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  1. Article: Mycobacterium porcinum

    Wei, Wenjie / Luo, Renrui / Chen, Zhikui / He, Jianbin

    Infection and drug resistance

    2023  Volume 16, Page(s) 7305–7311

    Abstract: In the available reports on clinical medicine, the infection sites ... ...

    Abstract In the available reports on clinical medicine, the infection sites of
    Language English
    Publishing date 2023-11-21
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S432987
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  2. Article ; Online: Evaluating insomnia queries from an artificial intelligence chatbot for patient education.

    Alapati, Rahul / Campbell, Daniel / Molin, Nicole / Creighton, Erin / Wei, Zhikui / Boon, Maurits / Huntley, Colin

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2024  Volume 20, Issue 4, Page(s) 583–594

    Abstract: Study objectives: We evaluated the accuracy of ChatGPT in addressing insomnia-related queries for patient education and assessed ChatGPT's ability to provide varied responses based on differing prompting scenarios.: Methods: Four identical sets of 20 ...

    Abstract Study objectives: We evaluated the accuracy of ChatGPT in addressing insomnia-related queries for patient education and assessed ChatGPT's ability to provide varied responses based on differing prompting scenarios.
    Methods: Four identical sets of 20 insomnia-related queries were posed to ChatGPT. Each set differed by the context in which ChatGPT was prompted: no prompt, patient-centered, physician-centered, and with references and statistics. Responses were reviewed by 2 academic sleep surgeons, 1 academic sleep medicine physician, and 2 sleep medicine fellows across 4 domains: clinical accuracy, prompt adherence, referencing, and statistical precision, using a binary grading system. Flesch-Kincaid grade-level scores were calculated to estimate the grade level of the responses, with statistical differences between prompts analyzed via analysis of variance and Tukey's test. Interrater reliability was calculated using Fleiss's kappa.
    Results: The study revealed significant variations in the Flesch-Kincaid grade-level scores across 4 prompts: unprompted (13.2 ± 2.2), patient-centered (8.1 ± 1.9), physician-centered (15.4 ± 2.8), and with references and statistics (17.3 ± 2.3,
    Conclusions: ChatGPT can be used to generate clinically accurate responses to insomnia-related inquiries.
    Citation: Alapati R, Campbell D, Molin N, et al. Evaluating insomnia queries from an artificial intelligence chatbot for patient education.
    MeSH term(s) Humans ; Artificial Intelligence ; Sleep Initiation and Maintenance Disorders/diagnosis ; Reproducibility of Results ; Patient Education as Topic ; Software
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10948
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  3. Article ; Online: Creep Properties and Creep Modelling of Guilin Red Clay

    Hailong Wei / Zhanfei Gu / Zhikui Liu / Yipeng Wang / Yansong Shi

    Applied Sciences, Vol 13, Iss 21, p

    2023  Volume 12052

    Abstract: In order to explore the creep characteristics of red clay under different pressures, the stress–strain curve and stress–strain–time curve of red clay under different pressures were obtained, and the triaxial shear and creep characteristics of red clay ... ...

    Abstract In order to explore the creep characteristics of red clay under different pressures, the stress–strain curve and stress–strain–time curve of red clay under different pressures were obtained, and the triaxial shear and creep characteristics of red clay under different pressures were analysed. A triaxial shear test and creep test were carried out on red clay from Guilin as the research object under different pressures. The results show that: ➀ the cohesion and the angle of internal friction of red clay from Guilin, obtained from a triaxial shear test, are 57.20 kPa and 22.47°, respectively; ➁ according to the physical meaning of the parameters of the Burgers creep model, a simple and practical parameter inversion method is proposed, which can be used to obtain the parameters of the Burgers model for red clay under different perimeter pressures and differing deviatoric stress; and ➂ when comparing the calculation results with the test results, the correlation coefficients R 2 of the two are above 0.9, with a good fitting effect, so the model can accurately describe the creep characteristics of red clay from Guilin. This study can provide a theoretical basis and technical support for engineering construction in the red clay area of Guilin.
    Keywords red clay ; triaxial creep ; Burgers model ; Guilin area ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 690
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  4. Article ; Online: Sleep Disturbance and Metabolic Dysfunction

    Zhikui Wei / You Chen / Raghu P. Upender

    International Journal of Molecular Sciences, Vol 23, Iss 1706, p

    The Roles of Adipokines

    2022  Volume 1706

    Abstract: Adipokines are a growing group of peptide or protein hormones that play important roles in whole body metabolism and metabolic diseases. Sleep is an integral component of energy metabolism, and sleep disturbance has been implicated in a wide range of ... ...

    Abstract Adipokines are a growing group of peptide or protein hormones that play important roles in whole body metabolism and metabolic diseases. Sleep is an integral component of energy metabolism, and sleep disturbance has been implicated in a wide range of metabolic disorders. Accumulating evidence suggests that adipokines may play a role in mediating the close association between sleep disorders and systemic metabolic derangements. In this review, we briefly summarize a group of selected adipokines and their identified function in metabolism. Moreover, we provide a balanced overview of these adipokines and their roles in sleep physiology and sleep disorders from recent human and animal studies. These studies collectively demonstrate that the functions of adipokine in sleep physiology and disorders could be largely twofold: (1) adipokines have multifaceted roles in sleep physiology and sleep disorders, and (2) sleep disturbance can in turn affect adipokine functions that likely contribute to systemic metabolic derangements.
    Keywords adipokine ; cardiometabolic disease ; metabolic syndrome ; sleep disorder ; obstructive sleep apnea ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  5. Article ; Online: Retraction Note: BCORL1 is an independent prognostic marker and contributes to cell migration and invasion in human hepatocellular carcinoma.

    Yin, Guozhi / Liu, Zhikui / Wang, Yufeng / Dou, Changwei / Li, Chao / Yang, Wei / Yao, Yingmin / Liu, Qingguang / Tu, Kangsheng

    BMC cancer

    2023  Volume 23, Issue 1, Page(s) 542

    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Retraction of Publication
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-11051-6
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  6. Article ; Online: Sleep Disturbance and Metabolic Dysfunction: The Roles of Adipokines.

    Wei, Zhikui / Chen, You / Upender, Raghu P

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: Adipokines are a growing group of peptide or protein hormones that play important roles in whole body metabolism and metabolic diseases. Sleep is an integral component of energy metabolism, and sleep disturbance has been implicated in a wide range of ... ...

    Abstract Adipokines are a growing group of peptide or protein hormones that play important roles in whole body metabolism and metabolic diseases. Sleep is an integral component of energy metabolism, and sleep disturbance has been implicated in a wide range of metabolic disorders. Accumulating evidence suggests that adipokines may play a role in mediating the close association between sleep disorders and systemic metabolic derangements. In this review, we briefly summarize a group of selected adipokines and their identified function in metabolism. Moreover, we provide a balanced overview of these adipokines and their roles in sleep physiology and sleep disorders from recent human and animal studies. These studies collectively demonstrate that the functions of adipokine in sleep physiology and disorders could be largely twofold: (1) adipokines have multifaceted roles in sleep physiology and sleep disorders, and (2) sleep disturbance can in turn affect adipokine functions that likely contribute to systemic metabolic derangements.
    MeSH term(s) Adipokines/metabolism ; Adipokines/physiology ; Animals ; Humans ; Metabolic Diseases/metabolism ; Metabolic Diseases/physiopathology ; Sleep ; Sleep Apnea, Obstructive ; Sleep Wake Disorders/metabolism ; Sleep Wake Disorders/physiopathology
    Chemical Substances Adipokines
    Language English
    Publishing date 2022-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031706
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  7. Article ; Online: Adipokines in Sleep Disturbance and Metabolic Dysfunction: Insights from Network Analysis.

    Wei, Zhikui / Chen, You / Upender, Raghu P

    Clocks & sleep

    2022  Volume 4, Issue 3, Page(s) 321–331

    Abstract: Adipokines are a growing group of secreted proteins that play important roles in obesity, sleep disturbance, and metabolic derangements. Due to the complex interplay between adipokines, sleep, and metabolic regulation, an integrated approach is required ... ...

    Abstract Adipokines are a growing group of secreted proteins that play important roles in obesity, sleep disturbance, and metabolic derangements. Due to the complex interplay between adipokines, sleep, and metabolic regulation, an integrated approach is required to better understand the significance of adipokines in these processes. In the present study, we created and analyzed a network of six adipokines and their molecular partners involved in sleep disturbance and metabolic dysregulation. This network represents information flow from regulatory factors, adipokines, and physiologic pathways to disease processes in metabolic dysfunction. Analyses using network metrics revealed that obesity and obstructive sleep apnea were major drivers for the sleep associated metabolic dysregulation. Two adipokines, leptin and adiponectin, were found to have higher degrees than other adipokines, indicating their central roles in the network. These adipokines signal through major metabolic pathways such as insulin signaling, inflammation, food intake, and energy expenditure, and exert their functions in cardiovascular, reproductive, and autoimmune diseases. Leptin, AMP activated protein kinase (AMPK), and fatty acid oxidation were found to have global influence in the network and represent potentially important interventional targets for metabolic and sleep disorders. These findings underscore the great potential of using network based approaches to identify new insights and pharmaceutical targets in metabolic and sleep disorders.
    Language English
    Publishing date 2022-06-22
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2624-5175
    ISSN (online) 2624-5175
    DOI 10.3390/clockssleep4030027
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  8. Article ; Online: LEGAN: A Light and Effective Generative Adversarial Network for medical image synthesis.

    Gao, Jing / Zhao, Wenhan / Li, Peng / Huang, Wei / Chen, Zhikui

    Computers in biology and medicine

    2022  Volume 148, Page(s) 105878

    Abstract: Medical image synthesis plays an important role in clinical diagnosis by providing auxiliary pathological information. However, previous methods usually utilize the one-step strategy designed for wild image synthesis, which are not sensitive to local ... ...

    Abstract Medical image synthesis plays an important role in clinical diagnosis by providing auxiliary pathological information. However, previous methods usually utilize the one-step strategy designed for wild image synthesis, which are not sensitive to local details of tissues within medical images. In addition, these methods consume a great number of computing resources in generating medical images, which seriously limits their applicability in clinical diagnosis. To address the above issues, a Light and Effective Generative Adversarial Network (LEGAN) is proposed to generate high-fidelity medical images in a lightweight manner. In particular, a coarse-to-fine paradigm is designed to imitate the painting process of humans for medical image synthesis within a two-stage generative adversarial network, which guarantees the sensitivity to local information of medical images. Furthermore, a low-rank convolutional layer is introduced to construct LEGAN for lightweight medical image synthesis, which utilizes principal components of full-rank convolutional kernels to reduce model redundancy. Additionally, a multi-stage mutual information distillation is devised to maximize dependencies of distributions between generated and real medical images in model training. Finally, extensive experiments are conducted in two typical tasks, i.e., retinal fundus image synthesis and proton density weighted MR image synthesis. The results demonstrate that LEGAN outperforms the comparison methods by a significant margin in terms of Fréchet inception distance (FID) and Number of parameters (NoP).
    MeSH term(s) Algorithms ; Fundus Oculi ; Humans ; Image Processing, Computer-Assisted
    Language English
    Publishing date 2022-07-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2022.105878
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  9. Article ; Online: Erratum: Hypoxia-induced up-regulation of VASP promotes invasiveness and metastasis of hepatocellular carcinoma: Erratum.

    Liu, Zhikui / Wang, Yufeng / Dou, Changwei / Xu, Meng / Sun, Liankang / Wang, Liang / Yao, Bowen / Li, Qing / Yang, Wei / Tu, Kangsheng / Liu, Qingguang

    Theranostics

    2023  Volume 13, Issue 3, Page(s) 910–912

    Abstract: This corrects the article DOI: 10.7150/thno.26789.]. ...

    Abstract [This corrects the article DOI: 10.7150/thno.26789.].
    Language English
    Publishing date 2023-01-11
    Publishing country Australia
    Document type Published Erratum
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.79069
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  10. Article ; Online: Retraction Note: MicroRNA-1468 promotes tumor progression by activating PPAR-γ-mediated AKT signaling in human hepatocellular carcinoma.

    Liu, Zhikui / Wang, Yufeng / Dou, Changwei / Sun, Liankang / Li, Qing / Wang, Liang / Xu, Qiuran / Yang, Wei / Liu, Qingguang / Tu, Kangsheng

    Journal of experimental & clinical cancer research : CR

    2022  Volume 41, Issue 1, Page(s) 272

    Language English
    Publishing date 2022-09-13
    Publishing country England
    Document type Retraction of Publication
    ZDB-ID 803138-1
    ISSN 1756-9966 ; 0392-9078
    ISSN (online) 1756-9966
    ISSN 0392-9078
    DOI 10.1186/s13046-022-02487-y
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