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Article ; Online: Use of magnetic resonance image‐guided radiotherapy for breast cancer

Alexandra Berlangieri / Sarah Elliott / Jason Wasiak / Michael Chao / Farshad Foroudi

Journal of Medical Radiation Sciences, Vol 69, Iss 1, Pp 122-

a scoping review

2022 Volume 133

Abstract: Abstract In recent years, we have seen the integration of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence MR linear accelerators (MR‐linac). Currently, there are limited studies to demonstrate the clinical ... ...

Abstract	Abstract In recent years, we have seen the integration of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence MR linear accelerators (MR‐linac). Currently, there are limited studies to demonstrate the clinical effectiveness of MRI guided radiotherapy (MRIgRT) treatment for breast cancer patients. The objective of this scoping review was to identify and map the existing evidence surrounding the clinical implementation of MRIgRT for breast cancer patients. We also identified the challenges and knowledge gaps in the literature. The scoping review was reported in accordance with the Preferred Reporting Items for Systematic reviews and Meta‐Analysis (PRISMA) extension for Scoping Reviews reporting guidelines. Titles and abstracts were screened by two independent reviewers. Quantitative and qualitative data were extracted and summarised using thematically organised tables. Results identify that accelerated partial breast irradiation (APBI) is the most common form of treatment for MRIgRT. The presence of the magnet does not affect target coverage or violate organ at risk (OAR) constraints compared to standard radiotherapy methods. Consideration is advised for skin and chest wall (CW) due to the electron return effect (ERE) and areas such as armpit and chin due to the electron stream effect (ESE). Clinically, bolus has been used to protect and prevent unwanted dose in these areas. Overall treatment for APBI on the MR‐linac is feasible.
Keywords	Accelerated partial breast irradiation ; breast cancer ; electron return effect ; MR simulation ; MRI guided radiotherapy ; MR‐linac ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Use of magnetic resonance imaging-guided radiotherapy for breast cancer: a scoping review protocol.

Elliott, Sarah / Berlangieri, Alexandra / Wasiak, Jason / Chao, Michael / Foroudi, Farshad

Systematic reviews

2021 Volume 10, Issue 1, Page(s) 44

Abstract: Background: In recent years, we have seen the incorporation of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence of the new technology of MR linacs. However, the significant health care resources associated with ... ...

Abstract	Background: In recent years, we have seen the incorporation of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence of the new technology of MR linacs. However, the significant health care resources associated with this advanced technology impact immediate widespread use and availability. There are currently limited studies to demonstrate the clinical effectiveness and inform decision-making on the use of MRI in radiotherapy. The objective of this scoping review is to identify and map the existing evidence surrounding the clinical implementation of MRI-guided radiotherapy in patients with breast cancer. It also aims to identify challenges and knowledge gaps in the literature. Methods: We will perform a comprehensive search in MEDLINE and EMBASE databases from January 2010 onwards. Grey literature sources will include the WHO International Clinical Trials Registry Platform. We will include systematic reviews, randomised and non-randomised controlled studies published in English. Literature should examine the use of magnetic resonance imaging-guided radiotherapy in adults with breast cancer, regardless of cancer stage or severity. Two reviewers will independently screen all titles, abstracts and full-text reports. Data will be extracted and summarised using qualitative (e.g. content and thematic analysis) methods and presented in tables. Discussion: The results from this review will consolidate the evidence surrounding MRI-guided radiotherapy for breast cancer, contributing to the development and optimisation of patient selection, simulation, planning, treatment delivery, quality assurance and research, to help improve patient outcomes, cancer care and treatment for women with breast cancer. Systematic review registration: The protocol is available on Open Science Framework at DOI https://doi.org/10.17605/OSF.IO/8TEV6.
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/radiotherapy ; Delivery of Health Care ; Female ; Humans ; Review Literature as Topic
Language	English
Publishing date	2021-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2662257-9
ISSN	2046-4053 ; 2046-4053
ISSN (online)	2046-4053
ISSN	2046-4053
DOI	10.1186/s13643-021-01594-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Use of magnetic resonance image-guided radiotherapy for breast cancer: a scoping review.

Berlangieri, Alexandra / Elliott, Sarah / Wasiak, Jason / Chao, Michael / Foroudi, Farshad

Journal of medical radiation sciences

2021 Volume 69, Issue 1, Page(s) 122–133

Abstract: In recent years, we have seen the integration of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence MR linear accelerators (MR-linac). Currently, there are limited studies to demonstrate the clinical effectiveness of ... ...

Abstract	In recent years, we have seen the integration of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence MR linear accelerators (MR-linac). Currently, there are limited studies to demonstrate the clinical effectiveness of MRI guided radiotherapy (MRIgRT) treatment for breast cancer patients. The objective of this scoping review was to identify and map the existing evidence surrounding the clinical implementation of MRIgRT for breast cancer patients. We also identified the challenges and knowledge gaps in the literature. The scoping review was reported in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) extension for Scoping Reviews reporting guidelines. Titles and abstracts were screened by two independent reviewers. Quantitative and qualitative data were extracted and summarised using thematically organised tables. Results identify that accelerated partial breast irradiation (APBI) is the most common form of treatment for MRIgRT. The presence of the magnet does not affect target coverage or violate organ at risk (OAR) constraints compared to standard radiotherapy methods. Consideration is advised for skin and chest wall (CW) due to the electron return effect (ERE) and areas such as armpit and chin due to the electron stream effect (ESE). Clinically, bolus has been used to protect and prevent unwanted dose in these areas. Overall treatment for APBI on the MR-linac is feasible.
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/radiotherapy ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy ; Radiation Oncology ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Image-Guided/methods
Language	English
Publishing date	2021-09-15
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2734841-6
ISSN	2051-3909 ; 2051-3909
ISSN (online)	2051-3909
ISSN	2051-3909
DOI	10.1002/jmrs.545
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Response to 'Response to 'Chemical burns: Diphoterine untangled' by KS Alexander [Burns 2017]'.

Alexander, K Skaria / Wasiak, Jason / Cleland, Heather

Burns : journal of the International Society for Burn Injuries

2018 Volume 44, Issue 4, Page(s) 1012–1013

MeSH term(s)	Burns ; Burns, Chemical ; Eye Burns ; Humans ; Organic Chemicals
Chemical Substances	Organic Chemicals ; diphoterine
Language	English
Publishing date	2018-02-01
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2017.12.007
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Article ; Online: Use of magnetic resonance imaging-guided radiotherapy for breast cancer

Sarah Elliott / Alexandra Berlangieri / Jason Wasiak / Michael Chao / Farshad Foroudi

Systematic Reviews, Vol 10, Iss 1, Pp 1-

a scoping review protocol

2021 Volume 7

Abstract: Abstract Background In recent years, we have seen the incorporation of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence of the new technology of MR linacs. However, the significant health care resources associated ... ...

Abstract	Abstract Background In recent years, we have seen the incorporation of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence of the new technology of MR linacs. However, the significant health care resources associated with this advanced technology impact immediate widespread use and availability. There are currently limited studies to demonstrate the clinical effectiveness and inform decision-making on the use of MRI in radiotherapy. The objective of this scoping review is to identify and map the existing evidence surrounding the clinical implementation of MRI-guided radiotherapy in patients with breast cancer. It also aims to identify challenges and knowledge gaps in the literature. Methods We will perform a comprehensive search in MEDLINE and EMBASE databases from January 2010 onwards. Grey literature sources will include the WHO International Clinical Trials Registry Platform. We will include systematic reviews, randomised and non-randomised controlled studies published in English. Literature should examine the use of magnetic resonance imaging-guided radiotherapy in adults with breast cancer, regardless of cancer stage or severity. Two reviewers will independently screen all titles, abstracts and full-text reports. Data will be extracted and summarised using qualitative (e.g. content and thematic analysis) methods and presented in tables. Discussion The results from this review will consolidate the evidence surrounding MRI-guided radiotherapy for breast cancer, contributing to the development and optimisation of patient selection, simulation, planning, treatment delivery, quality assurance and research, to help improve patient outcomes, cancer care and treatment for women with breast cancer. Systematic review registration The protocol is available on Open Science Framework at DOI https://doi.org/10.17605/OSF.IO/8TEV6
Keywords	Breast cancer ; MRI-guided radiotherapy ; MR simulation ; MR linac ; Scoping review ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Appraisal of systematic reviews on the management of peri-implant diseases with two methodological tools.

Faggion, Clovis Mariano / Monje, Alberto / Wasiak, Jason

Journal of clinical periodontology

2018 Volume 45, Issue 6, Page(s) 754–766

Abstract: Aim: This study aimed to evaluate and compare the performance of two methodological instruments to appraise systematic reviews and to identify potential disagreements of systematic review authors regarding risk of bias (RoB) evaluation of randomized ... ...

Abstract	Aim: This study aimed to evaluate and compare the performance of two methodological instruments to appraise systematic reviews and to identify potential disagreements of systematic review authors regarding risk of bias (RoB) evaluation of randomized controlled trials (RCTs) included in systematic reviews on peri-implant diseases. Material/methods: We searched Medline, Web of Science, Cochrane Library, PubMed Central, and Google Scholar for systematic reviews on peri-implant diseases published before July 11, 2017. Two authors independently evaluated the RoB and methodological quality of the systematic reviews by applying the Risk of Bias in Systematic Reviews (ROBIS) tool and Assessing the Methodological Quality of Systematic Reviews (AMSTAR) checklist, respectively. We assessed the RoB scores of the same RCTs published in different systematic reviews. Results: Of the 32 systematic reviews identified, 23 reviews addressed the clinical topic of peri-implantitis. A high RoB was detected for most systematic reviews (n=25) using ROBIS, whilst five systematic reviews displayed low methodological quality by AMSTAR. Almost 30% of the RoB comparisons (for the same RCTs) had different RoB ratings across systematic reviews. Conclusions: The ROBIS tool appears to provide more conservative results than AMSTAR checklist. Considerable disagreement was found among systematic review authors rating the same RCT included in different systematic reviews.
MeSH term(s)	Bias ; Humans ; Peri-Implantitis/therapy ; Randomized Controlled Trials as Topic ; Research Design ; Systematic Reviews as Topic
Language	English
Publishing date	2018-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	188647-2
ISSN	1600-051X ; 0303-6979
ISSN (online)	1600-051X
ISSN	0303-6979
DOI	10.1111/jcpe.12893
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Burns: dressings.

Wasiak, Jason / Cleland, Heather

BMJ clinical evidence

2015 Volume 2015

Abstract: Introduction: Burns are classified according to depth. This overview concerns the treatments for partial-thickness burns, which can be expected or have the potential to heal spontaneously (superficial partial-thickness and mid-dermal partial-thickness ... ...

Abstract	Introduction: Burns are classified according to depth. This overview concerns the treatments for partial-thickness burns, which can be expected or have the potential to heal spontaneously (superficial partial-thickness and mid-dermal partial-thickness burns). Injuries that involve the deeper part of the dermis and require surgical treatments to achieve healing are not the focus of this overview. Methods and outcomes: We conducted a systematic overview and aimed to answer the following clinical question: What are the effects of treatments for partial-thickness burns? We searched: Medline, Embase, The Cochrane Library, and other important databases up to January 2014 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this review). Results: At this update, searching of electronic databases retrieved 322 studies. After deduplication and removal of conference abstracts, 193 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 160 studies and the further review of 33 full publications. Of the 33 full articles evaluated, two systematic reviews and two RCTs were added at this update. We performed a GRADE evaluation for 30 PICO combinations. Conclusions: In this systematic overview, we categorised the efficacy for 10 interventions, based on information relating to the effectiveness and safety of alginate dressing, biosynthetic dressing, chlorhexidine-impregnated paraffin gauze dressing, hydrocolloid dressing, hydrogel dressing, paraffin gauze dressing, polyurethane film, silicone-coated nylon dressing, silver-impregnated dressing, and silver sulfadiazine cream.
Language	English
Publishing date	2015-07-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2393858-4
ISSN	1752-8526 ; 1757-0816 ; 1475-9225
ISSN (online)	1752-8526
ISSN	1757-0816 ; 1475-9225
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Being-in-the-City

Jason Wasiak

Culture Unbound: Journal of Current Cultural Research, Vol 1, Iss

A Phenomenological Approach to Technological Experience

2009 Volume 2

Abstract: This paper examines dynamics surrounding the negotiation and articulation of the body-technology relationship necessarily characterizing the experience of being-in-the-city. Nowhere is everyday experience more mediated by technology than in the city. ... ...

Abstract	This paper examines dynamics surrounding the negotiation and articulation of the body-technology relationship necessarily characterizing the experience of being-in-the-city. Nowhere is everyday experience more mediated by technology than in the city. Being-in-the-city involves being embodied by technology at levels ranging from micro to macro. Despite the fact that technologies are constantly evolving in city space, relations with technology tend to become quickly normalized — mundane — transparent. Given this normalization as well as the sheer pervasiveness of technology in constituting city space it is important to examine the ways in which technology comes to shape the experiential contexts of everyday life. In urban space, technologies result is new sights to be seen, sounds to be heard, smells to be smelt, textures to be felt, as well as altogether new modes of experiencing the everyday. In exploring the dynamics surrounding the ongoing, multi-layered negotiation and articulation of the body-technology relationship necessarily characterizing the experience of being-in-the-city a phenomenological perspective is adopted. Heidegger’s writing on technology, Merleau-Ponty’s writing on embodiment and perception, and Don Ihde’s writing on the body and technology contribute to a theoretical framework for a phenomenological examination of the experiential implications of being-in-the-city, a technological ecology.
Keywords	being-in-the-city ; technology ; embodiment ; perception ; phenomenology ; technological ecology ; General Works ; A
Subject code	100
Language	English
Publishing date	2009-12-01T00:00:00Z
Publisher	Linköping University Electronic Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Being in the City

Jason Wasiak

Culture Unbound: Journal of Current Cultural Research, Vol 1, Pp 349-

A Phenomenological Approach to Technological Experience

2009 Volume 366

Abstract	This paper examines dynamics surrounding the negotiation and articulation of the body-technology relationship necessarily characterizing the experience of being-in-the-city. Nowhere is everyday experience more mediated by technology than in the city. Being-in-the-city involves being embodied by technology at levels ran-ging from micro to macro. Despite the fact that technologies are constantly evolving in city space, relations with technology tend to become quickly normalized - mundane - transparent. Given this normalization as well as the sheer pervasiveness of technology in constituting city space it is important to examine the ways in which technology comes to shape the experiential contexts of everyday life. In urban space, technologies result is new sights to be seen, sounds to be heard, smells to be smelt, textures to be felt, as well as altogether new modes of experiencing the everyday. In exploring the dynamics surrounding the ongoing, multi-layered negotiation and articulation of the body-technology relationship necessarily characterizing the experience of being-in-the-city a phenomenological perspective is adopted. Heidegger's writing on technology, Merleau-Ponty's wri-ting on embodiment and perception, and Don Ihde's writing on the body and technology contribute to a theoretical framework for a phenomenological examination of the experiential implications of being-in-the-city, a technological ecology.
Keywords	being-in-the-city ; technology ; embodiment ; perception ; phenomenology ; technological ecology ; General Works ; A
Subject code	100
Language	English
Publishing date	2009-12-01T00:00:00Z
Publisher	Linköping University Electronic Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chemical burns: Diphoterine untangled.

Alexander, K Skaria / Wasiak, Jason / Cleland, Heather

Burns : journal of the International Society for Burn Injuries

2017 Volume 44, Issue 4, Page(s) 752–766

Abstract: Objective: Diphoterine is a hypertonic, amphoteric, polyvalent and chelating decontamination solution used in the treatment of cutaneous and ocular chemical burns. Due to infrequent use by emergency physicians along with the small number of available ... ...

Abstract	Objective: Diphoterine is a hypertonic, amphoteric, polyvalent and chelating decontamination solution used in the treatment of cutaneous and ocular chemical burns. Due to infrequent use by emergency physicians along with the small number of available studies, its debate in the literature as to its efficacy and safety remains inconclusive. Methods: A structured literature search was performed in MEDLINE, EMBASE BIOLOGICAL ABSTRACTS and TOXNET to June 2016 for original English-language studies reporting on the safety and effectiveness of Diphoterine. Methodological and reporting quality of pre-clinical animal studies was assessed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) risk of bias tool and Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines. Clinical studies were assessed using Chambers' criteria. Results: 13 studies (seven in the pre-clinical, five in the clinical setting and one mixed) met the study inclusion criteria. Pre-clinical studies showed a faster resolution of pH and reduced tissue necrosis with Diphoterine. Clinical studies showed reduced tissue necrosis/severity of symptoms, faster pH resolution and a reduction in pain when using Diphoterine. No adverse events were attributable to Diphoterine. Reporting and methodology of the studies was poor or showed a high risk of bias. Conclusions: Diphoterine appears to be safe to use and is probably superior to other rinsing solutions. However, immediate decontamination is imperative and if Diphoterine is not available a different rinsing solution should be used. The methodology of the published literature for Diphoterine is generally poor and future publications should use the frameworks given as templates.
MeSH term(s)	Burns, Chemical/drug therapy ; Eye Burns/chemically induced ; Eye Burns/drug therapy ; Humans ; Organic Chemicals/therapeutic use ; Skin/injuries
Chemical Substances	Organic Chemicals ; diphoterine
Language	English
Publishing date	2017-10-10
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2017.09.017
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