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  1. Article: Use of veno-arterial extracorporeal membrane oxygenation ian the first successful combined lung-liver transplantation patient in China.

    Huang, Man / Xu, Yong-Shan / Yan, Sheng / Shi, Yan-Jun / Pan, Sai-Bo / Chen, Yi-Bing / Gao, Chen-Yang / Chen, Jing-Yu / Wang, Wei-Lin

    World journal of emergency medicine

    2022  Volume 13, Issue 5, Page(s) 412–414

    Language English
    Publishing date 2022-09-12
    Publishing country China
    Document type Journal Article
    ZDB-ID 2753264-1
    ISSN 1920-8642
    ISSN 1920-8642
    DOI 10.5847/wjem.j.1920-8642.2022.090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Ian McHarg’s Ecological Planning in The Woodlands, Texas: Lessons Learned after Four Decades

    Yang, Bo / Li, Ming-Han / Huang, Chang-Shan

    Landscape research. 2015 Oct. 3, v. 40, no. 7

    2015  

    Abstract: The Woodlands, Texas, is well known as a new town development (29,000 acres) that followed Ian ...

    Abstract The Woodlands, Texas, is well known as a new town development (29,000 acres) that followed Ian McHarg’s ecological planning approach. Primarily by literature review, this paper indicated that early development that followed McHarg’s approach has met the original planning goals to preserve the forest environment and to minimize the development impacts on watershed hydrology. McHarg’s approach was largely abandoned after the ownership change in 1997. Barriers came from each side of the development: homeowner (demand), developer (provider), designer (professional service) and government (policy-maker). The Woodlands’ environmental planning success in early development was also attributed to developer George Mitchell’s personal commitment and financial support, the US Housing and Urban Development’s $50 million loan, and the relatively flexible planning system in the 1970s. However, in the current planning and economic systems, it would be a hard undertaking to replicate McHarg’s ecological planning approach at this scale.
    Keywords early development ; economic systems ; forest reserves ; funding ; loans ; objectives ; ownership ; planning ; urban development ; watershed hydrology ; woodlands ; Texas
    Language English
    Dates of publication 2015-1003
    Size p. 773-794.
    Publishing place Routledge
    Document type Article
    ZDB-ID 2020719-0
    ISSN 0142-6397 ; 1469-9710 ; 0142-6397
    ISSN (online) 0142-6397 ; 1469-9710
    ISSN 0142-6397
    DOI 10.1080/01426397.2014.987223
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Editorial: AI and data science in pulmonary and critical care physiology and medicine.

    Huang, Yuh-Chin / Giri, Paresh / Ioachimescu, Octavian / Wong, An-Kwok Ian

    Frontiers in physiology

    2024  Volume 15, Page(s) 1375414

    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2024.1375414
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  4. Article: Should de Winter T-Wave Electrocardiography Pattern Be Treated as ST-Segment Elevation Myocardial Infarction Equivalent with Consequent Reperfusion? A Dilemmatic Experience in Rural Area of Indonesia

    Pranata, Raymond / Huang, Ian / Damay, Vito

    Case reports in cardiology, 2018:6868204

    2018  

    Abstract: BACKGROUND: Although de Winter T-wave electrocardiography pattern is rare, it signifies proximal left anterior descending artery occlusion and is often unrecognized by physicians. The aim of this case report was to highlight the dilemma in the management ...

    Abstract BACKGROUND: Although de Winter T-wave electrocardiography pattern is rare, it signifies proximal left anterior descending artery occlusion and is often unrecognized by physicians. The aim of this case report was to highlight the dilemma in the management of a patient with de Winter T-wave pattern in the hospital without interventional cardiology facility. CASE PRESENTATION: A 65-year-old male presented with typical chest pain since 2 hours before admission, and ECG showed sinus rhythm of 57 bpm and >1 mm upsloping ST depression with symmetric tall T in lead V2-3 characteristic of de Winter T-wave ECG pattern. He was given dual antiplatelet therapy, nitrate, statin, and anticoagulant. He refused referral to interventional cardiology available hospital. 3 hours after admission, the electrocardiography transformed into Q-waves consistent with final stages of acute STEMI and ST-segment elevation that barely meets the threshold in the guideline, and thrombolytic was administered and successful. There is a suggestion that de Winter T-wave electrocardiography should be treated as ST-segment myocardial infarction equivalent and should undergo coronary angiography; however, not every hospital has the luxury of interventional cardiology facility. The other modality for reperfusion is thrombolysis; however, without a clear guideline and scarcity of study, we prefer to resort to conservative treatment. “Fortunately,” transformation into ST-segment elevation helps us to determine the course of action which is reperfusion using thrombolytic. CONCLUSIONS: de Winter T-wave ECG pattern is not mentioned in any guidelines regarding acute coronary syndromes, and there are no clear recommendations. Physicians in rural area without interventional cardiology facility face a dilemma with the lack of evidence-based guideline. Fibrinolytic may be appropriate in those without contraindications with strong chest pain consistent with acute coronary occlusion, less than 3 hours of symptoms, and convincing de Winter T-wave ECG pattern for a rural non-PCI hospital far away from PCI capable hospital.
    Language English
    Document type Article
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  5. Article ; Online: Artificial intelligence in neuroimaging of brain tumors: reality or still promise?

    Pan, Ian / Huang, Raymond Y

    Current opinion in neurology

    2023  Volume 36, Issue 6, Page(s) 549–556

    Abstract: Purpose of review: To provide an updated overview of artificial intelligence (AI) applications in neuro-oncologic imaging and discuss current barriers to wider clinical adoption.: Recent findings: A wide variety of AI applications in neuro-oncologic ... ...

    Abstract Purpose of review: To provide an updated overview of artificial intelligence (AI) applications in neuro-oncologic imaging and discuss current barriers to wider clinical adoption.
    Recent findings: A wide variety of AI applications in neuro-oncologic imaging have been developed and researched, spanning tasks from pretreatment brain tumor classification and segmentation, preoperative planning, radiogenomics, prognostication and survival prediction, posttreatment surveillance, and differentiating between pseudoprogression and true disease progression. While earlier studies were largely based on data from a single institution, more recent studies have demonstrated that the performance of these algorithms are also effective on external data from other institutions. Nevertheless, most of these algorithms have yet to see widespread clinical adoption, given the lack of prospective studies demonstrating their efficacy and the logistical difficulties involved in clinical implementation.
    Summary: While there has been significant progress in AI and neuro-oncologic imaging, clinical utility remains to be demonstrated. The next wave of progress in this area will be driven by prospective studies measuring outcomes relevant to clinical practice and go beyond retrospective studies which primarily aim to demonstrate high performance.
    MeSH term(s) Humans ; Artificial Intelligence ; Prospective Studies ; Retrospective Studies ; Neuroimaging ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/therapy
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000001213
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  6. Article ; Online: Large Growth Deformations of Thin Tissue Using Solid-Shells.

    Huang, Danny / Stavness, Ian

    IEEE transactions on visualization and computer graphics

    2023  Volume 29, Issue 3, Page(s) 1893–1909

    Abstract: Simulating large scale expansion of thin structures, such as in growing leaves, is challenging. Solid-shells have a number of potential advantages over conventional thin-shell methods, but have thus far only been investigated for small plastic ... ...

    Abstract Simulating large scale expansion of thin structures, such as in growing leaves, is challenging. Solid-shells have a number of potential advantages over conventional thin-shell methods, but have thus far only been investigated for small plastic deformation cases. In response, we present a new general-purpose FEM growth framework for handling a wide range of challenging growth scenarios using the solid-shell element. Solid-shells are a middle-ground between traditional volume and thin-shell elements where volumetric characteristics are retained while being treatable as a 2D manifold much like thin-shells. These elements are adaptable to accommodate the many techniques that are required for simulating large and intricate plastic deformations, including morphogen diffusion, plastic embedding, strain-aware adaptive remeshing, and collision handling. We demonstrate the capabilities of growing solid-shells in reproducing buckling, rippling, curling, and collision deformations, relevant towards animating growing leaves, flowers, and other thin structures. Solid-shells are compared side-by-side with thin-shells to examine their bending behavior and runtime performance. The experiments demonstrate that solid-shells are a viable alternative to thin-shells for simulating large and intricate growth deformations.
    MeSH term(s) Biomechanical Phenomena ; Computer Graphics ; Plastics ; Tissues
    Chemical Substances Plastics
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1941-0506
    ISSN (online) 1941-0506
    DOI 10.1109/TVCG.2022.3217008
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  7. Article: EFFICIENT ESTIMATION OF THE MAXIMAL ASSOCIATION BETWEEN MULTIPLE PREDICTORS AND A SURVIVAL OUTCOME.

    Huang, Tzu-Jung / Luedtke, Alex / McKeague, Ian W

    Annals of statistics

    2023  Volume 51, Issue 5, Page(s) 1965–1988

    Abstract: This paper develops a new approach to post-selection inference for screening high-dimensional predictors of survival outcomes. Post-selection inference for right-censored outcome data has been investigated in the literature, but much remains to be done ... ...

    Abstract This paper develops a new approach to post-selection inference for screening high-dimensional predictors of survival outcomes. Post-selection inference for right-censored outcome data has been investigated in the literature, but much remains to be done to make the methods both reliable and computationally-scalable in high-dimensions. Machine learning tools are commonly used to provide
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1476670-X
    ISSN 2168-8966 ; 0090-5364
    ISSN (online) 2168-8966
    ISSN 0090-5364
    DOI 10.1214/23-aos2313
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  8. Article: Effect of Acupoint Stimulation on Controlling Pain from Heel Lance in Neonates: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    Tou, Sio-Ian / Huang, Chia-Yu / Yen, Hung-Rong

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 6

    Abstract: To evaluate the effect of acupoint stimulation compared to other interventions on pain control in neonates who underwent heel lance, we searched for randomized controlled trials across six databases (CINAHL, Cochrane Library, EMBASE, Medline, PubMed, and ...

    Abstract To evaluate the effect of acupoint stimulation compared to other interventions on pain control in neonates who underwent heel lance, we searched for randomized controlled trials across six databases (CINAHL, Cochrane Library, EMBASE, Medline, PubMed, and Web of Science) published up to January 2023. Studies comparing acupoint stimulation and other interventions for controlling heel lance pain in neonates were included. These reports measured at least one of the following variables: pain score, crying time, oxygenation saturation, heart rate, respiration rate, and duration of the procedure. The data were independently extracted by two authors, and the PRISMA guidelines for study selection were followed. A total of 79 articles were screened, and 10 studies, with results on 813 neonates, were included in the final selection. The pain scores recorded during the heel lance procedure were not significantly different between the acupoint stimulation cohort and the control cohort (SMD of -0.26, 95% confidence interval (CI) from -0.52 to 0.01;
    Language English
    Publishing date 2023-06-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10061024
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  9. Article ; Online: Engineering artificial photosynthesis based on rhodopsin for CO

    Tu, Weiming / Xu, Jiabao / Thompson, Ian P / Huang, Wei E

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 8012

    Abstract: Microbial rhodopsin, a significant contributor to sustaining life through light harvesting, holds untapped potential for carbon fixation. Here, we construct an artificial photosynthesis system which combines the proton-pumping ability of rhodopsin with ... ...

    Abstract Microbial rhodopsin, a significant contributor to sustaining life through light harvesting, holds untapped potential for carbon fixation. Here, we construct an artificial photosynthesis system which combines the proton-pumping ability of rhodopsin with an extracellular electron uptake mechanism, establishing a pathway to drive photoelectrosynthetic CO
    MeSH term(s) Carbon Dioxide/metabolism ; Rhodopsin/genetics ; Rhodopsin/metabolism ; Photosynthesis/genetics ; Cyanobacteria/genetics ; Cyanobacteria/metabolism
    Chemical Substances Carbon Dioxide (142M471B3J) ; Rhodopsin (9009-81-8)
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43524-4
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  10. Article ; Online: Phasic dopamine signals are reduced in the spontaneously hypertensive rat and increased by methylphenidate.

    Li, Yu-Ting / Huang, Yi-Ling / Chen, Jia-Jin Jason / Hyland, Brian Ian / Wickens, Jeffery R

    The European journal of neuroscience

    2024  Volume 59, Issue 7, Page(s) 1567–1584

    Abstract: The spontaneously hypertensive rat (SHR) is a selectively bred animal strain that is frequently used to model attention-deficit hyperactivity disorder (ADHD) because of certain genetically determined behavioural characteristics. To test the hypothesis ... ...

    Abstract The spontaneously hypertensive rat (SHR) is a selectively bred animal strain that is frequently used to model attention-deficit hyperactivity disorder (ADHD) because of certain genetically determined behavioural characteristics. To test the hypothesis that the characteristically altered response to positive reinforcement in SHRs may be due to altered phasic dopamine response to reward, we measured phasic dopamine signals in the SHRs and Sprague Dawley (SD) rats using in vivo fast-scan cyclic voltammetry. The effects of the dopamine reuptake inhibitor, methylphenidate, on these signals were also studied. Phasic dopamine signals during the pairing of a sensory cue with electrical stimulation of midbrain dopamine neurons were significantly smaller in the SHRs than in the SD rats. Over repeated pairings, the dopamine response to the sensory cue increased, whereas the response to the electrical stimulation of dopamine neurons decreased, similarly in both strains. However, the final amplitude of the response to the sensory cue after pairing was significantly smaller in SHRs than in the SD rats. Methylphenidate increased responses to sensory cues to a significantly greater extent in the SHRs than in the SD rats, due largely to differences in the low dose effect. At a higher dose, methylphenidate increased responses to sensory cues and electrical stimulation similarly in SHRs and SD rats. The smaller dopamine responses may explain the reduced salience of reward-predicting cues previously reported in the SHR, whereas the action of methylphenidate on the cue response suggests a potential mechanism for the therapeutic effects of low-dose methylphenidate in ADHD.
    MeSH term(s) Rats ; Animals ; Methylphenidate/pharmacology ; Methylphenidate/therapeutic use ; Rats, Inbred SHR ; Dopamine ; Rats, Inbred WKY ; Rats, Sprague-Dawley ; Disease Models, Animal ; Central Nervous System Stimulants/pharmacology
    Chemical Substances Methylphenidate (207ZZ9QZ49) ; Dopamine (VTD58H1Z2X) ; Central Nervous System Stimulants
    Language English
    Publishing date 2024-02-05
    Publishing country France
    Document type Journal Article
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.16269
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