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  1. Article ; Online: Herman Waldmann, FRS, FRCP, FMEDSci: Emeritus Professor of Pathology, Sir William Dunn School of Pathology, University of Oxford, United Kingdom.

    Waldmann, Hermann

    Transplantation

    2018  Volume 102, Issue 11, Page(s) 1785–1786

    MeSH term(s) Alemtuzumab/history ; Alemtuzumab/therapeutic use ; Allergy and Immunology/history ; Biomedical Research/history ; Career Choice ; History, 20th Century ; History, 21st Century ; Immunologic Factors/history ; Immunologic Factors/therapeutic use
    Chemical Substances Immunologic Factors ; Alemtuzumab (3A189DH42V)
    Language English
    Publishing date 2018-10-22
    Publishing country United States
    Document type Biography ; Historical Article ; Interview ; Portrait
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000002408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
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    Zs.MO 509: Show issues

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  2. Article ; Online: Regulatory T cells and transplantation tolerance: Emerging from the darkness?

    Waldmann, Herman

    European journal of immunology

    2021  Volume 51, Issue 7, Page(s) 1580–1591

    Abstract: The field of tissue transplantation has revolutionized the treatment of patients with failing organs. Its success, thus far, has depended on combinations of immunosuppressive drugs that damp host immunity, while also imposing numerous unwanted side- ... ...

    Abstract The field of tissue transplantation has revolutionized the treatment of patients with failing organs. Its success, thus far, has depended on combinations of immunosuppressive drugs that damp host immunity, while also imposing numerous unwanted side-effects. There is a longstanding recognition that better treatment outcomes, will come from replacing these drugs, fully or in part, by taking advantage of tractable physiological mechanisms of self-tolerance. The past 50 years have seen many advances in the field of self-tolerance, but perhaps, the most tractable of these has been the more recent discovery of a subset T-cells (Treg) whose role is to regulate or damp immunity. This article is intended to first provide the reader with some historical background to explain why we have been slow to identify these cells, despite numerous clues to their existence, and also to indicate how little we know about how they achieve their regulatory function in averting transplant rejection. However, as is often the case in immunology, the therapeutic needs often dictate that our advances move to translation even before detailed explanations of the science are available. The final part of the article will briefly summarize how Treg are being harnessed as agents to interface with or perhaps, replace current drug combinations.
    MeSH term(s) Animals ; Graft Rejection/immunology ; Humans ; Immune Tolerance/immunology ; Immunosuppressive Agents/immunology ; T-Lymphocytes, Regulatory/immunology ; Transplantation Tolerance/immunology
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2021-05-16
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202048795
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    Zs.A 489: Show issues Location:
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    Zs.MG 85: Show issues

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  3. Article ; Online: Human Monoclonal Antibodies: The Benefits of Humanization.

    Waldmann, Herman

    Methods in molecular biology (Clifton, N.J.)

    2018  Volume 1904, Page(s) 1–10

    Abstract: The major reasons for developing human monoclonal antibodies were to be able to efficiently manipulate their effector functions while avoiding immunogenicity seen with rodent antibodies. Those effector functions involve interactions with the complement ... ...

    Abstract The major reasons for developing human monoclonal antibodies were to be able to efficiently manipulate their effector functions while avoiding immunogenicity seen with rodent antibodies. Those effector functions involve interactions with the complement system and naturally occurring Fc receptors on diverse blood white cells. Antibody immunogenicity results from the degree to which the host immune system can recognize and react to these therapeutic agents. Thus far, there is still no generally applicable technology guaranteed to render therapeutic antibodies antigenically silent. This is not to say that the task is impossible, but rather that we need to train the immune system to help us. This can be achieved if we take advantage of natural mechanisms by which an individual can be rendered tolerant of "foreign" antigens, and as a corollary minimize the potential immunogenicity of any contaminating protein aggregates, or "aggregates" arising from antibodies complexing with their antigen. I here summarize our efforts to engineer antibodies to harness optimal effector functions, while also minimizing their immunogenicity. Potential avenues to achieve the latte are predicted from classical work showing that monomeric "foreign" immunoglobulins are good tolerogens, while aggregates of immunoglobulins ate intrinsically immunogenic. Consequently, I argue that one solution to the immunogenicity problem lies in ensuring a temporal quantitative advantage of tolerogenic non-cell-bound monomer over the cell-binding immunogenic form.
    MeSH term(s) Animals ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/genetics ; Antibodies, Monoclonal, Humanized/immunology ; Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibody Affinity/immunology ; Antigens/immunology ; Genetic Engineering ; Humans ; Immune System/cytology ; Immune System/immunology ; Immune System/metabolism ; Immunoglobulin G/immunology ; Mutagenesis ; Receptors, Fc/metabolism
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antigens ; Immunoglobulin G ; Receptors, Fc
    Language English
    Publishing date 2018-12-11
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-8958-4_1
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  4. Article ; Online: Infectious tolerance. What are we missing?

    Waldmann, Herman / Graca, Luis

    Cellular immunology

    2020  Volume 354, Page(s) 104152

    MeSH term(s) Animals ; Humans ; Immune Tolerance ; Immunologic Deficiency Syndromes/immunology ; Immunologic Deficiency Syndromes/therapy ; Immunosuppression ; Immunotherapy/trends ; Lymphopenia/immunology ; Lymphopenia/therapy ; Mice ; T-Lymphocytes, Regulatory/immunology
    Language English
    Publishing date 2020-06-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2020.104152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 417: Show issues Location:
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  5. Article ; Online: Mechanisms of immunological tolerance.

    Waldmann, Herman

    Clinical biochemistry

    2016  Volume 49, Issue 4-5, Page(s) 324–328

    Abstract: There is increasing interest in establishing diagnostic markers of immunological tolerance applicable to efforts to minimize drug immunosuppression in transplantation and chronic immunological diseases. It is hoped that an understanding of the diverse ... ...

    Abstract There is increasing interest in establishing diagnostic markers of immunological tolerance applicable to efforts to minimize drug immunosuppression in transplantation and chronic immunological diseases. It is hoped that an understanding of the diverse mechanisms that can contribute to tolerance will guide efforts to establish diagnostic tolerance biomarkers. Not only would these be valuable for management of autoimmune diseases, transplants and allergies, but they might also guide efforts to override tolerance processes in cancer and vaccine development. Where tolerance is generated by deletion or inactivation of antigen reactive lymphocytes, it is unlikely that any long-term-valid blood biomarkers might be found. Where tolerance is mediated by active regulatory mechanisms, indicators that can be usefully measured may emerge, but these would likely show significant heterogeneity reflecting the diversity of active tolerance processes operating in different individuals. Given this, the most useful "kits" might be those "smart" enough to detect this diversity of tolerance players.
    MeSH term(s) Humans ; Immune Tolerance ; T-Lymphocytes, Regulatory/immunology
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 390372-2
    ISSN 1873-2933 ; 0009-9120
    ISSN (online) 1873-2933
    ISSN 0009-9120
    DOI 10.1016/j.clinbiochem.2015.05.019
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    Zs.A 624: Show issues Location:
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  6. Article ; Online: Drug minimization in transplantation: an opinion.

    Waldmann, Herman

    Current opinion in organ transplantation

    2014  Volume 19, Issue 4, Page(s) 331–333

    MeSH term(s) Cell Transplantation ; Graft vs Host Disease/prevention & control ; Humans ; Immunosuppressive Agents/therapeutic use ; Organ Transplantation ; Periodicals as Topic
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2014-08
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1390429-2
    ISSN 1531-7013 ; 1087-2418
    ISSN (online) 1531-7013
    ISSN 1087-2418
    DOI 10.1097/MOT.0000000000000099
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    Zs.A 5609: Show issues Location:
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  7. Article ; Online: Human monoclonal antibodies: the residual challenge of antibody immunogenicity.

    Waldmann, Herman

    Methods in molecular biology (Clifton, N.J.)

    2014  Volume 1060, Page(s) 1–8

    Abstract: One of the major reasons for seeking human monoclonal antibodies has been to eliminate immunogenicity seen with rodent antibodies. Thus far, there has yet been no approach which absolutely abolishes that risk for cell-binding antibodies. In this short ... ...

    Abstract One of the major reasons for seeking human monoclonal antibodies has been to eliminate immunogenicity seen with rodent antibodies. Thus far, there has yet been no approach which absolutely abolishes that risk for cell-binding antibodies. In this short article, I draw attention to classical work which shows that monomeric immunoglobulins are intrinsically tolerogenic if they can be prevented from creating aggregates or immune complexes. Based on these classical studies two approaches for active tolerization to therapeutic antibodies are described.
    MeSH term(s) Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/immunology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Humans ; Immune Tolerance/immunology
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2014-05-02
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-62703-586-6_1
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  8. Book: Monoclonal antibody therapy

    Waldmann, Herman

    2 tab

    (Progress in allergy ; 45)

    1988  

    Author's details vol. ed. Herman Waldmann
    Series title Progress in allergy ; 45
    Collection
    Keywords Antibodies, Monoclonal / therapeutic use ; Monoklonaler Antikörper ; Therapie
    Subject Medizinische Behandlung ; Behandlung ; Krankenbehandlung
    Language English
    Size VIII, 173 S. : graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT003229720
    ISBN 3-8055-4803-6 ; 978-3-8055-4803-8
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Uh III Zs 129 -45- verfügbar in Königswinter Königswinter

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  9. Article ; Online: Impact of parylene coating on heating performance of intravenous fluid warmer: a bench study.

    Bayoro, Danielle K / Groepenhoff, Herman / Hoolihan, Daniel / Rose, Edward A / Pedro, Michael J / Waldmann, Andreas D

    BMC anesthesiology

    2022  Volume 22, Issue 1, Page(s) 44

    Abstract: Background: Perioperative hypothermia is a common occurrence, particularly with the elderly and pediatric age groups. Hypothermia is associated with an increased risk of perioperative complications. One method of preventing hypothermia is warming the ... ...

    Abstract Background: Perioperative hypothermia is a common occurrence, particularly with the elderly and pediatric age groups. Hypothermia is associated with an increased risk of perioperative complications. One method of preventing hypothermia is warming the infused fluids given during surgery. The enFlow™ intravenous fluid warmer has recently been reintroduced with a parylene coating on its heating blocks. In this paper, we evaluated the impact of the parylene coating on the new enFlow's fluid warming capacity.
    Methods: Six coated and six uncoated enFlow cartridges were used. A solution of 10% propylene glycol and 90% distilled H
    Results: The parylene coated fluid warming cartridge delivered very stable output of 40 °C temperatures at flow rates of 2, 10, and 50 ml/min regardless of the temperature of the infusate. At higher flow rates, the cartridges were not able to achieve the target temperature with the colder fluid. Both cartridges performed with similar efficacy across all flow rates at all temperatures.
    Conclusions: At low flow rates, the parylene coated enFlow cartridges was comparable to the original uncoated cartridges. At higher flow rates, the coated and uncoated cartridges were not able to achieve the target temperature. The parylene coating on the aluminum heating blocks of the new enFlow intravenous fluid warmer does not negatively affect its performance compared to the uncoated model.
    MeSH term(s) Administration, Intravenous/methods ; Equipment Design ; Heating/instrumentation ; Heating/methods ; Humans ; Infusions, Intravenous ; Polymers ; Xylenes
    Chemical Substances Polymers ; Xylenes ; parylene (25722-33-2)
    Language English
    Publishing date 2022-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091252-3
    ISSN 1471-2253 ; 1471-2253
    ISSN (online) 1471-2253
    ISSN 1471-2253
    DOI 10.1186/s12871-022-01585-w
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  10. Article: Levels of leachable elements from long-term use of enFlow fluid warmer.

    Bayoro, Danielle / Groepenhoff, Herman / Pedro, Michael / Rose, Edward A / Waldmann, Andreas D

    SAGE open medicine

    2022  Volume 10, Page(s) 20503121221108927

    Abstract: Objective: In the delivery of intravenous fluids, in-line warming devices frequently transfer heat using a metal heating plate, which if uncoated can risk elution. This bench study examined extractable elements detected following long-term use of the ... ...

    Abstract Objective: In the delivery of intravenous fluids, in-line warming devices frequently transfer heat using a metal heating plate, which if uncoated can risk elution. This bench study examined extractable elements detected following long-term use of the parylene-coated enFlow
    Methods: We tested 16 clinically relevant challenge fluids typical of the surgical setting, including commercially available single donor blood and blood products as well as intravenous saline and electrolyte solutions. After 72 h of warming at 40°C (104°F) via the enFlow, analytical chemistry identified and quantified the most clinically significant extractable elements (arsenic, barium, cadmium, copper, and lead) to estimate chemical exposure. We also measured the extracted concentrations of these five elements following simulated use of the device with three solutions (Sterofundin ISO, Plasma-Lyte 148, and whole blood) that were pumped through the warmed device at two different flow rates (0.2 and 5.5 mL min
    Results: Across all scenarios of acute and long-term exposures for different populations, the enFlow demonstrated low toxicological risks as measured by the calculation of tolerable exposure for extracted arsenic, barium, cadmium, copper, and lead.
    Conclusion: The results suggest biological safety for the use of parylene-coated enFlow with a variety of intravenous solutions and in different therapeutic scenarios.
    Language English
    Publishing date 2022-07-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2735399-0
    ISSN 2050-3121
    ISSN 2050-3121
    DOI 10.1177/20503121221108927
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