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Article ; Online: Blessing or curse: the role of authoritarian filial piety and self-efficacy in caregiver gains among Chinese family caregivers caring for physically impaired older adults.

Zhang, Jiyuan / Sun, Xin / Yan, Zi

2024 Volume 24, Issue 1, Page(s) 163

Abstract: Background: This study investigated the effects of authoritarian filial piety (AFP) and caregiver self-efficacy on the caregiving experience of adult children of physically impaired older adults. Socio-cultural stress and coping model was applied to ... ...

Abstract	Background: This study investigated the effects of authoritarian filial piety (AFP) and caregiver self-efficacy on the caregiving experience of adult children of physically impaired older adults. Socio-cultural stress and coping model was applied to test the influence of AFP on caregiver gains. Methods: A total of 601 Chinese adult children caregivers and care-recipient dyads participated in this cross-sectional study in 2021. Four instruments were used to collect data: the 4-item Zarit Burden Interview, Positive Aspects of Caregiving Scale, Caregiver Task Inventory Scale, and Authoritarian Filial Piety Scale. All mediation and moderated mediation effects were estimated using SPSS 26.0. Results: Caregiver self-efficacy was found to not only mediate but also help family caregivers convert their burden into positive gains. AFP moderates the association between caregiver burden and self-efficacy, as well as between caregiver burden and caregiver gains. Conclusions: This study provides valuable insights into filial piety, elucidating AFP's comprehensive impact on cognitive appraisals of caregiving. Culturally sensitive psychoeducational therapy, addressing AFP expectations and boosting caregiver self-efficacy, is recommended to enhance positive caregiving outcomes.
MeSH term(s)	Humans ; Aged ; Caregivers/psychology ; alpha-Fetoproteins ; Cross-Sectional Studies ; Self Efficacy ; China
Chemical Substances	alpha-Fetoproteins
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-024-04768-x
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Article ; Online: Radiopharmaceuticals heat anti-tumor immunity.

Sun, Qi / Li, Jiyuan / Ding, Zexuan / Liu, Zhibo

Theranostics

2023 Volume 13, Issue 2, Page(s) 767–786

Abstract: Radiopharmaceutical therapy (RPT) has proven to be an effective cancer treatment with minimal toxicity. With several RPT agents approved by FDA, the remarkable potential of this therapy is now being recognized, and the anti-tumor immunity induced by RPT ... ...

Abstract	Radiopharmaceutical therapy (RPT) has proven to be an effective cancer treatment with minimal toxicity. With several RPT agents approved by FDA, the remarkable potential of this therapy is now being recognized, and the anti-tumor immunity induced by RPT is beginning to be noticed. This review evaluates the potential of RPT for immune activation, including promoting the release of danger associated-molecular pattern molecules that recruit inflammatory cells into the tumor microenvironment, and activating antigen-presenting cells and cytotoxic T cells. We also discuss the progress of combining RPT with immunotherapy to increase efficacy.
MeSH term(s)	Humans ; Radiopharmaceuticals/therapeutic use ; Hot Temperature ; Neoplasms/therapy ; T-Lymphocytes, Cytotoxic ; Immunotherapy ; Tumor Microenvironment
Chemical Substances	Radiopharmaceuticals
Language	English
Publishing date	2023-01-01
Publishing country	Australia
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.79806
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Article ; Online: Research on the Hydrodynamic Performance of a Pentamaran in Calm Water and Regular Waves

Bowen Zhao / Haoyu Jiang / Jiyuan Sun / Dapeng Zhang

Applied Sciences, Vol 13, Iss 4461, p

2023 Volume 4461

Abstract: As a typical multi-hull ship, the pentamaran has a wider deck, higher damage stability, and low-speed seaworthiness in harsh sea conditions compared with other multi-hull types such as the catamaran and trimaran, having more potential for becoming a new ... ...

Abstract	As a typical multi-hull ship, the pentamaran has a wider deck, higher damage stability, and low-speed seaworthiness in harsh sea conditions compared with other multi-hull types such as the catamaran and trimaran, having more potential for becoming a new type of freight merchant ship in line with the development trend of the marine economy. In this paper, on the basis of the finite volume method, the numerical simulations and detailed comparative analysis of the monohull and pentamaran in viscous flow were carried out. The resistance prediction in calm water and regular waves and the changes of each resistance component of the pentamaran were explored. The dynamic fluid body interaction (DFBI) module was used for the calculations in calm water, and the overset mesh was used for the calculations in regular waves. The results show that in calm water, the adverse effect of the side hulls on the resistance was mainly reflected in the low-speed range. In the high-speed range, the influence of the side hulls on the resistance can be ignored. At high speeds, the main hull and side hulls of the pentamaran will produce favorable wave-making interference, thereby improving the wave-making performance of the pentamaran. In regular waves, although the added resistance of the pentamaran increased most of the time, its amplitude was smaller than that of the monohull under the same wave condition. This work provides a technical basis for the research on the design and hydrodynamic performance of the pentamaran.
Keywords	pentamaran ; monohull ; RANS ; regular waves ; hydrodynamic performance ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	621
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Efficient C-N coupling for urea electrosynthesis on defective Co

Li, Pengsong / Zhu, Qinggong / Liu, Jiyuan / Wu, Tianbin / Song, Xinning / Meng, Qinglei / Kang, Xinchen / Sun, Xiaofu / Han, Buxing

Chemical science

2024 Volume 15, Issue 9, Page(s) 3233–3239

Abstract: Urea electrosynthesis under ambient conditions is emerging as a promising alternative to conventional synthetic protocols. However, the weak binding of reactants/intermediates on the catalyst surface induces multiple competing pathways, hindering ... ...

Abstract	Urea electrosynthesis under ambient conditions is emerging as a promising alternative to conventional synthetic protocols. However, the weak binding of reactants/intermediates on the catalyst surface induces multiple competing pathways, hindering efficient urea production. Herein, we report the synthesis of defective Co
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc06579k
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Article ; Online: Structural changes in spinal cord following optic neuritis: Insights from quantitative spinal MRI.

Wang, Jiyuan / Huang, Jing / Sun, Zheng / Dong, Huiqing / Li, Kuncheng / Lu, Jie

Brain research

2024 Volume 1831, Page(s) 148830

Abstract: Objectives: Previous studies have demonstrated that optic neuritis (ON) affects brain plasticity. However, whether ON affects the spinal cord remains unclear. We aimed to investigate the spinal cord changes in ON and their associations with disability.!# ...

Abstract	Objectives: Previous studies have demonstrated that optic neuritis (ON) affects brain plasticity. However, whether ON affects the spinal cord remains unclear. We aimed to investigate the spinal cord changes in ON and their associations with disability. Methods: A total of 101 ON patients, and 41 healthy controls (HC) were retrospectively recruited. High-resolution imaging was conducted using a Magnetization Prepared Rapid Acquisition Gradient-Echo (MP-RAGE) sequence for T1-weighted images and an echo planar imaging (EPI) sequence for Diffusion Tensor Imaging (DTI) data collection. Additionally, patients' disability and cognitive impairment were evaluated using the Expanded Disability Status Scale (EDSS) and the Paced Auditory Serial Addition Test (PASAT), respectively. The quantitative spinal MRI was employed to examine the cross-sectional area (CSA) and diffusion indicators, with a specific focus on calculating the average values across the C2-C7 cervical spinal cord segments. CSA, fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were compared between groups. Correlation analyses were performed between CSA, diffusion indicators, and clinical variables. Results: No significant differences were found in CSA between ON patients and HCs. MD (p = 0.007) and RD (p = 0.018) were increased in ON patients compared with HCs, and AD was decreased in ON (p = 0.013). The AD values of the ON patients were significantly positively correlated with PASAT scores (r = 0.37, p < 0.001). Conclusions: This study provided imaging evidence for DTI abnormalities in patients with ON. Spinal cord DTI can improve our knowledge of the path physiology of ON, and clinical progression.
MeSH term(s)	Humans ; Diffusion Tensor Imaging/methods ; Retrospective Studies ; Spinal Cord/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Spinal Cord Injuries
Language	English
Publishing date	2024-02-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2024.148830
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Article ; Online: Key Contributions of the Overexpressed

Liu, Jiyuan / Tian, Zhen / Li, Ruichi / Ni, Shujun / Sun, Hong / Yin, Fei / Li, Zhenyu / Zhang, Yalin / Li, Yifan

Journal of agricultural and food chemistry

2024 Volume 72, Issue 5, Page(s) 2560–2572

Abstract: The overexpression of insect detoxification enzymes is a typical adaptive evolutionary strategy for insects to cope with insecticide pressure. In this study, we identified a ... ...

Abstract	The overexpression of insect detoxification enzymes is a typical adaptive evolutionary strategy for insects to cope with insecticide pressure. In this study, we identified a glutathione
MeSH term(s)	Animals ; Insecticides/pharmacology ; Moths/genetics ; Glutathione Transferase/metabolism ; Gene Expression ; RNA Interference ; Insecticide Resistance/genetics ; Larva/metabolism
Chemical Substances	Insecticides ; Glutathione Transferase (EC 2.5.1.18)
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c09458
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Zs.A 1172: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Influence of lattice water molecules on the magnetization dynamics of binuclear dysprosium(III) compounds: insights from magnetic and

Du, Jiyuan / Wei, Shilong / Jiang, Zhijie / Ke, Hongshan / Sun, Lin / Zhang, Yiquan / Chen, Sanping

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 16, Page(s) 11717–11724

Abstract: Lattice water effects on the structures and magnetic properties of single-molecule magnets (SMMs) have attracted considerable attention. Herein, we have successfully synthesized two centrosymmetric binuclear compounds [ ... ...

Abstract	Lattice water effects on the structures and magnetic properties of single-molecule magnets (SMMs) have attracted considerable attention. Herein, we have successfully synthesized two centrosymmetric binuclear compounds [Dy
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d2cp06074d
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Article ; Online: Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway.

Yang, Yan / Qiu, Wen / Xiao, Jiyuan / Sun, Jie / Ren, Xuan / Jiang, Luxia

Journal of translational medicine

2024 Volume 22, Issue 1, Page(s) 309

Abstract: Background: Dihydromyricetin (DHM), a flavonoid compound of natural origin, has been identified in high concentrations in ampelopsis grossedentata and has a broad spectrum of biological and pharmacological functions, particularly in regulating glucose ... ...

Abstract	Background: Dihydromyricetin (DHM), a flavonoid compound of natural origin, has been identified in high concentrations in ampelopsis grossedentata and has a broad spectrum of biological and pharmacological functions, particularly in regulating glucose and lipid metabolism. The objective of this research was to examine how DHM affected nonalcoholic fatty liver disease (NAFLD) and its underlying mechanisms involved in the progression of NAFLD in a rat model subjected to a high-fat diet (HFD). Additionally, the study examines the underlying mechanisms in a cellular model of steatohepatitis using palmitic acid (PA)-treated HepG2 cells, with a focus on the potential correlation between autophagy and hepatic insulin resistance (IR) in the progress of NAFLD. Methods: SD rats were exposed to a HFD for a period of eight weeks, followed by a treatment with DHM (at doses of 50, 100, and 200 mg·kg Results: The administration of DHM demonstrated efficacy in ameliorating hepatic steatosis, as seen in both in vivo and in vitro experimental models. Moreover, DHM administration significantly increased GLUT2 expression, decreased G6Pase and PEPCK expression, and improved IR in the hepatic tissue of rats fed a HFD and in cells exhibiting steatosis. DHM treatment elevated Beclin 1, ATG 5, and LC3-II levels in hepatic steatosis models, correlating with autolysosome formation. The expression of AMPK levels and its downstream target PGC-1α, and PPARα were decreased in HFD-fed rats and PA-treated hepatocytes, which were reversed through DHM treatment. AMPK/ PGC-1α and PPARα knockdown reduced the impact of DHM on hepatic autophagy, IR and accumulation of hepatic lipid. Conclusions: Our findings revealed that AMPK/ PGC-1α, PPARα-dependent autophagy pathways in the pathophysiology of IR and hepatic steatosis has been shown, suggesting that DHM might potentially serve as a promising treatment option for addressing this disease.
MeSH term(s)	Rats ; Animals ; Mice ; Non-alcoholic Fatty Liver Disease/pathology ; PPAR alpha/metabolism ; AMP-Activated Protein Kinases/metabolism ; Insulin Resistance/physiology ; Rats, Sprague-Dawley ; Liver/pathology ; Lipid Metabolism ; Palmitic Acid/metabolism ; Palmitic Acid/pharmacology ; Palmitic Acid/therapeutic use ; Autophagy ; Diet, High-Fat ; Mice, Inbred C57BL ; Flavonols
Chemical Substances	dihydromyricetin (KD8QND6427) ; PPAR alpha ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Palmitic Acid (2V16EO95H1) ; Flavonols
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-024-05060-7
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Article ; Online: Dynamic Analysis of Underwater Torpedo during Straight-Line Navigation

Bowen Zhao / Jiyuan Sun / Dapeng Zhang / Keqiang Zhu / Haoyu Jiang

Applied Sciences, Vol 13, Iss 4169, p

2023 Volume 4169

Abstract: Torpedoes play an irreplaceable role in naval warfare; therefore, it is significant to study the dynamic response of the direct navigation of torpedoes. In order to study the dynamic response of torpedoes under different Munk moment coefficients, the ... ...

Abstract	Torpedoes play an irreplaceable role in naval warfare; therefore, it is significant to study the dynamic response of the direct navigation of torpedoes. In order to study the dynamic response of torpedoes under different Munk moment coefficients, the dynamic equation of torpedoes is established based on the momentum theorem and the momentum moment theorem. The linear motion mathematical model of torpedoes is obtained. The relationship between the torpedo and the Munk moment coefficient is derived. The straight-line motion model of the torpedo under different Munk moments is established, and the dynamic properties of the space motion of the torpedo are analyzed. It is found that the Munk moment coefficient increase will lead to an increase in the deflection of the torpedo’s direct motion on each degree of freedom, and the Munk moment coefficient is related to the additional mass matrix. During the design of the torpedo, the added mass should be reduced by changing the shape of the torpedo as much as possible so as to reduce the pitch moment, yaw, and roll moments of the torpedo.
Keywords	torpedo ; dynamic response ; Munk moment ; lumped-mass method ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	629
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Numerical modelling of micron particle inhalation in a realistic nasal airway with pediatric adenoid hypertrophy: A virtual comparison between pre- and postoperative models.

Sun, Qinyuan / Dong, Jingliang / Zhang, Ya / Tian, Lin / Tu, Jiyuan

Frontiers in pediatrics

2023 Volume 11, Page(s) 1083699

Abstract: Adenoid hypertrophy (AH) is an obstructive condition due to enlarged adenoids, causing mouth breathing, nasal blockage, snoring and/or restless sleep. While reliable diagnostic techniques, such as lateral soft tissue x-ray imaging or flexible ... ...

Abstract	Adenoid hypertrophy (AH) is an obstructive condition due to enlarged adenoids, causing mouth breathing, nasal blockage, snoring and/or restless sleep. While reliable diagnostic techniques, such as lateral soft tissue x-ray imaging or flexible nasopharyngoscopy, have been widely adopted in general practice, the actual impact of airway obstruction on nasal airflow and inhalation exposure to drug aerosols remains largely unknown. In this study, the effects of adenoid hypertrophy on airflow and micron particle inhalation exposure characteristics were analysed by virtually comparing pre- and postoperative models based on a realistic 3-year-old nasal airway with AH. More specifically, detailed comparison focused on anatomical shape variations, overall airflow and olfactory ventilation, associated particle deposition in overall and local regions were conducted. Our results indicate that the enlarged adenoid tissue can significantly alter the airflow fields. By virtually removing the enlarged tissue and restoring the airway, peak velocity and wall shear stress were restored, and olfactory ventilation was considerably improved (with a 16∼63% improvement in terms of local ventilation speed). Furthermore, particle deposition results revealed that nasal airway with AH exhibits higher particle filtration tendency with densely packed deposition hot spots being observed along the floor region and enlarged adenoid tissue area. While for the postoperative model, the deposition curve was shifted to the right. The local deposition efficiency results demonstrated that more particles with larger inertia can be delivered to the targeted affected area following Adenoidectomy (Adenoid Removal). Research findings are expected to provide scientific evidence for adenoidectomy planning and aerosol therapy following Adenoidectomy, which can substantially improve present clinical treatment outcomes.
Language	English
Publishing date	2023-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1083699
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