LIVIVO - Search results -

Search results

Result 1 - 10 of total 86

Search options

Article ; Online: Association between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer Development.

Huang, Hsiang-Wei / Chang, Cheng-Chih / Wang, Chia-Siu / Lin, Kwang-Huei

2021 Volume 10, Issue 1

Abstract: Gastrointestinal cancer is highly associated with inflammatory processes inducing the release of cytokines from cancer or immune cells, including interferons, interleukins, chemokines, colony-stimulating factors, and growth factors, which promote or ... ...

Abstract	Gastrointestinal cancer is highly associated with inflammatory processes inducing the release of cytokines from cancer or immune cells, including interferons, interleukins, chemokines, colony-stimulating factors, and growth factors, which promote or suppress tumor progression. Inflammatory cytokines within the tumor microenvironment promote immune cell infiltration. Infiltrating immune, and tumor-surrounding stromal cells support tumor growth, angiogenesis, metastasis, and immunosuppression through communication with inflammatory cytokines and cell adhesion molecules. Notably, infiltrating immune and tumor cells present immunosuppressive molecules, such as programmed death-ligand 1 (PD-L1) and CD80/CD86. Suppression of cytotoxic T cells promotes tumor avoidance of immune surveillance and greater malignancy. Moreover, glycosylation and sialylation of proteins hyperexpressed on the cancer cell surface have been shown to enhance immune escape and metastasis. Cytokine treatments and immune checkpoint inhibitors are widely used in clinical practice. However, the tumor microenvironment is a rapidly changing milieu involving several factors. In this review, we have provided a summary of the interactions of inflammation and cell adhesion molecules between cancer and other cell types, to improve understanding of the tumor microenvironment.
MeSH term(s)	Animals ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Adhesion Molecules/metabolism ; Cell Communication ; Gastrointestinal Neoplasms/metabolism ; Gastrointestinal Neoplasms/pathology ; Gastrointestinal Neoplasms/therapy ; Humans ; Inflammation/metabolism ; Tumor Microenvironment
Chemical Substances	Cell Adhesion Molecules
Language	English
Publishing date	2021-01-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10010067
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Association between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer Development

Hsiang-Wei Huang / Cheng-Chih Chang / Chia-Siu Wang / Kwang-Huei Lin

Cells, Vol 10, Iss 67, p

2021 Volume 67

Abstract	Gastrointestinal cancer is highly associated with inflammatory processes inducing the release of cytokines from cancer or immune cells, including interferons, interleukins, chemokines, colony-stimulating factors, and growth factors, which promote or suppress tumor progression. Inflammatory cytokines within the tumor microenvironment promote immune cell infiltration. Infiltrating immune, and tumor-surrounding stromal cells support tumor growth, angiogenesis, metastasis, and immunosuppression through communication with inflammatory cytokines and cell adhesion molecules. Notably, infiltrating immune and tumor cells present immunosuppressive molecules, such as programmed death-ligand 1 (PD-L1) and CD80/CD86. Suppression of cytotoxic T cells promotes tumor avoidance of immune surveillance and greater malignancy. Moreover, glycosylation and sialylation of proteins hyperexpressed on the cancer cell surface have been shown to enhance immune escape and metastasis. Cytokine treatments and immune checkpoint inhibitors are widely used in clinical practice. However, the tumor microenvironment is a rapidly changing milieu involving several factors. In this review, we have provided a summary of the interactions of inflammation and cell adhesion molecules between cancer and other cell types, to improve understanding of the tumor microenvironment.
Keywords	gastrointestinal cancer ; inflammation ; tumor microenvironment ; cell adhesion molecule ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Functional roles of non-coding RNAs regulated by thyroid hormones in liver cancer

Po-Shuan Huang / Cheng-Chih Chang / Chia-Siu Wang / Kwang-Huei Lin

Biomedical Journal, Vol 44, Iss 3, Pp 272-

2021 Volume 284

Abstract: Recent reports have shown the important role of the non-coding part of human genome RNA (ncRNA) in cancer formation and progression. Among several kinds of ncRNAs, microRNAs (miRNA) play a pivotal role in cancer biology. Accumulating researches have been ...

Abstract	Recent reports have shown the important role of the non-coding part of human genome RNA (ncRNA) in cancer formation and progression. Among several kinds of ncRNAs, microRNAs (miRNA) play a pivotal role in cancer biology. Accumulating researches have been focused on the importance of non-coding genes in various diseases. In addition to miRNAs, long non-coding RNAs (lncRNAs) have also been extensively documented. Recently, the study of human liver cancer has gradually shifted to these non-coding RNAs that were originally considered “junk”. Notably, dysregulated ncRNAs maybe influence on cell proliferation, angiogenesis, anti-apoptosis, and metastasis. Thyroid hormones play critical roles in human development and abnormalities in thyroid hormone levels are associated with various diseases, such as liver cancer. Thyroid hormone receptors (TR) act as ligand-activated nuclear transcription factors to affect multiple functions through the gene-level regulation in the cells and several studies have revealed that thyroid hormone associated with ncRNAs expression. TR actions are complex and tissue- and time-specific, aberrant expression of the various TR isoforms have different effects and are associated with different types of tumor or stages of development. In this review, we discuss various aspects of the research on the thyroid hormones modulated ncRNAs to affect the functions of human liver cells.
Keywords	Non-coding RNA ; Thyroid ; Receptors ; Hepatocellular carcinoma ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Functional roles of non-coding RNAs regulated by thyroid hormones in liver cancer.

Huang, Po-Shuan / Chang, Cheng-Chih / Wang, Chia-Siu / Lin, Kwang-Huei

Biomedical journal

2020 Volume 44, Issue 3, Page(s) 272–284

Abstract	Recent reports have shown the important role of the non-coding part of human genome RNA (ncRNA) in cancer formation and progression. Among several kinds of ncRNAs, microRNAs (miRNA) play a pivotal role in cancer biology. Accumulating researches have been focused on the importance of non-coding genes in various diseases. In addition to miRNAs, long non-coding RNAs (lncRNAs) have also been extensively documented. Recently, the study of human liver cancer has gradually shifted to these non-coding RNAs that were originally considered "junk". Notably, dysregulated ncRNAs maybe influence on cell proliferation, angiogenesis, anti-apoptosis, and metastasis. Thyroid hormones play critical roles in human development and abnormalities in thyroid hormone levels are associated with various diseases, such as liver cancer. Thyroid hormone receptors (TR) act as ligand-activated nuclear transcription factors to affect multiple functions through the gene-level regulation in the cells and several studies have revealed that thyroid hormone associated with ncRNAs expression. TR actions are complex and tissue- and time-specific, aberrant expression of the various TR isoforms have different effects and are associated with different types of tumor or stages of development. In this review, we discuss various aspects of the research on the thyroid hormones modulated ncRNAs to affect the functions of human liver cells.
MeSH term(s)	Humans ; Liver Neoplasms/genetics ; MicroRNAs/genetics ; RNA, Long Noncoding/genetics ; RNA, Untranslated/genetics ; Thyroid Hormones
Chemical Substances	MicroRNAs ; RNA, Long Noncoding ; RNA, Untranslated ; Thyroid Hormones
Language	English
Publishing date	2020-08-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2698541-X
ISSN	2320-2890 ; 2320-2890
ISSN (online)	2320-2890
ISSN	2320-2890
DOI	10.1016/j.bj.2020.08.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma.

Huang, Po-Shuan / Wang, Chia-Siu / Yeh, Chau-Ting / Lin, Kwang-Huei

International journal of molecular sciences

2019 Volume 20, Issue 20

Abstract: Oxidative stress occurs as a result of imbalance between the generation of reactive oxygen species (ROS) and antioxidant genes in cells, causing damage to lipids, proteins, and DNA. Accumulating damage of cellular components can trigger various diseases, ...

Abstract	Oxidative stress occurs as a result of imbalance between the generation of reactive oxygen species (ROS) and antioxidant genes in cells, causing damage to lipids, proteins, and DNA. Accumulating damage of cellular components can trigger various diseases, including metabolic syndrome and cancer. Over the past few years, the physiological significance of microRNAs (miRNA) in cancer has been a focus of comprehensive research. In view of the extensive level of miRNA interference in biological processes, the roles of miRNAs in oxidative stress and their relevance in physiological processes have recently become a subject of interest. In-depth research is underway to specifically address the direct or indirect relationships of oxidative stress-induced miRNAs in liver cancer and the potential involvement of the thyroid hormone in these processes. While studies on thyroid hormone in liver cancer are abundantly documented, no conclusive information on the potential relationships among thyroid hormone, specific miRNAs, and oxidative stress in liver cancer is available. In this review, we discuss the effects of thyroid hormone on oxidative stress-related miRNAs that potentially have a positive or negative impact on liver cancer. Additionally, supporting evidence from clinical and animal experiments is provided.
MeSH term(s)	Animals ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; MicroRNAs/genetics ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Thyroid Hormones/metabolism
Chemical Substances	MicroRNAs ; Reactive Oxygen Species ; Thyroid Hormones
Language	English
Publishing date	2019-10-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20205220
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma

Po-Shuan Huang / Chia-Siu Wang / Chau-Ting Yeh / Kwang-Huei Lin

International Journal of Molecular Sciences, Vol 20, Iss 20, p

2019 Volume 5220

Abstract	Oxidative stress occurs as a result of imbalance between the generation of reactive oxygen species (ROS) and antioxidant genes in cells, causing damage to lipids, proteins, and DNA. Accumulating damage of cellular components can trigger various diseases, including metabolic syndrome and cancer. Over the past few years, the physiological significance of microRNAs (miRNA) in cancer has been a focus of comprehensive research. In view of the extensive level of miRNA interference in biological processes, the roles of miRNAs in oxidative stress and their relevance in physiological processes have recently become a subject of interest. In-depth research is underway to specifically address the direct or indirect relationships of oxidative stress-induced miRNAs in liver cancer and the potential involvement of the thyroid hormone in these processes. While studies on thyroid hormone in liver cancer are abundantly documented, no conclusive information on the potential relationships among thyroid hormone, specific miRNAs, and oxidative stress in liver cancer is available. In this review, we discuss the effects of thyroid hormone on oxidative stress-related miRNAs that potentially have a positive or negative impact on liver cancer. Additionally, supporting evidence from clinical and animal experiments is provided.
Keywords	oxidative stress ; microrna ; thyroid hormone ; liver cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610 ; 500
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: CMAHP promotes metastasis by reducing ubiquitination of Snail and inducing angiogenesis via GM-CSF overexpression in gastric cancer.

Huang, Hsiang-Wei / Chen, Ching-Ying / Huang, Ya-Hui / Yeh, Chau-Ting / Wang, Chia-Siu / Chang, Cheng-Chih / Lin, Kwang-Huei

Oncogene

2021 Volume 41, Issue 2, Page(s) 159–172

Abstract: Pseudogenes are generally considered "junk" DNA or "genomic fossils" generated during the evolution process that lack biological activity. However, accumulating reports indicate that pseudogenes have biological functions critical for cancer development. ... ...

Abstract	Pseudogenes are generally considered "junk" DNA or "genomic fossils" generated during the evolution process that lack biological activity. However, accumulating reports indicate that pseudogenes have biological functions critical for cancer development. Experiments from the current study showed marked overexpression of the cytidine monophospho-N-acetylneuraminic acid hydroxylase pseudogene (CMAHP) in gastric cancer, which was associated with poor overall survival. However, the mechanisms underlying the activity of CMAHP in tumor development are largely unknown. Gene Set Enrichment Analysis (GSEA) revealed that CMAHP-correlated genes are significantly involved in epithelial-mesenchymal transition (EMT) and angiogenesis. Functional studies further confirmed that CMAHP mediates metastasis and angiogenesis in vitro and in vivo. Furthermore, CMAHP promoted cancer cell migration, invasion, and metastasis through Snail overexpression, which decreased ubiquitination mediated by NF-κB signaling. Angiogenesis is known to be induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulation. CMAHP increased GM-CSF transactivation via promoting direct binding of c-Jun to the -1981/-1975 region of the GM-CSF promoter. Notably, CMAHP interacts with Histone H1.4 promoting histone acetylation to enhance c-Jun and RelA (p65) expression. Our collective findings provide novel evidence that CMAHP contributes to tumor progression and modulates metastasis and angiogenesis in gastric cancer.
MeSH term(s)	Angiogenesis Inducing Agents/pharmacology ; Angiogenesis Inducing Agents/therapeutic use ; Cell Line, Tumor ; Granulocyte-Macrophage Colony-Stimulating Factor/genetics ; Humans ; Stomach Neoplasms/genetics ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Survival Analysis ; Ubiquitination/drug effects
Chemical Substances	Angiogenesis Inducing Agents ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
Language	English
Publishing date	2021-10-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/s41388-021-02087-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2218: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: C-reactive protein and malignancy: clinico-pathological association and therapeutic implication.

Wang, Chia-Siu / Sun, Chien-Feng

Chang Gung medical journal

2009 Volume 32, Issue 5, Page(s) 471–482

Abstract: C-reactive protein (CRP) is a widely used systemic biomarker for diagnosing acute and chronic inflammation. During the past decade, serum CRP has been re-emphasized by extending its clinical use to the prediction or diagnosis of cardiovascular diseases ... ...

Abstract	C-reactive protein (CRP) is a widely used systemic biomarker for diagnosing acute and chronic inflammation. During the past decade, serum CRP has been re-emphasized by extending its clinical use to the prediction or diagnosis of cardiovascular diseases and other conditions, particularly malignancies. Serum CRP has also been found to be elevated in patients with many malignancies, implying a close linkage between inflammation and malignancy. Prospective studies have shown a higher risk of developing cancer in those with elevated serum CRP. CRP is produced by hepatocytes in response to inflammatory cytokines, particularly, interleukin-6 from the tumor microenvironment. Preoperative CRP levels are parallel to the progression or pathological stages of malignancies, including gastric cancer in patients in our series. Elevated CRP is a determinant predictor of lower survival rates in patients with several cancers, including esophageal, colorectal, hepatocellular, pancreatic, urinary bladder, renal,ovarian and cervical cancer, after surgical resection. The measurement of serum CRP is simple, cheap, and available in daily practice. It can serve as an additional prognostic predictor for survival and post-treatment monitoring in cancer patients. In the future, CRP-lowering agents might offer a promising benefit in the prevention and therapy of many different types of cancer.
MeSH term(s)	C-Reactive Protein/analysis ; C-Reactive Protein/physiology ; Cyclooxygenase 2/blood ; Humans ; Interleukin-6/blood ; Neoplasms/blood ; Neoplasms/drug therapy ; Neoplasms/etiology ; Serum Amyloid A Protein/analysis ; Stomach Neoplasms/blood
Chemical Substances	Interleukin-6 ; Serum Amyloid A Protein ; C-Reactive Protein (9007-41-4) ; Cyclooxygenase 2 (EC 1.14.99.1) ; PTGS2 protein, human (EC 1.14.99.1)
Language	English
Publishing date	2009-09
Publishing country	China (Republic : 1949- )
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1156932-3
ISSN	2309-835X ; 2072-0939 ; 0255-8270
ISSN (online)	2309-835X
ISSN	2072-0939 ; 0255-8270
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2723: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Author Correction: A highly sensitive and specific real-time quantitative PCR for BRAF V600E/K mutation screening.

Lung, Jrhau / Hung, Ming-Szu / Lin, Yu-Ching / Jiang, Yuan Yuan / Fang, Yu-Hung / Lu, Ming-Shian / Hsieh, Ching-Chuan / Wang, Chia-Siu / Kuan, Feng-Che / Lu, Chang-Hsien / Chen, Ping-Tsung / Lin, Chieh-Mo / Chou, Yen-Li / Lin, Chin-Kuo / Yang, Tsung-Ming / Chen, Fen Fen / Lin, Paul Yann / Hsieh, Meng-Jer / Tsai, Ying Huang

Scientific reports

2021 Volume 11, Issue 1, Page(s) 12952

Language	English
Publishing date	2021-06-15
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-92318-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Author Correction

Jrhau Lung / Ming‑Szu Hung / Yu‑Ching Lin / Yuan Yuan Jiang / Yu‑Hung Fang / Ming‑Shian Lu / Ching‑Chuan Hsieh / Chia‑Siu Wang / Feng‑Che Kuan / Chang‑Hsien Lu / Ping‑Tsung Chen / Chieh‑Mo Lin / Yen‑Li Chou / Chin‑Kuo Lin / Tsung‑Ming Yang / Fen Fen Chen / Paul Yann Lin / Meng‑Jer Hsieh / Ying Huang Tsai

Scientific Reports, Vol 11, Iss 1, Pp 1-

A highly sensitive and specific real-time quantitative PCR for BRAF V600E/K mutation screening

2021 Volume 1

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

Abstract	An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED