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Article ; Online: A Named Entity Recognition Model Based on Multi-Task Learning and Cascading Pointer Network

Geng Chaoyang / Liu Peng / Li Yi / Zhao Jiejie

International Journal of Advanced Network, Monitoring, and Controls, Vol 7, Iss 3, Pp 52-

2023 Volume 62

Abstract: Because, the existing named entity recognition models lack the Specificity of the field, and most of their combine the prediction of entity Location and entity category, which results in the accumulation of errors. So, named entity recognition model ... ...

Abstract	Because, the existing named entity recognition models lack the Specificity of the field, and most of their combine the prediction of entity Location and entity category, which results in the accumulation of errors. So, named entity recognition model based on multi-task learning and pointer network is proposed, and innovations are made in the task Construction and domain entity information utilization in the model of Named entity recognition. This model is based on Transformer with multi-Head attention mechanism, and decomposes traditional tasks in entity recognition tasks and entity classification tasks, and carries out multi-tasks Task learning to reduce the accumulation of errors between tasks. Model in this paper also uses the similarity calculation based on the Comprehensive description of the entity category in entity classification Task for better pertinence of the domain entity. Experiments are conducted on public datasets and domain datasets to prove the advancement of the Model.
Keywords	named entity recognition ; multi-tasks task learning ; transformer ; Computer engineering. Computer hardware ; TK7885-7895 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	006
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article ; Online: Research on Extraction Method of Financial Knowledge Based on How Net

Geng Chaoyang / Zhao JieJie / Liu Peng / Yang Dan

International Journal of Advanced Network, Monitoring, and Controls, Vol 8, Iss 1, Pp 50-

2023 Volume 57

Abstract: In order to obtain the knowledge information of financial texts more efficiently and make the extracted information such as entity relation attribute more accurate, this paper studies the grammatical features of financial news texts and the semantic ... ...

Abstract	In order to obtain the knowledge information of financial texts more efficiently and make the extracted information such as entity relation attribute more accurate, this paper studies the grammatical features of financial news texts and the semantic features of How Net, and puts forward the scheme of financial information extraction based on How Net. First, the phrase matching is carried out in the dictionary. Then the neural network is used for weighting, BiLSTM is used for character vector feature enhancement training, and then conditional random field (CRF) is used to complete named entity recognition, and then the relationship extraction of entity pairs from the dependency syntax is carried out to complete the research on the construction method of knowledge extraction of text in the financial field. The experimental results show that this model is superior to the other three models in entity recognition, and the overall performance is improved by about 1.2%. In relation extraction, the accuracy and recall rate of the model algorithm adopted in this paper are improved by 5% and 1.5% respectively, which shows that the improvement of the algorithm is effective.
Keywords	named entity identification in the financial sector ; relation extraction ; how net ; Computer engineering. Computer hardware ; TK7885-7895 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	006
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article: Founder Effects Contribute to the Population Genetic Structure of the Major Dermatophytosis Pathogen

Geng, Yuanyuan / Wu, Weiwei / Li, Rouyu / Xu, Juan / Gu, Ruixue / Lu, Jiejie / Zheng, Wenai / Zhao, Fei / Zhang, Jianzhong / Gong, Jie

Clinical, cosmetic and investigational dermatology

2021 Volume 14, Page(s) 1569–1577

Abstract: Background: Founder events have been observed among numerous plants and animal species living on oceanic islands due to the geographic separation of these islands and the small amount of original life they harbor. However, there has been little research ...

Abstract	Background: Founder events have been observed among numerous plants and animal species living on oceanic islands due to the geographic separation of these islands and the small amount of original life they harbor. However, there has been little research on the ecological characteristics of pathogenic microorganisms on islands. Objective: To study the phylogenetic characteristics and the distribution pattern of genetic polymorphism of Methods: In the present study, we sequenced and analyzed the genetic characteristics of 204 Results: The majority of the isolates from Hainan Island clustered together. Mixed Conclusion: This study is the first to discuss general ecological and evolutionary principles related to pathogenic fungi. Our findings reveal a founder effect during the origination of
Language	English
Publishing date	2021-10-27
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S329569
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Article ; Online: NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury.

Feng, Zhuan / Qin, Yifei / Huo, Fei / Jian, Zhe / Li, Xiaomin / Geng, Jiejie / Li, Yong / Wu, Jiao

Biochimica et biophysica acta. Molecular basis of disease

2021 Volume 1868, Issue 1, Page(s) 166287

Abstract: Oxidative stress and lipid peroxidation are major causes of skin injury induced by ultraviolet (UV) irradiation. Ferroptosis is a form of regulated necrosis driven by iron-dependent peroxidation of phospholipids and contributes to kinds of tissue ... ...

Abstract	Oxidative stress and lipid peroxidation are major causes of skin injury induced by ultraviolet (UV) irradiation. Ferroptosis is a form of regulated necrosis driven by iron-dependent peroxidation of phospholipids and contributes to kinds of tissue injuries. However, it remains unclear whether the accumulation of lipid peroxides in UV irradiation-induced skin injury could lead to ferroptosis. We generated UV irradiation-induced skin injury mice model to examine the accumulation of the lipid peroxides and iron. Lipid peroxides 4-HNE, the oxidative enzyme COX2, the oxidative DNA damage biomarker 8-OHdG, and the iron level were increased in UV irradiation-induced skin. The accumulation of iron and lipid peroxidation was also observed in UVB-irradiated epidermal keratinocytes without actual ongoing ferroptotic cell death. Ferroptosis was triggered in UV-irradiated keratinocytes stimulated with ferric ammonium citrate (FAC) to mimic the iron overload. Although GPX4 protected UVB-injured keratinocytes against ferroptotic cell death resulted from dysregulation of iron metabolism and the subsequent increase of lipid ROS, keratinocytes enduring constant UVB treatment were markedly sensitized to ferroptosis. Nicotinamide mononucleotide (NMN) which is a direct and potent NAD
MeSH term(s)	8-Hydroxy-2'-Deoxyguanosine/pharmacology ; Aldehydes/pharmacology ; Animals ; Cyclooxygenase 2/genetics ; DNA Damage/drug effects ; DNA Damage/radiation effects ; Ferric Compounds/pharmacology ; Ferroptosis/drug effects ; Ferroptosis/radiation effects ; Glutathione/genetics ; Humans ; Iron/metabolism ; Keratinocytes/drug effects ; Keratinocytes/radiation effects ; Lipid Peroxidation/drug effects ; Lipid Peroxidation/radiation effects ; Lipid Peroxides/pharmacology ; Mice ; Nicotinamide Mononucleotide/pharmacology ; Oxidative Stress/drug effects ; Oxidative Stress/genetics ; Oxidative Stress/radiation effects ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics ; Quaternary Ammonium Compounds/pharmacology ; Skin/drug effects ; Skin/injuries ; Skin/metabolism ; Skin/pathology ; Ultraviolet Rays/adverse effects
Chemical Substances	Aldehydes ; Ferric Compounds ; Lipid Peroxides ; Quaternary Ammonium Compounds ; Nicotinamide Mononucleotide (1094-61-7) ; 8-Hydroxy-2'-Deoxyguanosine (88847-89-6) ; Iron (E1UOL152H7) ; Phospholipid Hydroperoxide Glutathione Peroxidase (EC 1.11.1.12) ; glutathione peroxidase 4, mouse (EC 1.11.1.9) ; Ptgs2 protein, mouse (EC 1.14.99.-) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Glutathione (GAN16C9B8O) ; 4-hydroxy-2-nonenal (K1CVM13F96) ; ferric ammonium citrate (UVP74NG1C5)
Language	English
Publishing date	2021-10-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbadis.2021.166287
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Article ; Online: TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models

Jiao Wu / Zhuan Feng / Liang Chen / Yong Li / Huijie Bian / Jiejie Geng / Zhao-Hui Zheng / Xianghui Fu / Zhuo Pei / Yifei Qin / Liu Yang / Yilin Zhao / Ke Wang / Ruo Chen / Qian He / Gang Nan / Xuejun Jiang / Zhi-Nan Chen / Ping Zhu

Nature Communications, Vol 13, Iss 1, Pp 1-

2022 Volume 16

Abstract: Expansion of synovial fibroblast is associated with rheumatoid arthritis (RA) progression, but how this expansion is regulated is still not clear. Here the authors use a mouse RA model, single cell RNA sequencing and in vitro analyses to show that ... ...

Abstract	Expansion of synovial fibroblast is associated with rheumatoid arthritis (RA) progression, but how this expansion is regulated is still not clear. Here the authors use a mouse RA model, single cell RNA sequencing and in vitro analyses to show that inducing ferroptosis and suppressing TNF signaling reduce fibroblast numbers and ameliorate experimental arthritis.
Keywords	Science ; Q
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models.

Wu, Jiao / Feng, Zhuan / Chen, Liang / Li, Yong / Bian, Huijie / Geng, Jiejie / Zheng, Zhao-Hui / Fu, Xianghui / Pei, Zhuo / Qin, Yifei / Yang, Liu / Zhao, Yilin / Wang, Ke / Chen, Ruo / He, Qian / Nan, Gang / Jiang, Xuejun / Chen, Zhi-Nan / Zhu, Ping

Nature communications

2022 Volume 13, Issue 1, Page(s) 676

Abstract: Ferroptosis is a nonapoptotic cell death process that requires cellular iron and the accumulation of lipid peroxides. In progressive rheumatoid arthritis (RA), synovial fibroblasts proliferate abnormally in the presence of reactive oxygen species (ROS) ... ...

Abstract	Ferroptosis is a nonapoptotic cell death process that requires cellular iron and the accumulation of lipid peroxides. In progressive rheumatoid arthritis (RA), synovial fibroblasts proliferate abnormally in the presence of reactive oxygen species (ROS) and elevated lipid oxidation. Here we show, using a collagen-induced arthritis (CIA) mouse model, that imidazole ketone erastin (IKE), a ferroptosis inducer, decreases fibroblast numbers in the synovium. Data from single-cell RNA sequencing further identify two groups of fibroblasts that have distinct susceptibility to IKE-induced ferroptosis, with the ferroptosis-resistant fibroblasts associated with an increased TNF-related transcriptome. Mechanistically, TNF signaling promotes cystine uptake and biosynthesis of glutathione (GSH) to protect fibroblasts from ferroptosis. Lastly, low dose IKE together with etanercept, a TNF antagonist, induce ferroptosis in fibroblasts and attenuate arthritis progression in the CIA model. Our results thus imply that the combination of TNF inhibitors and ferroptosis inducers may serve as a potential candidate for RA therapy.
MeSH term(s)	Animals ; Arthritis, Experimental/genetics ; Arthritis, Experimental/metabolism ; Arthritis, Experimental/prevention & control ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/metabolism ; Arthritis, Rheumatoid/prevention & control ; Cells, Cultured ; Disease Models, Animal ; Drug Therapy, Combination ; Etanercept/pharmacology ; Etanercept/therapeutic use ; Ferroptosis/drug effects ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Glutathione/metabolism ; Humans ; Imidazoles/pharmacology ; Imidazoles/therapeutic use ; Ketones/pharmacology ; Ketones/therapeutic use ; Lipid Peroxidation/drug effects ; Mice ; Piperazines/pharmacology ; Piperazines/therapeutic use ; Reactive Oxygen Species/metabolism ; Synovial Membrane/cytology ; Tumor Necrosis Factor Inhibitors/pharmacology ; Tumor Necrosis Factor Inhibitors/therapeutic use
Chemical Substances	Imidazoles ; Ketones ; Piperazines ; Reactive Oxygen Species ; Tumor Necrosis Factor Inhibitors ; imidazole ketone erastin ; Glutathione (GAN16C9B8O) ; Etanercept (OP401G7OJC)
Language	English
Publishing date	2022-02-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-27948-4
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Article ; Online: CD98-induced CD147 signaling stabilizes the Foxp3 protein to maintain tissue homeostasis.

Geng, JieJie / Chen, Ruo / Yang, Feng-Fan / Lin, Peng / Zhu, Yu-Meng / Fu, Xianghui / Wang, Ke / Feng, Zhuan / Wu, Jiao / Zhang, Hai / Li, Qi-Jing / Chen, Zhi-Nan / Zhu, Ping

Cellular & molecular immunology

2021 Volume 18, Issue 12, Page(s) 2618–2631

Abstract: Regulatory T cell (Treg) stability is necessary for the proper control of immune activity and tissue homeostasis. However, it remains unclear whether Treg stability must be continually reinforced or is established during development under physiological ... ...

Abstract	Regulatory T cell (Treg) stability is necessary for the proper control of immune activity and tissue homeostasis. However, it remains unclear whether Treg stability must be continually reinforced or is established during development under physiological conditions. Foxp3 has been characterized as a central mediator of the genetic program that governs Treg stability. Here, we demonstrate that to maintain Foxp3 protein expression, Tregs require cell-to-cell contact, which is mediated by the CD147-CD98 interaction. As Tregs are produced, CD147, which is expressed on their surface, is stimulated by CD98, which is widely expressed in the physiological environment. As a result, CD147's intracellular domain binds to CDK2 and retains it near the membrane, leading to Foxp3 dephosphorylation and the prevention of Foxp3 degradation. In addition, the optimal distribution of Foxp3+ Tregs under both pathological and physiological conditions depends on CD98 expression. Thus, our study provides direct evidence that Foxp3-dependent Treg stability is reinforced in the periphery by the interaction between CD147 and CD98 in the surrounding environment. More importantly, Tregs with high CD147 expression effectively inhibit inflammatory responses and maintain Foxp3 stability, which has guiding significance for the application of Tregs in immunotherapy.
MeSH term(s)	Animals ; Basigin/metabolism ; Forkhead Transcription Factors/metabolism ; Fusion Regulatory Protein-1/metabolism ; Homeostasis/genetics ; Humans ; Immunotherapy ; Mice ; Signal Transduction ; T-Lymphocytes, Regulatory
Chemical Substances	FOXP3 protein, human ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; Fusion Regulatory Protein-1 ; Basigin (136894-56-9)
Language	English
Publishing date	2021-11-10
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2435097-7
ISSN	2042-0226 ; 1672-7681
ISSN (online)	2042-0226
ISSN	1672-7681
DOI	10.1038/s41423-021-00785-7
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Article ; Online: CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis.

Wu, Jiao / Chen, Liang / Qin, Chuan / Huo, Fei / Liang, Xue / Yang, Xu / Zhang, Kui / Lin, Peng / Liu, Jiangning / Feng, Zhuan / Zhou, Jiansheng / Pei, Zhuo / Wang, Yatao / Sun, Xiu-Xuan / Wang, Ke / Geng, Jiejie / Zheng, Zhaohui / Fu, Xianghui / Liu, Man /

Wang, Qingyi / Zhang, Zheng / Bian, Huijie / Zhu, Ping / Chen, Zhi-Nan

Signal transduction and targeted therapy

2022 Volume 7, Issue 1, Page(s) 382

Abstract: COVID-19 patients can develop clinical and histopathological features associated with fibrosis, but the pathogenesis of fibrosis remains poorly understood. CD147 has been identified as a universal receptor for SARS-CoV-2 and its variants, which could ... ...

Abstract	COVID-19 patients can develop clinical and histopathological features associated with fibrosis, but the pathogenesis of fibrosis remains poorly understood. CD147 has been identified as a universal receptor for SARS-CoV-2 and its variants, which could initiate COVID-19-related cytokine storm. Here, we systemically analyzed lung pathogenesis in SARS-CoV-2- and its delta variant-infected humanized CD147 transgenic mice. Histopathology and Transmission Electron Microscopy revealed inflammation, fibroblast expansion and pronounced fibrotic remodeling in SARS-CoV-2-infected lungs. Consistently, RNA-sequencing identified a set of fibrosis signature genes. Furthermore, we identified CD147 as a crucial regulator for fibroblast activation induced by SARS-CoV-2. We found conditional knockout of CD147 in fibroblast suppressed activation of fibroblasts, decreasing susceptibility to bleomycin-induced pulmonary fibrosis. Meplazumab, a CD147 antibody, was able to inhibit the accumulation of activated fibroblasts and the production of ECM proteins, thus alleviating the progression of pulmonary fibrosis caused by SARS-CoV-2. In conclusion, we demonstrated that CD147 contributed to SARS-CoV-2-triggered progressive pulmonary fibrosis and identified CD147 as a potential therapeutic target for treating patients with post-COVID-19 pulmonary fibrosis.
MeSH term(s)	Mice ; Animals ; Pulmonary Fibrosis/genetics ; SARS-CoV-2 ; COVID-19/genetics
Chemical Substances	meplazumab (0EL07E29VQ)
Language	English
Publishing date	2022-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2886872-9
ISSN	2059-3635 ; 2095-9907
ISSN (online)	2059-3635
ISSN	2095-9907
DOI	10.1038/s41392-022-01230-5
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Article ; Online: Immunological and metabolic characteristics of the Omicron variants infection.

Geng, Jiejie / Yang, Xu / Wang, Kun / Wang, Ke / Chen, Ruo / Chen, Zhi-Nan / Qin, Chuan / Wu, Guizhen / Wang, Youchun / Xu, Ke / Du, Peng / Liu, Jiangning / Chen, Shirui / Zhang, Tao / Sun, Xiuxuan / Guo, Ting / Shi, Ying / Zhang, Zheng / Wei, Ding /

Lin, Peng / Wang, Qingyi / Yuan, Jing / Qu, Jiuxin / Zou, Jin / Liu, Yingxia / Lu, Hongzhou / Zhu, Ping / Bian, Huijie / Chen, Liang

Signal transduction and targeted therapy

2023 Volume 8, Issue 1, Page(s) 42

Abstract: The Omicron variants of SARS-CoV-2, primarily authenticated in November 2021 in South Africa, has initiated the 5th wave of global pandemics. Here, we systemically examined immunological and metabolic characteristics of Omicron variants infection. We ... ...

Abstract	The Omicron variants of SARS-CoV-2, primarily authenticated in November 2021 in South Africa, has initiated the 5th wave of global pandemics. Here, we systemically examined immunological and metabolic characteristics of Omicron variants infection. We found Omicron resisted to neutralizing antibody targeting receptor binding domain (RBD) of wildtype SARS-CoV-2. Omicron could hardly be neutralized by sera of Corona Virus Disease 2019 (COVID-19) convalescents infected with the Delta variant. Through mass spectrometry on MHC-bound peptidomes, we found that the spike protein of the Omicron variants could generate additional CD8 + T cell epitopes, compared with Delta. These epitopes could induce robust CD8 + T cell responses. Moreover, we found booster vaccination increased the cross-memory CD8 + T cell responses against Omicron. Metabolic regulome analysis of Omicron-specific T cell showed a metabolic profile that promoted the response of memory T cells. Consistently, a greater fraction of memory CD8 + T cells existed in Omicron stimulated peripheral blood mononuclear cells (PBMCs). In addition, CD147 was also a receptor for the Omicron variants, and CD147 antibody inhibited infection of Omicron. CD147-mediated Omicron infection in a human CD147 transgenic mouse model induced exudative alveolar pneumonia. Taken together, our data suggested that vaccination booster and receptor blocking antibody are two effective strategies against Omicron.
MeSH term(s)	Humans ; Animals ; Mice ; COVID-19/genetics ; Leukocytes, Mononuclear ; SARS-CoV-2 ; Antibodies, Neutralizing ; Epitopes ; Mice, Transgenic
Chemical Substances	Antibodies, Neutralizing ; Epitopes
Language	English
Publishing date	2023-01-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2886872-9
ISSN	2059-3635 ; 2095-9907
ISSN (online)	2059-3635
ISSN	2095-9907
DOI	10.1038/s41392-022-01265-8
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Article ; Online: [Characteristic comparison of mouse primary macrophages cultured in L929 cell conditioned medium].

Wang, Wei / Qin, Yi / Wang, Yaru / Zou, Jiejie / Chen, Jing / Chen, Jinwu / Zhang, Yan / Geng, Ming / Xu, Zhongdong / Dai, Min / Pan, Lilong

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

2020 Volume 36, Issue 7, Page(s) 1431–1439

Abstract: The purpose of this study is to provide a culture for mouse bone marrow-derived macrophages (BMDM) and peritoneal macrophages (PM) and to characterize their molecular and cellular biology. The cell number and purity from the primary culture were assessed ...

Abstract	The purpose of this study is to provide a culture for mouse bone marrow-derived macrophages (BMDM) and peritoneal macrophages (PM) and to characterize their molecular and cellular biology. The cell number and purity from the primary culture were assessed by cell counter and flow cytometry, respectively. Morphological features were evaluated by inverted microscope. Phagocytosis by macrophages was detected by the neutral red dye uptake assay. Phenotypic markers were analyzed by real-time fluorescent quantitative PCR. Our results show that the cell number was much higher from culture of BMDM than PM, while there was no significant difference regarding the percentage of F4/80+CD11b+ cells (98.30%±0.53% vs. 94.83%±1.42%; P>0.05). The proliferation rate of BMDM was significantly higher than PM in the presence of L929 cell conditioned medium, by using CCK-8 assay. However, PM appeared to adhere to the flask wall and extend earlier than BMDM. The phagocytosis capability of un-stimulated BMDM was significantly higher than PM, as well as lipopolysaccharide (LPS)-stimulated BMDM, except the BMDM stimulated by low dose LPS (0.1 μg/mL). Furthermore, Tnfα expression was significantly higher in un-stimulated BMDM than PM, while Arg1 and Ym1 mRNA expression were significantly lower than PM. The expression difference was persistent if stimulated by LPS+IFN-γ or IL-4. Our data indicate that bone marrow can get larger amounts of macrophages than peritoneal cavity. However, it should be aware that the molecular and cellular characteristics were different between these two culture systems.
MeSH term(s)	Animals ; Bone Marrow Cells/physiology ; Cells, Cultured ; Culture Media, Conditioned ; Lipopolysaccharides/metabolism ; Macrophages/classification ; Macrophages/physiology ; Mice ; Phagocytosis
Chemical Substances	Culture Media, Conditioned ; Lipopolysaccharides
Language	Chinese
Publishing date	2020-08-04
Publishing country	China
Document type	Comparative Study ; Journal Article
ZDB-ID	1042206-7
ISSN	1872-2075 ; 1042-749X
ISSN (online)	1872-2075
ISSN	1042-749X
DOI	10.13345/j.cjb.190517
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