibrosis (CF). Pseudomonas produces a chronic infection that increases the morbidity and mortality in affected individuals. The rapid identification of Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa is a significant cause of lung infections in patients with cystic fibrosis (CF). Pseudomonas produces a chronic infection that increases the morbidity and mortality in affected individuals. The rapid identification of Pseudomonas in these individuals enables conventional antimicrobial treatment to be started. However, over the years, treatment of P. aeruginosa has become problematic and very challenging due to their intrinsic and acquired antibiotic resistance. Microbiology plays an essential role in determining the antimicrobial susceptibility/resistance profiles of isolated strains, helping to optimize antimicrobial treatment for affected patients. In addition to the conventional susceptibility analysis, whole genome sequencing has emerged as a powerful tool for determining specific genomic variants, both in specific geographic areas and globally. Thus, molecular epidemiologic surveillance could help to establish a better treatment strategy and counter the spread of high-risk, P. aeruginosa variants among CF individuals.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Child ; Cystic Fibrosis/complications ; Cystic Fibrosis/genetics ; Genomics ; Humans ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/genetics
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-09-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1156844-6
    ISSN 1873-5487 ; 0188-4409 ; 0188-0128
    ISSN (online) 1873-5487
    ISSN 0188-4409 ; 0188-0128
    DOI 10.1016/j.arcmed.2022.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The nucleoid protein HU positively regulates the expression of type VI secretion systems in

    Hernández-Martínez, Gabriela / Ares, Miguel A / Rosales-Reyes, Roberto / Soria-Bustos, Jorge / Yañez-Santos, Jorge Antonio / Cedillo, María L / Girón, Jorge A / Martínez-Laguna, Ygnacio / Leng, Fenfei / Ibarra, J Antonio / De la Cruz, Miguel A

    mSphere

    2024  , Page(s) e0006024

    Abstract: Enterobacter cloacae: Importance: T6SS is a nanomachine that functions as a weapon of bacterial destruction crucial for successful colonization in a specific niche. ...

    Abstract Enterobacter cloacae
    Importance: T6SS is a nanomachine that functions as a weapon of bacterial destruction crucial for successful colonization in a specific niche.
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00060-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clinical pathology, diagnostic and treatment in SARS-CoV-2 infection.

    Mucito-Varela, Eduardo / Osorio-Juárez, Ricardo Arturo / Rosales-Reyes, Roberto / Jiménez-Hernández, Luis Enrique

    Revista medica del Instituto Mexicano del Seguro Social

    2021  Volume 58, Issue Supl 2, Page(s) S292–300

    Abstract: SARS-CoV-2 is a new virus causing an infection and illness referred to as COVID-19. As of July ... ...

    Title translation Patología clínica, diagnóstico y tratamiento en la infección por SARS-CoV-2.
    Abstract SARS-CoV-2 is a new virus causing an infection and illness referred to as COVID-19. As of July 7
    Language Spanish
    Publishing date 2021-10-25
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 732133-8
    ISSN 2448-5667 ; 0443-5117 ; 0484-7849
    ISSN (online) 2448-5667
    ISSN 0443-5117 ; 0484-7849
    DOI 10.24875/RMIMSS.M20000141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: SARS-CoV-2: Evolution and Emergence of New Viral Variants.

    Flores-Vega, Verónica Roxana / Monroy-Molina, Jessica Viridiana / Jiménez-Hernández, Luis Enrique / Torres, Alfredo G / Santos-Preciado, José Ignacio / Rosales-Reyes, Roberto

    Viruses

    2022  Volume 14, Issue 4

    Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent responsible for the coronavirus disease 2019 (COVID-19). The high rate of mutation of this virus is associated with a quick emergence of new viral variants that ... ...

    Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent responsible for the coronavirus disease 2019 (COVID-19). The high rate of mutation of this virus is associated with a quick emergence of new viral variants that have been rapidly spreading worldwide. Several mutations have been documented in the receptor-binding domain (RBD) of the viral spike protein that increases the interaction between SARS-CoV-2 and its cellular receptor, the angiotensin-converting enzyme 2 (ACE2). Mutations in the spike can increase the viral spread rate, disease severity, and the ability of the virus to evade either the immune protective responses, monoclonal antibody treatments, or the efficacy of current licensed vaccines. This review aimed to highlight the functional virus classification used by the World Health Organization (WHO), Phylogenetic Assignment of Named Global Outbreak (PANGO), Global Initiative on Sharing All Influenza Data (GISAID), and Nextstrain, an open-source project to harness the scientific and public health potential of pathogen genome data, the chronological emergence of viral variants of concern (VOCs) and variants of interest (VOIs), the major findings related to the rate of spread, and the mutations in the spike protein that are involved in the evasion of the host immune responses elicited by prior SARS-CoV-2 infections and by the protection induced by vaccination.
    MeSH term(s) COVID-19 ; Humans ; Mutation ; Phylogeny ; Protein Binding ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-03-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14040653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Fibrosis quística: patogenia bacteriana y moduladores del CFTR (regulador de conductancia transmembranal de la fibrosis quística).

    Vargas-Roldán, Silvia Y / Lezana-Fernández, José L / Cerna-Cortés, Jorge F / Partida-Sánchez, Santiago / Santos-Preciado, José I / Rosales-Reyes, Roberto

    Boletin medico del Hospital Infantil de Mexico

    2022  Volume 79, Issue 4, Page(s) 215–221

    Abstract: Cystic fibrosis is an autosomal recessive inherited disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR). CFTR is a protein that transports ions across the membrane of lung epithelial cells. Loss of its ... ...

    Title translation Cystic fibrosis: bacterial pathogenesis and CFTR (cystic fibrosis transmembrane conductance regulator) modulators.
    Abstract Cystic fibrosis is an autosomal recessive inherited disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR). CFTR is a protein that transports ions across the membrane of lung epithelial cells. Loss of its function leads to the production of thick sticky mucus, where various bacterial pathogens can establish and adapt, contributing to the gradual loss of lung function. In this review, evidence of the molecular mechanisms used by Pseudomonas aeruginosa and Burkholderia cenocepacia to survive and persist in the pulmonary environment will be provided. Additionally, new therapeutic strategies based on CFTR function modulators will be described.
    MeSH term(s) Cystic Fibrosis ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/therapeutic use ; Epithelial Cells/metabolism ; Epithelial Cells/microbiology ; Fibrosis ; Humans ; Pseudomonas aeruginosa
    Chemical Substances CFTR protein, human ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2022-09-11
    Publishing country Mexico
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 730519-9
    ISSN 1665-1146 ; 1665-1146 ; 0539-6115 ; 0539-6123
    ISSN (online) 1665-1146
    ISSN 1665-1146 ; 0539-6115 ; 0539-6123
    DOI 10.24875/BMHIM.21000128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Pseudomonas Aeruginosa: Genetic Adaptation, A Strategy for its Persistence in Cystic Fibrosis.

    Rosales-Reyes, Roberto / Vargas-Roldán, Silvia Yalid / Lezana-Fernández, José Luis / Santos-Preciado, José Ignacio

    Archives of medical research

    2020  Volume 52, Issue 4, Page(s) 357–361

    Abstract: Cystic fibrosis (CF) is a progressive autosomal recessive genetic disease that principally affects the respiratory and digestive systems. It is a chronic disease that has no cure. Symptoms often include chronic cough, lung infections, and shortness of ... ...

    Abstract Cystic fibrosis (CF) is a progressive autosomal recessive genetic disease that principally affects the respiratory and digestive systems. It is a chronic disease that has no cure. Symptoms often include chronic cough, lung infections, and shortness of breath. Children with cystic fibrosis present failure to thrive as manifested by low weight and height for age. CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator (cftr) gene that codes for a cell membrane protein of epithelial tissues and affects multiple organ systems in the human body. Mutations on the CFTR causes dysfunctional electrolyte regulation affecting intracellular water content. Defective CFTR function in airways produce a dehydrated and sticky mucus that leads the establishment of bacterial chronic infection that ultimate decrease the lung function. During the first decade of life, affected individuals are colonized principally by non typable Haemophilus influenzae and Staphylococcus aureus. During the second decade, Pseudomonas aeruginosa becomes the most dominant pathogen and persists throughout the remainder of their lives. In this work, we describe the mechanisms used by P. aeruginosa to adapt and persist in lungs of individuals with cystic fibrosis.
    MeSH term(s) Cystic Fibrosis/genetics ; Humans ; Lung ; Pseudomonas Infections ; Pseudomonas aeruginosa
    Language English
    Publishing date 2020-12-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1156844-6
    ISSN 1873-5487 ; 0188-4409 ; 0188-0128
    ISSN (online) 1873-5487
    ISSN 0188-4409 ; 0188-0128
    DOI 10.1016/j.arcmed.2020.12.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bacterial Subversion of Autophagy in Cystic Fibrosis.

    Flores-Vega, Verónica Roxana / Vargas-Roldán, Silvia Yalid / Lezana-Fernández, José Luis / Lascurain, Ricardo / Santos-Preciado, José Ignacio / Rosales-Reyes, Roberto

    Frontiers in cellular and infection microbiology

    2021  Volume 11, Page(s) 760922

    Abstract: Cystic fibrosis (CF) is a genetic disease affecting more than 70,000 people worldwide. It is caused by a mutation in ... ...

    Abstract Cystic fibrosis (CF) is a genetic disease affecting more than 70,000 people worldwide. It is caused by a mutation in the
    MeSH term(s) Autophagy ; Burkholderia cenocepacia ; Cystic Fibrosis ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Humans ; Pseudomonas Infections ; Pseudomonas aeruginosa
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2021-10-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.760922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Two-Component System CpxRA Represses Salmonella Pathogenicity Island 2 by Directly Acting on the

    León-Montes, Nancy / Nava-Galeana, Jessica / Rodríguez-Valverde, Diana / Soria-Bustos, Jorge / Rosales-Reyes, Roberto / Rivera-Gutiérrez, Sandra / Hirakawa, Hidetada / Ares, Miguel A / Bustamante, Víctor H / De la Cruz, Miguel A

    Microbiology spectrum

    2022  Volume 10, Issue 5, Page(s) e0271022

    Abstract: The acquisition of Salmonella pathogenicity island 2 (SPI-2) conferred on Salmonella the ability to survive and replicate within host cells. ... ...

    Abstract The acquisition of Salmonella pathogenicity island 2 (SPI-2) conferred on Salmonella the ability to survive and replicate within host cells. The
    MeSH term(s) Mice ; Animals ; Genomic Islands ; Gene Expression Regulation, Bacterial ; Type III Secretion Systems/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Operon ; Salmonella typhimurium/genetics ; Salmonella typhimurium/metabolism
    Chemical Substances Type III Secretion Systems ; Transcription Factors ; Bacterial Proteins
    Language English
    Publishing date 2022-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02710-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Burkholderia cenocepacia

    Rosales-Reyes, Roberto / Sánchez-Gómez, Concepción / Ortiz-Navarrete, Vianney / Santos-Preciado, José Ignacio

    BioMed research international

    2018  Volume 2018, Page(s) 4271560

    Abstract: Burkholderia ... ...

    Abstract Burkholderia cenocepacia
    MeSH term(s) Animals ; Bacterial Secretion Systems ; Burkholderia cenocepacia/physiology ; Female ; Macrophages/microbiology ; Macrophages/ultrastructure ; Mice, Inbred BALB C ; Pinocytosis
    Chemical Substances Bacterial Secretion Systems
    Language English
    Publishing date 2018-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2018/4271560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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