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Article ; Online: The incidence and etiology of sperm DNA fragmentation in the ejaculates of males with spinal cord injuries.

Vargas-Baquero, Eduardo / Johnston, Stephen / Sánchez-Ramos, Antonio / Arévalo-Martín, Angel / Wilson, Richard / Gosálvez, Jaime

Spinal cord

2020 Volume 58, Issue 7, Page(s) 803–810

Abstract: Study design: Retrospective descriptive study.: Objectives: To determine the incidence and probable etiology of sperm DNA fragmentation (SDF) in a sample of males with spinal cord injury (SCI).: Setting: Hospital in Toledo, Spain; University-based ...

Abstract	Study design: Retrospective descriptive study. Objectives: To determine the incidence and probable etiology of sperm DNA fragmentation (SDF) in a sample of males with spinal cord injury (SCI). Setting: Hospital in Toledo, Spain; University-based Genetics laboratory in Madrid, Spain. Methods: Semen collected by vibro-stimulation from 27 males with various levels of spinal cord injury. Classical semen parameters, SDF, leukocytospermia and pro-oxidant capacity were assessed and compared with a cohort of normozoospermic fertile donors (n = 10). Results: Males with SCI presented with lower semen quality compared with normozoospermic donors with respect to progressive motility (p = 0.0002), SDF (p < 0.00005), pro-oxidant capacity (p = 0.0191) and leukocytospermia (p < 0.00005). Although there was no significant correlation between semen quality and time since the lesion occurred, the period of abstinence appeared to be positively correlated with SDF (r = 0.486; p = 0.041). When the semen parameters of males with SCI were categorized based on those with cervical and thoracic lesions, sperm concentration was higher for those with cervical damage (p = 0.0257). Males with complete lesions (AIS A) had ejaculates that were lower in progressive motility (p = 0.0040) than those with incomplete injuries (AIS B-D). Conclusions: Ejaculates of males with SCI have excessively elevated SDF when compared with normozoospermic donors, which is likely to be associated with coincident high levels of leucocytospermia and pro-oxidant capacity. We propose that these phenomena are caused by the accumulation and degeneration of spermatozoa in the cauda epididymidis.
MeSH term(s)	Adult ; Cervical Cord/injuries ; DNA Fragmentation ; Humans ; Incidence ; Infertility, Male/epidemiology ; Infertility, Male/etiology ; Male ; Retrospective Studies ; Semen/cytology ; Semen/metabolism ; Semen Analysis ; Sperm Motility/physiology ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/pathology ; Thoracic Vertebrae/injuries
Language	English
Publishing date	2020-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1316161-1
ISSN	1476-5624 ; 1362-4393
ISSN (online)	1476-5624
ISSN	1362-4393
DOI	10.1038/s41393-020-0426-6
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Zs.A 198: Show issues

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Article ; Online: Endocannabinoid signaling in oligodendroglia.

Molina-Holgado, Eduardo / Esteban, Pedro F / Arevalo-Martin, Ángel / Moreno-Luna, Rafael / Molina-Holgado, Francisco / Garcia-Ovejero, Daniel

Glia

2022 Volume 71, Issue 1, Page(s) 91–102

Abstract: In the central nervous system, oligodendrocytes synthesize the myelin, a specialized membrane to wrap axons in a discontinuous way allowing a rapid saltatory nerve impulse conduction. Oligodendrocytes express a number of growth factors and ... ...

Abstract	In the central nervous system, oligodendrocytes synthesize the myelin, a specialized membrane to wrap axons in a discontinuous way allowing a rapid saltatory nerve impulse conduction. Oligodendrocytes express a number of growth factors and neurotransmitters receptors that allow them to sense the environment and interact with neurons and other glial cells. Depending on the cell cycle stage, oligodendrocytes may respond to these signals by regulating their survival, proliferation, migration, and differentiation. Among these signals are the endocannabinoids, lipidic molecules synthesized from phospholipids in the plasma membrane in response to cell activation. Here, we discuss the evidence showing that oligodendrocytes express a full endocannabinoid signaling machinery involved in physiological oligodendrocyte functions that can be therapeutically exploited to promote remyelination in central nervous system pathologies.
MeSH term(s)	Endocannabinoids/metabolism ; Oligodendroglia/metabolism ; Myelin Sheath/metabolism ; Axons/metabolism ; Central Nervous System/metabolism ; Cell Differentiation/physiology
Chemical Substances	Endocannabinoids
Language	English
Publishing date	2022-04-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639414-0
ISSN	1098-1136 ; 0894-1491
ISSN (online)	1098-1136
ISSN	0894-1491
DOI	10.1002/glia.24180
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Zs.A 2345: Show issues

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Article ; Online: Subarachnoid Fibrosis in Human Post-Traumatic Syringomyelia: A Prospective Observational Clinical Study.

Grassner, Lukas / Riemenschneider, Markus J / Altendorfer, Barbara / Grillhösl, Andreas / Arevalo-Martin, Angel / Garcia-Ovejero, Daniel / Mach, Orpheus / Maier, Doris / Bierschneider, Michael / Strowitzki, Martin / Thomé, Claudius / Aigner, Ludwig

Journal of neuropathology and experimental neurology

2022 Volume 81, Issue 2, Page(s) 149–153

MeSH term(s)	Adult ; Aged ; Fibrosis ; Humans ; Male ; Middle Aged ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/pathology ; Subarachnoid Space/pathology ; Syringomyelia/etiology ; Syringomyelia/pathology
Language	English
Publishing date	2022-01-29
Publishing country	England
Document type	Letter ; Observational Study
ZDB-ID	3088-0
ISSN	1554-6578 ; 0022-3069
ISSN (online)	1554-6578
ISSN	0022-3069
DOI	10.1093/jnen/nlab121
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Ui II Zs.134: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Ui II Zs.194: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Trajectory of Serum Levels of Glial Fibrillary Acidic Protein Within Four Weeks Post-Injury Is Related to Neurological Recovery During the Transition from Acute to Chronic Spinal Cord Injury.

Leister, Iris / Altendorfer, Barbara / Maier, Doris / Mach, Orpheus / Wutte, Christof / Grillhösl, Andreas / Arevalo-Martin, Angel / Garcia-Ovejero, Daniel / Aigner, Ludwig / Grassner, Lukas

Journal of neurotrauma

2022 Volume 40, Issue 9-10, Page(s) 999–1006

Abstract: The use of biomarkers in spinal cord injury (SCI) research has evolved rapidly in recent years whereby most studies focused on the acute post-injury phase. Since SCI is characterized by persisting neurological impairments, the question arises whether ... ...

Abstract	The use of biomarkers in spinal cord injury (SCI) research has evolved rapidly in recent years whereby most studies focused on the acute post-injury phase. Since SCI is characterized by persisting neurological impairments, the question arises whether blood biomarkers remain altered during the subacute post-injury time. Sample collection in the subacute phase might provide a better insight in the ongoing SCI specific molecular mechanism with fewer confounding factors compared with the acute phase where, amongst other complications, individuals receive a substantial amount of medication. This study aimed to determine if the temporal dynamics of serum biomarkers of neurodegeneration differ between individuals depending on their extent of neurological recovery in the transition phase between acute and chronic SCI. We performed a secondary analysis of biomarkers in patients with SCI (
MeSH term(s)	Humans ; Glial Fibrillary Acidic Protein ; Intermediate Filaments ; Spinal Cord Injuries ; Biomarkers ; Neurofilament Proteins
Chemical Substances	Glial Fibrillary Acidic Protein ; Biomarkers ; Neurofilament Proteins
Language	English
Publishing date	2022-12-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2022.0326
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Zs.A 2016: Show issues

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Article ; Online: Heterogeneity of the Endocannabinoid System Between Cerebral Cortex and Spinal Cord Oligodendrocytes.

Moreno-Luna, R / Esteban, P F / Paniagua-Torija, B / Arevalo-Martin, A / Garcia-Ovejero, D / Molina-Holgado, E

Molecular neurobiology

2020 Volume 58, Issue 2, Page(s) 689–702

Abstract: In the last years, regional differences have been reported between the brain and spinal cord oligodendrocytes, which should be considered when designing therapeutic strategies for myelin repair. Promising targets to achieve myelin restoration are the ... ...

Abstract	In the last years, regional differences have been reported between the brain and spinal cord oligodendrocytes, which should be considered when designing therapeutic strategies for myelin repair. Promising targets to achieve myelin restoration are the different components of the endocannabinoid system (ECS) that modulate oligodendrocyte biology, but almost all studies have been focused on brain-derived cells. Therefore, we compared the ECS between the spinal cord and cerebral cortex-derived oligodendrocyte precursor cells (OPCs) and mature oligodendrocytes (OLs). Cells from both regions express synthesizing and degrading enzymes for the endocannabinoid 2-arachidonoylglycerol, and degrading enzymes increase with maturation, more notably in the spinal cord (monoglyceride lipase-MGLL, alpha/beta hydrolase domain-containing 6-ABHD6, and alpha/beta hydrolase domain-containing 12-ABHD12). In addition, spinal cord OPCs express higher levels of the synthesizing enzymes diacylglycerol lipases alpha (DAGLA) and beta (DAGLB) than cortical ones, DAGLA reaching statistical significance. Cells from both the cortex and spinal cord express low levels of NAEs synthesizing enzymes, except for the glycerophosphodiester phosphodiesterase 1 (GDE-1) but high levels of the degrading enzyme fatty acid amidohydrolase (FAAH) that increases with maturation. Finally, cells from both regions show similar levels of CB
MeSH term(s)	Animals ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Cerebral Cortex/metabolism ; Endocannabinoids/metabolism ; Female ; Male ; Oligodendroglia/cytology ; Oligodendroglia/metabolism ; Rats, Wistar ; Receptors, Cannabinoid/metabolism ; Spheroids, Cellular/metabolism ; Spinal Cord/metabolism ; Rats
Chemical Substances	Endocannabinoids ; Receptors, Cannabinoid
Language	English
Publishing date	2020-10-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-020-02148-1
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Zs.A 2411: Show issues

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Article ; Online: Cannabinoids to treat spinal cord injury.

Arevalo-Martin, Angel / Molina-Holgado, Eduardo / Garcia-Ovejero, Daniel

Progress in neuro-psychopharmacology & biological psychiatry

2016 Volume 64, Page(s) 190–199

Abstract: Spinal cord injury (SCI) is a devastating condition for which there is no standard treatment beyond rehabilitation strategies. In this review, we discuss the current knowledge on the use of cannabinoids to treat this condition. The endocannabinoid system ...

Abstract	Spinal cord injury (SCI) is a devastating condition for which there is no standard treatment beyond rehabilitation strategies. In this review, we discuss the current knowledge on the use of cannabinoids to treat this condition. The endocannabinoid system is expressed in the intact spinal cord, and it is dramatically upregulated after lesion. Endogenous activation of this system counteracts secondary damage following SCI, and treatments with endocannabinoids or synthetic cannabinoid receptor agonists promote a better functional outcome in experimental models. The use of cannabinoids in SCI is a new research field and many questions remain open. Here, we discuss caveats and suggest some future directions that may help to understand the role of cannabinoids in SCI and how to take advantage of this system to regain functions after spinal cord damage.
MeSH term(s)	Animals ; Cannabinoids/therapeutic use ; Endocannabinoids/metabolism ; Humans ; Neuroprotective Agents/therapeutic use ; Spinal Cord/drug effects ; Spinal Cord/metabolism ; Spinal Cord Injuries/drug therapy ; Spinal Cord Injuries/metabolism
Chemical Substances	Cannabinoids ; Endocannabinoids ; Neuroprotective Agents
Language	English
Publishing date	2016-01-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2015.03.008
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Zs.A 1342: Show issues

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Article ; Online: Event-related potentials associated with attentional networks evidence changes in executive and arousal vigilance.

Luna, Fernando Gabriel / Aguirre, María Julieta / Martín-Arévalo, Elisa / Ibáñez, Agustín / Lupiáñez, Juan / Barttfeld, Pablo

Psychophysiology

2023 Volume 60, Issue 8, Page(s) e14272

Abstract: Attention is regulated by three independent but interacting networks, that is, alerting, comprising phasic alertness and vigilance, orienting, and executive control. Previous studies analyzing event-related potentials (ERPs) associated with attentional ... ...

Abstract	Attention is regulated by three independent but interacting networks, that is, alerting, comprising phasic alertness and vigilance, orienting, and executive control. Previous studies analyzing event-related potentials (ERPs) associated with attentional networks have focused on phasic alertness, orienting, and executive control, without an independent measure of vigilance. ERPs associated with vigilance have been instead measured in separate studies and via different tasks. The present study aimed to differentiate ERPs associated with attentional networks by simultaneously measuring vigilance along with phasic alertness, orienting, and executive control. Forty participants (34 women, age: M = 25.96; SD = 4.96) completed two sessions wherein the electroencephalogram was recorded while they completed the Attentional Networks Test for Interactions and Vigilance-executive and arousal components, a task that measures phasic alertness, orienting, and executive control along with executive (i.e., detection of infrequent critical signals) and arousal (i.e., sustaining a fast reaction to environmental stimuli) vigilance. ERPs previously associated with attentional networks were replicated here: (a) N1, P2, and contingent negative variation for phasic alertness; (b) P1, N1, and P3 for orienting; and (c) N2 and slow positivity for executive control. Importantly, different ERPs were associated with vigilance: while the executive vigilance decrement was associated with an increase in P3 and slow positivity across time-on-task, arousal vigilance loss was associated with reduced N1 and P2 amplitude. The present study shows that attentional networks can be described by different ERPs simultaneously observed in a single session, including independent measures of executive and arousal vigilance on its assessment.
MeSH term(s)	Humans ; Female ; Reaction Time ; Psychomotor Performance ; Attention ; Arousal ; Executive Function ; Evoked Potentials
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	209486-1
ISSN	1540-5958 ; 0048-5772
ISSN (online)	1540-5958
ISSN	0048-5772
DOI	10.1111/psyp.14272
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Article ; Online: Serum Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein Are Related to the Neurological Impairment and Spinal Edema after Traumatic Spinal Cord Injury.

Leister, Iris / Altendorfer, Barbara / Maier, Doris / Mach, Orpheus / Wutte, Christof / Grillhösl, Andreas / Arevalo-Martin, Angel / Garcia-Ovejero, Daniel / Aigner, Ludwig / Grassner, Lukas

Journal of neurotrauma

2021 Volume 38, Issue 24, Page(s) 3431–3439

Abstract: Neurological examination in the acute phase after spinal cord injury (SCI) is often impossible and severely confounded by pharmacological sedation or concomitant injuries. Therefore, diagnostic biomarkers that objectively characterize severity or the ... ...

Abstract	Neurological examination in the acute phase after spinal cord injury (SCI) is often impossible and severely confounded by pharmacological sedation or concomitant injuries. Therefore, diagnostic biomarkers that objectively characterize severity or the presence of SCI are urgently needed to facilitate clinical decision-making. This study aimed to determine if serum markers of neural origin are related to: 1) presence and severity of SCI, and 2) magnetic resonance imaging (MRI) parameters in the very acute post-injury phase. We performed a secondary analysis of serological parameters, as well as MRI findings in patients with acute SCI (
MeSH term(s)	Adult ; Aged ; Case-Control Studies ; Edema/blood ; Edema/etiology ; Female ; Glial Fibrillary Acidic Protein/blood ; Humans ; Male ; Middle Aged ; Neurofilament Proteins/blood ; Phosphopyruvate Hydratase/blood ; Spinal Cord Injuries/blood ; Spinal Cord Injuries/complications ; Time Factors
Chemical Substances	GFAP protein, human ; Glial Fibrillary Acidic Protein ; Neurofilament Proteins ; neurofilament protein L ; ENO2 protein, human (EC 4.2.1.11) ; Phosphopyruvate Hydratase (EC 4.2.1.11)
Language	English
Publishing date	2021-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2021.0264
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Zs.A 2016: Show issues

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Article ; Online: The Structure of the Spinal Cord Ependymal Region in Adult Humans Is a Distinctive Trait among Mammals.

Torrillas de la Cal, Alejandro / Paniagua-Torija, Beatriz / Arevalo-Martin, Angel / Faulkes, Christopher Guy / Jiménez, Antonio Jesús / Ferrer, Isidre / Molina-Holgado, Eduardo / Garcia-Ovejero, Daniel

Cells

2021 Volume 10, Issue 9

Abstract: In species that regenerate the injured spinal cord, the ependymal region is a source of new cells and a prominent coordinator of regeneration. In mammals, cells at the ependymal region proliferate in normal conditions and react after injury, but in ... ...

Abstract	In species that regenerate the injured spinal cord, the ependymal region is a source of new cells and a prominent coordinator of regeneration. In mammals, cells at the ependymal region proliferate in normal conditions and react after injury, but in humans, the central canal is lost in the majority of individuals from early childhood. It is replaced by a structure that does not proliferate after damage and is formed by large accumulations of ependymal cells, strong astrogliosis and perivascular pseudo-rosettes. We inform here of two additional mammals that lose the central canal during their lifetime: the Naked Mole-Rat (NMR,
MeSH term(s)	Adolescent ; Adult ; Animals ; Biomarkers/metabolism ; Cell Proliferation ; Ependyma/cytology ; Ependyma/metabolism ; Female ; Humans ; Macaca mulatta ; Male ; Mice, Mutant Strains ; Middle Aged ; Mole Rats ; Pan troglodytes ; Point Mutation ; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins/genetics ; Species Specificity ; Spinal Canal/cytology ; Spinal Canal/metabolism ; Spinal Cord/cytology ; Spinal Cord/metabolism ; Spinal Cord Injuries/metabolism ; Spinal Cord Injuries/pathology ; Young Adult ; Mice
Chemical Substances	Biomarkers ; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins
Language	English
Publishing date	2021-08-28
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10092235
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Article ; Online: Post-COVID Complications after Pressure Ulcer Surgery in Patients with Spinal Cord Injury Associate with Creatine Kinase Upregulation in Adipose Tissue.

Martínez-Torija, Mario / Esteban, Pedro F / Espino-Rodríguez, Francisco Javier / Paniagua-Torija, Beatriz / Molina-Holgado, Eduardo / Ceruelo, Silvia / Barroso-Garcia, Gemma / Arandilla, Alba G / Lopez-Almodovar, Luis F / Arevalo-Martin, Angel / Moreno, Juan Antonio / Garcia-Ovejero, Daniel / Durán-Ruiz, Mª Carmen / Moreno-Luna, Rafael

Cells

2022 Volume 11, Issue 8

Abstract: The risk of complications following surgical procedures is significantly increased in patients with SARS-CoV-2 infection. However, the mechanisms underlying these correlations are not fully known. Spinal cord injury (SCI) patients who underwent ... ...

Abstract	The risk of complications following surgical procedures is significantly increased in patients with SARS-CoV-2 infection. However, the mechanisms underlying these correlations are not fully known. Spinal cord injury (SCI) patients who underwent reconstructive surgery for pressure ulcers (PUs) before and during the COVID-19 pandemic were included in this study. The patient's postoperative progression was registered, and the subcutaneous white adipose tissue (s-WAT) surrounding the ulcers was analyzed by proteomic and immunohistochemical assays to identify the molecular/cellular signatures of impaired recovery. Patients with SCI and a COVID-19-positive diagnosis showed worse recovery and severe postoperative complications, requiring reintervention. Several proteins were upregulated in the adipose tissue of these patients. Among them, CKMT2 and CKM stood out, and CKM increased for up to 60 days after the COVID-19 diagnosis. Moreover, CKMT2 and CKM were largely found in MGCs within the s-WAT of COVID patients. Some of these proteins presented post-translational modifications and were targeted by autoantibodies in the serum of COVID patients. Overall, our results indicate that CKMT2, CKM, and the presence of MGCs in the adipose tissue surrounding PUs in post-COVID patients could be predictive biomarkers of postsurgical complications. These results suggest that the inflammatory response in adipose tissue may underlie the defective repair seen after surgery.
MeSH term(s)	Adipose Tissue/metabolism ; COVID-19/complications ; COVID-19 Testing ; Creatine Kinase/metabolism ; Creatine Kinase, Mitochondrial Form/metabolism ; Humans ; Pandemics ; Pressure Ulcer/epidemiology ; Pressure Ulcer/etiology ; Pressure Ulcer/surgery ; Proteomics ; SARS-CoV-2 ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/surgery ; Suppuration/complications ; Up-Regulation
Chemical Substances	CKMT2 protein, human (EC 2.7.3.2) ; Creatine Kinase (EC 2.7.3.2) ; Creatine Kinase, Mitochondrial Form (EC 2.7.3.2)
Language	English
Publishing date	2022-04-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11081282
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