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Book ; Online: Saliva and Oral Diseases

Lopez-Jornet, Pia

2021

Keywords	Medicine ; salivary biomarkers ; oral neoplasia ; periodontal disease/periodontitis ; smoking ; ethanol consumption ; real-time quantitative PCR ; enzyme-linked immune-sorbent assay ; immunohistochemistry ; bacteria ; HS-SPME-GC-MS ; MALDI-TOF MS ; silver nanoparticles ; VOCs ; obesity ; periodontitis ; cytokine ; inflammation ; saliva ; biomarkers ; oral cancer ; oral lichen planus ; psoriasis ; oral diseases ; oxidative stress ; antioxidants ; plaque psoriasis ; salivary glands ; cytokines ; nitrosative stress ; IgA ; alpha-amylase ; uric acid ; stress ; dental implants ; corrosion ; titanium ; metallic ions ; human papillomavirus ; oropharyngeal cancer ; meta-analysis ; n/a
Size	1 electronic resource (152 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel, Switzerland
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021291131
ISBN	9783036507774 ; 3036507779
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online ; E-Book: Saliva in Health and Disease

Tvarijonaviciute, Asta / Martínez-Subiela, Silvia / López-Jornet, Pia / Lamy, Elsa

The Present and Future of a Unique Sample for Diagnosis

2020

Abstract: Saliva as a unique sample for health assessment is gaining attention among researchers of different fields in the last 20 years; being reflected in an impressive increase in the number of papers published studying saliva from different biological aspects ...

Author's details	edited by Asta Tvarijonaviciute, Silvia Martínez-Subiela, Pia López-Jornet, Elsa Lamy
Abstract	Saliva as a unique sample for health assessment is gaining attention among researchers of different fields in the last 20 years; being reflected in an impressive increase in the number of papers published studying saliva from different biological aspects in human and veterinary species. Once deemed merely a digestive juice is now considered a biological fluid capable of communicating information about physiopathological processes occurring in organisms, since saliva has been shown to contain molecular and bacterial compounds that can change in response to local and systemic pathologies. Furthermore, the interest of saliva as a diagnostic, prognostic and monitoring biofluid is forced by its non-invasive nature being of easy and inexpensive sampling, involving only minimal discomfort and allowing the collection of multiple/repeated specimens at anytime, anywhere and without need for specialized staff. In this contributed volume, the authors bring together, summarize and reflect the generated knowledge about saliva as a source of biomarkers for health and welfare evaluation in humans and animal models. This volume also highlights the importance of confounding factors, such as sampling methods, flow, total protein content, contamination, or storage. This book will serve as a manual for graduates, practitioners and researchers by providing general ideas about the possibilities and utilities of saliva in clinical practice or investigation, and indicating the main cautions each should have in mind before saliva usage.
Keywords	Human physiology ; Laboratory medicine ; Pathology ; Animal physiology ; Human Physiology ; Laboratory Medicine ; Animal Physiology ; Glàndules salivals ; Marcadors bioquímics ; Salut
Subject code	616.316
Language	English
Size	1 online resource (X, 326 p. 23 illus., 19 illus. in color.)
Edition	1st ed. 2020.
Publisher	Springer International Publishing ; Imprint: Springer
Publishing place	Cham
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-030-37681-8 ; 3-030-37680-X ; 978-3-030-37681-9 ; 978-3-030-37680-2
DOI	10.1007/978-3-030-37681-9
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Diagnostic Infrared Thermography of the Tongue and Taste Perception in Patients with Oral Lichen Planus: Case-Control Study.

Nicolas-Rodriguez, Elena / Pons-Fuster, Eduardo / López-Jornet, Pia

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: Oral lichen planus (OLP) is a chronic inflammatory disease of autoimmune origin that affects the skin and mucous membranes. The aim of this study was to assess the effectiveness of infrared thermography (IRT) as a diagnostic tool in patients with oral ... ...

Abstract	Oral lichen planus (OLP) is a chronic inflammatory disease of autoimmune origin that affects the skin and mucous membranes. The aim of this study was to assess the effectiveness of infrared thermography (IRT) as a diagnostic tool in patients with oral lichen planus (OLP), as well as disturbances in taste perception, in cases with and without tongue involvement. A case-control study was carried out in a sample of 87 patients divided into three groups: healthy individuals (controls;
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020435
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Recurrence of Oral Leukoplakia after CO

Rodriguez-Lujan, Adela / López-Jornet, Pia / Pons-Fuster López, Eduardo

Cancers

2022 Volume 14, Issue 21

Abstract: Aim: The aim of this study is to assess the efficacy of CO: Materials and methods: A prospective clinical study regarding CO: Results: In the analysis of the final results 18 months after baseline, a treatment success rate of 43.75% was observed. ... ...

Abstract	Aim: The aim of this study is to assess the efficacy of CO Materials and methods: A prospective clinical study regarding CO Results: In the analysis of the final results 18 months after baseline, a treatment success rate of 43.75% was observed. Oral leukoplakia recurred in 54.17% of cases, and 2.08% of leukoplakias progressed to cancer. Among all the studied variables (age, tobacco use, size, location, clinical type or histology), no significant differences were found with regard to recurrence. Conclusion: The use of CO
Language	English
Publishing date	2022-11-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14215455
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Survival among treated tongue cancer patients: a single-center experience.

Veiga-San Roman, Pablo / Villanueva San Vicente, Victor / Rodriguez-Gonzalez, M Angeles / López-Jornet, Pia

Discover oncology

2024 Volume 15, Issue 1, Page(s) 127

Abstract: Objective: To describe overall survival (OS) and disease-free survival (DFS) in a cohort of tongue cancer patients, together with the corresponding demographic, tumor and surgical characteristics.: Methods: A retrospective study was made of 205 ... ...

Abstract	Objective: To describe overall survival (OS) and disease-free survival (DFS) in a cohort of tongue cancer patients, together with the corresponding demographic, tumor and surgical characteristics. Methods: A retrospective study was made of 205 consecutive patients with primary tongue cancer subjected to surgery and adjuvant therapy according to the stage of the disease, in Hospital Clínico Universitario Virgen de la Arrixaca (HUVA) (Murcia, Spain) during the period 2000-2020. Survival was evaluated based on the Kaplan-Meier method, and the existence of significant differences between the different study variables was analyzed using the log-rank test. Cox regression analysis was performed for the identification of risk factors. Results: In relation to overall survival, 72.6% of the patients survived for a mean time of 14.43 years [standard error (SE) = 0.74; 95% CI: 12.98-15.87], with a cumulative survival rate of 49.8 ± 3%. Survival was reduced by the presence of tumor adjacent to resection margins [hazard ratio (HR) 2.20; 95% CI 1.09-4.43] (p = 0.028) and infiltrated resection margins (HR 3.86, 95% CI 1.56-9.57) (p = 0.004). Lymphadenectomy in turn increased survival (HR 0.15; 95% CI 0.06-0.42) (p < 0.001). In relation to disease-free survival, 55.3% of the patients suffered no relapse over a mean period of 9.91 years (SE = 0.66; 95% CI: 8.61-11.2), with a cumulative survival rate of 26.6% ± 8.4%. Conclusions: In tongue cancer patients, overall and specific survival were reduced in the presence of infiltrated resection margins. Lymphadenectomy in turn improved survival compared with patients in which this procedure was not carried out.
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ISSN	2730-6011
ISSN (online)	2730-6011
DOI	10.1007/s12672-024-00989-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Preliminary Evaluation Salivary Biomarkers in Patients with Oral Potentially Malignant Disorders (OPMD): A Case-Control Study.

López-Jornet, Pia / Olmo-Monedero, Aitana / Peres-Rubio, Camila / Pons-Fuster, Eduardo / Tvarijonaviciute, Asta

Cancers

2023 Volume 15, Issue 21

Abstract: Introduction: Oral potentially malignant disorders (OPMD) are lesions associated with an increased risk of transformation (MT) into cancer.: Objective: A study was made of the salivary levels of adenosine deaminase (ADA), ferritin (FRR) and total ... ...

Abstract	Introduction: Oral potentially malignant disorders (OPMD) are lesions associated with an increased risk of transformation (MT) into cancer. Objective: A study was made of the salivary levels of adenosine deaminase (ADA), ferritin (FRR) and total proteins (TP) in healthy individuals and in patients with oral potentially malignant disorders (OPMD), assessing the potential role of saliva as a diagnostic tool. Methods: A total of 91 subjects participated in the study, divided into two groups-59 patients with OPMD (oral leukoplakia or oral lichen planus) and 32 healthy controls-with measurements being made of salivary ADA, ferritin (FRR) and total proteins (TP). Results: There were no significant differences in salivary mean ADA between the OPMD group 0.85 ± 2.18 UI/I and the controls 0.71 ± 1.72 UI/I ( Conclusions: Ferritin and total proteins may constitute potential salivary biomarkers for oral lichen planus, though further studies are still needed in this field. In addition, saliva testing is a reliable and noninvasive diagnostic tool and appears to be a reliable strategy offering an interesting alternative for the screening of large populations.
Language	English
Publishing date	2023-11-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15215256
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Efficacy of Photobiomodulation in Reducing Symptomatology and Improving the Quality of Life in Patients with Xerostomia and Hyposalivation: A Randomized Controlled Trial.

Ferrandez-Pujante, Alba / Pons-Fuster, Eduardo / López-Jornet, Pia

Journal of clinical medicine

2022 Volume 11, Issue 12

Abstract: Objectives: To evaluate the efficacy of photobiomodulation (PBM) treatment in patients with xerostomia and hyposalivation and assess their quality of life over a one year of follow-up. Material and methods: A single-blind randomized controlled trial. A ... ...

Abstract	Objectives: To evaluate the efficacy of photobiomodulation (PBM) treatment in patients with xerostomia and hyposalivation and assess their quality of life over a one year of follow-up. Material and methods: A single-blind randomized controlled trial. A total of 60 patients with xerostomia were included (30 PBM cases and 30 placebo controls). Photobiomodulation was performed with a diode laser (810 nm, 6 J/cm2), while the controls underwent simulated treatment. One weekly session was carried out for a total of 6 weeks (total six sessions). The study parameters were recorded at baseline, after three and six weeks, and at one year post-treatment. Xerostomia was assessed using a salivary flow visual analog scale (VAS) and the Xerostomia Inventory (XI). The Hospital Anxiety and Depression (HAD) scale, Oral Health Impact Profile (OHIP-14), Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were also administered. Results: The patients subjected to PBM therapy showed a significant improvement of xerostomia based on the drainage test, and of oral quality of life (p < 0.001). The depression score of the HAD (HAD-D) and the ESS showed improvement, though without reaching statistical significance (p > 0.05). The placebo group showed significant changes in the xerostomia VAS score at 6 weeks (p = 0.009), with no variations in any of the other studied parameters (p > 0.05). The beneficial effects of the diode laser in the PBM group persisted at one year post-treatment. Conclusions: Photobiomodulation with the diode laser is effective in patients with xerostomia and hyposalivation, and thus should be taken into account as a treatment option.
Language	English
Publishing date	2022-06-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11123414
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Experiences, perceptions, and decision-making capacity towards oral biopsy among dental students and dentists.

Cassol Spanemberg, Juliana / Velázquez Cayón, Rocío / Romanini, Juliana / Trevizani Martins, Marco Antonio / López-Jornet, Pía / Carrard, Vinicius Coelho

Scientific reports

2023 Volume 13, Issue 1, Page(s) 22937

Abstract: The dentist plays a crucial role in identifying oral lesions as it is their responsibility to conduct the clinical examination for diagnosing diseases in this anatomical region. Dentists should be able to perform simple oral biopsies when this procedure ... ...

Abstract	The dentist plays a crucial role in identifying oral lesions as it is their responsibility to conduct the clinical examination for diagnosing diseases in this anatomical region. Dentists should be able to perform simple oral biopsies when this procedure is necessary. However, several studies point out that dentists lack experience and perceive themselves incapable of performing biopsies. This analytical cross-sectional study aimed to assess participants' experiences and perceptions regarding a continuing education activity focused on the biopsy procedure. The secondary aim was to evaluate their ability to determine when a biopsy is indicated. The sample consisted of 228 individuals: 143 dentists and 85 undergraduate dental students who completed questionnaires related to a lecture held in May/2021, as part of the continuing educational activities of the "Red May" Project. Participants completed two questionnaires: the first assessed their experience and self-confidence in performing oral biopsies, whereas the second evaluated their capacity to define when the biopsy is indicated by means the evaluation of 10 clinical cases. The results reveal no significant difference in the percentage of correct answers between dental students and dentists. Regarding the frequency of performing the biopsy procedure, most respondents (69.7%) reported doing so rarely or never. Furthermore, while 31.6% of the participants stated that they perform biopsies depending on the case, 68.4% prefer to refer patients to specialists, such as professionals in Stomatology/Oral Medicine. These findings highlight limitations in the educational preparation of the study population concerning biopsy procedures, oral lesions, and their management. They also indicate a concerning tendency to overestimate knowledge in this area. Thus, this study emphasizes the importance of continuing education and underscores the need to revise academic curricula and provide complementary education for all dental professionals.
MeSH term(s)	Humans ; Students, Dental ; Cross-Sectional Studies ; Dentists ; Surveys and Questionnaires ; Biopsy ; Attitude of Health Personnel
Language	English
Publishing date	2023-12-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50323-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy of Photobiomodulation in Reducing Symptomatology and Improving the Quality of Life in Patients with Xerostomia and Hyposalivation

Alba Ferrandez-Pujante / Eduardo Pons-Fuster / Pia López-Jornet

Journal of Clinical Medicine, Vol 11, Iss 3414, p

A Randomized Controlled Trial

2022 Volume 3414

Abstract	Objectives: To evaluate the efficacy of photobiomodulation (PBM) treatment in patients with xerostomia and hyposalivation and assess their quality of life over a one year of follow-up. Material and methods: A single-blind randomized controlled trial. A total of 60 patients with xerostomia were included (30 PBM cases and 30 placebo controls). Photobiomodulation was performed with a diode laser (810 nm, 6 J/cm 2 ), while the controls underwent simulated treatment. One weekly session was carried out for a total of 6 weeks (total six sessions). The study parameters were recorded at baseline, after three and six weeks, and at one year post-treatment. Xerostomia was assessed using a salivary flow visual analog scale (VAS) and the Xerostomia Inventory (XI). The Hospital Anxiety and Depression (HAD) scale, Oral Health Impact Profile (OHIP-14), Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were also administered. Results: The patients subjected to PBM therapy showed a significant improvement of xerostomia based on the drainage test, and of oral quality of life ( p < 0.001). The depression score of the HAD (HAD-D) and the ESS showed improvement, though without reaching statistical significance ( p > 0.05). The placebo group showed significant changes in the xerostomia VAS score at 6 weeks ( p = 0.009), with no variations in any of the other studied parameters ( p > 0.05). The beneficial effects of the diode laser in the PBM group persisted at one year post-treatment. Conclusions: Photobiomodulation with the diode laser is effective in patients with xerostomia and hyposalivation, and thus should be taken into account as a treatment option.
Keywords	Xerostomia ; quality of life ; sleep disturbances ; anxiety-depression ; laser therapy ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction to: Salivary biomarkers in breast cancer: a cross-sectional study.

López-Jornet, Pía / Aznar, Cristina / Ceron, Jose J / Tvarijonaviciute, Asta

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2020 Volume 29, Issue 2, Page(s) 897

Language	English
Publishing date	2020-11-18
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-020-05851-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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