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  1. Article ; Online: The Pyroptosis-Related Signature Composed of GSDMC Predicts Prognosis and Contributes to Growth and Metastasis of Hepatocellular Carcinoma.

    Li, Min / Jiang, Qiuyu / Liu, Xinyi / Han, Liping / Chen, She / Xue, Ruyi

    Frontiers in bioscience (Landmark edition)

    2023  Volume 28, Issue 10, Page(s) 235

    Abstract: Background: Pyroptosis-related genes (PRG) are closely associated with the progression and metastasis of hepatocellular carcinoma (HCC). The predictive power of PRGs could be used to assess the clinical outcomes of HCC.: Methods: The Cancer Genome ... ...

    Abstract Background: Pyroptosis-related genes (PRG) are closely associated with the progression and metastasis of hepatocellular carcinoma (HCC). The predictive power of PRGs could be used to assess the clinical outcomes of HCC.
    Methods: The Cancer Genome Atlas (TCGA) RNA-seq data and clinical information from patients with liver hepatocellular carcinoma (LIHC) were used to identify PRG with differentially expressed between HCC and normal samples. Univariate Cox regression, least absolute shrinkage and selection operator (LASSO) Cox method, and multivariate Cox regression analysis were used to develop a prognostic model that included three PRGs. Gene set enrichment analysis (GSEA) was performed to identify differential immune cells and their associated pathways. The expression of Gasdermin C (
    Results: Of 52 PRGs,
    Conclusions: The three PRGs signatures containing
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/genetics ; Pyroptosis/genetics ; Liver Neoplasms/genetics ; Transcriptional Activation ; Biomarkers, Tumor/genetics ; Pore Forming Cytotoxic Proteins
    Chemical Substances GSDMC protein, human ; Biomarkers, Tumor ; Pore Forming Cytotoxic Proteins
    Language English
    Publishing date 2023-11-02
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2810235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Inhibiting PLA2G7 reverses the immunosuppressive function of intratumoral macrophages and augments immunotherapy response in hepatocellular carcinoma.

    Zhang, Feng / Liu, Wenfeng / Meng, Fansheng / Jiang, Qiuyu / Tang, Wenqing / Liu, Zhiyong / Lin, Xiahui / Xue, Ruyi / Zhang, Si / Dong, Ling

    Journal for immunotherapy of cancer

    2024  Volume 12, Issue 1

    Abstract: Background: Hepatocellular carcinoma (HCC) is an exceptionally immunosuppressive malignancy characterized by limited treatment options and a dismal prognosis. Macrophages constitute the primary and heterogeneous immune cell population within the HCC ... ...

    Abstract Background: Hepatocellular carcinoma (HCC) is an exceptionally immunosuppressive malignancy characterized by limited treatment options and a dismal prognosis. Macrophages constitute the primary and heterogeneous immune cell population within the HCC microenvironment. Our objective is to identify distinct subsets of macrophages implicated in the progression of HCC and their resistance to immunotherapy.
    Methods: Intratumoral macrophage-specific marker genes were identified via single-cell RNA sequencing analyses. The clinical relevance of phospholipase A2 Group VII (PLA2G7), a pivotal enzyme in phospholipid metabolism, was assessed in patients with HCC through immunohistochemistry and immunofluorescence. Flow cytometry and an in vitro co-culture system were used to elucidate the specific role of PLA2G7 in macrophages. Orthotopic and subcutaneous HCC mouse models were employed to evaluate the potential of the PLA2G7 inhibitor in complementing immune checkpoint blockade (ICB) therapy.
    Results: Single-cell RNA sequencing analyses disclosed predominant PLA2G7 expression in intratumoral macrophages within the HCC microenvironment. The macrophage-specific PLA2G7 was significantly correlated with poorer prognosis and immunotherapy resistance in patients with HCC. PLA2G7
    Conclusions: Macrophage-specific PLA2G7 serves as a novel biomarker capable of prognosticating immunotherapy responsiveness and inhibiting PLA2G7 has the potential to enhance the efficacy of ICB therapy for HCC.
    MeSH term(s) Mice ; Animals ; Humans ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Macrophages ; Immunotherapy ; Prognosis ; Tumor Microenvironment ; 1-Alkyl-2-acetylglycerophosphocholine Esterase/therapeutic use
    Chemical Substances PLA2G7 protein, human (EC 3.1.1.47) ; 1-Alkyl-2-acetylglycerophosphocholine Esterase (EC 3.1.1.47)
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2023-008094
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  3. Article ; Online: Anisotropic interlayer Dzyaloshinskii-Moriya interactions in synthetic ferromagnetic multilayers.

    Chen, Ruyi / Xu, Feng / Cui, Qirui / Liang, Jinghua / Zhou, Yongjian / Wang, Ning / Pan, Feng / Xue, Fei / Yang, Hongxin / Song, Cheng

    Science bulletin

    2023  Volume 68, Issue 9, Page(s) 878–882

    Language English
    Publishing date 2023-04-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2023.04.008
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  4. Article: Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: Markers predicting immune-checkpoint inhibitor efficacy and immune-related adverse events.

    Jiang, Qiu-Yu / Xue, Ru-Yi

    World journal of gastrointestinal oncology

    2024  Volume 16, Issue 3, Page(s) 577–582

    Abstract: We conducted a comprehensive review of existing prediction models pertaining to the efficacy of immune-checkpoint inhibitor (ICI) and the occurrence of immune-related adverse events (irAEs). The predictive potential of neutrophil-to-lymphocyte ratio (NLR) ...

    Abstract We conducted a comprehensive review of existing prediction models pertaining to the efficacy of immune-checkpoint inhibitor (ICI) and the occurrence of immune-related adverse events (irAEs). The predictive potential of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in determining ICI effectiveness has been extensively investigated, while limited research has been conducted on predicting irAEs. Furthermore, the combined model incorporating NLR and PLR, either with each other or in conjunction with additional markers such as carcinoembryonic antigen, exhibits superior predictive capabilities compared to individual markers alone. NLR and PLR are promising markers for clinical applications. Forthcoming models ought to incorporate established efficacious models and newly identified ones, thereby constituting a multifactor composite model. Furthermore, efforts should be made to explore effective clinical application approaches that enhance the predictive accuracy and efficiency.
    Language English
    Publishing date 2024-04-03
    Publishing country China
    Document type Editorial
    ZDB-ID 2573696-6
    ISSN 1948-5204
    ISSN 1948-5204
    DOI 10.4251/wjgo.v16.i3.577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Full-Length Transcriptome of the Great Himalayan Leaf-Nosed Bats (

    Bao, Mingyue / Wang, Xue / Sun, Ruyi / Wang, Zhiqiang / Li, Jiqian / Jiang, Tinglei / Lin, Aiqing / Wang, Hui / Feng, Jiang

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: The Great Himalayan Leaf-nosed bat ( ...

    Abstract The Great Himalayan Leaf-nosed bat (
    MeSH term(s) Animals ; Chiroptera/physiology ; Transcriptome ; Genome ; Protein Isoforms/genetics ; Plant Leaves
    Chemical Substances Protein Isoforms
    Language English
    Publishing date 2023-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054937
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  6. Article ; Online: Facile one-step synthesis of mesoporous Pt-based alloy nanospheres for ethanol electrooxidation.

    Wang, Ruyi / Gu, Shichun / Li, Dexiang / Wang, Chaoman / Zhai, Chongyuan / Sun, Yu / Wang, Xue / Huang, Hui / Guo, Zhongcheng / He, Yapeng

    Chemical communications (Cambridge, England)

    2023  Volume 60, Issue 1, Page(s) 122–125

    Abstract: Mesoporous Pt-based alloy nanospheres were ... ...

    Abstract Mesoporous Pt-based alloy nanospheres were prepared
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc04416e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mechanistic Understanding toward the Maternal Transfer of Nanoplastics in

    Xue, Runze / Lan, Ruyi / Su, Wenli / Wang, Zhenyu / Li, Xinyu / Zhao, Jian / Ma, Chuanxin / Xing, Baoshan

    ACS nano

    2023  Volume 17, Issue 14, Page(s) 13488–13499

    Abstract: Nanoplastics induce transgenerational toxicity to aquatic organisms, but the specific pathways for the maternal transfer of nanoplastics remain unclear. Herein, laser scanning confocal microscopy (LSCM) observations identified the specific pathways on ... ...

    Abstract Nanoplastics induce transgenerational toxicity to aquatic organisms, but the specific pathways for the maternal transfer of nanoplastics remain unclear. Herein, laser scanning confocal microscopy (LSCM) observations identified the specific pathways on the maternal transfer of polystyrene (PS) nanoplastics (25 nm) in
    MeSH term(s) Animals ; Female ; Daphnia/metabolism ; Microplastics/metabolism ; Water Pollutants, Chemical ; Nanoparticles ; Polystyrenes
    Chemical Substances Microplastics ; Water Pollutants, Chemical ; Polystyrenes
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c01847
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  8. Article ; Online: The Pyroptosis-Related Signature Composed of GSDMC Predicts Prognosis and Contributes to Growth and Metastasis of Hepatocellular Carcinoma

    Min Li / Qiuyu Jiang / Xinyi Liu / Liping Han / She Chen / Ruyi Xue

    Frontiers in Bioscience-Landmark, Vol 28, Iss 10, p

    2023  Volume 235

    Abstract: Background: Pyroptosis-related genes (PRG) are closely associated with the progression and metastasis of hepatocellular carcinoma (HCC). The predictive power of PRGs could be used to assess the clinical outcomes of HCC. Methods: The Cancer Genome Atlas ( ... ...

    Abstract Background: Pyroptosis-related genes (PRG) are closely associated with the progression and metastasis of hepatocellular carcinoma (HCC). The predictive power of PRGs could be used to assess the clinical outcomes of HCC. Methods: The Cancer Genome Atlas (TCGA) RNA-seq data and clinical information from patients with liver hepatocellular carcinoma (LIHC) were used to identify PRG with differentially expressed between HCC and normal samples. Univariate Cox regression, least absolute shrinkage and selection operator (LASSO) Cox method, and multivariate Cox regression analysis were used to develop a prognostic model that included three PRGs. Gene set enrichment analysis (GSEA) was performed to identify differential immune cells and their associated pathways. The expression of Gasdermin C (GSDMC) in the HCC samples was detected by western blotting, and the function of GSDMC in HCC proliferation and metastasis was detected by the Cell Counting Kit-8 (CCK-8), colony formation, cell invasion, and wound healing assays. Results: Of 52 PRGs, GSDMC, Bcl-2 homologusantagonist/ killer 1 (BAK1), and NOD-like receptor thermal protein domain associated protein 6 (NLRP6) were selected to establish a prognostic model. The model successfully differentiated HCC patients with varied survival in the TCGA training and test cohorts, as well as the International Cancer Genome Consortium (ICGC) validation cohorts. The risk score was proven to be an independent prognostic factor. In addition, we also reported a marked upregulation of GSDMC in HCC tissues, which could be induced by CD274 (PD-L1). Overexpression of GSDMC contributes to HCC cells invasion, proliferation, and migration. Conclusions: The three PRGs signatures containing GSDMC independently predicted HCC prognosis. As a new driver molecule, GSDMC could play a tumor-promoting role by facilitating HCC growth and metastasis.
    Keywords hepatocellular carcinoma ; pyroptosis ; gsdmc ; prognosis ; immune checkpoint ; Biochemistry ; QD415-436 ; Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher IMR Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Molecular adaptations underlying high-frequency hearing in the brain of CF bats species.

    Li, Xintong / Wang, Hui / Wang, Xue / Bao, Mingyue / Sun, Ruyi / Dai, Wentao / Sun, Keping / Feng, Jiang

    BMC genomics

    2024  Volume 25, Issue 1, Page(s) 279

    Abstract: Background: The majority of bat species have developed remarkable echolocation ability, especially for the laryngeally echolocating bats along with high-frequency hearing. Adaptive evolution has been widely detected for the cochleae in the laryngeally ... ...

    Abstract Background: The majority of bat species have developed remarkable echolocation ability, especially for the laryngeally echolocating bats along with high-frequency hearing. Adaptive evolution has been widely detected for the cochleae in the laryngeally echolocating bats, however, limited understanding for the brain which is the central to echolocation signal processing in the auditory perception system, the laryngeally echolocating bats brain may also undergo adaptive changes.
    Result: In order to uncover the molecular adaptations related with high-frequency hearing in the brain of laryngeally echolocating bats, the genes expressed in the brain of Rhinolophus ferrumequinum (CF bat) and Myotis pilosus (FM bat) were both detected and also compared. A total of 346,891 genes were detected and the signal transduction mechanisms were annotated by the most abundant genes, followed by the transcription. In hence, there were 3,088 DEGs were found between the two bat brains, with 1,426 highly expressed in the brain of R. ferrumequinum, which were significantly enriched in the neuron and neurodevelopmental processes. Moreover, we found a key candidate hearing gene, ADCY1, playing an important role in the R. ferrumequinum brain and undergoing adaptive evolution in CF bats.
    Conclusions: Our study provides a new insight to the molecular bases of high-frequency hearing in two laryngeally echolocating bats brain and revealed different nervous system activities during auditory perception in the brain of CF bats.
    MeSH term(s) Animals ; Chiroptera/genetics ; Hearing/genetics ; Echolocation/physiology ; Brain
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-024-10212-6
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  10. Article ; Online: Macrophage SHP2 Deficiency Alleviates Diabetic Nephropathy via Suppression of MAPK/NF-κB- Dependent Inflammation.

    Han, Xue / Wei, Jiajia / Zheng, Ruyi / Tu, Yu / Wang, Mengyang / Chen, Lingfeng / Xu, Zheng / Zheng, Lei / Zheng, Chao / Shi, Qiaojuan / Ying, Huazhong / Liang, Guang

    Diabetes

    2024  Volume 73, Issue 5, Page(s) 780–796

    MeSH term(s) Humans ; Mice ; Animals ; Diabetic Nephropathies/metabolism ; NF-kappa B/metabolism ; Mitogen-Activated Protein Kinases/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Inflammation/pathology ; Cytokines/metabolism ; Mice, Knockout ; Macrophages/metabolism ; Fibrosis
    Chemical Substances NF-kappa B ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Cytokines
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/db23-0700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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