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  1. Article ; Online: Modulation of the mitochondrial Ca

    Patel, Akshar / Pietromicca, Julia G / Venkatesan, Manigandan / Maity, Soumya / Bard, Jonathan E / Madesh, Muniswamy / Alevriadou, B Rita

    Physiological reports

    2023  Volume 11, Issue 3, Page(s) e15588

    Abstract: Mitochondrial calcium ( ...

    Abstract Mitochondrial calcium (
    MeSH term(s) Mice ; Humans ; Animals ; Endothelial Cells/metabolism ; Mitochondrial Membrane Transport Proteins/genetics ; Calcium Channels/genetics ; Calcium Channels/metabolism ; Mitochondria/metabolism ; Heart ; Calcium/metabolism ; Calcium-Binding Proteins/metabolism
    Chemical Substances Mitochondrial Membrane Transport Proteins ; Calcium Channels ; Calcium (SY7Q814VUP) ; MICU1 protein, mouse ; Calcium-Binding Proteins
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The mitochondrial Ca

    Patel, Akshar / Simkulet, Matthew / Maity, Soumya / Venkatesan, Manigandan / Matzavinos, Anastasios / Madesh, Muniswamy / Alevriadou, B Rita

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 21161

    Abstract: The mitochondrial calcium ( ... ...

    Abstract The mitochondrial calcium (Ca
    MeSH term(s) Endothelial Cells
    Language English
    Publishing date 2022-12-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-25583-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Modeling the role of endoplasmic reticulum-mitochondria microdomains in calcium dynamics.

    Moshkforoush, Arash / Ashenagar, Baarbod / Tsoukias, Nikolaos M / Alevriadou, B Rita

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 17072

    Abstract: Upon inositol trisphosphate ( ... ...

    Abstract Upon inositol trisphosphate (IP
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium Signaling ; Cytosol/metabolism ; Endoplasmic Reticulum/metabolism ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Mitochondria/metabolism ; Models, Biological ; Models, Theoretical
    Chemical Substances Inositol 1,4,5-Trisphosphate Receptors ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-11-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-53440-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Monocyte recruitment and fate specification after myocardial infarction.

    Mentkowski, Kyle I / Euscher, Lindsey M / Patel, Akshar / Alevriadou, B Rita / Lang, Jennifer K

    American journal of physiology. Cell physiology

    2020  Volume 319, Issue 5, Page(s) C797–C806

    Abstract: Monocytes are critical mediators of the inflammatory response following myocardial infarction (MI) and ischemia-reperfusion injury. They are involved in both initiation and resolution of inflammation and play an integral role in cardiac repair. The ... ...

    Abstract Monocytes are critical mediators of the inflammatory response following myocardial infarction (MI) and ischemia-reperfusion injury. They are involved in both initiation and resolution of inflammation and play an integral role in cardiac repair. The antagonistic nature of their function is dependent on their subset heterogeneity and biphasic response following injury. New advancements in single-cell transcriptomics and mass cytometry have allowed us to identify smaller, transcriptionally distinct clusters that may have functional relevance in disease and homeostasis. Additionally, recent insights into the spatiotemporal dynamics of monocytes following ischemic injury and their subsequent interactions with the endothelium and other immune cells reveal a complex interplay between monocytes and the cardiac milieu. In this review, we highlight recent findings on monocyte functional heterogeneity, present new mechanistic insight into monocyte recruitment and fate specification following MI, and discuss promising therapeutic avenues targeting monocytes for the treatment of ischemic heart disease.
    MeSH term(s) Animals ; Cell Lineage/drug effects ; Cell Lineage/genetics ; Cell Lineage/immunology ; Chemokines/genetics ; Chemokines/immunology ; Disease Models, Animal ; Exosomes/transplantation ; Gene Expression Regulation ; Humans ; Inflammation ; Interleukin 1 Receptor Antagonist Protein/pharmacology ; Interleukins/genetics ; Interleukins/immunology ; Isoflavones/pharmacology ; Mice ; Monocytes/drug effects ; Monocytes/immunology ; Monocytes/pathology ; Myocardial Infarction/genetics ; Myocardial Infarction/immunology ; Myocardial Infarction/pathology ; Myocardial Infarction/therapy ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/immunology ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/therapy ; Receptors, Chemokine/genetics ; Receptors, Chemokine/immunology ; Recovery of Function/drug effects ; Transcriptome/drug effects ; Transcriptome/immunology
    Chemical Substances Chemokines ; Interleukin 1 Receptor Antagonist Protein ; Interleukins ; Isoflavones ; Receptors, Chemokine ; puerarin (Z9W8997416)
    Language English
    Publishing date 2020-09-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00330.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The mitochondrial Ca2+ uniporter channel synergizes with fluid shear stress to induce mitochondrial Ca2+ oscillations

    Akshar Patel / Matthew Simkulet / Soumya Maity / Manigandan Venkatesan / Anastasios Matzavinos / Muniswamy Madesh / B. Rita Alevriadou

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 15

    Abstract: Abstract The mitochondrial calcium (Ca2+) uniporter (MCU) channel is responsible for mitochondrial Ca2+ influx. Its expression was found to be upregulated in endothelial cells (ECs) under cardiovascular disease conditions. Since the role of MCU in ... ...

    Abstract Abstract The mitochondrial calcium (Ca2+) uniporter (MCU) channel is responsible for mitochondrial Ca2+ influx. Its expression was found to be upregulated in endothelial cells (ECs) under cardiovascular disease conditions. Since the role of MCU in regulating cytosolic Ca2+ homeostasis in ECs exposed to shear stress (SS) is unknown, we studied mitochondrial Ca2+ dynamics (that is known to decode cytosolic Ca2+ signaling) in sheared ECs. To understand cause-and-effect, we ectopically expressed MCU in ECs. A higher percentage of MCU-transduced ECs exhibited mitochondrial Ca2+ transients/oscillations, and at higher frequency, under SS compared to sheared control ECs. Transients/oscillations correlated with mitochondrial reactive oxygen species (mROS) flashes and mitochondrial membrane potential (ΔΨm) flickers, and depended on activation of the mechanosensitive Piezo1 channel and the endothelial nitric oxide synthase (eNOS). A positive feedback loop composed of mitochondrial Ca2+ uptake/mROS flashes/ΔΨm flickers and endoplasmic reticulum Ca2+ release, in association with Piezo1 and eNOS, provided insights into the mechanism by which SS, under conditions of high MCU activity, may shape vascular EC energetics and function.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Modeling the role of endoplasmic reticulum-mitochondria microdomains in calcium dynamics

    Arash Moshkforoush / Baarbod Ashenagar / Nikolaos M. Tsoukias / B. Rita Alevriadou

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Volume 16

    Abstract: Abstract Upon inositol trisphosphate (IP3) stimulation of non-excitable cells, including vascular endothelial cells, calcium (Ca2+) shuttling between the endoplasmic reticulum (ER) and mitochondria, facilitated by complexes called Mitochondria-Associated ...

    Abstract Abstract Upon inositol trisphosphate (IP3) stimulation of non-excitable cells, including vascular endothelial cells, calcium (Ca2+) shuttling between the endoplasmic reticulum (ER) and mitochondria, facilitated by complexes called Mitochondria-Associated ER Membranes (MAMs), is known to play an important role in the occurrence of cytosolic Ca2+ concentration ([Ca2+]Cyt) oscillations. A mathematical compartmental closed-cell model of Ca2+ dynamics was developed that accounts for ER-mitochondria Ca2+ microdomains as the µd compartment (besides the cytosol, ER and mitochondria), Ca2+ influx to/efflux from each compartment and Ca2+ buffering. Varying the distribution of functional receptors in MAMs vs. the rest of ER/mitochondrial membranes, a parameter called the channel connectivity coefficient (to the µd), allowed for generation of [Ca2+]Cytoscillations driven by distinct mechanisms at various levels of IP3 stimulation. Oscillations could be initiated by the transient opening of IP3 receptors facing either the cytosol or the µd, and subsequent refilling of the respective compartment by Ca2+ efflux from the ER and/or the mitochondria. Only under conditions where the µd became the oscillation-driving compartment, silencing the Mitochondrial Ca2+ Uniporter led to oscillation inhibition. Thus, the model predicts that alternative mechanisms can yield [Ca2+]Cyt oscillations in non-excitable cells, and, under certain conditions, the ER-mitochondria µd can play a regulatory role.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The shear stress of busting blood clots.

    Wootton, David M / Alevriadou, B Rita

    The New England journal of medicine

    2012  Volume 367, Issue 14, Page(s) 1361–1363

    MeSH term(s) Animals ; Drug Carriers ; Fibrinolytic Agents/administration & dosage ; Hemorheology ; Humans ; Hydrodynamics ; Mice ; Nanoparticles ; Thrombosis/drug therapy ; Tissue Plasminogen Activator/administration & dosage
    Chemical Substances Drug Carriers ; Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2012-10-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcibr1207994
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    Ua VI Zs.34: Show issues Location:
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  8. Article ; Online: Molecular nature and physiological role of the mitochondrial calcium uniporter channel.

    Alevriadou, B Rita / Patel, Akshar / Noble, Megan / Ghosh, Sagnika / Gohil, Vishal M / Stathopulos, Peter B / Madesh, Muniswamy

    American journal of physiology. Cell physiology

    2020  Volume 320, Issue 4, Page(s) C465–C482

    Abstract: ... Calcium ( ... ...

    Abstract Calcium (Ca
    MeSH term(s) Animals ; Apoptosis ; Calcium Channels/chemistry ; Calcium Channels/drug effects ; Calcium Channels/genetics ; Calcium Channels/metabolism ; Calcium Signaling/drug effects ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/pathology ; Energy Metabolism/drug effects ; Gene Expression Regulation ; Humans ; Membrane Potential, Mitochondrial ; Mitochondria/drug effects ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Diseases/drug therapy ; Mitochondrial Diseases/genetics ; Mitochondrial Diseases/metabolism ; Mitochondrial Diseases/pathology ; Molecular Targeted Therapy ; Muscular Diseases/drug therapy ; Muscular Diseases/genetics ; Muscular Diseases/metabolism ; Muscular Diseases/pathology ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Protein Conformation ; Reactive Oxygen Species/metabolism ; Structure-Activity Relationship
    Chemical Substances Calcium Channels ; Reactive Oxygen Species ; mitochondrial calcium uniporter
    Language English
    Publishing date 2020-12-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00502.2020
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  9. Article ; Online: Mitochondrial Ca

    Alevriadou, B Rita / Shanmughapriya, Santhanam / Patel, Akshar / Stathopulos, Peter B / Madesh, Muniswamy

    Journal of the Royal Society, Interface

    2017  Volume 14, Issue 137

    Abstract: ... Calcium ( ... ...

    Abstract Calcium (Ca
    MeSH term(s) Animals ; Calcium Signaling ; Calcium-Binding Proteins/chemistry ; Calcium-Binding Proteins/metabolism ; Calcium-Binding Proteins/physiology ; Cation Transport Proteins/chemistry ; Cation Transport Proteins/metabolism ; Cation Transport Proteins/physiology ; Endothelium/metabolism ; Homeostasis ; Humans ; Mechanotransduction, Cellular ; Membrane Potential, Mitochondrial ; Mitochondria/metabolism ; Mitochondrial Membrane Transport Proteins/chemistry ; Mitochondrial Membrane Transport Proteins/metabolism ; Mitochondrial Membrane Transport Proteins/physiology ; Models, Biological ; Oxidation-Reduction
    Chemical Substances Calcium-Binding Proteins ; Cation Transport Proteins ; MICU1 protein, human ; Mitochondrial Membrane Transport Proteins
    Language English
    Publishing date 2017-12-13
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2156283-0
    ISSN 1742-5662 ; 1742-5689
    ISSN (online) 1742-5662
    ISSN 1742-5689
    DOI 10.1098/rsif.2017.0672
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  10. Article: CAMs and Rho small GTPases: gatekeepers for leukocyte transendothelial migration. Focus on "VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration".

    Alevriadou, B Rita

    American journal of physiology. Cell physiology

    2003  Volume 285, Issue 2, Page(s) C250–2

    MeSH term(s) Animals ; Cell Adhesion/physiology ; Cell Adhesion Molecules/metabolism ; Chemotaxis, Leukocyte/physiology ; Endothelium, Vascular/enzymology ; Humans ; Leukocytes/enzymology ; Leukocytes/physiology ; Models, Biological ; Signal Transduction/physiology ; rho GTP-Binding Proteins/metabolism
    Chemical Substances Cell Adhesion Molecules ; rho GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2003-07-03
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00189.2003
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